Article
Neurosciences
Fei-xiang Wang, Chi-liang Xu, Can Su, Jiang Li, Jing-yan Lin
Summary: Waste removal is crucial for maintaining homeostasis and the normal function of the central nervous system (CNS). The glymphatic system, based on AQP4 water channels on astrocytes, has been discovered as a pathway for excreting metabolic waste products of the CNS. Previous studies have suggested that BHB can increase the expression of SNTA1, which in turn restores the polarity of AQP4. This study aims to evaluate the neuroprotective mechanism of BHB in rats with PDN.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Guo-Qiang Wang, Fei-Xiang Wang, Yi-Na He, Jing-Yan Lin
Summary: This study evaluated the plasticity of the spinal glymphatic system in male SD rats with painful diabetic neuropathy (PDN) induced by type 2 diabetes mellitus. The results showed that there were functional changes in the glymphatic system in PDN rats.
JOURNAL OF NEUROSCIENCE RESEARCH
(2022)
Article
Medicine, Research & Experimental
Uros Pecikoza, Maja Tomic, Katarina Nastic, Ana Micov, Radica Stepanovic-Petrovic
Summary: The study found that metformin can reduce pain hypersensitivity in diabetic animals and has a synergistic effect with analgesics/vitamin B-12, resulting in reduced drug dosage. Co-treatment with metformin may enhance analgesic efficacy and allow for lower doses of analgesics in treating PDN.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Clinical Neurology
Troels S. Jensen, Pall Karlsson, Sandra S. Gylfadottir, Signe T. Andersen, David L. Bennett, Hatice Tankisi, Nanna B. Finnerup, Astrid J. Terkelsen, Karolina Khan, Andreas C. Themistocleous, Alexander G. Kristensen, Mustapha Itani, Soren H. Sindrup, Henning Andersen, Morten Charles, Eva L. Feldman, Brian C. Callaghan
Summary: Peripheral neuropathy is a common complication of diabetes, with the most common type being distal symmetric polyneuropathy. Diagnosis of diabetic neuropathy remains challenging due to lack of a single established diagnostic standard, leading to a reliance on a hierarchical system combining symptoms, signs, and confirmatory tests for research purposes. Treatments for diabetic neuropathy focus on glycemic control and symptomatic management, with a need for large randomized clinical trials to identify the most effective interventions for improved patient outcomes.
Review
Clinical Neurology
Josianna Henson, Narayana C. Varhabhatla, Zvonimir Bebic, Alan D. Kaye, R. Jason Yong, Richard D. Urman, Justin S. Merkow
Summary: Painful diabetic neuropathy is a common disease causing significant pain and disability. Spinal cord stimulation has shown moderate-quality evidence for safety and efficacy in treating this condition. Further high-quality research, including large-scale randomized controlled trials, is needed to confirm its effectiveness.
Review
Neurosciences
Thea Overgaard Wichmann, Helle Hasager Damkier, Michael Pedersen
Summary: A comprehensive understanding of the cerebrospinal fluid (CSF) system is crucial for understanding the health and disease of the central nervous system (CNS). Recent research has significantly improved our knowledge of the CSF system in both health and disease, but there are still aspects that require further investigation.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Biology
Ryszard Stefan Gomolka, Lauren M. Hablitz, Humberto Mestre, Michael Giannetto, Ting Du, Natalie Linea Hauglund, Lulu Xie, Weiguo Peng, Paula Melero Martinez, Maiken Nedergaard, Yuki Mori, Saad Jbabdi
Summary: The glymphatic system is a fluid transport network that plays a crucial role in clearing interstitial solutes from the brain. The expression of AQP4 water channels facilitates cerebrospinal fluid transport and its genetic deletion results in abnormalities in brain structure and water transport. This study used advanced imaging techniques to explore the disruption of glymphatic function in AQP4 KO mice.
Review
Clinical Neurology
Jacek Szczygielski, Marta Kopanska, Anna Wysocka, Joachim Oertel
Summary: In the past, water homeostasis of the brain was thought to be a quantitative equilibrium of water content, but recent advancements suggest that all fluid compartments form a continuous entity, with AQP4 playing a central role in cerebral fluid balance.
FRONTIERS IN NEUROLOGY
(2021)
Article
Chemistry, Multidisciplinary
Jinglei Gong, Chengxinyue Ye, Jinhui Ran, Xin Xiong, Xinyi Fang, Xueman Zhou, Yating Yi, Xiong Lu, Jun Wang, Chaoming Xie, Jin Liu
Summary: The study describes a silk fibroin/gelatin patch incorporating polydopamine-mediated ultralong silk microfibers and metformin-loaded zeolitic imidazolate framework, which promotes periodontal soft and hard tissue regeneration by regulating the immunomodulatory microenvironment. The patch has reactive oxygen species-scavenging ability and anti-inflammatory activity, reducing the inflammatory response and improving periodontal ligament reconstruction. The sustained release of metformin and zinc ions from the patch confers anti-aging and immunomodulatory abilities, promoting bone regeneration.
Article
Clinical Neurology
Andrea Arighi, Marina Arcaro, Giorgio Giulio Fumagalli, Tiziana Carandini, Anna Margherita Pietroboni, Luca Sacchi, Chiara Fenoglio, Maria Serpente, Federica Sorrentino, Giovanni Isgro, Federico Turkheimer, Elio Scarpini, Daniela Galimberti
Summary: This study reveals that AQP4 levels are significantly elevated in neurodegenerative diseases and positively correlated with total tau levels. This finding may open up new avenues for future research on the clinical assessment of lymphatic function and neurodegeneration.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Rowida Almomani, Maurice Sopacua, Margherita Marchi, Milena Sleczkowska, Patrick Lindsey, Bianca T. A. de Greef, Janneke G. J. Hoeijmakers, Erika Salvi, Ingemar S. J. Merkies, Maryam A. Ferdousi, Rayaz Malik, Dan Ziegler, Kasper W. J. Derks, Gidon Boenhof, Filippo Martinelli-Boneschi, Daniele Cazzato, Raffaella Lombardi, Sulayman G. Dib-Hajj, Stephen Waxman, Hubert J. M. M. Smeets, Monique G. Gerrits, Catharina Faber, Giuseppe Lauria
Summary: Rare SCG genetic variants may contribute to the development of painful neuropathy. Genetic profiling and SCG variant identification can provide better understanding of the genetic variability in patients with painful and painless neuropathy, leading to improved risk stratification and personalized pain treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Clinical Neurology
Ting Yi, Ping Gao, Tianmin Zhu, Haiyan Yin, Shuoguo Jin
Summary: Sleep is crucial for overall health, but poor sleep can significantly impact patients with headache disorders. Dysfunction of the glymphatic system may play a role in sleep disorders and headache pain. This study reviews the current literature and proposes acupuncture as a non-invasive approach to improve glymphatic function, enhance sleep quality, and alleviate headache pain.
FRONTIERS IN NEUROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Francesca R. Buccellato, Marianna D'Anca, Maria Serpente, Andrea Arighi, Daniela Galimberti
Summary: Alzheimer's disease (AD) and Parkinson's disease (PD) are neurodegenerative disorders characterized by the accumulation of toxic proteins. Recent studies have explored the role of the glymphatic system in the pathogenesis of these diseases. This review aims to present the current knowledge linking the glymphatic system to the development of AD and PD, as well as the influence of lifestyle factors such as sleep deprivation and exercise on glymphatic system function. The potential of neuroimaging approaches to detect glymphatic system changes is also discussed.
Article
Medicine, General & Internal
Anne Worthington, Alise Kalteniece, Maryam Ferdousi, Luca D'Onofrio, Shaishav Dhage, Shazli Azmi, Clare Adamson, Shaheen Hamdy, Rayaz A. Malik, Nigel A. Calcutt, Andrew G. Marshall
Summary: Impaired rate-dependent depression of the Hoffman reflex (HRDD) may serve as a biomarker of impaired spinal inhibition in patients with painful diabetic neuropathy. Stimulus averages at 1 Hz show potential in distinguishing patients with and without pain.
Article
Endocrinology & Metabolism
Uazman Alam, Ioannis N. Petropoulos, Georgios Ponirakis, Maryam Ferdousi, Omar Asghar, Maria Jeziorska, Andrew Marshall, Andrew J. M. Boulton, Nathan Efron, Rayaz A. Malik
Summary: The study suggests that vitamin D deficiency and insufficiency are associated with painful diabetic neuropathy, with more severe symptoms in patients with painful neuropathy compared to painless neuropathy. The serum 25(OH)D levels were significantly lower in patients with painful neuropathy compared to those with painless neuropathy and healthy controls.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2021)
