Review
Virology
Kimiyasu Shiraki, Shinichiro Yasumoto, Nozomu Toyama, Hiroaki Fukuda
Summary: Acyclovir, valacyclovir, and famciclovir are commonly used for the treatment of herpes simplex virus and varicella-zoster virus infections. However, recent studies have shown that amenamevir, a helicase-primase inhibitor, has novel mechanisms of action against these viruses with promising clinical efficacy. Its antiviral activity is not influenced by the viral replication cycle and has been demonstrated to be non-inferior to valacyclovir in treating herpes zoster.
Article
Oncology
Karen Muller Ramalho, Sandra Ribeiro Cunha, Flavia Goncalves, Gustavo Silva Escudeiro, Carolina Steiner-Oliveira, Anna Carolina Rato Tempestini Horliana, Carlos de Paula Eduardo
Summary: The study compared photodynamic therapy, topical acyclovir, and the combination of both in the treatment of herpes simplex virus type 1 recurrences. It was found that on day 1, photodynamic therapy showed better results in treating herpes lesions compared to acyclovir.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2021)
Article
Medicine, General & Internal
Laure F. Pittet, Cecilia L. Moore, Ellie McDonald, Simone Barry, Marc Bonten, John Campbell, Julio Croda, Margareth Dalcolmo, Andrew Davidson, Mark W. Douglas, Kaya Gardiner, Amanda Gwee, Bruno Jardim, Marcus V. G. Lacerda, Michaela Lucas, David J. Lynn, Laurens Manning, Roberto D. de Oliveira, Kirsten P. Perrett, Cristina Prat-Aymerich, Peter C. Richmond, Jorge L. Rocha, Jesus Rodriguez-Bano, Adilia Warris, Nicholas J. Woods, Nicole L. Messina, Nigel Curtis
Summary: This study aimed to investigate the impact of the bacille Calmette-Guerin (BCG) vaccine on cold sore recurrences. The results showed that BCG vaccination could delay the recurrence of cold sores, especially in males with frequent recurrences. However, BCG vaccination also increased the risk of a first episode of cold sore.
Article
Dermatology
Deepthi Konda, Laxmisha Chandrashekar, Rahul Dhodapkar, Rajesh Nachiappa Ganesh, Devinder Mohan Thappa
Summary: This study characterized the clinical markers of herpes simplex virus (HSV) infection among patients with pemphigus vulgaris. It was found that male sex, presence of fissures, hemorrhagic crusts, erosions with angulated margins, linear erosions, and raised erythrocyte sedimentation rate were significantly associated with HSV infection. Hemorrhagic crusts and linear erosions were identified as independent predictors of HSV infection.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Article
Immunology
Makoto Kawashima, Shinichi Imafuku, Kosuke Fujio, Hiroshi Komazaki
Summary: This study confirmed the effectiveness of patient-initiated single-dose amenamevir treatment for recurrent genital herpes, which can reduce the healing time of all lesions, without any significant safety concerns.
OPEN FORUM INFECTIOUS DISEASES
(2022)
Article
Chemistry, Multidisciplinary
Xin Li, Tryfon Zarganes-Tzitzikas, Katarzyna Kurpiewska, Alexander Domling
Summary: We present a concise, convenient and sustainable synthesis of Amenamevir, an approved anti-herpes zoster drug. Our approach, based on the Ugi-4CR reaction, enables a simple, rapid and one-pot synthesis of Amenamevir. Compared to other reported syntheses, our method is more sustainable, shorter, and provides higher yields. We also report the X-ray crystal structures of key intermediate 3-(4-isocyanophenyl)-1,2,4-oxadiazole 4 and Amenamevir for the first time. Computational retrosynthesis using four popular freeware failed to propose our one-pot synthesis.
Review
Medicine, General & Internal
Bisant A. Labib, DeGaulle Chigbu
Summary: Herpes simplex virus (HSV) keratitis is a leading cause of blindness worldwide and affects a large population. Although there are currently no vaccines available, treatment options such as antiviral drugs and steroids can help manage the disease. However, these treatments do not eliminate the virus and are ineffective against recurrent infections, highlighting the need for further research on alternative therapies.
Letter
Medicine, General & Internal
Charles-Edouard Luyt, David Hajage, Sonia Burrel, Sami Hraiech, Mamadou Hassimiou Diallo, Laurent Papazian, David Boutolleau
Summary: This analysis investigated the efficacy of acyclovir in preventing oropharyngeal HSV reactivation among mechanically ventilated patients.
Article
Integrative & Complementary Medicine
Tahereh Toulabi, Bahram Delfan, Marzieh Rashidipour, Sajad Yarahmadi, Farzaneh Ravanshad, Amir Javanbakht, Mohammad Almasian
Summary: This study compared the clinical effects of Olive Leaf Extract (OLE) and Acyclovir on Herpes simplex virus-1 (HSV-1). The results showed that OLE was superior to Acyclovir in reducing symptoms and had a shorter treatment duration.
EXPLORE-THE JOURNAL OF SCIENCE AND HEALING
(2022)
Article
Pathology
Melissa Krystel-Whittemore, May P. Chan, Sara C. Shalin, Kenan J. Sauder, Amy Hudson, Ruth K. Foreman, Mai P. Hoang, Jeoffry B. Brennick, Shaofeng Yan, Rosalynn M. Nazarian
Summary: This study presents the first known report of herpes virus infecting deep stromal cells of the dermis, highlighting the importance of considering cutaneous stromal herpes in patients with atypical clinical lesions, especially when immunocompromised. Establishing the correct diagnosis is crucial for initiating therapy.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2021)
Review
Dermatology
Hideo Asada
Summary: Herpes zoster is a disease caused by reactivation of the latent varicella-zoster virus and is more common among the elderly. In Japan, the incidence of herpes zoster has been steadily increasing and is expected to further rise. In recent years, new antiviral drugs with novel pharmacological effects and a new subunit vaccine have been introduced, leading to a new era in the treatment of herpes zoster.
JOURNAL OF DERMATOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Pasquale Santamaria, Ruth C. E. Bowyer, Luigi Nibali
Summary: This study aimed to explore the role of host genetic factors in the reactivation of Herpes Simplex Labialis (HSL). The findings suggest that a single nucleotide polymorphism in the Vitamin D Receptor (VDR) gene may be associated with the occurrence and recurrence of cold sores.
ARCHIVES OF ORAL BIOLOGY
(2023)
Review
Engineering, Biomedical
Ana Waleska Pessoa Barros, Pedro Henrique da Hora Sales, Paulo Goberlanio de Barros Silva, Ana Claudia Amorim Gomes, Alessandra Albuquerque Tavares Carvalho, Jair Carneiro Leao
Summary: This systematic review aimed to evaluate the effectiveness of low-level laser therapy in treating herpes labialis. The findings showed that low-level laser therapy significantly reduced tissue healing time, but had no significant effect on crust formation time. However, due to the high risk of bias in the included studies, more standardized research is needed to prove the effectiveness of this therapy.
LASERS IN MEDICAL SCIENCE
(2022)
Article
Immunology
Malgorzata Krzyzowska, Anders Jarneborn, Karolina Thorn, Kristina Eriksson, Tao Jin
Summary: This study provides evidence that treatment with tofacitinib may increase the risk of disease aggravation and severe encephalitis in primary herpes simplex infection by impairing antiviral response induced by monocytes and microglia.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Cooper K. Hayes, Christopher K. Villota, Fiona B. McEnany, Stacey Ceron, Sita Awasthi, Moriah L. Szpara, Harvey M. Friedman, David A. Leib, Richard Longnecker, Matthew D. Weitzman, Lisa N. Akhtar
Summary: Clinical HSV-2 isolates collected from neonates with encephalitis are more neurovirulent in human neuronal cell culture and murine models as compared to isolates from neonates with skin-limited disease, suggesting that viral factors contribute to neurologic outcome following human neonatal infection.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Shigeru Hishinuma, Hiroshi Komazaki, Hiroyuki Fukui, Masaru Shoji
JOURNAL OF NEUROCHEMISTRY
(2010)
Article
Pharmacology & Pharmacy
Shigeru Hishinuma, Yuko Sato, Yusuke Kobayashi, Hiroshi Komazaki, Masaki Saito
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2008)
Article
Medicine, General & Internal
Kenji Kabashima, Takayo Matsumura, Hiroshi Komazaki, Makoto Kawashima
NEW ENGLAND JOURNAL OF MEDICINE
(2020)
Article
Dermatology
K. Kabashima, T. Matsumura, H. Komazaki, M. Kawashima
Summary: Long-term administration of nemolizumab in patients with inadequately controlled moderate-to-severe pruritus in AD showed continuous improvement in pruritus, signs of AD, and quality of life for up to 68 weeks, with a favorable safety profile, based on two long-term phase III studies.
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Article
Immunology
Makoto Kawashima, Shinichi Imafuku, Kosuke Fujio, Hiroshi Komazaki
Summary: This study confirmed the effectiveness of patient-initiated single-dose amenamevir treatment for recurrent genital herpes, which can reduce the healing time of all lesions, without any significant safety concerns.
OPEN FORUM INFECTIOUS DISEASES
(2022)
Article
Mathematical & Computational Biology
Hiroshi Komazaki, Masaaki Doi, Naohiro Yonemoto, Tosiya Sato
Summary: Missing data in clinical trials can lead to serious misinterpretation of the results. To address this, it is important to collect post-randomization data, known as auxiliary variables, which can be used to construct missingness and imputation models. This article proposes a new method that extends a previously developed estimator to longitudinal data by using weighted generalized estimating equations with new weights.
STATISTICS IN BIOPHARMACEUTICAL RESEARCH
(2023)
Article
Dermatology
Kenji Kabashima, Takayo Matsumura, Hiroshi Komazaki, Makoto Kawashima
Summary: This study investigated the impact of nemolizumab on the quality of life in patients with atopic dermatitis. The results showed that nemolizumab treatment improved sleep quality, interpersonal relationships, and work activities.
DERMATOLOGY AND THERAPY
(2023)