Increasing role of the cancer chemotherapeutic doxorubicin in cellular metabolism

Mitochondria-Derived Reactive Oxygen Species Play an Important Role in Doxorubicin-Induced Platelet Apoptosis

(2015) Zhicheng Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Autophagy in DNA Damage Response

(2015) Piotr Czarny et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Doxorubicin-induced necrosis is mediated by poly-(ADP-ribose) polymerase 1 (PARP1) but is independent of p53

(2015) Hyeon-Jun Shin et al.   Scientific Reports

Schisandrin B Prevents Doxorubicin Induced Cardiac Dysfunction by Modulation of DNA Damage, Oxidative Stress and Inflammation through Inhibition of MAPK/p53 Signaling

(2015) Rajarajan A. Thandavarayan et al.   PLoS One

Programmed necrosis and necroptosis signalling

(2014) Maria Feoktistova et al.   FEBS Journal

Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation

(2014) Yoshihiko Ichikawa et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondrial form and function

(2014) Jonathan R. Friedman et al.   NATURE

ROS-induced DNA damage and PARP-1 are required for optimal induction of starvation-induced autophagy

(2012) José Manuel Rodríguez-Vargas et al.   CELL RESEARCH

Doxorubicin-Induced In Vivo Nephrotoxicity Involves Oxidative Stress- Mediated Multiple Pro- and Anti-Apoptotic Signaling Pathways

(2012) Tejas S. Lahoti et al.   CURRENT NEUROVASCULAR RESEARCH

Myocardial performance index and biochemical markers for early detection of doxorubicin-induced cardiotoxicity in children with acute lymphoblastic leukaemia

(2012) Antonio Ruggiero et al.   International Journal of Clinical Oncology

Doxorubicin: an update on anticancer molecular action, toxicity and novel drug delivery systems

(2012) Oktay Tacar et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Probing the Dynamics of Doxorubicin-DNA Intercalation during the Initial Activation of Apoptosis by Fluorescence Lifetime Imaging Microscopy (FLIM)

(2012) Nai-Tzu Chen et al.   PLoS One

Activation of AMP-Activated Protein Kinase Contributes to Doxorubicin-Induced Cell Death and Apoptosis in Cultured Myocardial H9c2 Cells

(2011) Min-Bin Chen et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Exercise as a beneficial adjunct therapy during Doxorubicin treatment—Role of mitochondria in cardioprotection

(2011) António Ascensão et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Exercise protects against doxorubicin-induced markers of autophagy signaling in skeletal muscle

(2011) Ashley J. Smuder et al.   JOURNAL OF APPLIED PHYSIOLOGY

Individualized Liposomal Doxorubicin-Based Treatment in Elderly Patients with Non-Hodgkin’s Lymphoma

(2011) Bo Guo et al.   ONKOLOGIE

Silymarin modulates doxorubicin-induced oxidative stress, Bcl-xL and p53 expression while preventing apoptotic and necrotic cell death in the liver

(2010) Nirav Patel et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Cardiomyocyte death in doxorubicin-induced cardiotoxicity

(2009) Yi-Wei Zhang et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Apoptosis, autophagy, accelerated senescence and reactive oxygen in the response of human breast tumor cells to Adriamycin

(2009) Xu Di et al.   BIOCHEMICAL PHARMACOLOGY

Doxorubicin Cardiomyopathy

(2009) Kanu Chatterjee et al.   CARDIOLOGY

Autophagy in disease: a double-edged sword with therapeutic potential

(2009) Wim Martinet et al.   CLINICAL SCIENCE

Doxorubicin: The Good, the Bad and the Ugly Effect

(2009) Cristina Carvalho et al.   CURRENT MEDICINAL CHEMISTRY

Heterogeneity of Mitochondria and Mitochondrial Function within Cells as Another Level of Mitochondrial Complexity

(2009) Andrey Kuznetsov et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

When apoptosis meets autophagy: deciding cell fate after trauma and sepsis

(2009) Ya-Ching Hsieh et al.   TRENDS IN MOLECULAR MEDICINE

Induction of premature senescence in cardiomyocytes by doxorubicin as a novel mechanism of myocardial damage

(2008) Yasuhiro Maejima et al.   AGING CELL

Accelerated senescence: An emerging role in tumor cell response to chemotherapy and radiation

(2008) David A. Gewirtz et al.   BIOCHEMICAL PHARMACOLOGY

Cardiac-Targeted Expression of Soluble Fas Attenuates Doxorubicin-Induced Cardiotoxicity in Mice

(2008) J. Niu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Directing cancer cells to self-destruct with pro-apoptotic receptor agonists

(2008) Avi Ashkenazi   NATURE REVIEWS DRUG DISCOVERY

Promotion of autophagy and inhibition of apoptosis by low concentrations of cadmium in vascular endothelial cells

(2008) Zhiwu Dong et al.   TOXICOLOGY IN VITRO