Article
Oncology
Lingli Long, Yue Hu, Tengfei Long, Xiaofang Lu, Ying Tuo, Yubing Li, Zunfu Ke
Summary: This study revealed a positive relationship between the formation of OvCa-TAMs spheroids and the malignancy of OvCa cells, with M2-TAMs inducing the epithelial-mesenchymal transition of OvCa cells through the release of CCL18. The overexpression of ZEB1 in OvCa cells in ovarian mice models promoted the formation of OvCa-TAMs spheroids in ascites, leading to faster transcoelomic metastasis.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Multidisciplinary Sciences
Huy Q. Dinh, Feng Pan, Geng Wang, Qing-Feng Huang, Claire E. Olingy, Zhi-Yong Wu, Shao-Hong Wang, Xin Xu, Xiu-E Xu, Jian-Zhong He, Qian Yang, Sandra Orsulic, Marcela Haro, Li-Yan Li, Guo-Wei Huang, Joshua J. Breunig, H. Phillip Koeffler, Catherine C. Hedrick, Li-Yan Xu, De-Chen Lin, En-Min Li
Summary: This study utilized single-cell RNA sequencing to characterize the heterogeneous microenvironment of ESCC, identifying a tumor-specific subset of CST1(+) myofibroblasts with prognostic values and immunosuppressive features. The analysis of stromal cell types in the ESCC microenvironment provides a rich resource for further understanding of ESCC biology.
NATURE COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Adele Chimento, Maria D'Amico, Vincenzo Pezzi, Francesca De Amicis
Summary: Dysregulation of the Notch signaling pathway promotes breast cancer progression through various mechanisms, including the maintenance of stem cells, cell proliferation, and migration/invasion. Additionally, Notch plays a crucial role in juxtracrine and paracrine communication between tumor and stroma. The complex interplay between the abnormal Notch pathway and the activation of other signals and cellular heterogeneity contributes to remodeling of the tumor microenvironment. These changes, along with tumor evolution and treatment pressure, drive breast cancer drug resistance. Preclinical studies have demonstrated that targeting the Notch pathway can prevent or reverse resistance and reduce or eliminate breast cancer stem cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Bing Qiao, Lei Chen, Qianwen Cheng, Guangqi Wang, Qun Li, Bo Zhang, Junying Li, Yu Hu, Chunyan Sun
Summary: The aberrant expression of CCL18 is an independent prognostic factor for multiple myeloma. High levels of CCL18 are associated with renal impairment, hypercalcemia, and a lower proportion of complete remission. The expression of CCL18 is also associated with the survival period of MM patients.
Review
Biochemistry & Molecular Biology
Francisco Sadras, Gregory R. Monteith, Sarah J. Roberts-Thomson
Summary: Tumors interact with their microenvironment, particularly with cancer-associated fibroblasts (CAFs), which play a significant role in supporting cancer development through various processes like cell-cell contact, paracrine signaling, and extracellular matrix remodeling. Calcium signaling, a key player in intra- and intercellular pathways, is less explored in connection with CAFs, but it contributes to cancer progression, especially in processes like migration, proliferation, chemoresistance, and genetic instability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Haimeng Yan, Donghua He, Jianwei Qu, Yang Liu, Ruyi Xu, Huiyao Gu, Jing Chen, Yi Li, Enfan Zhang, Yi Zhao, Jingsong He, Zhen Cai
Summary: IL-32 is highly expressed in relapsed MM patients and is associated with infiltration of M2 M phi. IL-32γ promotes M phi-mediated MM cell protection and induces polarization of M2 M phi partly through increasing CSF1 expression. These findings provide a crucial theoretical basis for targeted M phi immunotherapy.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Oncology
Gabriela A. Pizzurro, Chang Liu, Kathryn Bridges, Amanda F. Alexander, Alice Huang, Janani P. Baskaran, Julie Ramseier, Marcus W. Bosenberg, Michael Mak, Kathryn Miller-Jensen
Summary: The study developed a tumor-in-a-dish experimental system to investigate early events promoting tumor growth and immune suppression in metastatic melanoma. Through co-culturing murine melanoma tumor cells, fibroblasts, and macrophages in a 3D collagen matrix, the researchers found that macrophages acquired features consistent with those in in vivo melanoma tumors over 7 days. This system provides a platform for studying macrophage-stromal interactions in the melanoma microenvironment and testing potential therapies to stimulate immune activity in macrophages.
Article
Multidisciplinary Sciences
Roberta De Matteis, Magdalena B. Flak, Maria Gonzalez-Nunez, Shani Austin-Williams, Francesco Palmas, Romain A. Colas, Jesmond Dalli
Summary: Inflammation is linked to colorectal cancer, and aspirin mediates its immunomodulatory effects by increasing the concentration of aspirin-triggered specialized proresolving mediators (AT-SPM) and reducing the expression of programmed cell death protein-1. These findings reveal a central role for AT-SPM in regulating inflammation-associated colorectal cancer.
Article
Gastroenterology & Hepatology
Ashley Velez-Delgado, Katelyn L. Donahue, Kristee L. Brown, Wenting Du, Valerie Irizarry-Negron, Rosa E. Menjivar, Emily L. Lasse Opsahl, Nina G. Steele, Stephanie The, Jenny Lazarus, Veerin R. Sirihorachai, Wei Yan, Samantha B. Kemp, Samuel A. Kerk, Murali Bollampally, Sion Yang, Michael K. Scales, Faith R. Avritt, Fatima Lima, Costas A. Lyssiotis, Arvind Rao, Howard C. Crawford, Filip Bednar, Timothy L. Frankel, Benjamin L. Allen, Yaqing Zhang, Marina Pasca di Magliano
Summary: This study reveals that non-cell autonomous oncogenic KRAS signaling can reprogram pancreatic fibroblasts, leading to an inflammatory response and affecting the tumor microenvironment, thereby promoting tumor development.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Oncology
Luo-Jiao Liang, Yang Yang, Wen-Fei Wei, Xiang-Guang Wu, Rui-Ming Yan, Chen-Fei Zhou, Xiao-Jing Chen, Sha Wu, Wei Wang, Liang-Sheng Fan
Summary: In this study, it was found that Wnt2B secreted by cervical cancer cells promotes the activation of fibroblasts into cancer-associated fibroblasts (CAFs) through exosome-mediated transfer. The circulating exosomal Wnt2B also contributes to CAF conversion in vitro and is significantly elevated in cervical cancer patients. These findings provide insights for the development of diagnostic and therapeutic targets for cervical cancer progression.
Article
Medicine, Research & Experimental
Katayoon Pakravan, Majid Mossahebi-Mohammadi, Mohammad H. H. Ghazimoradi, William C. C. Cho, Majid Sadeghizadeh, Sadegh Babashah
Summary: This study investigated the role of cancer-associated fibroblasts (CAFs) in promoting breast cancer (BC) cell progression. The researchers found that CAFs recruited monocytes and induced the formation of pro-tumoral macrophages. Moreover, CAFs were also able to differentiate human monocytes into anti-inflammatory macrophages and increase reactive oxygen species (ROS) generation, which is required for proper macrophage polarization. Importantly, CAF-educated monocytes and their exosomes suppressed T-cell proliferation and promoted BC cell proliferation and migration. In addition, the authors observed an up-regulation of miR-181a in BC, which was positively correlated with tumor aggressiveness. They further demonstrated that miR-181a transfer from CAF-educated monocytes to BC cells through exosomes activated the AKT signaling pathway. These findings highlight the important role of CAFs in tumor progression and provide a potential therapeutic target for BC.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Ajay Dixit, Aaron Sarver, Jon Zettervall, Huocong Huang, Kexin Zheng, Rolf A. Brekken, Paolo P. Provenzano
Summary: Pancreatic ductal adenocarcinoma (PDA) is resistant to immune therapies due to its fibrotic and immunosuppressive tumor microenvironments. Excessive accumulation of immunosuppressive macrophages has been found to influence immunotherapy resistance. Intervention studies targeting macrophages in combination with checkpoint blockade show promising results.
Article
Oncology
YingQiu Song, Kai Sun, LiLan Gong, LinLi Shi, Tao Qin, ShuSen Wang, WuGuo Deng, WangBing Chen, FeiMeng Zheng, GuiLing Li
Summary: CPSF4 plays a role in regulating tumor-initiating cells in lung cancer, promoting tumor-initiating phenotype and chemoresistance. It achieves this by activating the transcription of VEGF and NRP2 and inducing TAZ expression. High expression of CPSF4 is associated with poor prognosis.
Article
Medicine, Research & Experimental
Chrysavgi N. Kosti, Photene C. Vaitsi, Apostolos G. Pappas, Marianthi P. Iliopoulou, Katherina K. Psarra, Sophia F. Magkouta, Ioannis T. Kalomenidis
Summary: MPE formation involves complex interactions among tumor cells, inflammatory cells, and the vasculature, with M2 macrophage numbers correlating with poor prognosis. Targeting the CSF1/CSF1R axis may be a vital strategy for limiting MPE.
Article
Oncology
Michael Wessolly, Elena Mairinger, Sabrina Borchert, Agnes Bankfalvi, Pawel Mach, Kurt Werner Schmid, Rainer Kimmig, Paul Buderath, Fabian Dominik Mairinger
Summary: This study successfully links CAF-associated signaling pathways to therapy failure in high-grade serous ovarian cancer (HGSOC) and general epithelial ovarian cancer (EOC), indicating a potential conserved mechanism. Stratifying HGSOC patients based on CAF activity and considering alternative treatment options may be beneficial.
FRONTIERS IN ONCOLOGY
(2022)
Article
Engineering, Multidisciplinary
Huilun Xu, Kejun Liu, Yimeng Su, Zhengjiang Liu, Yan Wei, Yinchun Hu, Liqin Zhao, Lingfeng Chen, Xiaojie Lian, Di Huang
Summary: Cardiovascular disease is the leading cause of death and creating reliable small diameter artificial blood vessels remains a challenge. To meet the requirements, researchers have successfully developed a micro diameter vessel using polyvinyl alcohol and alginate interpenetrating polymer networks through coaxial printing. The artificial blood vessel combines high strength and mimics the compliance of natural blood vessels. It also exhibits excellent anticoagulation properties and promotes tissue integration after implantation.
COMPOSITES PART B-ENGINEERING
(2023)
Review
Chemistry, Inorganic & Nuclear
Su Yimeng, Xu Huilun, Liao Ziming, Liu Kejun, Merzougui Chaima, Zhang Xiangyu, Hu Yinchun, Wei Yan, Huang Di
Summary: This review summarizes the synthetic methods, antibacterial mechanisms, and applications of copper-based nanoparticles, and discusses the prospects of copper-based nanoparticle antibacterial agents in biomedical and clinical fields.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Di Huang, Dan Zhao, Ming Li, Si-Yu Chang, Ya-Dong Xue, Ning Xu, Si-Jia Li, Nan-Nan Tang, Li-Ling Gong, Yi-Ning Liu, Hang Yu, Qing-Sui Li, Peng-Yu Li, Jia-Li Liu, Hai-Xin Chen, Ming-Bin Liu, Wan-Yu Zhang, Xing-Miao Zhao, Xian-Zhi Lang, Zhen-Dong Li, Yu Liu, Zhi-Yong Ma, Jia-Min Li, Ning Wang, Hai Tian, Ben-Zhi Cai
Summary: This study reveals that PML is upregulated in cardiac fibrotic tissue and activated cardiac fibroblasts treated with TGF-beta 1. The interaction between PML and p53 regulates the activation of cardiac fibroblasts and has a significant role in cardiac fibrosis.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Physics, Multidisciplinary
Wenbo Ma, Abdusalam Abdukerim, Chen Cheng, Zihao Bo, Wei Chen, Xun Chen, Yunhua Chen, Zhaokan Cheng, Xiangyi Cui, Yingjie Fan, Deqing Fang, Changbo Fu, Mengting Fu, Lisheng Geng, Karl Giboni, Linhui Gu, Xuyuan Guo, Chencheng Han, Ke Han, Changda He, Jinrong He, Di Huang, Yanlin Huang, Zhou Huang, Ruquan Hou, Xiangdong Ji, Yonglin Ju, Chenxiang Li, Jiafu Li, Mingchuan Li, Shu Li, Shuaijie Li, Qing Lin, Jianglai Liu, Xiaoying Lu, Lingyin Luo, Yunyang Luo, Yugang Ma, Yajun Mao, Nasir Shaheed, Yue Meng, Xuyang Ning, Ningchun Qi, Zhicheng Qian, Xiangxiang Ren, Changsong Shang, Xiaofeng Shang, Guofang Shen, Lin Si, Wenliang Sun, Andi Tan, Yi Tao, Anqing Wang, Meng Wang, Qiuhong Wang, Shaobo Wang, Siguang Wang, Wei Wang, Xiuli Wang, Zhou Wang, Yuehuan Wei, Mengmeng Wu, Weihao Wu, Jingkai Xia, Mengjiao Xiao, Xiang Xiao, Pengwei Xie, Binbin Yan, Xiyu Yan, Jijun Yang, Yong Yang, Chunxu Yu, Jumin Yuan, Ying Yuan, Zhe Yuan, Xinning Zeng, Dan Zhang, Minzhen Zhang, Peng Zhang, Shibo Zhang, Shu Zhang, Tao Zhang, Yingxin Zhang, Yuanyuan Zhang, Li Zhao, Qibin Zheng, Jifang Zhou, Ning Zhou, Xiaopeng Zhou, Yong Zhou, Yubo Zhou
Summary: A search is conducted for interactions from solar 8B neutrinos elastically scattering off xenon nuclei using PandaX-4T commissioning data. The energy threshold for this search is lowered compared to previous dark matter searches, and various techniques are employed to suppress background. Analyzing the data with an effective exposure of 0.48 tonne year, no significant excess of events is observed. The study provides the most stringent constraint on the solar 8B neutrino flux and a more stringent limit on the cross section between dark matter and nucleon in the mass range from 3 to 9 GeV/c2.
PHYSICAL REVIEW LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Tianyuan Jia, Pan Wu, Bin Liu, Miaomiao Liu, Huiqian Mu, Dan Liu, Min Huang, Linxing Li, Yi Wei, Lu Wang, Qian Yang, Yutao Liu, Bin Yang, Di Huang, Liang Yang
Summary: Escherichia coli strains including enterohemorrhagic E. coli (EHEC) and enteropathogenic E. coli (EPEC) can cause severe gastroenteritis. An RNA called EsrL promotes the pathogenicity, adhesion, and biofilm formation of these strains. The expression of EsrL is repressed by PhoB under low-phosphate conditions, but relieved in a phosphate-rich environment. EsrL interacts with and stabilizes important transcripts, leading to increased adhesion and colonization in the host intestine.
Article
Chemistry, Multidisciplinary
Dong Seob Kim, Di Huang, Chunhao Guo, Kejun Li, Dario Rocca, Frank Y. Gao, Jeongheon Choe, David Lujan, Ting-Hsuan Wu, Kung-Hsuan Lin, Edoardo Baldini, Li Yang, Shivani Sharma, Raju Kalaivanan, Raman Sankar, Shang-Fan Lee, Yuan Ping, Xiaoqin Li
Summary: A long-standing pursuit in materials science is to identify suitable magnetic semiconductors for integrated information storage, processing, and transfer. Van der Waals magnets have brought forth new material candidates for this purpose. Recently, sharp exciton resonances in antiferromagnet NiPS3 have been reported to correlate with magnetic order, that is, the exciton photoluminescence intensity diminishes above the Neel temperature. Here, it is found that the polarization of maximal exciton emission rotates locally, revealing three possible spin chain directions. This study shows that anisotropic exciton photoluminescence can be used to read out local spin chain directions in antiferromagnets and realize multi-functional devices via spin-photon transduction.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Analytical
Yanzuo Jiang, Di Huang, Hongjia Zhang, Wei Xu, Ting Jiang
Summary: Similar to smartphones, smart or automatic level is crucial for miniature mass spectrometers. In this study, a miniature mass spectrometer combined with intelligent algorithms was used for rapid and accurate identification. The system achieved an average accuracy of 97% in differentiating ten fruits and determining the freshness of strawberries. By utilizing molecular ions, fragment ions, and dimer ions in the full mass spectrum, a satisfactory prediction accuracy (>99%) for 63 volatile organic compounds (VOCs) was achieved.
ANALYTICAL CHEMISTRY
(2023)
Article
Astronomy & Astrophysics
R. Alfaro, C. Alvarez, J. C. Arteaga-Velazquez, D. Avila Rojas, H. A. Ayala Solares, R. Babu, E. Belmont-Moreno, K. S. Caballero-Mora, T. Capistran, A. Carraminana, S. Casanova, O. Chaparro-Amaro, U. Cotti, J. Cotzomi, E. De la Fuente, R. Diaz Hernandez, B. L. Dingus, M. A. DuVernois, M. Durocher, J. C. Diaz-Velez, C. Espinoza, K. L. Fan, N. Fraija, J. A. Garcia-Gonzalez, F. Garfias, M. M. Gonzalez, J. P. Harding, S. Hernandez-Cadena, D. Huang, F. Hueyotl-Zahuantitla, A. Iriarte, V. Joshi, S. Kaufmann, D. Kieda, J. Lee, H. Leon Vargas, J. T. Linnemann, A. L. Longinotti, G. Luis-Raya, K. Malone, O. Martinez, J. Martinez-Castro, J. A. Matthews, E. Moreno, M. Mostafa, A. Nayerhoda, L. Nellen, N. Omodei, Y. Perez Araujo, E. G. Perez-Perez, C. D. Rho, D. Rosa-Gonzalez, H. Salazar, D. Salazar-Gallegos, A. Sandoval, J. Serna-Franco, Y. Son, R. W. Springer, O. Tibolla, K. Tollefson, I. Torres, R. Torres-Escobedo, R. Turner, F. Urena-Mena, L. Villasenor, X. Wang, E. Willox, H. Zhou, C. de Leon, V. Gammaldi, E. Karukes, P. Salucci
Summary: We present the results of dark matter (DM) searches in 31 dwarf irregular (dIrr) galaxies within the field of view of the HAWC Observatory. Although no statistically significant DM signal is observed in these galaxies, we provide exclusion limits for WIMP candidates with masses between 1 and 100 TeV. The exclusion limits from dIrr galaxies are comparable to those from classical dSph galaxies and weaker than ultrafaint dSph limits by about two orders of magnitude.
ASTROPHYSICAL JOURNAL
(2023)
Article
Engineering, Biomedical
Yaping Song, Liqin Zhao, Baolong Niu, Hongyun Zhao, Yinchun Hu, Yan Wei, Di Huang, Tongxin Wang, XiaoJie Lian
Summary: In this study, a novel self-hardening β-tricalcium phosphate (β-TCP) bone cement was investigated. The addition of cellulose phosphate sodium (CF) and micrometer hydroxyapatite (HA) in β-TCP bone cement allowed for tunable setting time, mechanical properties, and anti-washout ability. The addition of CF and HA shortened the setting time and improved the compressive strength of the modified composite. The composites with CF as the curing liquid showed good anti-collapse performance. The weight loss ratio of the bone cement was between -0.18% to 12.08% in 4 weeks. Amorphous β-TCP deposited as hydroxyapatite and formed plate-like structures on the surface of the composite during the degradation process. The alkaline phosphatase activity of the composites using CF as the curing liquid remained high on the 14th day.
JOURNAL OF BIOMATERIALS APPLICATIONS
(2023)
Article
Nanoscience & Nanotechnology
Xiaofeng Luan, Pengbin Liu, Di Huang, Haiping Zhao, Yuang Li, Sheng Sun, Wenchang Zhang, Lingqian Zhang, Mingxiao Li, Tian Zhi, Yang Zhao, Chengjun Huang
Summary: Real-time transformation is crucial for impedance flow cytometry in practice, but the translation of raw data to cellular intrinsic electrical properties is time-consuming. We proposed a fast parallel physical fitting solver that characterizes single cells' electrical properties within 0.62 ms/cell. Based on this solver, we implemented physics-informed real-time impedance flow cytometry (piRT-IFC), which showed comparable speed but higher accuracy than the fully connected neural network predictor. In addition, we demonstrated the advantages of piRT-IFC in handling unfamiliar samples without pretraining.
MICROSYSTEMS & NANOENGINEERING
(2023)
Article
Engineering, Biomedical
Yinchun Hu, Min Kang, Xiangfei Yin, Yizhu Cheng, Zexin Liu, Yan Wei, Di Huang
Summary: The mineralized polyacrylamide (PAM-Mineralized) hydrogel demonstrated good ALP activity, cell adhesion, and biocompatibility for subchondral bone tissue engineering. It exhibited well-distributed layers of hydroxyapatite mineralization on the surface, improving the mechanical properties and osteogenic differentiation potential.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2023)
Article
Chemistry, Physical
Hao Cheng, Niuniu Wang, Yongqiang Yang, Xiong Jiao, Peide Han, Wangping Duan, Di Huang, Meiwen An, Weiyi Chen, Xiaohong Yao, Xiangyu Zhang
Summary: Graphitic carbon nitride (g-C3N4) has been widely studied as a metal-free polymeric photocatalyst for antibacterial application. However, its weak photocatalytic activity under visible light hinders its practical use. In this study, g-C3N4 was modified with Zinc (II) meso-tetrakis (4-carboxyphenyl) porphyrin (ZnTCPP) to improve its utilization of visible light and reduce electron-hole recombination. The resulting composite (ZP/CN) exhibited enhanced photocatalytic activity, achieving 99.99% bacterial inactivation within 10 minutes under visible light irradiation. The improved performance was attributed to the excellent electrical conductivity at the ZnTCPP-g-C3N4 interface. In vitro and in vivo tests demonstrated that ZP/CN not only possessed strong antibacterial activity, but also promoted angiogenesis and suppressed inflammation. Therefore, ZP/CN shows great potential as an effective platform for healing bacteria-infected wounds.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Yuhui Wang, Xiaohan Wang, Guozhen Ma, Lijie Xie, Dan Liu, Yanling Wang, Xinyu Zhao, Yingying Su, Andrei V. Perepelov, Peng Ding, Xiao Zhang, Bo Xu, Bin Liu, Di Huang
Summary: Urinary tract infection (UTI) caused by uropathogenic Escherichia coli (UPEC) is a common infectious disease, with the prevalent serogroup O4 showing high antibiotic resistance. This study developed an O-glycosylation Escherichia coli chassis to biosynthesize a polysaccharide-based glycoprotein for the development of vaccines against UPEC infection. By optimizing the expression of enzymes and fermentation conditions, a high-yield glycoprotein was produced, which effectively reduced bacterial burden in mice after vaccination.
Article
Materials Science, Multidisciplinary
Ruihuang Zhao, Pengcheng Wan, Ling Zhou, Di Huang, Haiqin Guo, Hao Xia, Junjie Du
Summary: For electron optics in graphene, the only available physical mechanism has been the propagation effect. However, this results in large-sized electronic components that need to operate at low temperatures. This paper introduces the concept of electron metasurfaces in graphene, which are the electronic counterparts of optical metasurfaces. The metasurfaces allow for the bending and splitting of electron beams, with the functionalities controlled by applied gate biases. These electron metasurfaces can shape the wavefront of electron beams within a short distance at room temperature, enabling the realization of optics-inspired electronic devices that can operate under ambient conditions. The concept of metasurface electron optics also holds promise for applications such as electron metalenses, metasurface holography, and metasurface-based digital coding technology in graphene.
Article
Engineering, Multidisciplinary
Jiamin Li, Hongru Xue, Ning Xu, Liling Gong, Ming Li, Sijia Li, Di Huang, Qingwei Zhang, Pengyu Li, Qingsui Li, Hang Yu, Yining Liu, Yadong Xue, Haixin Chen, Jiali Liu, Wanyu Zhang, Mingbin Liu, Siyu Chang, Xianzhi Lang, Xingmiao Zhao, Weijie Du, Benzhi Cai, Ning Wang, Baofeng Yang
Summary: This study investigates the regulatory role and mechanisms of long noncoding RNAs (lncRNAs) in myocardial remodeling during myocardial infarction (MI). It identifies a new conserved lncRNA called CPAL, which is upregulated in the myocardial border zone of MI mice. CPAL functions as an activator of nuclear factor kappa B (NFjB) and promotes cardiomyocyte pyroptosis. It also upregulates caspase-1 expression and facilitates the release of interleukin-18 (IL-18) and interleukin-1b (IL-1b) from cardiomyocytes. These findings suggest that CPAL could be a potential therapeutic target for protecting cardiomyocytes against ischemic injury in infarcted hearts.