Review
Plant Sciences
Narges Marefati, Vahideh Ghorani, Farzaneh Shakeri, Marzie Boskabady, Farzaneh Kianian, Ramin Rezaee, Mohammad Hosein Boskabady
Summary: Onion and its derivatives possess anti-inflammatory, antioxidant, and immunomodulatory effects, indicating their therapeutic value in treating diseases associated with oxidative stress, inflammation, and immune dysregulation.
PHARMACEUTICAL BIOLOGY
(2021)
Article
Environmental Sciences
Mysoon M. Al-Ansari, Latifah Al-Humaid, Majdoleen Aldawsari, Islem Faraj Abid, G. K. Jhanani, Rajasree Shanmuganathan
Summary: In this study, ethanol extraction was used to optimize the maximum yield of quercetin from small onions, and its antioxidant activity was investigated. The highest quercetin yield was obtained with an ethanol: water ratio. RP-HPLC analysis revealed the presence of 2,122 mg/g of quercetin and 0.34 mg/g of isorhamnetin in the extracted material. The onion skin extract had a total phenolic content of 301.03 mg GAE/g dry weight and 156 mg/g of quercetin equivalents. DPPH and ABTS free radical scavenging potentials of the extract were dose-dependent, with IC50 values of 62.27 mu g/mL and 53.65 mu g/mL, respectively. Therefore, the study suggests that small onion skin extract rich in quercetin may have potential as an antioxidant and anticancer agent.
ENVIRONMENTAL RESEARCH
(2023)
Article
Agronomy
Ju-Hui Kim, Ji-Su Kim, Si-Hyun Kim, Su-Hyeon Jeong, Un-Yul Jeong, Ji-Eun Jung, Sun-Kyung Lee, Sung-Hyen Lee
Summary: This study compared the functional activities of whole onions with quercetin, revealing that whole onions exhibited high antioxidant and anti-inflammatory effects, which could be a novel potential therapeutic candidate.
Article
Food Science & Technology
Oya Irmak Sahin, Ayse Neslihan Dundar, Kubra Uzuner, Mahmud Ekrem Parlak, Adnan Fatih Dagdelen, Furkan Turker Saricaoglu
Summary: This paper discusses the use of nanophytosomes loaded with anthocyanins extracted from red onion peel to overcome bio-stability issues during digestion. The characteristics of the nanophytosomes were investigated, including entrapment efficiency, particle size, poly-dispersity index, zeta-potential, morphological properties, in vitro bioaccessibility, and release kinetics. The results showed that the nanophytosomes had good entrapment efficiency and a two-fold increase in release in the intestinal medium. However, some limitations of the current nanoliposomes process were identified.
Article
Chemistry, Applied
Kaliyan Barathikannan, Ramachandran Chelliah, Su-Jung Yeon, Akanksha Tyagi, Fazle Elahi, Selvakumar Vijayalakshmi, Paul Agastian, Vijayakumar Arockiasami, Deog Hawn Oh
Summary: The bioconversion of onion extracts with P. acidilactici MNL5 enhances metabolites and has a synergistic lipid-reduction impact for anti-obesity studies. The fermented onion extracts show enhanced inhibitory activity against pancreatic lipase and increased antioxidant properties compared to raw onion extract.
Article
Biochemistry & Molecular Biology
Ana V. Gonzalez-de-Peredo, Mercedes Vazquez-Espinosa, Estrella Espada-Bellido, Ceferino Carrera, Marta Ferreiro-Gonzalez, Gerardo F. Barbero, Miguel Palma
Summary: The study developed an ultrasound-assisted extraction method to obtain onion extracts with high flavonol content and antioxidant activity, which showed similar efficacy to individual optimizations but with reduced costs, time, and work. This method, optimized through multi-response optimization, proved to be a suitable technique for extracting bioactive compounds from onion matrices.
Article
Plant Sciences
Hyun-Seung Lee, Yong-Jin Kwon, Eun-Bi Seo, Seul-Ki Kim, Haeri Lee, Jin-Tae Lee, Pahn-Shick Chang, Young Jin Choi, Sung-Hyen Lee, Sang-Kyu Ye
Summary: The peel extract of Allium cepa (AP50E) exhibits anti-inflammatory effects in LPS-induced RAW264.7 mouse macrophages by directly inhibiting the JAK-STAT signaling pathway. These findings suggest that AP50E may be a potential candidate for the development of preventive or therapeutic agents against inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Irina Chernukha, Nadezhda Kupaeva, Daniil Khvostov, Yuliya Bogdanova, Jutta Smirnova, Elena Kotenkova
Summary: Antioxidants play a crucial role in the food industry, and there is a growing preference for natural antioxidants without undesired side effects. This study evaluated the effect of adding Allium cepa husk extract to meat pate and found that it maintained increased content of antioxidants, reducing lipid peroxidation. The results support the use of yellow onion husk extract to improve the functionality of meat products and provide clean-label foods.
Article
Food Science & Technology
Mariangela Marrelli, Maria Pia Argentieri, Ersilia Alexa, Daniela Meleleo, Giancarlo Statti, Pinarosa Avato, Filomena Conforti, Rosanna Mallamaci
Summary: The study investigated the bioactive metabolites and protective effects of Trapea red onion extract on human Caco-2 colon adenocarcinoma cells and its antioxidant effects. The extract showed high levels of bioactive compounds and strong antioxidant activity. It also inhibited the release of NO in a dose-dependent manner. The extract provided higher cytoprotection and significantly reduced cell damage caused by Cd exposure. MTT and LDH assays indicated that the extract could effectively prevent Cd-induced cytotoxicity after 24 hours.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Plant Sciences
Pranjali A. Gedam, Dhananjay V. Shirsat, Thangasamy Arunachalam, Sourav Ghosh, Suresh J. Gawande, Vijay Mahajan, Amar Jeet Gupta, Major Singh
Summary: Waterlogging-tolerant onion genotypes were identified and evaluated in this study. The tolerant genotypes exhibited better growth and yield characteristics under stress conditions. These tolerant genotypes can be used for onion breeding programs.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Irina Chernukha, Nadezhda Kupaeva, Elena Kotenkova, Daniil Khvostov
Summary: The effective management of agro-industry organic waste for developing high-commercial-value products is a promising facet of the circular economy. Red onion husks exhibited the highest antioxidant potential and flavonoid content among the different onion colors.
Article
Environmental Sciences
Oksal Macar
Summary: The study demonstrated that various toxic, cytotoxic, and genotoxic effects of tetraconazole fungicide occurred at different doses on the meristematic cells of onion root tips.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Cristina Moliner, Sonia Nunez, Guillermo Casedas, Marta Sofia Valero, Maria Ines Dias, Lillian Barros, Victor Lopez, Carlota Gomez-Rincon
Summary: This study aimed to determine the polyphenolic profile of onion flowers and evaluate their antioxidant and anti-obesity capacity. The phenolic compounds kaempferol and isorhamnetin glucosides were identified, and the flower extract exhibited the ability to reduce fat accumulation, inhibit digestive enzyme activity, and enhance antioxidant activity. This suggests that onion flowers have potential as functional foods and nutraceuticals.
Article
Chemistry, Medicinal
Ana Gonzalez-de-Peredo, Mercedes Vazquez-Espinosa, Ceferino Carrera, Estrella Espada-Bellido, Marta Ferreiro-Gonzalez, Gerardo F. Barbero, Miguel Palma
Summary: Onion is rich in antioxidant compounds, especially quercetin derivatives. A rapid UHPLC-PDA method was developed to separate major flavonols in onions, with excellent precision and robustness. This method improves the analysis of raw materials and enhances the quality of onions and their byproducts in terms of bioactive compounds.
Article
Microbiology
Ram Dutta, K. Jayalakshmi, Sharath M. Nadig, Dalasanuru Chandregowda Manjunathagowda, Vishal S. Gurav, Major Singh
Summary: Onions are a valuable vegetable-spice crop in India but are susceptible to diseases caused by fungi, bacteria, viruses, and nematodes. Anthracnose, caused by Colletotrichum spp., is a major issue as it severely affects bulb production. Twister disease is a common problem in onion production, particularly in humid regions, reducing productivity and value. This review provides updated knowledge on onion anthracnose, including the pathogen, disease cycle, infection pathways, and management techniques to benefit growers.
Article
Food Science & Technology
Songtao Fan, Zhihong Zhang, Yansheng Zhao, Maria Daglia, Jiayan Zhang, Ying Zhu, Juan Bai, Lin Zhu, Xiang Xiao
Summary: Diet-related diseases are characterized by imbalanced gut microbiomes, which can be targeted for therapeutic interventions. Microbiome-based therapies have shown inconsistent results due to individual variability. Personalized microbiome-targeted nutrition therapies are being developed to modulate gut microbiomes more effectively. This review explores the concept of targeted prebiotics, which are specific fibers that can manipulate the gut microbial community. The application of targeted prebiotics in personalized nutrition aims to achieve predictable shifts in the gut microbiome composition and function.
CURRENT OPINION IN FOOD SCIENCE
(2023)
Review
Food Science & Technology
Yu Zhang, Ruojie Hao, Junda Chen, Sen Li, Kai Huang, Hongwei Cao, Mohamed A. A. Farag, Maurizio Battino, Maria Daglia, Esra Capanoglu, Fan Zhang, Qiqi Sun, Jianbo Xiao, Zhenliang Sun, Xiao Guan
Summary: Saponins, consisting of sapogenins and carbohydrate chains, are compounds widely found in plants and marine organisms. Their complex structure limits the investigation of their absorption and metabolism, hindering the understanding of their bioactivities. Despite their low bioavailability, saponins interact with the gastrointestinal environment and gut microbiota, playing a significant role in their potential health benefits. However, there is still a lack of research on the metabolic pathways and interactions of saponins with gut microbiota.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Chemistry, Medicinal
Muhammad Imran, Arshad Iqbal, Syed Lal Badshah, Ayaz Ali Sher, Hammad Ullah, Muhammad Ayaz, Osama F. Mosa, Nada M. Mostafa, Maria Daglia
Summary: Seaweed is known for its beneficial effects on human health, and Dictyota dichotoma extracts contain various bioactive components such as proteins, fats, and carbohydrates. The extracts also contain multiple compounds, including undecane, cetylic acid, hexadecenoic acid, Z-11-, and myristic acid.
Article
Chemistry, Multidisciplinary
Imad Ahmad, Aleksey E. E. Kuznetsov, Abdul Saboor Pirzada, Khalaf F. F. Alsharif, Maria Daglia, Haroon Khan
Summary: In this study, the drug-related properties of 4-Hydroxyisoleucine were determined using ADMETLab 2.0. The results showed that it possesses important drug-like physicochemical properties and is compliant with drug-ability rules. It also has satisfactory cell permeability and is non-toxic to both the environment and human body.
FRONTIERS IN CHEMISTRY
(2023)
Article
Food Science & Technology
Hammad Ullah, Alessandro Di Minno, Anna Di Filippis, Eduardo Sommella, Daniele Giuseppe Buccato, Lorenza Francesca De Lellis, Hesham R. El-Seedi, Shaden A. M. Khalifa, Roberto Piccinocchi, Massimiliano Galdiero, Pietro Campiglia, Maria Daglia
Summary: Plant extracts from Cistus x incanus L. and Scutellaria lateriflora L. show potential for treating gingivitis due to their polyphenol content, which exhibit inhibitory effects against Porphyromonas gingivalis.
Article
Biochemistry & Molecular Biology
Danilo D'Avino, Ida Cerqua, Hammad Ullah, Michele Spinelli, Rita Di Matteo, Elisabetta Granato, Raffaele Capasso, Lucianna Maruccio, Armando Ialenti, Maria Daglia, Fiorentina Roviezzo, Antonietta Rossi
Summary: The root of Astragalus membranaceus (Fisch.) Bunge is used in Chinese medicine for its immunomodulating activities. Recent studies have shown that it has beneficial effects on allergic diseases. This study investigated the anti-inflammatory properties of a commercial extract of A. membranaceus and its therapeutic application in asthma. The extract was found to inhibit inflammation and improve lung function, making it a potential treatment option for asthma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Medicinal
Hesham R. El-Seedi, Mohamed F. El-Mallah, Nermeen Yosri, Muaaz Alajlani, Chao Zhao, Muhammad A. Mehmood, Ming Du, Hammad Ullah, Maria Daglia, Zhiming Guo, Shaden A. M. Khalifa, Qiyang Shou
Summary: This paper discusses the historical and existential records of marine cyanobacteria and their role in understanding their evolution. Recent advancements focus on isolating and screening bioactive compounds and their medicinal properties, highlighting compounds with potential pharmacological effects such as cytotoxicity, anticancer, and antiparasitic properties.
Article
Nutrition & Dietetics
Hammad Ullah, Eduardo Sommella, Alessandro Di Minno, Roberto Piccinocchi, Daniele Giuseppe Buccato, Lorenza Francesca De Lellis, Costanza Riccioni, Alessandra Baldi, Hesham R. El-Seedi, Shaden A. M. Khalifa, Gaetano Piccinocchi, Pietro Campiglia, Roberto Sacchi, Maria Daglia
Summary: This study aimed to evaluate the efficacy of a new food supplement based on a chemically characterized pomegranate extract and hydro-soluble vitamins (B complex and C) in reducing prolonged fatigue in healthy subjects. The food supplement showed significant reductions in fatigue severity scores but had no considerable effect on psychological well-being.
Article
Agronomy
Arwa A. Al-Huqail, Adnan A. Bekhit, Hammad Ullah, Muhammad Ayaz, Nada M. Mostafa
Summary: This study identified compounds in marigold flower extract and evaluated their potential as anti-leishmanial and anti-malarial agents. The results showed that marigold flowers are rich in flavonoids and have antibacterial effects against certain diseases.
Review
Biochemistry & Molecular Biology
Carla Renata Arciola, Stefano Ravaioli, Rasoul Mirzaei, Paolo Dolzani, Lucio Montanaro, Maria Daglia, Davide Campoccia
Summary: This passage discusses the interactions between neutrophils and bacterial biofilms in implant infections, as well as the defensive and offensive mechanisms of neutrophils against biofilms. Understanding these interactions is important for designing therapeutic strategies and functionalized biomaterials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Davide Campoccia, Stefano Ravaioli, Rasoul Mirzaei, Gloria Bua, Maria Daglia, Carla Renata Arciola
Summary: This paper discusses the formation of biofilms on orthopedic implants and their lethal impact on prosthetics, exploring the role of neutrophils in combating biofilm formation. The interactions between various components of the biofilm matrix and neutrophils are crucial for understanding health and treatment outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Hammad Ullah, Alessandro Di Minno, Roberto Piccinocchi, Daniele Giuseppe Buccato, Lorenza Francesca De Lellis, Alessandra Baldi, Hesham R. El-Seedi, Shaden A. M. Khalifa, Gaetano Piccinocchi, Xiang Xiao, Roberto Sacchi, Maria Daglia
Summary: This study assessed the effectiveness and tolerability of supplementing a normal diet with a multi-enzyme blend obtained from fungal fermentation in functional dyspepsia. The results showed improvement in quality of life, sleep quality, and a decrease in pain severity after supplementation with digestive enzymes. Overall, treatment with digestive enzymes was found to be effective and well-tolerated in reducing functional dyspepsia symptoms.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
