期刊
MOLECULES
卷 27, 期 24, 页码 -出版社
MDPI
DOI: 10.3390/molecules27248835
关键词
contaminants of emerging concern; analytical methods; instrumentation; evaluation; bioassay; non-targeted analysis
资金
- National Institutes of Health
- National Institute of Environmental Health Sciences (NIH-NIEHS) Center for Environmental Exposures and Disease (CEED) [P30 ES005022, T32 ES019854]
Ingestion of water is a major pathway for human exposure to environmental contaminants, and emerging contaminants known as endocrine-disrupting compounds (EDCs) have gained recent attention. EDCs, which exist as mixtures of multiple classes of compounds in trace amounts, can cause adverse health effects even at low concentrations. Therefore, it is crucial to have the ability to evaluate EDC contamination with high sensitivity and accuracy.
Ingestion of water is a major route of human exposure to environmental contaminants. There have been numerous studies exploring the different compounds present in drinking water, with recent attention drawn to a new class of emerging contaminants: endocrine-disrupting compounds (EDCs). EDCs encompass a broad range of physio-chemically diverse compounds; from naturally occurring to manmade. Environmentally, EDCs are found as mixtures containing multiple classes at trace amounts. Human exposure to EDCs, even at low concentrations, is known to lead to adverse health effects. Therefore, the ability to evaluate EDC contamination with a high degree of sensitivity and accuracy is of the utmost importance. This review includes (i) discussion on the perceived and actual risks associated with EDC exposure (ii) regulatory actions that look to limit EDC contamination (iii) analytical methods, including sample preparation, instrumentation and bioassays that have been advanced and employed for multiclass EDC identification and quantitation.
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