Chiral recognition in amyloid fiber growth

Antibody drugs for Alzheimer’s show glimmers of promise

(2015) Sara Reardon   NATURE

Structure of the toxic core of α-synuclein from invisible crystals

(2015) Jose A. Rodriguez et al.   NATURE

Peptide dimer structure in an Aβ(1–42) fibril visualized with cryo-EM

(2015) Matthias Schmidt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular structure of monomorphic peptide fibrils within a kinetically trapped hydrogel network

(2015) Katelyn Nagy-Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Racemic DNA Crystallography

(2014) Pradeep K. Mandal et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Atomic-Resolution Three-Dimensional Structure of Amyloid β Fibrils Bearing the Osaka Mutation

(2014) Anne K. Schütz et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The amyloid state and its association with protein misfolding diseases

(2014) Tuomas P. J. Knowles et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Synthesis and folding of a mirror-image enzyme reveals ambidextrous chaperone activity

(2014) M. T. Weinstock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Physical and structural basis for polymorphism in amyloid fibrils

(2014) Robert Tycko   PROTEIN SCIENCE

Molecular Structures of Amyloid and Prion Fibrils: Consensus versus Controversy

(2013) Robert Tycko et al.   ACCOUNTS OF CHEMICAL RESEARCH

Intrinsic Structural Heterogeneity and Long-Term Maturation of Amyloid β Peptide Fibrils

(2013) Jianqiang Ma et al.   ACS Chemical Neuroscience

Bringing the Science of Proteins into the Realm of Organic Chemistry: Total Chemical Synthesis of SEP (Synthetic Erythropoiesis Protein)

(2013) Stephen B. H. Kent   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The therapeutics of Alzheimer's disease: Where we stand and where we are heading

(2013) Dennis J. Selkoe   ANNALS OF NEUROLOGY

The Adaptable Major Histocompatibility Complex (MHC) Fold: Structure and Function of Nonclassical and MHC Class I–Like Molecules

(2013) Erin J. Adams et al.   Annual Review of Immunology

Molecular Structure of β-Amyloid Fibrils in Alzheimer’s Disease Brain Tissue

(2013) Jun-Xia Lu et al.   CELL

d-Polyglutamine Amyloid Recruits l-Polyglutamine Monomers and Kills Cells

(2013) Karunakar Kar et al.   JOURNAL OF MOLECULAR BIOLOGY

Infrared, Vibrational Circular Dichroism, and Raman Spectral Simulations for β-Sheet Structures with Various Isotopic Labels, Interstrand, and Stacking Arrangements Using Density Functional Theory

(2013) William R. W. Welch et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Structural Analyses of Experimental 13C Edited Amide I′ IR and VCD for Peptide β-Sheet Aggregates and Fibrils Using DFT-Based Spectral Simulations

(2013) William R. W. Welch et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Self-Assembly of Left- and Right-Handed Molecular Screws

(2013) Fei Xu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Both the cis-trans equilibrium and isomerization dynamics of a single proline amide modulate  2-microglobulin amyloid assembly

(2013) V. Y. Torbeev et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Atomic structure and hierarchical assembly of a cross-  amyloid fibril

(2013) A. W. P. Fitzpatrick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Solid-State NMR Spectroscopy of Functional Amyloid from a Fungal Hydrophobin: A Well-Ordered β-Sheet Core Amidst Structural Heterogeneity

(2012) Vanessa K. Morris et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Racemic Protein Crystallography

(2012) Todd O. Yeates et al.   Annual Review of Biophysics

An FT-IR Study on Packing Defects in Mixed β-Aggregates of Poly(l-glutamic acid) and Poly(d-glutamic acid): A High-Pressure Rescue from a Kinetic Trap

(2012) Yudai Yamaoki et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Coassembly of Enantiomeric Amphipathic Peptides into Amyloid-Inspired Rippled β-Sheet Fibrils

(2012) Ria J. Swanekamp et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Amyloid β-sheet mimics that antagonize protein aggregation and reduce amyloid toxicity

(2012) Pin-Nan Cheng et al.   Nature Chemistry

Development of a Small D-Enantiomeric Alzheimer’s Amyloid-β Binding Peptide Ligand for Future In Vivo Imaging Applications

(2012) Susanne Aileen Funke et al.   PLoS One

Chemical synthesis and X-ray structure of a heterochiral {D-protein antagonist plus vascular endothelial growth factor} protein complex by racemic crystallography

(2012) K. Mandal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antiparallel  -sheet architecture in Iowa-mutant  -amyloid fibrils

(2012) W. Qiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Solid-State NMR Studies of Amyloid Fibril Structure

(2011) Robert Tycko   Annual Review of Physical Chemistry

Enhanced Mechanical Rigidity of Hydrogels Formed from Enantiomeric Peptide Assemblies

(2011) Katelyn J. Nagy et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation

(2011) Stuart A. Sievers et al.   NATURE

Intermolecular Alignment in β2-Microglobulin Amyloid Fibrils

(2010) Galia T. Debelouchina et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Magic Angle Spinning NMR Analysis of β2-Microglobulin Amyloid Fibrils in Two Distinct Morphologies

(2010) Galia T. Debelouchina et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Atomic-Resolution Three-Dimensional Structure of HET-s(218−289) Amyloid Fibrils by Solid-State NMR Spectroscopy

(2010) Hélène Van Melckebeke et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural polymorphism of Alzheimer Aβ and other amyloid fibrils

(2010) Marcus Fändrich et al.   Prion

D-peptide inhibitors of the p53-MDM2 interaction for targeted molecular therapy of malignant neoplasms

(2010) M. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biology of Amyloid: Structure, Function, and Regulation

(2010) Jason Greenwald et al.   STRUCTURE

Racemic β-Sheets as Templates of Relevance to the Origin of Homochirality of Peptides: Lessons from Crystal Chemistry

(2009) Isabelle Weissbuch et al.   ACCOUNTS OF CHEMICAL RESEARCH

Antiparallel β-sheet: a signature structure of the oligomeric amyloid β-peptide

(2009) Emilie Cerf et al.   BIOCHEMICAL JOURNAL

β arcades: recurring motifs in naturally occurring and disease-related amyloid fibrils

(2009) Andrey V. Kajava et al.   FASEB JOURNAL

Molecular structural basis for polymorphism in Alzheimer's  -amyloid fibrils

(2008) A. K. Paravastu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The fold of  -synuclein fibrils

(2008) M. Vilar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of cytotoxicity and amyloid fibril formation by a D-amino acid peptide that specifically binds to Alzheimer's disease amyloid peptide

(2008) K. Wiesehan et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Amyloid Fibrils of the HET-s(218-289) Prion Form a   Solenoid with a Triangular Hydrophobic Core

(2008) C. Wasmer et al.   SCIENCE