Evaluation of antibacterial, antioxidant, cytotoxic, and acetylcholinesterase inhibition activities of novel [1,4] benzoxazepines fused to heterocyclic systems with a molecular modeling study

Discovery of new PKN2 inhibitory chemotypes via QSAR-guided selection of docking-based pharmacophores

(2022) Mahmoud A. Al-Sha’er et al.   MOLECULAR DIVERSITY

Design, Synthesis, and Evaluation of Novel 2H-Benzo[b][1,4]thiazin-3(4H)-one Derivatives as New Acetylcholinesterase Inhibitors

(2022) Sazan Haji Ali et al.   MOLECULES

Synthesis of N ‐alkylated pyrazolo[3,4‐ d ]pyrimidine analogs and evaluation of acetylcholinesterase and carbonic anhydrase inhibition properties

(2021) Busra O. Aydin et al.   ARCHIV DER PHARMAZIE

Design, Synthesis, and Antimicrobial Evaluation of New Annelated Pyrimido[2,1-c][1,2,4]triazolo[3,4-f][1,2,4]triazines

(2020) Islam H. El Azab et al.   MOLECULES

Synthesis and Biological Evaluation of Quinoline Derivatives as a Novel Class of Broad-Spectrum Antibacterial Agents

(2019) Hai-Gen Fu et al.   MOLECULES

Discovery of new Phosphoinositide 3-kinase delta (PI3Kδ) inhibitors via virtual screening using crystallography-derived pharmacophore modelling and QSAR analysis

(2019) Mahmoud A. Al-Sha`er et al.   Medicinal Chemistry

Caffeic acid phenethyl ester (CAPE)-derivatives act as selective inhibitors of acetylcholinesterase

(2019) Josephine M. Gießel et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Medicinal chemistry of oxazines as promising agents in drug discovery

(2019) Dhafer S. Zinad et al.   Chemical Biology & Drug Design

Identification of some benzoxazepines as anticancer agents inducing cancer cell apoptosis

(2018) Mohamed S Rashad et al.   Future Medicinal Chemistry

SYNTHESIS OF BENZOXAZEPINE DERIVATIVES FROM PYRAZOLE-CHALCONE VIA A SIMPLE AND CONVENIENT PROTOCOL USING BASIC ALUMINA AS SOLID SUPPORT

(2018) D. Ashok et al.   JOURNAL OF THE CHILEAN CHEMICAL SOCIETY

Synthesis, carbonic anhydrase inhibitory activity and antioxidant activity of some 1,3-oxazine derivatives

(2018) Rabia Qamar et al.   DRUG DEVELOPMENT RESEARCH

Synthesis of a new polycyclic heterocyclic ring system. Part III. Benzo[b]imidazo[1,5-d][1,4]oxazepine-1,4(2H,5H)-diones

(2017) Desislava V. Stanisheva et al.   HETEROCYCLIC COMMUNICATIONS

Structure-Based Design of Tricyclic NF-κB Inducing Kinase (NIK) Inhibitors That Have High Selectivity over Phosphoinositide-3-kinase (PI3K)

(2017) Georgette M. Castanedo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis, crystal structure and fungicidal activity of (E)-5-(methoxyimino)-3,5-dihydrobenzo[e][1,2]oxazepin-4(1H)-one analogues

(2017) Dongyan Yang et al.   MedChemComm

Design of Selective Benzoxazepin PI3Kδ Inhibitors Through Control of Dihedral Angles

(2017) Brian S. Safina et al.   ACS Medicinal Chemistry Letters

Pre-clinical evaluation of a novel class of anti-cancer agents, the Pyrrolo-1, 5-benzoxazepines.

(2016) LM Greene et al.   Journal of Cancer

6,7-Dihydrobenzo[f]benzo[4,5]imidazo[1,2-d][1,4]oxazepine derivatives as selective inhibitors of PI3Kα

(2015) Yong Yin et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Evaluation of novel Akt1 inhibitors as anticancer agents using virtual co-crystallized pharmacophore generation

(2015) Mahmoud A. Al-Sha’er et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Preparation of neuroprotective condensed 1,4-benzoxazepines by regio- and diastereoselective domino Knoevenagel–[1,5]-hydride shift cyclization reaction

(2014) László Tóth et al.   Beilstein Journal of Organic Chemistry

The novel pyrrolo-1,5-benzoxazepine, PBOX-6, synergistically enhances the apoptotic effects of carboplatin in drug sensitive and multidrug resistant neuroblastoma cells

(2014) Jennifer C. Lennon et al.   BIOCHEMICAL PHARMACOLOGY

Inducamides A–C, Chlorinated Alkaloids from an RNA Polymerase Mutant Strain of Streptomyces sp.

(2014) Peng Fu et al.   ORGANIC LETTERS

Discovery of thiazolobenzoxepin PI3-kinase inhibitors that spare the PI3-kinase β isoform

(2013) Steven T. Staben et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and biological evaluation of novel tricyclic oxazine and oxazepine fused quinazolines. Part 1: Erlotinib analogs

(2013) Xiangfeng Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of 2-{3-[2-(1-Isopropyl-3-methyl-1H-1,2–4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl]-1H-pyrazol-1-yl}-2-methylpropanamide (GDC-0032): A β-Sparing Phosphoinositide 3-Kinase Inhibitor with High Unbound Exposure and Robust in Vivo Antitumor Activity

(2013) Chudi O. Ndubaku et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, Cytotoxicity, Antibacterial and Antileishmanial Activities of Imidazolidine and Hexahydropyrimidine Derivatives

(2013) Gustavo S. G. de Carvalho et al.   Medicinal Chemistry

The Evolution of Drugs on Schistosoma Treatment: Looking to the Past to Improve the Future

(2013) Maira Galdino da Rocha Pitta et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Structures of Human Acetylcholinesterase in Complex with Pharmacologically Important Ligands

(2012) Jonah Cheung et al.   JOURNAL OF MEDICINAL CHEMISTRY

Application of docking-based comparative intermolecular contacts analysis to validate Hsp90α docking studies and subsequent in silico screening for inhibitors

(2012) Mahmoud A. Al-Sha’er et al.   JOURNAL OF MOLECULAR MODELING

Attenuation of LPS-induced apoptosis in NGF-differentiated PC12 cells via NF-κB pathway and regulation of cellular redox status by an oxazine derivative

(2011) Niloufar Ansari et al.   BIOCHIMIE

Structure-based design of thienobenzoxepin inhibitors of PI3-kinase

(2011) Steven T. Staben et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

2-Ethoxy-4,5-diphenyl-1,3-oxazine-6-one activates the Nrf2/HO-1 axis and protects against oxidative stress-induced neuronal death

(2011) Niloufar Ansari et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Docking-Based Comparative Intermolecular Contacts Analysis as New 3-D QSAR Concept for Validating Docking Studies and in Silico Screening: NMT and GP Inhibitors as Case Studies

(2011) Mutasem O. Taha et al.   Journal of Chemical Information and Modeling

Synthesis and Biological Evaluation of Novel Analogues of the Pan Class I Phosphatidylinositol 3-Kinase (PI3K) Inhibitor 2-(Difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole (ZSTK474)

(2011) Gordon W. Rewcastle et al.   JOURNAL OF MEDICINAL CHEMISTRY

Rational Design of Phosphoinositide 3-Kinase α Inhibitors That Exhibit Selectivity over the Phosphoinositide 3-Kinase β Isoform

(2011) Timothy P. Heffron et al.   JOURNAL OF MEDICINAL CHEMISTRY

Sequential treatment with flavopiridol synergistically enhances pyrrolo-1,5-benzoxazepine-induced apoptosis in human chronic myeloid leukaemia cells including those resistant to imatinib treatment

(2010) Sandra A. Bright et al.   BIOCHEMICAL PHARMACOLOGY

Synthesis and biological activity of a series of tetrasubstituted-imidazoles as P2X7 antagonists

(2010) Robert J. Gleave et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines, induce cell cycle arrest and apoptosis in prostate cancer cells

(2010) Nathwani   ONCOLOGY REPORTS

Novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines, induce apoptosis in multi-drug-resistant cancer cells

(2009) Seema-Maria Nathwani et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Pyrrolizidine alkaloids from Echium glomeratum (Boraginaceae)

(2008) Feras Q. Alali et al.   PHYTOCHEMISTRY