Article
Neurosciences
Juliann D. Jaumotte, Alexis L. Franks, Erin M. Bargerstock, Edwina Philip Kisanga, Heather L. Menden, Alexis Ghersi, Mahmoud Omar, Liping Wang, Anthony Rudine, Kelly L. Short, Neerupama Silswal, Timothy J. Cole, Venkatesh Sampath, A. Paula Monaghan-Nichols, Donald B. DeFranco
Summary: Ciclesonide (CIC) is a promising prodrug for treating neonatal bronchopulmonary dysplasia (BPD) with limited adverse neurodevelopmental effects, activating glucocorticoid receptor (GR) in the lung without the systemic side effects associated with dexamethasone (DEX). Its potential in preventing fetal neurodevelopmental abnormalities caused by sGC use in pregnant women, such as in severe respiratory illnesses, makes CIC an attractive alternative to DEX.
NEUROBIOLOGY OF DISEASE
(2021)
Review
Physiology
Andrew Parsons, Adom Netsanet, Gregory Seedorf, Steven H. Abman, Elizabeth S. Taglauer
Summary: This review discusses the role of the placenta in predisposing to bronchopulmonary dysplasia (BPD) and proposes a unique placental-pulmonary connection. The authors explore this hypothesis through analysis of literature and preclinical models, and discuss the impact of antenatal steroids on fetal lung development.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2022)
Review
Pediatrics
Douglas Bush, Courtney Juliano, Selina Bowler, Caterina Tiozzo
Summary: Bronchopulmonary dysplasia (BPD) is a common cause of morbidity and mortality in premature infants, characterized by arrested lung development. While parenchymal lung changes in BPD are well-studied, the role of airways disease has received less attention. In preterm infants, the immature conducting airways are more susceptible to injury and disruption, leading to increased respiratory morbidity, particularly in those who require intubation and positive-pressure ventilation.
Article
Multidisciplinary Sciences
Monalisa Patel, Japmeet Sandhu, Fu-Sheng Chou
Summary: This study examined the feasibility of predicting respiratory outcomes in extremely preterm infants of Asian descent using a machine learning approach. The results suggested an interrelationship among racial/ethnic groups for respiratory outcomes in this population.
Article
Nutrition & Dietetics
Chengyin Ye, Jinghua Wu, Jonathan D. Reiss, Tiffany J. Sinclair, David K. Stevenson, Gary M. Shaw, Donald H. Chace, Reese H. Clark, Lawrence S. Prince, Xuefeng Bruce Ling, Karl G. Sylvester
Summary: By studying the metabolic patterns during the development of bronchopulmonary dysplasia (BPD) in premature infants, this research identified 27 metabolic variables associated with BPD. The findings have implications for the prevention and management of BPD.
Article
Medicine, General & Internal
Ann Hellstrom, Aldina Pivodic, Lotta Granse, Pia Lundgren, Ulrika Sjobom, Anders K. Nilsson, Helena Soderling, Anna-Lena Hard, Lois E. H. Smith, Chatarina Alice Lofqvist
Summary: This study found that higher mean daily serum levels of DHA during the first 28 postnatal days were associated with less severe ROP, even after adjustment for known risk factors, but only in infants with sufficiently high AA levels. Further research is needed to identify LC-PUFA supplementation strategies that may prevent ROP and other morbidities.
Article
Biochemistry & Molecular Biology
Shin Kato, Osuke Iwata, Hiroyuki Kato, Satoko Fukaya, Yukari Imai, Shinji Saitoh
Summary: This study reveals the involvement of furin in the alveolarization of immature lungs and its critical role in the pathogenesis of bronchopulmonary dysplasia (BPD). The findings highlight furin as a potential treatment target for ameliorating the impact of BPD.
Article
Critical Care Medicine
Samuel J. Gentle, Colm P. Travers, Matthew Clark, Waldemar A. Carlo, Namasivayam Ambalavanan
Summary: In extremely preterm infants on respiratory support on postnatal day 28, the presence and longer duration of patent ductus arteriosus (PDA) were associated with the development of bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH).
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Physiology
Rebecca J. Calthorpe, Caroline Poulter, Alan R. Smyth, Don Sharkey, Jayesh Bhatt, Gisli Jenkins, Amanda L. Tatler
Summary: As survival rates for extremely preterm infants improve, there is an increase in bronchopulmonary dysplasia (BPD), one of the most significant complications of preterm birth. BPD development is multifactorial, resulting from exposure to various antenatal and postnatal stressors. BPD has short-term and long-term implications, including respiratory, cardiovascular, and neurological issues. The review focuses on the role of transforming growth factor I3 (TGF-I3) in lung development, the impact of known risk factors on the TGF-I3 signaling pathway in BPD, and the effect of current and potential medications on TGF-I3 signaling for BPD prevention and treatment.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2023)
Article
Cell & Tissue Engineering
Marius A. Moebius, Steven R. Seidner, Donald C. McCurnin, Leonhard Menschner, Isabel Fuerboeter-Behnert, Julia Schoenfeld, Jenny Marzahn, Daniel Freund, Nadine Muench, Sandra Hering, Shamimunisa B. Mustafa, Diana G. Anzueto, Lauryn A. Winter, Cynthia L. Blanco, Martha A. Hanes, Mario Ruediger, Bernard Thebaud
Summary: Premature birth is a leading cause of childhood morbidity and mortality, and there is a lack of knowledge regarding the effects of mesenchymal stromal cell (MSC) therapy in actual premature-born lungs. This study investigated the use of MSC in premature-born baboons and found that while it improved cardiovascular stability, it had no short- to mid-term lung-protective effects. These findings highlight the need for further research on cell-based therapies for premature organisms.
STEM CELLS TRANSLATIONAL MEDICINE
(2023)
Article
Pediatrics
Milenka Cuevas Guaman, Paul H. Dahm, Stephen E. Welty
Summary: The definition of BPD has not kept pace with the changing pathogenesis and phenotype, and should incorporate a composite assessment including quantitative and qualitative measurements to better apply to different stages and timepoints.
PEDIATRIC PULMONOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Audrey N. Miller, Edward G. Shepherd, Amy Manning, Humra Shamim, Tendy Chiang, George El-Ferzli, Leif D. Nelin
Summary: Infants with severe bronchopulmonary dysplasia (BPD) may require tracheostomy for survival, but the decision is complex and challenging due to the associated risks and burdens. The specific indications and timing of tracheostomy in these infants remain unknown, leading to variations in practice among centers and clinicians.
Article
Pharmacology & Pharmacy
Cai Qing, Zhao Xinyi, Yu Xuefei, Xue Xindong, Fu Jianhua
Summary: Bronchopulmonary dysplasia (BPD) is a common devastating pulmonary complication in preterm infants, characterized by alveolar maldevelopment associated with oxidative stress and excessive apoptosis. Gap26, a connexin 43-inhibiting peptide, has been shown to improve alveolar development by inhibiting intercellular communication in BPD.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mary E. Robbins, Hye-Youn Cho, Jason M. Hansen, Joseph R. Luchsinger, Morgan L. Locy, Markus Velten, Steven R. Kleeberger, Lynette K. Rogers, Trent E. Tipple
Summary: Cellular antioxidants protect against hyperoxic lung injury. The role of the glutathione (GSH) system in lung development and bronchopulmonary dysplasia (BPD) pathogenesis has not been systematically investigated. The current study utilized GSH reductase-deficient (Gsr-KO) neonatal mice to test the hypothesis that early disruption of the GSH system negatively impacts lung development and hyperoxic responses. Overall, our data in Gsr-KO mice implicate the GSH system as a key regulator of lung development, cellular differentiation, and hyperoxic responses in neonatal mice.
Article
Pharmacology & Pharmacy
Giorgio Aquila, Yannick Regin, Xabier Murgia, Fabrizio Salomone, Costanza Casiraghi, Chiara Catozzi, Enrica Scalera, Matteo Storti, Francesca Stretti, Giancarlo Aquino, Giorgia Cavatorta, Roberta Volta, Carmelina Di Pasquale, Caterina Amato, Fabio Bignami, Davide Amidani, Barbara Pioselli, Elisa Sgarbi, Paolo Ronchi, Giuseppe Mazzola, Ignacio Valenzuela, Jaan Toelen
Summary: Thiazolidinediones (TZDs) have been shown to improve lung function in preterm rabbits by binding to PPARγ, but their effects in neonatal animals have not been studied. In this study, TZDs exhibited high epithelial permeability and lung tissue binding in vitro, with rosiglitazone showing the highest affinity for PPARγ. However, daily administration of rosiglitazone did not improve lung function and even worsened it at a higher dose, possibly due to upregulation of lung inflammation and lipid metabolism pathways. Additionally, daily administration of rosiglitazone caused dyslipidemia in preterm rabbits.
Article
Multidisciplinary Sciences
Clara Mannhardt, Tanja K. Rausch, Mats Ingmar Fortmann, Isabelle Swoboda, Alexander Humberg, Juliane Spiegler, Wolfgang Goepel
Article
Nutrition & Dietetics
Ingmar Fortmann, Janina Marissen, Bastian Siller, Juliane Spiegler, Alexander Humberg, Kathrin Hanke, Kirstin Faust, Julia Pagel, Leila Eyvazzadeh, Kim Brenner, Claudia Roll, Sabine Pirr, Dorothee Viemann, Dimitra Stavropoulou, Philipp Henneke, Birte Troeger, Thorsten Koerner, Anja Stein, Christoph Derouet, Michael Zemlin, Christian Wieg, Jan Rupp, Egbert Herting, Wolfgang Goepel, Christoph Haertel
Article
Pediatrics
Inga Geisler, Tanja Katrin Rausch, Wolfgang Gopel, Juliane Spiegler
Summary: This study aimed to develop growth charts for extremely preterm (EPT) and very preterm (VPT) children with a birth weight <1500 g. The results showed that the height and head circumference percentiles were comparable to German reference values, but the BMI was lower. The provided growth charts are useful for evaluating the growth of EPT and VPT children.
Article
Environmental Sciences
Asteria Brylka, Dieter Wolke, Sebastian Ludyga, Ayten Bilgin, Juliane Spiegler, Hayley Trower, Anna Gkiouleka, Markus Gerber, Serge Brand, Alexander Grob, Peter Weber, Kati Heinonen, Eero Kajantie, Katri Raikkonen, Sakari Lemola
Summary: The study found that higher levels of physical activity were associated with lower levels of peer problems, higher levels of psychological well-being, better self-perception/body image, and school related well-being. Overall, the effect-sizes were small and the associations did not differ significantly between very preterm and term born adolescents.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Hematology
Thomas Pincez, Simon S. K. Lee, Yann Ilboudo, Michael Preuss, Anne-Laure Pham Hung d'Alexandry d'Orengiani, Pablo Bartolucci, Frederic Galacteros, Philippe Joly, Daniel E. Bauer, Ruth J. F. Loos, R. Coleman Lindsley, Guillaume Lettre
Article
Genetics & Heredity
Quan Sun, Misa Graff, Bryce Rowland, Jia Wen, Le Huang, Tyne W. Miller-Fleming, Jeffrey Haessler, Michael H. Preuss, Jin-Fang Chai, Moa P. Lee, Christy L. Avery, Ching-Yu Cheng, Nora Franceschini, Xueling Sim, Nancy J. Cox, Charles Kooperberg, Kari E. North, Yun Li, Laura M. Raffield
Summary: Despite the underrepresentation of non-European populations in human genetics studies, this study conducted genome-wide association studies on diverse populations and identified novel genetic signals in African and South Asian participants, emphasizing the importance of utilizing existing genetic data for potential new discoveries even in modest sample sizes.
JOURNAL OF HUMAN GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Isotta Landi, Deepak A. Kaji, Liam Cotter, Tielman Van Vleck, Gillian Belbin, Michael Preuss, Ruth J. F. Loos, Eimear Kenny, Benjamin S. Glicksberg, Noam D. Beckmann, Paul O'Reilly, Eric E. Schadt, Eric D. Achtyes, Peter F. Buckley, Douglas Lehrer, Dolores P. Malaspina, Steven A. McCarroll, Mark H. Rapaport, Ayman H. Fanous, Michele T. Pato, Carlos N. Pato, Tim B. Bigdeli, Girish N. Nadkarni, Alexander W. Charney
Summary: Including polygenic risk scores does not enhance the performance of standard-of-care predictive models for disease outcomes in patients with psychosis, according to research analyzing clinical and genetic data from two multi-ethnic cohorts.
Article
Pediatrics
Kathrin Hanke, Tanja K. Rausch, Runa Sosnowski, Pia Paul, Juliane Spiegler, Mirja Mueller, Inke R. Koenig, Wolfgang Goepel, Egbert Herting, Christoph Haertel
Summary: The aim of this study was to determine the cerebral tissue oxygenation saturation (rcSO(2)) during early skin-to-skin contact (SSC) in preterm infants. The results showed that the rcSO(2) values during SSC were comparable to those during incubator care and resting time. This suggests that the additional monitoring supports safe implementation of SSC in extremely preterm infants in NICUs.
Article
Pediatrics
Benjamin Eurich, Catharina Nitsche, Margot Lau, Britta Hanker, Juliane Spiegler, Guido Stichtenoth
Summary: LCCS11 is a disease associated with GLDN gene mutations, leading to joint contracture and respiratory insufficiency, often causing death in childhood. This case report presents a young adult who developed severe respiratory insufficiency as a teenager and was diagnosed with LCCS11 through the discovery of GLDN mutations. The report emphasizes the importance of screening for neuromuscular diseases in childhood check-ups and follow-ups and highlights the need for adult practitioners to consider LCCS11 and other related diseases when diagnosing respiratory insufficiency.
Letter
Cardiac & Cardiovascular Systems
Carolina G. Downie, Heather M. Highland, Moa P. Lee, Laura M. Raffield, Michael Preuss, Eric A. Whitsel, Bruce M. Psaty, Colleen M. Sitlani, Mariaelisa Graff, Christy L. Avery
CIRCULATION RESEARCH
(2022)
Article
Endocrinology & Metabolism
Lauren A. Stalbow, Michael H. Preuss, Roelof A. J. Smit, Nathalie Chami, Lise Bjorkhaug, Ingvild Aukrust, Anna L. Gloyn, Ruth J. F. Loos
Summary: The study found that rare functional HNF1A variants are associated with an increased risk of type 2 diabetes in individuals of European ancestry, particularly when the variants are located in the functional domains. Polygenic risk scores can affect the association between HNF1A variants and type 2 diabetes risk. In the Hispanic-Latino population, rare functional HNF1A variants are associated with an earlier age at diagnosis.
Article
Pediatrics
Alexander Humberg, Mats Ingmar Fortmann, Juliane Spiegler, Tanja K. Rausch, Bastian Siller, Christine Silwedel, Janina Marissen, Egbert Herting, Wolfgang Goepel, Christoph Haertel
Summary: Extremely low birth weight infants who have survived recurrent blood culture-proven late-onset sepsis are more likely to have adverse long-term neurologic outcomes, particularly in motor development.
Article
Pediatrics
Martina Barthold, Anne Jurkutat, Regina Goetz, Lucia Schubring, Juliane Spiegler, Ann-Sophie Fries, Lucia Kiesel, Joerg Klepper
Summary: The aim of this research was to assess cognitive abilities in Glut1-Deficiency syndrome (Glut1DS) patients undergoing ketogenic diet therapy (KDT). Using the Wechsler Intelligence Scale (WISC-IV), the cognitive profiles of eight children were evaluated. The results showed a wide range of cognitive performance levels in Glut1DS patients, and the initiation and duration of KDT had a positive effect on overall IQ scores. The presence of expressive language test demands influenced the correlation between KDT initiation time and IQ scores, with minimal impact on linguistic cognitive abilities. Therefore, it is important to consider the individual access skills of test subjects to reduce the negative influence of motor deficits on intelligence assessment, and to focus on dysarthria during diagnosis and therapy for Glut1DS patients.
Meeting Abstract
Clinical Neurology
Marianna Spatola, Mar Petit Pedrol, Estibaliz Maudes, Mateus Simabukuro, Sergio Muniz-Castrillo, Anne-Laurie Pinto, Klaus-Peter Wandinger, Juliane Spiegler, Peter Schramm, Livia Almeida Dutra, Raffaele Iorio, Cornelia Kornblum, Romana Hoftberger, Frank Leypoldt, Maarten Titulaer, Peter Sillevis Smitt, Jerome Honnorat, Myrna Rosenfeld, Francesc Graus, Josep Dalmau
Article
Endocrinology & Metabolism
Lam O. Huang, Alexander Rauch, Eugenia Mazzaferro, Michael Preuss, Stefania Carobbio, Cigdem S. Bayrak, Nathalie Chami, Zhe Wang, Ursula M. Schick, Nancy Yang, Yuval Itan, Antonio Vidal-Puig, Marcel den Hoed, Susanne Mandrup, Tuomas O. Kilpelainen, Ruth J. F. Loos
Summary: This study identified genetic loci associated with higher obesity risk and lower cardiometabolic risk, highlighting the role of genes expressed in adipose tissue and influencing adipocyte function. Various mechanisms including insulin-glucose signaling, energy expenditure, white adipose tissue browning, and inflammation were involved. Some of these genes may serve as potential therapeutic targets for reducing cardiometabolic risk associated with excess adiposity.
Article
Pediatrics
Tarun Aurora, Audrey Cole, Parul Rai, Paul Lavoie, Carrie Mcivor, Lisa M. Klesges, Guolian Kang, Janaka S. S. Liyanage, Heather M. Brandt, Jane S. Hankins
Summary: This study evaluated the effectiveness of a vaccine strategy bundle in increasing HPV vaccine initiation and completion rates in a specialty clinic setting. By implementing the bundle, which included staff education, provider incentives, offering vaccines in clinics, and verifying vaccine completion, the clinic successfully improved HPV vaccine initiation and completion rates among sickle cell disease patients.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Nienke M. Halbmeijer, Wes Onland, Jeroen Dudink, Filip Cools, Anne Debeer, Anton H. van Kaam, Manon J. N. L. Benders, Niek E. van der Aa
Summary: In ventilated infants born preterm, high dose systemic hydrocortisone initiated between 7 and 14 days after birth did not have a significant impact on brain development.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Katherine Melton, Jianfang Liu, Hossein Sadeghi, Maureen George, Arlene Smaldone
Summary: This study aims to identify predictors of change in lung function and body weight during health care transition in cystic fibrosis (CF) patients. The study findings highlight the importance of CF RISE program engagement and reducing gaps in care for improving the transition of adolescents and young adults with CF.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Laura A. Duckworth, Kimberly A. Sutton, Nurmohammad Shaikh, Jinli Wang, Carla Hall-Moore, Lori R. Holtz, Phillip I. Tarr, Ronald C. Rubenstein
Summary: The study tested the usefulness of various biomarkers as indicators of gut dysfunction in cystic fibrosis (CF) and investigated the repeatability of these measures in individuals over short periods and their correlation with clinical outcomes. The results showed that elevated levels of fLcn2 in individuals with CF may predict worsened pulmonary function.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Lindsey Haack, Nikkan Das, Arvind Hoskoppal, Mark Debrunner, Tarek Alsaied, Gaurav Arora
Summary: RAE on ECG has a low positive predictive value for RAE on echocardiogram in previously healthy young patients. The highest yield for RAE on echocardiogram was observed in patients who were <1 year of age, had RAE in the anterior precordial leads, or displayed right ventricular hypertrophy on ECG.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Michael A. Padula, Khatija Naing, Tara L. Wenger, Irfan Ahmad, Carl H. Coghill, K. Taylor Wild, S. Alex Rottgers, Cory M. Resnick, Jeffrey Goldstein, Zarmina Ehsan, Donna Watkins, Nicole Deptula, Kuan-Chi Lai, Janet Lioy, Semsa Gogcu, Christopher M. Cielo
Summary: This study describes the spectrum of disease and burden of care in infants with congenital micrognathia. The results show that these infants commonly require surgical intervention and tube feedings, and disparities based on race and among centers were identified.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Michael P. Fundora, Manvitha Kalicheti, Guantao Zhao, Kevin O. Maher, Nicoleta Serban
Summary: This study investigated the variation of outpatient opioid prescribing in postoperative pediatric cardiac patients across the US. The results showed that there were significant differences in opioid prescribing by race, ethnicity, sex, and region.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Jia Guo, Brooklyn J. Fraser, Leigh Blizzard, Michael D. Schmidt, Terence Dwyer, Alison J. Venn, Costan G. Magnussen
Summary: There is a correlation between childhood and adulthood cardiorespiratory fitness.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Nianzhou Xiao, Michelle Starr, Adrienne Stolfi, Gilad Hamdani, Shireen Hashmat, Stefan G. Kiessling, Christina Sethna, Mahmoud Kallash, Robyn Matloff, Robert Woroniecki, Keia Sanderson, Ikuyo Yamaguchi, Stephen D. Cha, Michael G. Semanik, Rahul Chanchlani, Joseph T. Flynn, Mark Mitsnefes
Summary: This multicenter study reports that most infants diagnosed with idiopathic hypertension in the NICU will discontinue antihypertensive treatment within 2 years of discharge. Antenatal steroid treatment is associated with a decreased likelihood of needing antihypertensive therapy for more than 1 year.
JOURNAL OF PEDIATRICS
(2024)
Editorial Material
Pediatrics
Kanwaljit Singh, John Concato, Jonathan M. Davis
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Yaxing Meng, Harri Niinikoski, Suvi P. Rovio, Brooklyn J. Fraser, Feitong Wu, Antti Jula, Tapani Ronnemaa, Jorma S. A. Viikari, Olli T. Raitakari, Katja Pahkala, Costan G. Magnussen
Summary: This 26-year study shows a correlation between early-life non-HDL-C levels and future levels. Early dietary counseling can reduce the risk of high pediatric non-HDL-C, emphasizing the importance of early interventions in preventing cardiovascular risks.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Kelsey A. B. Gastineau, Rebecca Bell, Allison Hanes, Sandra Mckay, Eric Sigel, Filoteia Popescu, Evan C. Sommer, Shari Barkin
Summary: This study aimed to assess the self-reported counseling outcomes for a firearm safe storage counseling training program provided by the American Academy of Pediatrics. The results demonstrated significant improvement in counseling self-efficacy and frequency one month after the training.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Kathryn E. K. Berlin, William Scott, Sara Dawson, David Brousseau, Joanne M. Lagatta
Summary: This prospective cohort study aimed to investigate the impact of bronchopulmonary dysplasia (BPD) on the health-related quality of life (HRQL) of infants from NICU hospitalization to one year post-discharge. The study found that lower HRQL during NICU stay was associated with earlier gestational age, postnatal corticosteroid usage, outborn status, and gastrostomy tube placement. Lower HRQL at 3 and 12 months post-discharge was associated with readmissions, home oxygen use, parent-reported difficulty breathing, lower developmental scores, and not playing with other children. Most parents reported similar or improved HRQL after discharge, but parents of infants with respiratory symptoms experienced less improvement. Efforts to improve parent HRQL should focus on respiratory symptoms and social isolation.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Garett J. Griffith, Alan P. Wang, Robert I. Liem, Michael R. Carr, Tyler Corson, Kendra Ward
Summary: This study developed reference values for cardiorespiratory fitness in children aged 6-18 years without underlying heart disease, measured by peak oxygen uptake and treadmill time. Fitness levels increased with age in males but not females. Males generally exhibited higher fitness levels compared to females in the same age groups.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
David S. Liu, Patricia Miller, Anna Rothenberg, Carley Vuillermin, Peter M. Waters, Andrea S. Bauer
Summary: This study aims to determine if children with elbow flexion contracture (EFC) caused by brachial plexus birth injury (BPBI) are more likely to develop shoulder contracture and undergo surgical treatment. A retrospective review was conducted on children under 2 years old with BPBI who presented to a single children's hospital. The results showed that patients with EFC had reduced shoulder range of motion and higher odds of shoulder contracture and surgical treatment. Prompt referral to a BPBI specialty clinic is recommended for evaluation and potential surgery.
JOURNAL OF PEDIATRICS
(2024)
