期刊
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
卷 78, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.jddst.2022.103936
关键词
-
资金
- CooperVision, Inc. (Pleasanton, CA, USA)
- University of Brighton (Brighton, UK)
This review focuses on the recent trends and developments in the delivery of hydrophilic drugs, including nanomaterials and drug conjugates. It highlights the slow translation of novel technologies into viable pharmaceutical products and the lack of clinical trials. The review also discusses the technical, legislative, and commercial requirements for these novel technologies to be adopted in the real world.
The sustained and/or targeted delivery of hydrophilic drugs is an important field within drug delivery, presenting unique challenges when compared to that of hydrophobic drugs. Yet relatively few comprehensive reviews specific to hydrophilic drug delivery have been published recently. In this review, therefore, we seek to establish the recent trends in the delivery of hydrophilic drugs in particular, and recent developments including electrospun core-shell nanofibrous materials, stimuli -responsive hydrogel carriers, amphiphilic drug-drug conjugates (ADDCs), and nanomaterials including polymer nanoparticles (PNPs), solid lipid nanoparticles (SLNs), micelles, liposomes, and mesoporous silica nanoparticles (MSNs). A recurring trend in the field has been the relatively slow translation of novel technologies into viable pharmaceutical products, with few reaching clinical trial phase. Furthermore, we consider the bench-to-bedside potential of these novel technologies, taking into account the capabilities of these concepts to overcome the technical, legislative, and commercial requirements that must be met in order for a viable device to be adopted in the real world.
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