Antibody-modified DNase I micelles specifically recognize the neutrophil extracellular traps (NETs) and promote their degradation

Neutrophil extracellular traps (NETs) are structures consisting of decondensed chromatin with associated pro-teins, including histones and antimicrobial peptides, released from activated neutrophils. They are believed to be one of the body's first lines of defense against infectious agents. Despite their beneficial effect on the immune response process, some studies indicate that their excessive formation and the associated accumulation of extracellular DNA (eDNA) together with other polyelectrolytes (F-actin) plays an important role in the patho-genesis of many diseases. Thus NETs formation and removal are clinically significant. The monoclonal antibody 2C5 has strong specificity for intact nucleohistones (NS) and targets NS in NETs as we previously confirmed. Creation of a nano preparation that can specifically recognize and destroy NETs represents the aim for treatment many diseases. 2C5 antibody functionalized micelles coated with DNase I were created to achieve this aim.

Automated summary

Neutrophil extracellular traps (NETs) are structures released from activated neutrophils that consist of decondensed chromatin with associated proteins. While they play a beneficial role in the immune response, excessive NETs formation and accumulation of extracellular DNA (eDNA) have been implicated in the pathogenesis of various diseases. The monoclonal antibody 2C5 specifically targets intact nucleohistones (NS) in NETs, and the development of a nano preparation using 2C5 antibody functionalized micelles coated with DNase I aims to recognize and eliminate NETs for disease treatment.