Total alkaloids from the seed embryo of Nelumbo nucifera Gaertn. improve cognitive impairment in APP/PS1 mice and protect Aβ-damaged PC12 cells

Extracellular Vesicle Delivery of Neferine for the Attenuation of Neurodegenerative Disease Proteins and Motor Deficit in an Alzheimer’s Disease Mouse Model

(2022) Bin Tang et al.   Pharmaceuticals

Eriodictyol and Homoeriodictyol Improve Memory Impairment in Aβ25–35-Induced Mice by Inhibiting the NLRP3 Inflammasome

(2022) Pengli Guo et al.   MOLECULES

Tau: Enabler of diverse brain disorders and target of rapidly evolving therapeutic strategies

(2021) Che-Wei Chang et al.   SCIENCE

Metformin attenuates plaque-associated tau pathology and reduces amyloid-β burden in APP/PS1 mice

(2021) Yanxing Chen et al.   Alzheimers Research & Therapy

The role of nuclear Ca2+ in maintaining neuronal homeostasis and brain health

(2021) Pawel Mozolewski et al.   JOURNAL OF CELL SCIENCE

Neferine Protects against Hypoxic-Ischemic Brain Damage in Neonatal Rats by Suppressing NLRP3-Mediated Inflammasome Activation

(2021) Jin-jin Zhu et al.   Oxidative Medicine and Cellular Longevity

Neuroprotective Natural Products for Alzheimer’s Disease

(2021) Xin Chen et al.   Cells

Neferine alleviates memory and cognitive dysfunction in diabetic mice through modulation of the NLRP3 inflammasome pathway and alleviation of endoplasmic-reticulum stress

(2020) Xiao-Li Wu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Microglia facilitate loss of perineuronal nets in the Alzheimer's disease brain

(2020) Joshua D. Crapser et al.   EBioMedicine

Calmodulin Binding Proteins and Alzheimer’s Disease: Biomarkers, Regulatory Enzymes and Receptors That Are Regulated by Calmodulin

(2020) Danton H. O’Day   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cannabidiol (CBD) enhanced the hippocampal immune response and autophagy of APP/PS1 Alzheimer's mice uncovered by RNA-seq

(2020) Fengjin Hao et al.   LIFE SCIENCES

Plumula Nelumbinis: A review of traditional uses, phytochemistry, pharmacology, pharmacokinetics and safety

(2020) Sixuan Chen et al.   JOURNAL OF ETHNOPHARMACOLOGY

A Multilevel View of the Development of Alzheimer’s Disease

(2020) Jesús Avila et al.   NEUROSCIENCE

Alzheimer’s Disease Research Using Human Microglia

(2019) Lue et al.   Cells

Major compounds of red ginseng oil attenuate Aβ25–35-induced neuronal apoptosis and inflammation by modulating MAPK/NF-κB pathway

(2018) Seonah Lee et al.   Food & Function

Tau protein aggregation is associated with cellular senescence in the brain

(2018) Nicolas Musi et al.   AGING CELL

Mitochondrial protective effect of neferine through the modulation of nuclear factor erythroid 2-related factor 2 signalling in ischaemic stroke

(2018) Chuanhong Wu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation

(2017) Zhuohao He et al.   NATURE MEDICINE

Inhibitory effects of three bisbenzylisoquinoline alkaloids on lipopolysaccharide-induced microglial activation

(2017) Xue-Lian Meng et al.   RSC Advances

Alzheimer's Disease: The Role of Microglia in Brain Homeostasis and Proteopathy

(2017) Kevin A. Clayton et al.   Frontiers in Neuroscience

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

Three dimensions of the amyloid hypothesis: time, space and 'wingmen'

(2015) Erik S Musiek et al.   NATURE NEUROSCIENCE

BACE1 and cholinesterase inhibitory activities of Nelumbo nucifera embryos

(2014) Hyun Ah Jung et al.   ARCHIVES OF PHARMACAL RESEARCH

Cognitive Enhancing and Neuroprotective Effect of the Embryo of theNelumbo nuciferaSeed

(2014) Eun Sil Kim et al.   Evidence-based Complementary and Alternative Medicine

Calmodulin regulates the non-amyloidogenic metabolism of amyloid precursor protein in platelets

(2010) I. Canobbio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Anti-amnesic activity of neferine with antioxidant and anti-inflammatory capacities, as well as inhibition of ChEs and BACE1

(2010) Hyun Ah Jung et al.   LIFE SCIENCES

Predicting memapsin 2 (β-secretase) hydrolytic activity

(2010) Xiaoman Li et al.   PROTEIN SCIENCE

Microglial Physiology: Unique Stimuli, Specialized Responses

(2009) Richard M. Ransohoff et al.   Annual Review of Immunology