期刊
JOURNAL OF PEDIATRICS
卷 173, 期 -, 页码 188-+出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.jpeds.2016.02.049
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资金
- Influenza Division in the National Center for Immunizations and Respiratory Diseases at the Centers for Disease Control and Prevention (CDC), Utah [U18IP000491]
- Influenza Division in the National Center for Immunizations and Respiratory Diseases at the Centers for Disease Control and Prevention (CDC), Nashville [U18IP000488]
- Influenza Division in the National Center for Immunizations and Respiratory Diseases at the Centers for Disease Control and Prevention (CDC), Memphis [U18IP000489]
- Glaxo Smith Kline
- MedImmune
- Roche
- Abbvie
- BioFire Diagnostics, Inc from the National Institutes of Health [NCT01878383]
- Antimicrobial Therapy Inc
- Medscape Inc
- BioFire Diagnostics Inc.
- Vanderbilt University from Novartis
Objective To describe and compare the clinical characteristics, outcomes, and etiology of pneumonia among children hospitalized with community-acquired pneumonia (CAP) with neurologic disorders, non-neurologic underlying conditions, and no underlying conditions. Study design Children <18 years old hospitalized with clinical and radiographic CAP were enrolled at 3 US children's hospitals. Neurologic disorders included cerebral palsy, developmental delay, Down syndrome, epilepsy, non-Down syndrome chromosomal abnormalities, and spinal cord abnormalities. We compared the epidemiology, etiology, and clinical outcomes of CAP in children with neurologic disorders with those with non-neurologic underlying conditions, and those with no underlying conditions using bivariate, age-stratified, and multivariate logistic regression analyses. Results From January 2010-June 2012, 2358 children with radiographically confirmed CAP were enrolled; 280 (11.9%) had a neurologic disorder (52.1% of these individuals also had non-neurologic underlying conditions), 934 (39.6%) had non-neurologic underlying conditions only, and 1144 (48.5%) had no underlying conditions. Children with neurologic disorders were older and more likely to require intensive care unit (ICU) admission than children with non-neurologic underlying conditions and children with no underlying conditions; similar proportions were mechanically ventilated. In age-stratified analysis, children with neurologic disorders were less likely to have a pathogen detected than children with non-neurologic underlying conditions. In multivariate analysis, having a neurologic disorder was associated with ICU admission for children >= 2 years of age. Conclusions Children with neurologic disorders hospitalized with CAP were less likely to have a pathogen detected and more likely to be admitted to the ICU than children without neurologic disorders.
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