Article
Instruments & Instrumentation
Ran Tao, Li Liu, Yingxin Xiong, Qianyu Zhang, Xiangyu Lv, Linbo He, Fang Ren, Lu Zhou, Baoyan Chen, Kexin Wu, Yan Zhang, Huali Chen
Summary: The objective was to develop phospholipid-based injectable phase transition in situ gels (PTIGs) for sustained release of Brexpiprazole (Brex). Both in vitro and in vivo studies demonstrated that Brex-PTIGs could achieve sustained release compared to Brex-Sol or Brex-Sus.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Medicine, Research & Experimental
Elham Khodaverdi, Farzin Hadizadeh, Nilofarsadat Hoseini, Farhad Eisvand, Mohadeseh Tayebi, Hossein Kamali, Fatemeh Oroojalian
Summary: The study aimed to produce sustained-release buprenorphine using lipid-liquid crystal gels. The results showed that the lipid-liquid crystal system can be used to design slow-release platforms for buprenorphine, minimizing its side effects.
Article
Biochemistry & Molecular Biology
Blessing C. Ilochonwu, Marko Mihajlovic, Roel F. Maas-Bakker, Charis Rousou, Miao Tang, Mei Chen, Wim E. Hennink, Tina Vermonden
Summary: This study aims to develop a degradable in situ forming hydrogel that can be injected into the vitreous cavity for sustained release of therapeutic antibodies to treat retinal diseases. Through systematic experiments and analysis, the most suitable hydrogel formulation was identified and its effectiveness and bioactivity in vivo were demonstrated.
Article
Pharmacology & Pharmacy
Pallavi Gupta, Khushwant S. Yadav
Summary: This study compared the effectiveness of brinzolamide-loaded niosomes and niosomal in-situ gel in the treatment of glaucoma. The results showed that brinzolamide-loaded niosomes had high encapsulation efficiency and sustained release, while niosomal in-situ gel had good gelation capacity and spreadability. In in-vivo experiments on rabbits, brinzolamide-loaded niosomes sustained the reduction of intraocular pressure for 24 hours.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Stefan Mommer, David Gehlen, Takami Akagi, Mitsuru Akashi, Helmut Keul, Martin Moeller
Summary: Functionalized pullulan with thiolactones allows for cross-linking with diamines and/or amine-containing biological substrates, enhancing versatility for cell proliferation. Studies show that gelatin and GRGDS equally support proliferation of normal human dermal fibroblasts, while GRGDS and GHK significantly improve proliferation of hepatocytes. The strategy of producing biogels using biologically active substrates as cross-linkers is confirmed to be mild and biocompatible.
Article
Biochemistry & Molecular Biology
Chia Lin Chang, Zheqing Cai, Sheau Yu Teddy Hsu
Summary: This study found that palmitoylated adrenomedullin analogs with accommodating motifs showed enhanced receptor activation activity and improved stimulatory effects on human lymphatic endothelial cells compared to wild-type peptides. Additionally, these analogs self-assembled into liquid gels and subcutaneous administration led to sustained presence in the circulation. Subcutaneous injection of the analog gel also reduced blood pressure and increased vasodilation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Wen-xin Jiang, Jun-Ru Qi, Jin-song Liao, Xiao-Quan Yang
Summary: A gelling strategy for HP using ammonium sulfate (AS) as a co-solute in acidic environment was proposed. The gel strength of HP was mainly determined by its concentration, and the gel network of HP could limit the migration of AS and water. The release process of NH4+ in HP + AS gel was delayed compared to pure AS, indicating the potential of HP + AS gel in sustained-release fertilizers.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Pharmacology & Pharmacy
Marzieh Mohammadi, Malihe Karimi, Bizhan Malaekeh-Nikouei, Mohammad Torkashvand, Mona Alibolandi
Summary: Injectable in situ forming hydrogels are efficient local drug delivery systems for cancer therapy. They can provide sustained release of chemotherapeutics and potentially prevent post-surgical cancer recurrence. Various materials and crosslinking chemistry can be used to fabricate hybrid hydrogels with different characteristics, such as stimuli-sensitive platforms or multifunctional systems.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Food Science & Technology
Mingyu Yin, Ryosuke Matsuoka, Yinci Xi, Xichang Wang
Summary: The study found that phospholipids derived from egg yolk and soya bean exhibited significant antioxidant and lipid-lowering abilities in a high-fat-and-sucrose diet model, reducing liver burden and improving blood lipid and inflammation markers, with egg yolk phospholipids showing more effective therapeutic benefits.
Review
Biochemistry & Molecular Biology
Ilker S. Bayer
Summary: Polymer nanofibers have high surface area for efficient transport, while hydrogels combine flexibility and customizable transport properties. Combining nanofibers with hydrogels advances biomedical applications, especially in sustained drug delivery. Nanofiber hydrogels can maintain drug release rates for days to months and are crucial for 3D or 4D printable systems.
Article
Polymer Science
Ei Mon Khaing, Jongjan Mahadlek, Siriporn Okonogi, Thawatchai Phaechamud
Summary: This study investigates the effects of lime peel oil (LO) on the properties of rosin-based in situ forming gels loaded with doxycycline hyclate (DH). The presence of LO impacts gel formation, drug release, and antimicrobial activity. Adding 10% LO improves gel adhesion and antimicrobial activity. Loading LO into rosin-based gels is an effective treatment for periodontitis.
Article
Medicine, Research & Experimental
Ravi Saklani, Pavan K. Yadav, Mushtaq A. Nengroo, Santosh L. Gawali, Puthusserickal A. Hassan, Dipak Datta, Durga P. Mishra, Ingo Dierking, Manish K. Chourasia
Summary: An injectable in situ depot-forming lipidic lyotropic liquid crystal system (L3CS) has been developed for localized chemotherapy against unresectable solid tumors, providing spatiotemporal control over drug delivery. The system can be preprogrammed to release drugs intratumorally over a period of one week to one month, leading to over 10-fold reduction in tumor burden and increased survival rate in a murine tumor model.
MOLECULAR PHARMACEUTICS
(2022)
Article
Polymer Science
Kritamorn Jitrangsri, Ei Mon Khaing, Torsak Intaraphairot, Thawatchai Phaechamud, Jongjan Mahadlek
Summary: This study successfully prepared and characterized a gamboge-based nanomicelle system loaded with imatinib mesylate (IM) for localized delivery of an anticancer agent against colorectal carcinoma. The nanomicelle system demonstrated favorable flow behavior and mechanical properties, allowing for easy administration. It exhibited sustained release of IM for 14 days, with the release rate controlled by the solvent type and IM content. The developed nanomicelle system effectively inhibited colorectal cancer cells and has the potential to reduce the side effects of systemic chemotherapy.
Article
Engineering, Biomedical
Kelsey Hopkins, Elizabeth Wakelin, Natalie Romick, Jacqueline Kennedy, Emma Simmons, Luis Solorio
Summary: There is a need to reduce the frequency of injections for protein drugs, and in situ forming implants (ISFIs) have shown potential for controlled release. However, protein instability is a challenge due to the acidic microclimate within ISFIs. This study demonstrates that adding basic salts can neutralize the acidic environment, improving protein stability and the potential of ISFIs for delivering pH-sensitive biomolecules.
ANNALS OF BIOMEDICAL ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Jae Hwan Jung, Seong Shik Kim, Hyunwoo Chung, Amir Hejri, Mark R. Prausnitz
Summary: We developed an in-situ forming hydrogel for slow release of Bev, which can provide long-acting treatment for AMD. The hydrogel released Bev for over 6 months in the eye and showed good tolerance.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Chemistry, Physical
Shiqi Huang, Lang Deng, Hanming Zhang, Luyao Wang, Yicong Zhang, Qing Lin, Tao Gong, Xun Sun, Zhirong Zhang, Ling Zhang
Summary: In this study, a novel nanoplatform was developed to deliver TRAIL and PTX to lung melanoma tumor sites, effectively killing tumor cells and reducing local nutrition supply. This system showed remarkable anti-tumor effects and significantly prolonged the survival rate of melanoma lung metastasis bearing mice.
Article
Polymer Science
Sen Meng, Tao Gong, Xing Zhao, Chun-Yan Tang, Peng Yu, Rui-Ying Bao, Kai Ke, Zheng-Ying Liu, Ming-Bo Yang, Wei Yang
Summary: The study uses porous polymer elastomers to manufacture evaporators, with the pore size and porous structure dynamically controlled through annealing treatment to enhance evaporation performance and mechanical strength. This approach shows great potential for achieving low-cost sustainable seawater desalination and wastewater purification.
Article
Nanoscience & Nanotechnology
Yuai Li, Lan Yang, Xiaomin Xu, Min Li, Yicong Zhang, Qing Lin, Tao Gong, Xun Sun, Zhirong Zhang, Ling Zhang
Summary: Size expansion of nanocarriers can enhance tumor accumulation and drug release, leading to improved therapeutic efficacy against tumors.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Ming Qin, Guangsheng Du, Nan Qiao, Zhaofei Guo, Min Jiang, Chunting He, Shuting Bai, Penghui He, Yanhua Xu, Hairui Wang, Tao Gong, Zhirong Zhang, Xun Sun
Summary: A simple strategy has been developed to convert whole-cell vaccines into nanoscale size to promote their lymphatic migration and intracellular antigen presentation, aiming to enhance immune responses. The universal carrier-free nano-vaccine fabricated through a two-step vortex-sonification method based on alum-induced and cancer/bacterial cell membrane coated protein antigen nanoparticles can efficiently migrate to lymph nodes after subcutaneous vaccination, where they are taken up by APCs for antigen presentation and activation of immune processes.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Liqiang Chen, Chendong Liu, Yucheng Xiang, Jiayan Lyu, Zhou Zhou, Tao Gong, Huile Gao, Lian Li, Yuan Huang
Summary: A new strategy for targeting the endoplasmic reticulum (ER) is proposed in this study, which utilizes homologous cancer cell membrane-coated nanoparticles (HCC@NP) to overcome the limited accumulation and rapid exocytosis of nanodrugs in the ER. The strategy achieves high-efficiency and long-term ER retention, inducing potent immunogenic cell death and promoting anti-tumor immunity.
Article
Chemistry, Multidisciplinary
Yuan Xue, Shuting Bai, Leilei Wang, Shi Luo, Zhirong Zhang, Tao Gong, Ling Zhang
Summary: The study developed a multi-stimulus-responsive PS nanocarrier, significantly improving the efficacy of Ce6 in PDT, showing remarkable tumor-killing effects and increasing the survival rate of tumor-bearing mice.
Article
Chemistry, Multidisciplinary
Xiaofang Zhong, Guangsheng Du, Xuanyu Wang, Yangsen Ou, Hairui Wang, Yining Zhu, Xinyan Hao, Zhiqiang Xie, Yuandong Zhang, Tao Gong, Zhirong Zhang, Xun Sun
Summary: A proposed subcutis-to-intestine cascade using nanovaccines efficiently enhances cellular and mucosal immune responses. Experimental results demonstrate that nanovaccines can generate protective immunity against Salmonella challenge.
Article
Pharmacology & Pharmacy
Lei Wu, Lingling Wang, Xi Liu, Yuli Bai, Ruinan Wu, Xiang Li, Yutong Mao, Ling Zhang, Yongxiang Zheng, Tao Gong, Zhirong Zhang, Yuan Huang
Summary: Exosomes, as endogenous courier vesicles, have gained increasing attention as biomimetic drug delivery vehicles. In this study, insulin-loaded milk-derived exosomes were fabricated and demonstrated to exhibit superior hypoglycemic effects when orally administered, compared with subcutaneously injected insulin. Mechanism studies revealed the multi-functional properties of milk-derived exosomes, including active multi-targeting uptake, pH adaptation, signal pathway activation, and mucus penetration, which contribute to their excellent oral performance.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Nanoscience & Nanotechnology
Jiaxing Feng, Ling Xiang, Changlong Fang, Yulu Tan, Yan Li, Ting Gong, Qingsi Wu, Tao Gong, Zhirong Zhang
Summary: THP-PSA NPs exhibit stronger cytotoxicity against 4T1 and M2 macrophages compared with THP-HSA NPs in vitro. In vivo, MDSCs infiltration and immunosuppressive cytokines secretion significantly decrease after effective elimination of TAMs through THP-PSA NPs treatment, accompanied by an increase in immunostimulatory cytokine expression.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Engineering, Biomedical
Ting Zhao, Rongping Zhang, Qin He, Hongli Zhou, Xu Song, Tao Gong, Zhirong Zhang
Summary: This study established a CAF-targeting drug delivery system based on RBC vesicles partial protection for reprogramming the tumor microenvironment and enhancing tumor penetration and antitumor efficacy in PDAC. The results showed that the system improved the penetration of Dox in PDAC and inhibited tumor growth.
ACTA BIOMATERIALIA
(2022)
Article
Engineering, Biomedical
Haohuan Li, Caifeng Deng, Yulu Tan, Jianxia Dong, Yuanhao Zhao, Xiaorong Wang, Xingyue Yang, Jingwen Luo, Huile Gao, Yuan Huang, Zhi-Rong Zhang, Tao Gong
Summary: This study presents a promising approach for photodynamic immunotherapy of advanced cancers by using chondroitin sulfate-based prodrug nanoparticles to co-deliver a photosensitizer and retinoic acid. This approach can reduce the immunosuppression caused by photodynamic therapy and promote the maturation of dendritic cells. The strategy showed excellent antitumor efficacy in a mouse model.
ACTA BIOMATERIALIA
(2022)
Article
Chemistry, Physical
Xiaomin Xu, Yani Xu, Yuai Li, Min Li, Leilei Wang, Qiang Zhang, Bingjie Zhou, Qing Lin, Tao Gong, Xun Sun, Zhirong Zhang, Ling Zhang
Summary: In this study, a glucose-responsive system mimicking erythrocytes was designed by coupling glucose-responsive nanoparticles to red blood cells, allowing for long-term response to hyperglycemia and potential application in diabetes treatment.
Article
Chemistry, Multidisciplinary
Zhaofei Guo, Yining Zhu, Guangsheng Du, Ming Qin, Chunting He, Penghui He, Yuanshuai Song, Wenfei Chen, Shuting Bai, Fuhua Wu, Nan Qiao, Min Jiang, Xianjin Luo, Yuandong Zhang, Tao Gong, Zhirong Zhang, Xun Sun
Summary: This study reports a facile strategy for the rapid development of a highly effective cross-protective Pseudomonas aeruginosa vaccine. By loading cytosolic antigens derived from bacterial lysates into mesoporous silica nanospheres and fusing membrane antigens onto the surface, the engineered nano-vaccines induced potent humoral and cellular immune responses and protected against different strains of Pseudomonas aeruginosa infection.
Article
Materials Science, Biomaterials
Min Li, Xiaomin Xu, Rongying Shi, Yuai Li, Qing Lin, Tao Gong, Xun Sun, Zhirong Zhang, Ling Zhang
Summary: By using the erythrocyte-hitchhiking strategy, the blood circulation time of an insulin delivery system was significantly prolonged, allowing for long-term and automatic blood glucose control in diabetic patients. This approach shows great potential for future development due to its versatility and ability to interact with other substances.
BIOMATERIALS SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Yicong Zhang, Yuai Li, Shiqi Huang, Hanming Zhang, Qing Lin, Tao Gong, Xun Sun, Zhirong Zhang, Ling Zhang
Summary: Metastasis is a crucial factor in cancer-related deaths, and suppressing it can improve the survival rate of cancer patients. Nanoparticles with dual functionality have been developed to inhibit tumor metastasis and enhance the efficacy of loaded drugs against tumors. These versatile carriers show promise in treating invasive solid tumors and metastases by significantly reducing metastatic nodules.
