期刊
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
卷 162, 期 -, 页码 176-188出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jphotobiol.2016.06.036
关键词
Dihydroquinazolinone; Lysozyme; Interaction; Fluorescence; Spectrophotometry; Metabolism
资金
- DST-FTYS, Government of India, New Delhi [SB/FT/CS-113/2013]
- Deanship of Scientific Research at King Saud University [PRG-1437-28]
The main aim of this study is to investigate the interaction of 7-fluoro-2,2-dimethyl-2,3-dihydroguinazolin-4(1H)-one with lysozyme through various spectrophotometric studies. The graph such as Stern-Volmer plot, modified Stern Volmer plot, double logarithmic plot and Van't Hoff plot were plotted to determine the various parameters essential for predicting the interaction. The interaction of the ligand with the protein was further confirmed by circular dichroism and NMR study. The molecular docking was performed and the results obtained were correlated with the other studies. The importance of fluorine was justified through the prediction of plc values and the possible metabolic pathway using the in silico tools. In addition, the cytotoxicity of the compound was carried out using HeLa cancer cell. (C) 2016 Elsevier B.V. All rights reserved.
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