期刊
CELL
卷 161, 期 5, 页码 967-970出版社
CELL PRESS
DOI: 10.1016/j.cell.2015.04.045
关键词
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资金
- Austrian Research Fund [FWF W-1220, SFB-021, P-19530]
- Austrian Research Promotion Agency, FFG [827500]
- EU
- Johanna Mahlke geb. Obermann-Stiftung of the University of Vienna
RAF links RAS, one of the most potent human oncogenes, to its effector ERK and to proliferation. This role is evolutionarily conserved, but while simpler multicellular organisms express one RAF, mammals have three. This Minireview highlights common and divergent features of RAF paralogs, their signaling outputs, and roles in tumorigenesis.
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