Article
Biochemistry & Molecular Biology
Walker D. Short, Emily Steen, Aditya Kaul, Xinyi Wang, Oluyinka O. Olutoye, Hima V. Vangapandu, Natalie Templeman, Alexander J. Blum, Chad M. Moles, Daria A. Narmoneva, Timothy M. Crombleholme, Manish J. Butte, Paul L. Bollyky, Sundeep G. Keswani, Swathi Balaji
Summary: This study found that overexpression of IL-10 in dermal wounds recruits EPCs, increases vascular structures, and accelerates re-epithelialization.
Review
Biotechnology & Applied Microbiology
Fei Fan, Sanjoy Saha, Donny Hanjaya-Putra
Summary: Hydrogels play a crucial role in wound healing by supporting a hydrated environment and promoting better healing outcomes through the incorporation of biomolecules and supporting cells. Various types of hydrogels have been developed and modified to match different stages of wound healing, with challenges related to adoption and future perspectives discussed.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Amjad Husain, Arogya Khadka, Allen Ehrlicher, Magali Saint-Geniez, Ramaswamy Krishnan
Summary: The study reveals the underlying role of the PI3K/Akt/mTOR signaling pathway in regulating vascular endothelial growth factor-A (VEGF-A) mediated signaling and functions. The pathway is activated on stiffer substrates, amplified by VEGF-A stimulation, and correlated with enhanced endothelial cell (EC) proliferation, contraction, pro-angiogenic secretion, and capillary-like tube formation. These findings have important implications for understanding age-related macular degeneration and provide insight into potential therapeutic pathways.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Ophthalmology
Alison J. Clare, Jian Liu, David A. Copland, Sofia Theodoropoulou, Andrew D. Dick
Summary: AMD, a leading cause of blindness in the elderly, lacks effective treatments for the majority of patients affected by aAMD. However, IL-33, traditionally known for its proinflammatory role, shows promising therapeutic potential in treating AMD by modulating the immune response.
Article
Engineering, Biomedical
Jueying Chen, Jiahui He, Yutong Yang, Lipeng Qiao, Juan Hu, Jie Zhang, Baolin Guo
Summary: The development of compressible, stretchable and self-healing hydrogel dressings with good adhesive, antibacterial and angiogenesis properties is needed to promote the regeneration of diabetic wounds in clinical applications.
ACTA BIOMATERIALIA
(2022)
Article
Biochemistry & Molecular Biology
Yuan Gao, Chengliang Luo, Tongyu Rui, Yanyan Fan, Yi Yao, Hengji Shen, Cheng Gao, Tao Wang, Haochen Wang, Xueshi Chen, Jiaxin Zhang, Dongya Li, Chongjian Xia, Li-Li Li, Zufeng Wang, Mingyang Zhang, Xiping Chen, Luyang Tao
Summary: The studies found that inhibiting autophagy with 3-MA significantly increased wound closure rate, suppressed inflammation response, and alleviated pathological changes, while RAP treatment aggravated SWH-induced damage. Inflammatory indicators were modulated by the manipulation of autophagy, with 3-MA inhibiting their expression and RAP reversing the up-regulation caused by SWH.
Article
Biochemistry & Molecular Biology
Rong-Fu Chen, Keng-Fan Liu, Su-Shin Lee, Shu-Hung Huang, Yi-Chia Wu, Yun-Nan Lin, Chun-Ting Wang, Yur-Ren Kuo
Summary: The study revealed that FIR therapy could significantly accelerate diabetic wound healing, associated with suppressed inflammatory response, increased neovascularization, and tissue regeneration.
Article
Chemistry, Multidisciplinary
Wenfeng Li, Rui Qing, Haojie Zhang, Ziwei Wang, Yuhan Yuan, Lili Wang, Jia Deng, Bochu Wang, Shilei Hao
Summary: The study demonstrates the significant promise of trichocyte keratins in promoting wound healing, with distinct behaviors and advantages observed among different types. Transcriptomic analysis reveals the regulatory mechanisms of keratins in cell proliferation, migration, and blood vessel generation. These findings can contribute to the development and precision application of keratins.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Biotechnology & Applied Microbiology
Hamed Nosrati, Reza Aramideh Khouy, Ali Nosrati, Mohammad Khodaei, Mehdi Banitalebi-Dehkordi, Korosh Ashrafi-Dehkordi, Samira Sanami, Zohreh Alizadeh
Summary: The skin serves as the body's primary barrier against external pathogens and maintaining homeostasis. Damage to the skin can have significant impacts on health and quality of life. Tissue engineering aims to enhance tissue regeneration, with improving angiogenesis being one of the most effective treatments for skin tissue regeneration.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Endocrinology & Metabolism
Tangtang He, Pengfei Sun, Bo Liu, Shiwei Wan, Penghua Fang, Jun Chen, Guicheng Huang, Wen Min
Summary: The study found that puffball spores can accelerate diabetic wound healing by activating the Akt/Nrf2 signaling pathway, promoting the expression of antioxidant genes, and enhancing angiogenesis and collagen deposition. This provides a theoretical basis for the treatment of diabetic and refractory wounds.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Engineering, Biomedical
Que Bai, Caiyun Zheng, Na Sun, Wenting Chen, Qian Gao, Jinxi Liu, Fangfang Hu, Tong Zhou, Yanni Zhang, Tingli Lu
Summary: This study presents an oxygen-releasing hydrogel that promotes cell survival, migration, and tube formation under hypoxic conditions, and facilitates tissue repair by reducing inflammation, increasing angiogenesis, and collagen deposition.
ACTA BIOMATERIALIA
(2022)
Article
Nanoscience & Nanotechnology
Li Li, Zhiyu Wang, Kepeng Wang, Siyuan Fu, Dan Li, Mao Wang, Yi Cao, Houjuan Zhu, Ziyan Li, Lixing Weng, Zhiyang Li, Xianguang Ding, Lianhui Wang
Summary: An efficient extracellular vesicle (EV) ink was developed to regulate the inflammatory microenvironment and promote vascular regeneration for wound healing. This bioactive EV ink, called PAINT, utilizes bioactive EVs derived from M2 macrophages and sodium alginate precursor to form a biocompatible EV-Gel for application on wounds. The PAINT technology reprograms macrophage polarization and enhances angiogenesis, significantly accelerating cutaneous wound healing. It demonstrates the high potential of bioactive EV ink as a portable biomedical platform for healthcare when integrated with a 3D printing pen.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Yun-Lung Chung, Pei-Yu Chou, Ming-Jyh Sheu
Summary: This study evaluated the wound-healing activity of PEDOT: PSS and found that it significantly improved wound healing in SD rats. The treatment increased angiogenic behavior and VEGF expression, indicating its angiogenic effects. The results suggest that PEDOT: PSS can be potentially used as a dressing for medical use.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Guiting Liu, Yuan Zhou, Zejun Xu, Ziting Bao, Li Zheng, Jun Wu
Summary: In this study, a novel sodium alginate/chitosan (SA/CS) Janus hydrogel dressing was fabricated to combine the functions of anti-infection and neovascularization at the wound site. The inner CS-ArgMS hydrogel released L-arginine and promoted vascular regeneration, while the outer SA-AgNP hydrogel prevented infection. The SA-AgNP/CS-ArgMS hydrogel showed excellent biocompatibility and demonstrated antibacterial and angiogenesis characteristics, leading to enhanced diabetic wound healing in vivo.
CHINESE CHEMICAL LETTERS
(2023)
Article
Engineering, Environmental
Zhixin Ling, Zhikun Chen, Jin Deng, Yifu Wang, Bo Yuan, Xiao Yang, Hai Lin, Jun Cao, Xiangdong Zhu, Xingdong Zhang
Summary: A self-healing hydrogel with angiogenic and antibacterial properties was developed for skin wound repair in this study. The hydrogel exhibited good mechanical properties and biocompatibility, accelerating wound healing and reducing scar formation.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Audiology & Speech-Language Pathology
Bonnie B. Y. Cheng, Brooke J. Ryan, David A. Copland, Sarah J. Wallace
Summary: This study explored the perceptions and preferences of significant others of people with aphasia on receiving prognostic information. The findings suggest that their perspectives are influenced by the poststroke reality and may inadvertently shape the views of the person with aphasia. It highlights the importance of considering the needs of significant others in prognostication practices to facilitate recovery.
AMERICAN JOURNAL OF SPEECH-LANGUAGE PATHOLOGY
(2022)
Article
Ophthalmology
Ema Ozaki, Conor Delaney, Matthew Campbell, Sarah L. Doyle
Summary: As resident immune cells in the retina, microglia play crucial roles in maintaining immune regulation and protecting neurons. However, chronic microglia activation is common in degenerative retinal diseases. Minocycline, a semi-synthetic tetracycline antibiotic, has shown to inhibit proinflammatory microglia and protect against photoreceptor cell degeneration. Disease associated microglia (DAM), a subtype of microglia, have been associated with various central nervous system (CNS) diseases. This study investigates the infiltration of microglia towards the outer retina in rhodopsin knockout mice and identifies markers for both homeostatic function and DAM. The administration of minocycline to the mice leads to the suppression of DAM markers associated with lipid metabolism, thus protecting against inflammation-induced photoreceptor cell death.
EXPERIMENTAL EYE RESEARCH
(2022)
Review
Clinical Neurology
Marian C. Brady, Myzoon Ali, Kathryn VandenBerg, Linda J. Williams, Louise R. Williams, Masahiro Abo, Frank Becker, Audrey Bowen, Caitlin Brandenburg, Caterina Breitenstein, Stefanie Bruehl, David A. Copland, Tamara B. Cranfill, Marie Di Pietro-Bachmann, Pamela Enderby, Joanne Fillingham, Federica Lucia Galli, Marialuisa Gandolfi, Bertrand Glize, Erin Godecke, Neil Hawkins, Katerina Hilari, Jacqueline Hinckley, Simon Horton, David Howard, Petra Jaecks, Elizabeth Jefferies, Luis M. T. Jesus, Maria Kambanaros, Eun Kyoung Kang, Eman M. Khedr, Anthony Pak-Hin Kong, Tarja Kukkonen, Marina Laganaro, Matthew A. Lambon Ralph, Ann Charlotte Laska, Beatrice Leemann, Alexander P. Leff, Roxele R. Lima, Antje Lorenz, Brian MacWhinney, Rebecca Shisler Marshall, Flavia Mattioli, Ilknur Mavis, Marcus Meinzer, Reza Nilipour, Enrique Noe, Nam-Jong Paik, Rebecca Palmer, Ilias Papathanasiou, Brigida Patricio, Isabel Pavao Martins, Cathy Price, Tatjana Prizl Jakovac, Elizabeth Rochon, Miranda L. Rose, Charlotte Rosso, Ilona Rubi-Fessen, Marina B. Ruiter, Claerwen Snell, Benjamin Stahl, Jerzy P. Szaflarski, Shirley A. Thomas, Mieke van de Sandt-Koenderman, Ineke van der Meulen, Evy Visch-Brink, Linda Worrall, Heather Harris Wright
Summary: This study explored the association between speech and language therapy (SLT) interventions frequency, intensity, and dosage with language outcomes for stroke rehabilitation. Different age, sex, aphasia severity, and chronicity subgroups showed varying treatment responses to SLT parameters. While most subgroups experienced language gains, differences were observed among subgroups, highlighting the need for further research on precision rehabilitation approaches.
INTERNATIONAL JOURNAL OF STROKE
(2022)
Article
Clinical Neurology
Miranda L. Rose, Lyndsey Nickels, David Copland, Leanne Togher, Erin Godecke, Marcus Meinzer, Tapan Rai, Dominique A. Cadilhac, Joosup Kim, Melanie Hurley, Abby Foster, Marcella Carragher, Cassie Wilcox, John E. Pierce, Gillian Steel
Summary: This study investigated the therapeutic benefits of Constraint-Induced Aphasia Therapy Plus (CIAT-plus) and/or Multimodality Aphasia Therapy (M-MAT) compared to usual community care for post-stroke aphasia patients. Both CIAT-Plus and M-MAT showed significant improvements in word retrieval, functional communication, and quality of life, while the usual care group did not. Further research should explore predictive characteristics of responders and impacts of maintenance doses.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Neurosciences
Bonnie B. Y. Cheng, Brooke J. Ryan, David A. Copland, Sarah J. Wallace
Summary: This study provides valuable insights into the experiences of individuals with aphasia receiving prognoses post-stroke, revealing issues of mistrust in the patient-clinician relationship and complex emotions related to hope and adjustment.
NEUROPSYCHOLOGICAL REHABILITATION
(2023)
Article
Audiology & Speech-Language Pathology
Kirstine Shrubsole, David Copland, Annie Hill, Asaduzzaman Khan, Melissa Lawrie, Denise A. O'Connor, Moya Pattie, Amy Rodriguez, Elizabeth C. Ward, Linda Worrall, Marie-Pier Mcsween
Summary: This study aimed to identify potential barriers and facilitators to implementing Aphasia LIFT into existing healthcare services from the perspectives of clinical stakeholders and experienced LIFT clinicians, and develop a theory-informed implementation intervention for Aphasia LIFT, tailored to the intended implementation context.
Article
Audiology & Speech-Language Pathology
Elaine Kearney, Sonia L. E. Brownsett, David A. Copland, Katharine J. Drummond, Rosalind L. Jeffree, Sarah Olson, Emma Murton, Benjamin Ong, Gail A. Robinson, Valeriya Tolkacheva, Katie L. McMahon, Greig de Zubicaray
Summary: This study found that post-treatment communication-related quality of life was associated with residual tumor, edema, and peri-resection treatment effects as well as white matter disconnection. However, mood-related quality of life and the primary resection lesion maps were not significantly associated with HRQoL.
Article
Rehabilitation
Bethany Best, Jessica Campbell, Tracy Roxbury, Peter Worthy, David A. Copland
Summary: This exploratory research examined the usability and feasibility of a purpose-built music listening mobile application for people living with post-stroke aphasia in the community. The study found that the application was perceived as being usable and feasible, with high system usability rating and moderate effectiveness, efficiency, and satisfaction. This study provides a foundation for further examination of the usability of music listening technology in people with post-stroke aphasia and potential applications in acute care facilities and other clinical populations.
DISABILITY AND REHABILITATION
(2023)
Review
Psychology, Clinical
Ileana Camerino, Joao Ferreira, Jet M. M. Vonk, Roy P. C. Kessels, Frank-Erik de Leeuw, Ardi Roelofs, David Copland, Vitoria Piai
Summary: This systematic review and meta-analysis investigated word production impairments in clinical populations with basal ganglia pathologies. The results showed that patients with stroke affecting the basal ganglia, small vessel disease, Parkinson's disease, and Huntington's disease consistently performed worse than cognitively unimpaired adults in language production tasks. These impairments could not be fully explained by motor or processing-speed deficits.
NEUROPSYCHOLOGY REVIEW
(2022)
Article
Audiology & Speech-Language Pathology
Sarah J. Wallace, Linda Worrall, Tanya A. Rose, Reem S. W. Alyahya, Edna Babbitt, Suzanne Beeke, Carola de Beer, Arpita Bose, Audrey Bowen, Marian C. Brady, Caterina Breitenstein, Stefanie Bruehl, Lucy Bryant, Bonnie B. Y. Cheng, Leora R. Cherney, Paul Conroy, David A. Copland, Clare Croteau, Madeline Cruice, Lucy Dipper, Katerina Hilari, Tami Howe, Helen Kelly, Swathi Kiran, Ann-Charlotte Laska, Jane Marshall, Laura L. Murray, Janet Patterson, Gill Pearl, Jana Quinting, Elizabeth Rochon, Miranda L. Rose, Ilona Rubi-Fessen, Karen Sage, Nina Simmons-Mackie, Evy Visch-Brink, Anna Volkmer, Janet Webster, Anne Whitworth, Guylaine Le Dorze
Summary: The aim of this study was to establish consensus on a communication OMI for inclusion in the ROMA COS, and it was found that TST is the preferred choice. Implementation of the ROMA COS would improve the quality, relevance, transparency, replicability, and efficiency of aphasia treatment research.
INTERNATIONAL JOURNAL OF LANGUAGE & COMMUNICATION DISORDERS
(2023)
Article
Psychology, Experimental
Emma A. E. Schimke, Anthony J. Angwin, Sjaan R. Gomersall, David A. Copland
Summary: This study examined the impact of overnight sleep on associative novel word learning and found that overnight sleep can enhance the consolidation of novel words. Whether semantic information was provided or not, new words benefited from the overnight sleep period.
Article
Neurosciences
Aleksi J. Sihvonen, Veronika Vadinova, Kimberley L. Garden, Marcus Meinzer, Tracy Roxbury, Kate O'Brien, David Copland, Katie L. McMahon, Sonia L. E. Brownsett
Summary: Poststroke aphasia, caused by left-lateralized language network damage, is often accompanied by uncertainty in the contribution of the right hemisphere's homologues to aphasia recovery. In this study, the role of the right hemisphere's structural connectome in aphasia recovery was investigated. The results showed that certain pathways in the right hemisphere white matter made a maladaptive contribution to language recovery, while others supported the recovery of language comprehension abilities.
HUMAN BRAIN MAPPING
(2023)
Review
Clinical Neurology
Bridget Burton, Megan Isaacs, Emily Brogan, Kirstine Shrubsole, Monique F. Kilkenny, Emma Power, Erin Godecke, Dominique A. Cadilhac, David Copland, Sarah J. Wallace
Summary: The aim of this study was to identify and evaluate high-quality stroke guidelines that can inform aphasia management. We identified 9 high-quality guidelines and extracted 82 recommendations for aphasia management. Most recommendations were aphasia-related, but there were gaps in aphasia-specific recommendations in the areas of accessing community supports, return to work and leisure, driving, and interprofessional practice.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Neurosciences
Jade Dignam, Amy D. Rodriguez, Kate O'Brien, Penni Burfein, David A. Copland
Summary: This study explored the relationship between early within-therapy probe naming performance and treatment outcomes in individuals with aphasia. Results showed that early within-therapy probe naming performance was the strongest predictor of therapy gains for anomia, both immediately after therapy and at 1-month follow-up. These findings have important clinical implications and suggest that early probe naming performance can be used to identify potential response to treatment for aphasia.
NEUROPSYCHOLOGICAL REHABILITATION
(2023)
Review
Nutrition & Dietetics
Remi Fritzen, Amy Davies, Miriam Veenhuizen, Matthew Campbell, Samantha J. Pitt, Ramzi A. Ajjan, Alan J. Stewart
Summary: Magnesium (Mg2+) plays vital physiological roles in cardiovascular functioning, including regulation of cardiac excitation-contraction coupling, endothelial functioning, and haemostasis. It impacts both protein and cellular aspects of coagulation. This review explores the maintenance of Mg2+ homeostasis in the body, the molecular roles of Mg2+ in the cardiovascular system, the potential influence of magnesium deficiency on cardiac and vascular outcomes, and the use of magnesium supplements in preventing and treating cardiovascular disorders and managing cardiometabolic health.