Article
Biochemistry & Molecular Biology
Adriana Corina Hangan, Roxana Liana Lucaciu, Alexandru Turza, Lucia Dican, Bogdan Sevastre, Emoeke Pall, Luminita Simona Oprean, Gheorghe Borodi
Summary: The discovery of new non-toxic metal complexes with biological activity is an active area of research. Two Cu+2 complexes with new ligands were synthesized and characterized by X-ray crystallography. Both complexes showed in vitro biological activities, with complex C2 being more active. The complexes exhibited distorted square pyramidal square-planar geometries and were characterized by FT-IR and UV-Vis spectroscopy. The antibacterial activity of the complexes against four Gram-positive and two Gram-negative bacteria was determined using the microdilution method, and cytotoxicity studies were carried out on tumor cell lines and a normal cell line. Flow cytometric assessment of apoptosis induced by the complexes was also performed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Lina Rocio Davila Giraldo, Claudia Cristina Perez Jaramillo, Jonh Jairo Mendez Arteaga, Walter Murillo-Arango
Summary: This study evaluated the nutritional value of nine species of wild macrofungi from Ibague-Tolima, Colombia, as well as their antioxidant, antimicrobial, and cytotoxic activities. The results showed that Pleurotus and Lentinus genus had the highest protein percentages. The extracts from Phellinus gilvus and Ganoderma australe exhibited lower IC50 values and showed effective antimicrobial and antifungal activities.
Article
Chemistry, Inorganic & Nuclear
Sivaswamy Kanchanadevi, Frank R. Fronczek, Viswanathan Mahalingam
Summary: The newly synthesized ruthenium(III) complexes demonstrated significant antioxidant activity and cytotoxicity against cancer cells, binding to DNA in an intercalative mode and to proteins via static binding, showing high cytotoxicity even at low concentrations.
INORGANICA CHIMICA ACTA
(2021)
Article
Biochemistry & Molecular Biology
Jana Hricoviniova, Zuzana Hricoviniova, Katarina Kozics
Summary: This study examined a series of 2,3-substituted quinazolinone derivatives for their biological properties, revealing that derivatives with electron-donating moieties exhibited the most potent antioxidant and DNA-protective effects without genotoxicity. Additionally, these compounds showed higher cytotoxicity in renal carcinoma cells compared to renal epithelial cells. The findings suggest that these quinazolinones may serve as potential model structures for the development of pharmacologically active agents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Aaron Teran, Giarita Ferraro, Paola Imbimbo, Ana E. Sanchez-pelaez, Daria Maria Monti, Santiago Herrero, Antonello Merlino
Summary: This study explores the interaction between paddlewheel diruthenium complexes and proteins, and finds that their selectivity towards proteins is determined by their charge and steric properties. The anticancer activity of diruthenium derivatives is correlated with the number of ligands, steric hindrance, and core electronic density.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Physical
Atena Naeimi, Fereshteh Ezzati Ghadi, Seyed Mehdi Saadatkhah, Moones Honarmand
Summary: The present study aimed to investigate the effects of a novel SnO2/Calcite bio-nano composite on HepG2 cell line and its antioxidant and antimicrobial properties. The results demonstrated that the SnO2/Calcite bio-nano composite exhibited anti-cancer, antioxidant, and antimicrobial activities, and showed greater potential against bacteria and fungi compared to calcite and SnO2 nanoparticles.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Multidisciplinary
Yulia P. Tupolova, Leonid D. Popov, Valery G. Vlasenko, Konstantin B. Gishko, Anna A. Kapustina, Alexandra G. Berejnaya, Yuliya A. Golubeva, Lyubov S. Klyushova, Elizaveta V. Lider, Vladimir A. Lazarenko, Stanislav S. Bachurin, Igor N. Shcherbakov
Summary: Based on the bis-hetarylhydrazone H2L, a series of mononuclear copper(ii) coordination compounds were synthesized and their structures were studied using several methods. The copper center in these compounds is in a square pyramidal environment. The cytotoxic activity of the compounds against HepG2 and MRC-5 cell lines was evaluated, and the Cu(ii) complexes showed significant dose-dependent cytotoxic effects.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Biochemical Research Methods
Mehmet Fidan, Muhammad Muddassir Ali, Mehmet Emre Erez, Ibrahim Hakki Cigerci, Sadin Ozdemir, Fatih Sen
Summary: Fungi can be used as potent chemotherapeutic agents for treating various cancers. In this study, the extracts of Terfezia and Picoa species were evaluated for their phenolic content, antioxidant activity, ion-chelating impact, antimicrobial activity, and cytotoxic effects. The methanol and acetone extracts of T. boudieri exhibited the highest antioxidant activities. All tested truffle species showed dose-dependent ion-chelating impact. T. boudieri, T. claveryi, and T. albiensis extracts showed higher antimicrobial activities. T. claveryi and T. boudieri showed the highest protective effects against DNA damage, while T. olbiensis, P. lefebvrei, and P. juniperi showed the least protective effects. Overall, Terfezia species have significant protective effects against DNA damage and potential cytotoxic effects.
ANALYTICAL BIOCHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Sengul Uysal, Gokhan Zengin, Kouadio Ibrahime Sinan, Gunes Ak, Ramazan Ceylan, Mohamad Fawzi Mahomoodally, Ahmet Uysal, Nabeelah Bibi Sadeer, Jozsef Jeko, Zoltan Cziaky, Maria Joao Rodrigues, Evren Yildiztugay, Fevzi Elbasan, Luisa Custodio
Summary: The methanolic aerial extracts of Salvia ceratophylla exhibited the highest phenolic and flavonoid contents, while the hydro-methanolic aerial extract showed significant antioxidant activity and the hexane root extract displayed the strongest antimicrobial potential. Meanwhile, the methanolic root extract demonstrated the lowest cytotoxicity against HepG2 cells. The phytochemical analysis revealed the presence of important polyphenolic compounds like luteolin and gallic acid in the lemon-scented herb.
Article
Chemistry, Multidisciplinary
Fatma A. Elshibani, Hamdoon A. Mohammed, Amr S. Abouzied, Abdulnaser Kh. Abdulkarim, Riaz A. Khan, Suliman A. Almahmoud, Bader Huwaimel, Abdullah D. Alamami
Summary: This article presents the first documented phytochemical and biological evaluation report of Thymbra linearifolia, an endemic Libyan plant. The study revealed the presence of phenolic and flavonoid compounds in the plant, which exhibited strong antioxidant and anticancer activities. Additionally, the plant also showed moderate antimicrobial effects.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Physical
Aiping Xing, Dai Zeng, Zhihong Chen
Summary: Schiff bases are important chemical compounds with various biological activities, such as antioxidant, antibacterial, antifungal, antiviral, antitumor, and anti-inflammatory properties. In this study, three Schiff base compounds were synthesized and characterized, and their antioxidant capacity and free radical scavenging mechanism were evaluated. The results support the ET-PT mechanism for DPPH free radical scavenging, consistent with experimental findings.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Biochemistry & Molecular Biology
Ozlem Iscan, Resit Cemaloglu, Nuran Asmafiliz, Celal Tugrul Zeyrek, Zeynel Kilic, Leyla Acik, Betul Aydin, Mustafa Turk, Tuncer Hokelek
Summary: The study synthesized a series of phosphazene compounds with pendant arms and investigated their spectral, stereogenic, and biological properties. Some compounds exhibited chirality in the solid state. The antimicrobial activities, cytotoxicity, and interactions with DNA of these compounds were explored.
MOLECULAR DIVERSITY
(2022)
Article
Chemistry, Inorganic & Nuclear
Sivaswamy Kanchanadevi, Frank R. Fronczek, Charles Immanuel David, Raju Nandhakumar, Viswanathan Mahalingam
Summary: Two mononuclear complexes of Co(II) and Ni(II) and a binuclear copper(II) complex were synthesized and characterized for their biological activities, including DNA and protein-binding, antioxidant and anticancer activity. The interaction with DNA and protein, as well as radical scavenging ability, of the complexes were studied, and their cytotoxicity towards human cancer cell lines was tested.
INORGANICA CHIMICA ACTA
(2021)
Article
Biochemistry & Molecular Biology
Benedict Anak Samling, Zaini Assim, Woei-Yenn Tong, Chean-Ring Leong, Syarifah Ab Rashid, Nik Nur Syazni Nik Mohamed Kamal, Musthahimah Muhamad, Wen-Nee Tan
Summary: In this study, nanoencapsulation of Cynometra cauliflora essential oils (CCEOs) in chitosan nanoparticles (CSNPs) was successfully achieved using an emulsion-ionic gelation technique. The resulting CCEOs-CSNPs exhibited well dispersion and spherical shape with an average size of less than 100 nm. The encapsulation efficiency and loading capacity were high, indicating successful nanoencapsulation. The CCEOs-CSNPs showed significant antioxidant and antimicrobial activities, as well as cytotoxic effects against breast cancer cells while being non-toxic to normal cells. These findings suggest that nanoencapsulation using CSNPs could enhance the properties of CCEOs in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Physical
Shyam Goswami, Arabinda Ghosh, Karmajyoti Borah, Anupam Mahanta, Ankur K. Guha, Sanchay J. Bora
Summary: This study focuses on the structure and properties of the self-assembled gallic acid and 4-cyanopyridine adduct, showing promising antioxidant and antibacterial activities in its binary form.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Correction
Materials Science, Biomaterials
Dharmasivam Mahendiran, Raju Senthil Kumar, Aziz Kalilur Rahiman
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Microbiology
Mohanraj Gunasekaran, Beny Trabelcy, Ido Izhaki, Malka Halpern
Summary: Orange-tufted sunbirds feed on the nectar of the tobacco tree, which contains toxic alkaloids. Gut microbiota plays a key role in enabling the birds to cope with these toxins. Both in vivo and in vitro experiments show the ability of certain bacterial species to degrade the toxic metabolites.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
L. Ma, M. Gholam Azad, M. Dharmasivam, V Richardson, R. J. Quinn, Y. Feng, D. L. Pountney, K. F. Tonissen, G. D. Mellick, I Yanatori, D. R. Richardson
Summary: Studies indicate dysregulation of iron metabolism in Parkinson's disease, leading to increased neuronal iron levels and iron-mediated reactive oxygen species. Therapies utilizing limited iron chelation have shown success in treating PD. Further advancements in treatment are possible once the molecular pathways of iron processing are fully understood.
Article
Chemistry, Applied
Nithya Balakrishnan, Jebiti Haribabu, Mahendiran Dharmasivam, Srividya Swaminathan, Ramasamy Karvembu
Summary: Denticity of ligands plays a significant role in the cytotoxicity of metal complexes. This study evaluated the impact of ligand denticity in the Ru(II)-DMSO complexes on the cytotoxicity of cancer cells. Results showed that the complex with a tridentate chromone ligand exhibited better anticancer activity compared to the one with a bidentate chromene ligand. The stable nature of the tridentate system and the higher reactivity of the chloride ligand in the tridentate species were attributed to the observed differences in cytotoxicity. The complex demonstrated selective cytotoxicity against breast cancer cells and lower toxicity against normal cells, indicating its effective anticancer potential.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
O. Yu. Selyutina, P. A. Kononova, V. E. Koshman, E. A. Shelepova, M. Gholam Azad, R. Afroz, M. Dharmasivam, Paul V. Bernhardt, N. E. Polyakov, D. R. Richardson
Summary: Ascorbate-driven redox cycling enhances the anti-proliferative activity of Dp44mT and Emodin.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2022)
Article
Chemistry, Applied
Sumeer Ahmed, Mugamathu Ali Jayathuna, Dharmasivam Mahendiran, Sundaram Bharathi, Aziz Kalilur Rahiman
Summary: In this study, a series of new heteroleptic complexes of silver(I), nickel(II), and copper(II) with thiosemicarbazone and ciprofloxacin ligands were synthesized and characterized. The complexes showed different coordination behavior and exhibited higher activity against cancer cells, especially copper(II) complexes.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Mahendiran Dharmasivam, Mahan Gholam Azad, Rizwana Afroz, Vera Richardson, Patric J. Jansson, Des R. Richardson
Summary: This study demonstrates the potent and broad anti-proliferative activity of Dp44mT and particularly DpC, and is important for establishing optimized combinations with standard chemotherapies.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2022)
Article
Chemistry, Medicinal
D. R. Richardson, M. Gholam Azad, R. Afroz, V Richardson, M. Dharmasivam
Summary: This article discusses the development of compounds that target the bidirectional oncogenic signaling between pancreatic cancer cells and pancreatic stellate cells. It also explores the discovery of additional pathways involved in this signaling and highlights the therapeutic opportunity presented by suppressing bidirectional signaling between cell types.
FUTURE MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Padmanathan Arthi, Mahendiran Dharmasivam, Busra Kaya, Aziz Kalilur Rahiman
Summary: A series of pendant-armed mixed-ligand copper(II) complexes have been synthesized and analyzed using various spectroscopic methods. These complexes exhibit antibacterial activity, especially against gram-negative pathogens. They also show DNA-binding capability and interact significantly with the SARS-CoV-2 receptor, with higher binding energy and inhibition constant compared to standard drugs.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Chemistry, Medicinal
Mahendiran Dharmasivam, Busra Kaya, Tharushi Wijesinghe, Mahan Gholam Azad, Miguel A. Gonzalvez, Mohammad Hussaini, Jason Chekmarev, Paul Bernhardt, Des R. Richardson
Summary: A novel and selective antitumor agent, 3-thiosemicarbazone (PPP44mT), and its analogues with distinctive properties were synthesized and characterized. The inclusion of a styrene moiety prevented the oxidation of oxy-myoglobin or oxy-hemoglobin, which is different from other potent thiosemicarbazones such as DpC or Dp44mT. PPP44mT and its Cu(II) complexes exhibited immediate cytotoxicity against SK-N-MC tumor cells, while [Zn(PPP44mT)2] showed delayed antiproliferative efficacy and superior inhibition of cyclin D1 expression compared to DpC or Dp44mT.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Nithya Balakrishnan, Jebiti Haribabu, Mahendiran Dharmasivam, Jayachandra Prakasan Jayadharini, Dhanabalan Anandakrishnan, Srividya Swaminathan, Nattamai Bhuvanesh, Cesar Echeverria, Ramasamy Karvembu
Summary: This study investigates the influence of the structure of indole thiosemicarbazone derivatives on the anticancer activity of their ruthenium complexes. The complexes show good biomolecular interactions with DNA/protein and exhibit significant anticancer potential against MB-MDA-231 and MCF-7 cancer cells. The substitution of a benzyl group at the indoleN improves the cytotoxic profile of the complexes compared to the allyl group, and the para-substituted benzyl scaffolds show higher anticancer activity than the meta-substituted compounds.
Article
Chemistry, Multidisciplinary
Pandurangan Ganapathi, Kilivelu Ganesan, Mahendiran Dharmasivam, Mohammed Mujahid Alam, Amanullah Mohammed
Summary: This study reports a method for synthesizing dimeric nitro-substituted imidazolium salts, which is solvent-free and has many advantages. The research found that these compounds showed excellent inhibition against E. coli and P. aeruginosa bacteria and this was further supported by molecular docking studies.
Article
Chemistry, Applied
Dorothy Priyanka Dorairaj, Jebiti Haribabu, Dharmasivam Mahendiran, Rahime Eshaghi Malekshah, Sodio C. N. Hsu, Ramasamy Karvembu
Summary: We synthesized five new Cu(I) acylthiourea complexes (C1-C5) and characterized them using analytical and spectroscopic tools. The complexes exhibited a distorted tetrahedral geometry as observed from a single crystal X-ray diffraction study. Complex C4 showed the highest binding efficacy with biomolecules and demonstrated high cytotoxicity against breast cancer cell lines. It induced apoptosis through a reactive oxygen species (ROS)-mediated mitochondrial signaling pathway.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Srividya Swaminathan, Jebiti Haribabu, Mahendiran Dharmasivam, Nikhil Maroli, Jayachandra Prakasan Jayadharini, Nithya Balakrishnan, Nattamai Bhuvanesh, Cesar Echeverria, Ramasamy Karvembu
Summary: We designed and synthesized bipodal ligands with varying substitution on the phenyl group spacer. Ligands and complexes with different arene units were successfully synthesized and characterized. The coordination behavior of the ligands was minimally influenced by substitution change, but differences were observed in the anticancer activity of the complexes. DFT and X-ray diffraction studies revealed structural variations between the different substitutions, and UV-visible spectroscopy determined the correlation between anticancer activity, hydrolysis rate, and lipophilicity index of the complexes. Staining assays, flow cytometry, and Western blot analysis confirmed the apoptotic cell death mechanism of the active complexes.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Senthilnathan Govindaraj, Kilivelu Ganesan, Mahendiran Dharmasivam, Lakshmisundaram Raman, Kalaivani M. Kuppusamy, Viswanathan Pandiappan, Mohammed Mujahid Alam, Amanullah Mohammed
Summary: Flexible dimeric substituted pyridinium bromides with primary and tertiary amines were synthesized using conventional and solvent-free methods. Compound 4 showed potent anticancer activity against lung and breast cancer cell lines, and induced apoptosis via the extrinsic apoptotic pathway. It upregulated caspase 3 and caspase 9, while downregulating Bcl-2, Bcl-x, and Bad.
Article
Biochemistry & Molecular Biology
Girgis Obaid, Menitte Eroy, Jie Zhao, Shazia Bano, Mari Mino-Kenudson, Tayyaba Hasan
Summary: The presence of desmoplasia in pancreatic ductal adenocarcinoma (PDAC) is associated with poor treatment outcomes and reduced drug delivery. By analyzing collagen subtypes in PDAC tumors following different treatment regimens, immunofluorescence profiling can predict long-term survival and tumor growth inhibition. This information can aid in personalized treatment and improve patient survival.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Fatemeh Malekpour, Rashin Bahrami, Mahshid Hodjat, Neda Hakimiha, Behnam Bolhari, Aidin Sooratgar, Soheil Niavarzi
Summary: This study investigated the effect of photobiomodulation (PBM) therapy using an 808 nm diode laser on cellular modulation mechanisms in regenerative endodontic procedures (REPs). The results showed that PBM treatment significantly increased cell viability and migration, and enhanced the release of TGF-131 from dentin.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Pranathi Tata, Ramakrishnan Ganesan, Jayati Ray Dutta
Summary: Thin film coatings with potent antibacterial properties are widely used in medical devices, frequently touched surfaces, and food packaging. However, achieving antibacterial performance under both light and dark conditions remains a challenge. In this study, we successfully prepared AgBr-coated ZnO nanorod thin film architecture using a unique surfactant-mediated solution-phase spin-coating approach. The resulting structures showed dual functionality as antimicrobial agents and photosensitizers, effectively enhancing the visible-light photodisinfection efficacy of ZnO nanorods. The concentration of the surfactant-based precursor solution could be modulated to control the AgBr content. Additionally, components like urea and lactic acid were found to enhance the photocatalytic efficiency of the structures.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2024)