Article
Chemistry, Multidisciplinary
Guiyuan Chen, Xiangxia Li, Rui Li, Kecheng Wu, Zhouhang Lei, Ruike Dai, Kyle Roche, Andrew Z. Wang, Yuanzeng Min
Summary: Researchers hypothesized that treating cancer cells with ultrahigh doses of chemotherapeutics in vitro could artificially enhance the immunogenicity, thereby improving chemoimmunotherapy.
Review
Chemistry, Multidisciplinary
Elham Masoumi, Sahar Tahaghoghi-Hajghorbani, Leila Jafarzadeh, Mohammad-Javad Sanaei, Atieh Pourbagheri-Sigaroodi, Davood Bashash
Summary: This review provides an overview of the current research status of immune checkpoint blockades in breast cancer and discusses the efficacy and limitations of ICB therapy in breast cancer treatment.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Chemistry, Multidisciplinary
Jingmei Pan, Xilin Li, Binfen Shao, Funeng Xu, Xuehui Huang, Xing Guo, Shaobing Zhou
Summary: A nanocarrier that achieves self-blockade of PD-L1 in tumor cells and a detection kit to quantitatively measure the binding rate of PD-1/PD-L1 have been developed, improving the efficacy of PD-1/PD-L1 self-blocking therapy.
ADVANCED MATERIALS
(2022)
Article
Oncology
Jing Yang, Shilin Zhao, Jing Wang, Quanhu Sheng, Qi Liu, Yu Shyr
Summary: Cancer-Immu is a comprehensive platform that integrates various omics data and clinical phenotypes to explore immunogenomic connections. It provides easy access to data and helps researchers translate omics datasets into biological insights and clinical applications.
Article
Immunology
Yaping Chen, Hao Huang, Yuan Li, Wenlu Xiao, Yingting Liu, Rongzhang Chen, Yulan Zhu, Xiao Zheng, Changping Wu, Lujun Chen
Summary: Combination immunotherapy based on immune checkpoint inhibitors (ICIs) has shown great success in cancer treatment, and the combination of ablation and immunotherapy has potential for the treatment of liver metastasis of colorectal cancer (CRC). The expression of TIGIT was up-regulated after microwave ablation (MWA), and the combination of MWA and TIGIT blockade significantly promoted the expansion and functions of CD8(+) tumor-infiltrating lymphocytes (TILs) and reshaped myeloid cells in the tumor microenvironment (TME).
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
JianBin Wu, Yuanyuan Zhu, MingMin Luo, Lei Li
Summary: This study revealed the crucial role of pyroptosis in breast cancer, showing its association with tumor progression, prognosis, and immunotherapy response. Evaluating the PyroptosisScore of a single tumor can help understand the characteristics of tumor microenvironment infiltration and lead to the development of more effective immunotherapy strategies.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Mohammad Hossein Kazemi, Alireza Najafi, Jafar Karami, Foad Ghazizadeh, Hassan Yousefi, Reza Falak, Elahe Safari
Summary: Recent advancements in cancer immunotherapy, particularly immune checkpoint (IC) blockers, have shown promising results in clinical settings. Immunometabolism plays a crucial role in regulating immune responses, and dual targeting of ICs and metabolic pathways may help restore immune cells' antitumor activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Peiqi Zhao, Yuanlin Xu, Wei Ji, Lanfang Li, Lihua Qiu, Shiyong Zhou, Zhengzi Qian, Huilai Zhang
Summary: The hybrid membrane nanovaccine combined with immune checkpoint blockade is a powerful strategy for enhancing antitumor immunotherapy by inhibiting tumor growth, eliminating established tumors, and rejecting re-challenged tumors through regulating the immunosuppressive microenvironment and immunological memory effect.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Yao Xiao, Tian Zhang, Xianbin Ma, Qi-Chao Yang, Lei-Lei Yang, Shao-Chen Yang, Mengyun Liang, Zhigang Xu, Zhi-Jun Sun
Summary: The absence of tumor antigens poses a challenge in ICB therapy, but inducing tumor-specific pyroptosis while reducing injury in normal tissues is urgently needed. A ROS/GSH dual-responsive nano-prodrug called MCPP with high PTX and P18 loading is designed to selectively induce pyroptosis in tumor cells. Chemo-photodynamic therapy and controlled-release PTX synergistically induce pyroptosis, releasing DAMPs and enhancing ICB efficiency, suggesting a smart strategy to trigger pyroptosis and augment ICB efficiency.
Article
Chemistry, Multidisciplinary
Jiwoong Choi, Man Kyu Shim, Suah Yang, Hee Sook Hwang, Hanhee Cho, Jeongrae Kim, Wan Su Yun, Yujeong Moon, Jinseong Kim, Hong Yeol Yoon, Kwangmeyung Kim
Summary: Immune checkpoint blockade is a promising approach for cancer immunotherapy, but many patients do not respond due to the immunosuppressive tumor microenvironment. This study proposes visible-light-triggered prodrug nanoparticles (LT-NPs) to reverse the immunosuppressive tumor microenvironment and enhance checkpoint blockade immunotherapy, showing promising results in tumor models.
Review
Immunology
Yufei Xu, Fengli Zuo, Huiling Wang, Jing Jing, Xiujing He
Summary: ICB therapy has significantly changed the landscape of anticancer therapy, but only a subset of patients benefit from it and immune-related adverse events (irAEs) can occur. Finding predictive biomarkers to optimize patient outcomes and reduce toxicity risk is urgently needed. This review discusses current predictive and prognostic biomarkers for checkpoint immunotherapy in ovarian cancer (OC) and highlights emerging biomarkers to guide treatment with ICB.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Alexander Piening, Emily Ebert, Niloufar Khojandi, Elise Alspach, Ryan M. Teague
Summary: This study aims to investigate the impact of immune checkpoint blockade (ICB) on immune responses in cancer patients previously vaccinated against COVID-19. The study found that ICB treatment does not significantly enhance antibody titers and T cell responses in vaccinated individuals. These results provide evidence supporting the clinical safety and efficacy of COVID-19 vaccination in patients receiving ICB.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Qi-jie Zhang, Jiao-chen Luan, Le-bin Song, Rong Cong, Cheng-jian Ji, Xiang Zhou, Jia-dong Xia, Ning-hong Song
Summary: The study found no difference in efficacy between elderly and young patients in most cancer types, except for melanoma patients receiving anti-PD-1 therapy. Elderly patients showed higher treatment response rate and more favorable prognosis in certain cancer types, potentially attributed to their high mutational properties. This suggests that modulating immune function could be beneficial to immunotherapy in elderly patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Editorial Material
Oncology
Cinzia Solinas, Debora Fumagalli, Maria Vittoria Dieci
Summary: This article discusses how to manipulate the anti- or pro-tumor immune response in early stage HER2-positive breast cancer patients through immune checkpoint blockade, and the potential benefits and fatal drawbacks of this strategy.
Article
Immunology
Juanfeng Lao, Can Cao, Xiaoli Niu, Simei Deng, Siqi Ming, Siping Liang, Yuqi Shang, Yulin Yuan, Xiaomin Shi, Zibin Liang, Minhao Wu, Yongjian Wu
Summary: This study confirms the antitumor effects of anti-PD-1/OX40 combination in lung cancer patients and mouse models, providing a rationale for further clinical trials evaluating the therapeutic effect of this combination of antibodies for NSCLC immunotherapy.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Meng-Jie Zhang, Cong-Cong Wu, Shuo Wang, Lei-Lei Yang, Zhi-Jun Sun
Summary: This study found that the expression levels of LAG3, TIM3, and A2aR are significantly increased in AdCC and MEC and may be closely related to migration, TGF-beta 1, and oncogenic signaling pathways.
Article
Chemistry, Multidisciplinary
Wen Su, Wei Qiu, Shu-Jin Li, Shuo Wang, Jun Xie, Qi-Chao Yang, Jiming Xu, Junjie Zhang, Zhigang Xu, Zhi-Jun Sun
Summary: This study reports a combinational therapeutic strategy that combines tumor microenvironment-reactive oxygen species/pH dual-responsive signal transducers and activators of transcription 3 inhibitor nanoprodrugs with oncolytic herpes simplex virus 1 virotherapy to enhance immunotherapy. This strategy successfully activates robust T-cell-dependent antitumor responses, potentiating immune checkpoint blockade effects against local recurrence and pulmonary metastasis in preclinical cold murine triple-negative breast cancer and syngeneic oral cancer models.
ADVANCED MATERIALS
(2023)
Article
Engineering, Biomedical
Honglian Yu, Mengting He, Yongcan Li, Yuhan Liu, Zhigang Xu, Lei Zhang, Yuejun Kang, Peng Xue
Summary: Intracellular redox dyshomeostasis caused by tumor microenvironment modulation is an attractive therapeutic target for cancer management. In this study, a dual plasmonic nanoreactor ASC was developed by immobilizing sulfur defective Cu2-xS nanodots onto silk fibroin-capped Au nanoparticles. ASC effectively alleviates tumor hypoxia and generates singlet oxygen (O-1(2)) by catalase-mimic activity of Cu2-xS and electron scavenging by Au. Moreover, ASC consumes glucose and enhances oxidative damage and energy exhaustion of cancer cells, which can be further boosted by Cu2-xS-catalyzed O-2 self-replenishment in H2O2-rich TME. ASC also promotes M1 macrophage activation and therapy-induced immunogenetic cell death (ICD), leading to systematic tumor elimination.
Article
Oncology
Lei Chen, Shu-Cheng Wan, Liang Mao, Cong-Fa Huang, Lin-Lin Bu, Zhi-Jun Sun
Summary: This study found that the expression of NLRP3 in tumor-associated macrophages (TAMs) is positively correlated with TAM density in head and neck squamous cell carcinoma (HNSCC). High expression of NLRP3 in TAMs is associated with worse overall survival in HNSCC patients. NLRP3 activation in TAMs may contribute to tumor progression and have prognostic significance in HNSCC.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Chemistry, Multidisciplinary
Meng-Jie Zhang, Meng-Yun Liang, Shao-Chen Yang, Xian-Bin Ma, Shu-Cheng Wan, Qi-Chao Yang, Shuo Wang, Zhigang Xu, Zhi-Jun Sun
Summary: Glutathione-responsive nanogels (CDNPs) crosslinked with crosslinker DBHD incorporating BRAF inhibitor dabrafenib and COX2 inhibitor celecoxib were synthesized. The CDNPs can efficiently induce tumor cell pyroptosis and activate strong antitumor immunity. Furthermore, CDNPs combined with alpha PD-1 antibody significantly suppressed tumor growth and prolonged survival in a melanoma mouse model.
CHEMICAL COMMUNICATIONS
(2023)
Article
Materials Science, Multidisciplinary
Lingzhi Xie, Zhigang Xu, Yunzhe Qi, Jinrong Liang, Peng He, Qiang Shen, Chuanbin Wang
Summary: Fe-Mn-Al-C powder mixtures were synthesized with different ball milling time, and porous high-Mn and high-Al steel was produced by powder sintering. The size of the powder decreased and the morphology of the Fe powder became flatter with longer milling time. Phase transition of the powder mixture was minimally affected by prolonged milling. The sintered samples at 640 degrees C were mainly composed of alpha-Fe, alpha-Mn, and Al phases, with small amounts of Fe2Al5 and Al8Mn5. The phase composition shifted to gamma-Fe and alpha-Fe at 1200 degrees C. The weight loss fraction and Mn depletion region decreased as milling time increased. The total porosity decreased with milling time at 640 degrees C, but increased at 1200 degrees C. The compressive strength and ductility of the 1200 degrees C sintered porous steel improved with longer milling time.
INTERNATIONAL JOURNAL OF MINERALS METALLURGY AND MATERIALS
(2023)
Article
Dentistry, Oral Surgery & Medicine
H. Li, S. -W. Zhu, J. -J. Zhou, D. -R Chen, J. Liu, Z. -Z Wu, W. -Y Wang, M. -J Zhang, Z. -J Sun
Summary: Immune checkpoint blockade therapy targeting PD-1/PD-L1 shows limited efficacy in head and neck squamous cell carcinoma (HNSCC), however, recent findings suggest that the presence of tertiary lymphoid structures (TLSs) in tumor tissue is associated with better prognosis and response to therapy. This study analyzed TCGA-HNSCC data and identified an immune classification for the tumor microenvironment (TME) of HNSCC and found that TLS enrichment was correlated with improved prognosis and response to immune checkpoint blockade treatment. Further experiments demonstrated that inducing TLS formation enhanced the response to PD-1 blockade treatment in HPV- HNSCC mouse models by increasing the presence of specific immune cells in the TME. The results suggest that inducing TLS formation could be a potential therapeutic approach for improving the response rate to immune checkpoint blockade therapy in HPV- HNSCC patients.
JOURNAL OF DENTAL RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Shuo Wang, Zhi-Zhong Wu, Su-Wen Zhu, Shu-Cheng Wan, Meng-Jie Zhang, Bo-Xin Zhang, Qi-Chao Yang, Yao Xiao, Hao Li, Liang Mao, Zhi-Yong Wang, J. Silvio Gutkind, Zhi-Jun Sun
Summary: Immune checkpoint blockade (ICB) treatment is effective in oncology, but has limitations including low response rates and a lack of efficacy predictors. Gasdermin protein expression is associated with a favorable tumor immune microenvironment and prognosis in head and neck squamous cell carcinoma. CTLA-4 blockade treatment induces gasdermin-mediated pyroptosis of tumor cells, with gasdermin expression correlating with treatment effectiveness. CTLA-4 blockade activates CD8+ T cells and increases levels of IFN-g and TNF-a cytokines, triggering tumor cell pyroptosis and release of inflammatory substances and chemokines.
Article
Materials Science, Multidisciplinary
Cuicui Liu, Jian Peng, Zhigang Xu, Qiang Shen, Chuanbin Wang
Summary: Hard coatings were prepared on PCrNi1MoA steel substrates by direct current magnetron sputtering, and their growth and phase evolution were controlled by adjusting the substrate temperature (T-sub) and sputtering power (P-spu). The combined effect of T-sub and P-spu on the crystalline phase, surface morphology, and mechanical properties of the coatings was investigated. The optimized conditions resulted in the deposition of single-phased and homogeneous a-Ta coatings with improved hardness, toughness, and adhesion.
Article
Chemistry, Multidisciplinary
Liang Zhang, Shu-Cheng Wan, Jianyu Zhang, Meng-Jie Zhang, Qi-Chao Yang, Boxin Zhang, Wu-Yin Wang, Jianwei Sun, Ryan T. K. Kwok, Jacky W. Y. Lam, Hexiang Deng, Zhi-Jun Sun, Ben Zhong Tang
Summary: Covalent organic frameworks (COFs) have shown potential as porous materials for cancer phototherapy due to their unique characteristics. However, the aggregation-caused quenching effect and apoptosis resistance limit their effectiveness. This study demonstrated that linking AIEgens into COF networks was an effective strategy for inducing pyroptosis and enhancing antitumor immunity. The synergized system of AIE COF and αPD-1 effectively eradicated tumors and inhibited recurrence and metastasis in a tumor model.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Yuanyuan Chen, Jingting Wang, Qiming Wang, Xiaojuan Lei, Jichun Zhao, Zhigang Xu, Jian Ming
Summary: A fucoidan-based curcumin nanoparticle (FZC-NPs) was synthesized for cancer-targeted therapy, with small diameter, high stability, efficient drug loading, controlled release, and good cellular uptake. FZC-NPs showed stronger anticancer activity compared to free curcumin, inducing mitochondrial damage and inhibiting tumor cell invasion and migration. In vivo experiments demonstrated effective tumor accumulation, excellent antitumor activity, and good biocompatibility of FZC-NPs, confirming its potential as a safe and effective therapeutic agent.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2023)
Article
Dentistry, Oral Surgery & Medicine
Yuantong Liu, Shujin Li, Shuo Wang, Qichao Yang, Zhizhong Wu, Mengjie Zhang, Lei Chen, Zhijun Sun
Summary: Cancer stem cell-like cells (CSCs) play a crucial role in the heterogeneity, metastasis, and treatment resistance of head and neck squamous cell carcinoma (HNSCC). The gene LIMP-2 has been identified as a potential therapeutic target for regulating HNSCC progression and CSC properties. High expression of LIMP-2 suggests poor prognosis and potential immunotherapy resistance in HNSCC patients. Mechanistically, enhanced autophagy mediated by LIMP-2 helps HNSCC maintain stemness and facilitates the transcription of downstream target genes.
INTERNATIONAL JOURNAL OF ORAL SCIENCE
(2023)
Article
Chemistry, Physical
Sen Yang, Yinghao Wei, Qi Wang, Zhijun Sun, Ai-Hua Li
Summary: In this study, a high-performance microcrystal based on heavily doped Tm3+ was designed to achieve self-trapped excitons and Tm3+ near-infrared emission. The application of its luminescent properties in temperature sensing was also investigated.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)
Article
Chemistry, Multidisciplinary
Xintong Zhang, Yanhong Liu, Wei Liu, Liqing Chen, Mingji Jin, Zhonggao Gao, Wei Huang
Summary: This study developed a macrophage-hitchhiking gene delivery system for the treatment of rheumatoid arthritis. The system demonstrated excellent targeting ability and nuclear entry ability, leading to efficient transfection of interleukin-10 in macrophages and alleviation of inflammation symptoms. This research provides a novel strategy for gene therapy and gene delivery system design for rheumatoid arthritis and other similar inflammatory diseases.
Article
Chemistry, Multidisciplinary
Richard K. Cross, Dave Spurgeon, Claus Svendsen, Elma Lahive, Simon Little, Frank von der Kammer, Frederic Loosli, Marianne Matzke, Teresa F. Fernandes, Vicki Stone, Willie J. G. M. Peijnenburg, Eric A. J. Bleeker
Summary: Even small changes in physicochemical properties of nanoforms (NFs) can influence their environmental fate and hazard. Testing and characterizing each individual NF will not be feasible due to the large number of new materials being developed. Targeting the most relevant form of the NF for a given exposure is important for efficient risk assessment. In aquatic systems, functional fate processes play a key role in determining the exposure relevant form of NFs. Grouping of NFs and read-across based on functional fate pathways can be justified by considering the shared fate and hazard profile. A new Integrated Approaches to Testing and Assessment (IATA) is presented, focusing on dissolution, dispersion stability, chemical transformations, and the contribution to toxicity from particles and dissolved components. This IATA can be used as a template for future in vivo kinetic assessments.
Article
Chemistry, Multidisciplinary
Minhui Lu, Xiaoxuan Zhang, Lijun Cai, Jingjing Gan, Jinglin Wang, Yu Wang, Yuanjin Zhao
Summary: Researchers have proposed a novel black phosphorus-loaded hydrogel inverse opal microneedle patch that exhibits photothermal responsive capacity and vivid structural color screening for psoriasis treatment. With improved materials, structures, and functions, the microneedle patch enables intelligent drug delivery and enhances drug loading and controllable release.
Article
Chemistry, Multidisciplinary
Qianyun Tang, Dandan Wang, Jinhui Cui, Yiheng Zhang, Junyang Mei, Jing Du, Anyue Xia, Qian Sun, Dan Luo, Baosan Han, Mingzhe Gan, Peifeng Liu
Summary: This study presents a novel microfluidic platform for precise and flexible control of oxygen concentrations in microbial suspension culture. The platform demonstrates unique capabilities for spatiotemporal gas control and detection, allowing for applications in screening, studying, and culturing industrial or niche-specific environmental microbiomes.
Review
Chemistry, Multidisciplinary
Jiaen Wu, Hao Chen, Jiawei Xu, Muhammad Saif Ur Rahman, Shengmei Li, Jie Wang, Shifen Huang, Charles C. Han, Shanshan Xu, Ying Liu
Summary: This review categorizes the potential health risks of microplastic pollution by focusing on the three primary pollution sources. It provides an in-depth analysis of the pharmacokinetics, toxicity potential, and biological mechanism of microplastics in the human body. The review aims to fill knowledge gaps about the toxicity of microplastics on human health and provide ideas for repairing the damage caused by microplastics.
Article
Chemistry, Multidisciplinary
Fanshu Ma, Yi Cao, Jincong Yan, Zhongzhong Lu, Lina Sun, Zahid Hussain, Zheng Wang, Li Wang, Renjun Pei
Summary: This study proposes a simple yet powerful method to create multifunctional hybrid nanovesicles that combine the characteristics of oncolytic viruses and pyroptosis, leading to enhanced tumor targeting and improved immune response. The results demonstrate excellent tumor inhibition efficacy against melanoma and pulmonary metastasis.
Article
Chemistry, Multidisciplinary
Fangmian Wei, Johannes Karges, Siyuan Gao, Lili Wang, Xiting Zhang, Xing-Can Shen, Liangnian Ji, Hui Chao
Summary: This study presents the coordination of Ru(II) polypyridine complexes to graphitic carbon nitride nanosheets for oxygen-self-sufficient two-photon photodynamic immunotherapy. The conjugates were found with strong two-photon absorption and could generate reactive oxygen species (ROS) to induce cell death and inhibit tumor growth through immune system activation.
Article
Chemistry, Multidisciplinary
Weiwei Zheng, Shun-Yu Yao, Haijun Hu, Xiping Chen, Zhefeng Qian, Wenxing Liu, Yang Zhu, Zhengwei Mao, Dong-Sheng Guo, Changyou Gao
Summary: In this study, a hypoxia-responsive self-assembled peptide hydrogel was prepared for ischemic stroke treatment. The hydrogel showed the ability to release drugs and effectively improve motor function, reduce infarct volume, and alleviate inflammation.
Article
Chemistry, Multidisciplinary
Qianqian Qiao, Jinyu Wang, Kai Long, Linwei Li, Jiahao Chen, Yuhao Guo, Ziqiang Xu, Ying Kuang, Tianjiao Ji, Cao Li
Summary: This study developed a catalytic system using titanium-based MXene nanosheets to load enzymes and anticancer drugs. The nanosheets demonstrated catalase-like activity and photothermal capability, enabling enhanced cancer treatment through starvation therapy and alleviation of hypoxia. In vitro and in vivo studies confirmed the effective anticancer capability of this enzyme cascade system.
Article
Chemistry, Multidisciplinary
Shiyang Wu, Yan He, Ruiqi Zhou, Chunlin Chen, Dawei Chen, Haiyang Hu
Summary: In this research, LDHA@MIP-DSD nanoparticles were designed to enhance the effectiveness of immunogenic cell death (ICD) in cancer immunotherapy. LDHA@MIP-DSD improved the accessibility of nanodrugs to cancer cells by surface imprinting LDHA and induced autophagy with SLN. The combination of these two effects resulted in optimal immune stimulation and antitumor efficiency.
Article
Chemistry, Multidisciplinary
Xu Zhang, Kejian Shi, Jiahui Mao, Kerou Mao, Yangrui Jia, Jiakun Zhang, Qingzhen Wang, Ru Bai, Fene Gao, Shihui Liu, Mengyu Guo, Fenglan Qin, Shengmin Li, Chunying Chen, Huige Zhou, Jing Liu, Fulin Chen
Summary: Compared with vein injection, oral administration is a preferred non-invasive and self-help treatment option for cancer therapy. However, the harsh gastrointestinal tract and biological barriers limit the stability and efficiency of oral drug delivery systems. To overcome these challenges, researchers have developed Cyssome, a drug delivery platform that can maintain stability in harsh environments, penetrate biological barriers, and improve drug release and bioavailability.
