Stereoselectivity and Substrate Specificity of the Fe(II)/α-Ketoglutarate-Dependent Oxygenase TqaL

Discovery of a Cryptic Nitro Intermediate in the Biosynthesis of the 3-(trans-2′-Aminocyclopropyl)alanine Moiety of Belactosin A

(2022) Alicia Engelbrecht et al.   ORGANIC LETTERS

Molecular Basis for Enzymatic Aziridine Formation via Sulfate Elimination

(2022) Sumire Kurosawa et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biosynthesis of the Fungal Organophosphonate Fosfonochlorin Involves an Iron(II) and 2‐(Oxo)glutarate Dependent Oxacyclase

(2021) Simanga R. Gama et al.   CHEMBIOCHEM

Identification of Cyclopropane Formation in the Biosyntheses of Hormaomycins and Belactosins: Sequential Nitration and Cyclopropanation by Metalloenzymes

(2021) Xiaojun Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Stereodivergent Nitrocyclopropane Formation during Biosynthesis of Belactosins and Hormaomycins

(2021) Shotaro Shimo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Improved protein structure prediction using potentials from deep learning

(2020) Andrew W. Senior et al.   NATURE

Insight into enzyme-catalyzed aziridine formation mechanism in ficellomycin biosynthesis

(2020) Rong Yue et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Steric Enforcement of cis-Epoxide Formation in the Radical C–O-Coupling Reaction by Which (S)-2-Hydroxypropylphosphonate Epoxidase (HppE) Produces Fosfomycin

(2019) Shengbin Zhou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Installation of the Ether Bridge of Lolines by the Iron- and 2-Oxoglutarate-Dependent Oxygenase, LolO: Regio- and Stereochemistry of Sequential Hydroxylation and Oxacyclization Reactions

(2018) Juan Pan et al.   BIOCHEMISTRY

Remote C–H Hydroxylation by an α-Ketoglutarate-Dependent Dioxygenase Enables Efficient Chemoenzymatic Synthesis of Manzacidin C and Proline Analogs

(2018) Christian R. Zwick et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Recent examples of α-ketoglutarate-dependent mononuclear non-haem iron enzymes in natural product biosyntheses

(2018) Shu-Shan Gao et al.   NATURAL PRODUCT REPORTS

Changes in Regioselectivity of H Atom Abstraction during the Hydroxylation and Cyclization Reactions Catalyzed by Hyoscyamine 6β-Hydroxylase

(2018) Richiro Ushimaru et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biosynthesis of methyl-proline containing griselimycins, natural products with anti-tuberculosis activity

(2017) Peer Lukat et al.   Chemical Science

Ferrous iron and α-ketoglutarate-dependent dioxygenases in the biosynthesis of microbial natural products

(2016) Long-Fei Wu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Organocatalyzed nucleophilic addition of pyrazoles to 2H-azirines: asymmetric synthesis of 3,3-disubstituted aziridines and kinetic resolution of racemic 2H-azirines

(2016) Dong An et al.   CHEMICAL COMMUNICATIONS

Structural characterization of EasH (Aspergillus japonicus) – an oxidase involved in cycloclavine biosynthesis

(2016) Dorota Jakubczyk et al.   CHEMICAL COMMUNICATIONS

Oxidative Cyclization in Natural Product Biosynthesis

(2016) Man-Cheng Tang et al.   CHEMICAL REVIEWS

Oxidative cyclizations in orthosomycin biosynthesis expand the known chemistry of an oxygenase superfamily

(2015) Kathryn M. McCulloch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recent Advances in the Stereoselective Synthesis of Aziridines

(2014) Leonardo Degennaro et al.   CHEMICAL REVIEWS

An In Situ Directing Group Strategy for Chiral Anion Phase-Transfer Fluorination of Allylic Alcohols

(2014) Weiwei Zi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Characterization of Bacillus thuringiensis l-Isoleucine Dioxygenase for Production of Useful Amino Acids

(2011) Makoto Hibi et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Enzymatic Chemistry of Cyclopropane, Epoxide, and Aziridine Biosynthesis

(2011) Christopher J. Thibodeaux et al.   CHEMICAL REVIEWS

Mode of action and biosynthesis of the azabicycle-containing natural products azinomycin and ficellomycin

(2011) Jennifer Foulke-Abel et al.   NATURAL PRODUCT REPORTS

A novel l-isoleucine hydroxylating enzyme, l-isoleucine dioxygenase from Bacillus thuringiensis, produces (2S,3R,4S)-4-hydroxyisoleucine

(2009) Tomohiro Kodera et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structural basis for the erythro-stereospecificity of the l-arginine oxygenase VioC in viomycin biosynthesis

(2009) Verena Helmetag et al.   FEBS Journal

Biosynthetic Studies of Aziridine Formation in Azicemicins

(2009) Yasushi Ogasawara et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Characterization of the Azinomycin B Biosynthetic Gene Cluster Revealing a Different Iterative Type I Polyketide Synthase for Naphthoate Biosynthesis

(2008) Qunfei Zhao et al.   CHEMISTRY & BIOLOGY