Placental endoplasmic reticulum stress negatively regulates transcription of placental growth factor via ATF4 and ATF6β: implications for the pathophysiology of human pregnancy complications

If we know so much about preeclampsia, why haven’t we cured the disease?

(2013) James M. Roberts et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Suppression of Mitochondrial Electron Transport Chain Function in the Hypoxic Human Placenta: A Role for miRNA-210 and Protein Synthesis Inhibition

(2013) Francesca Colleoni et al.   PLoS One

Prolonged endoplasmic reticulum stress alters placental morphology and causes low birth weight

(2013) Takashige Kawakami et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Evidence of endoplasmic reticulum stress and protein synthesis inhibition in the placenta of non-native women at high altitude

(2012) Hong Wa Yung et al.   FASEB JOURNAL

Endoplasmic reticulum stress disrupts placental morphogenesis: implications for human intrauterine growth restriction

(2012) Hong wa Yung et al.   JOURNAL OF PATHOLOGY

Preeclampsia, a Disease of the Maternal Endothelium

(2011) Camille E. Powe et al.   CIRCULATION

Angiogenic growth factors in the diagnosis and prediction of pre-eclampsia

(2011) Stefan Verlohren et al.   CLINICAL SCIENCE

Regulation of placenta growth factor by microRNA-125b in hepatocellular cancer

(2011) Gianfranco Alpini et al.   JOURNAL OF HEPATOLOGY

Soluble FLT1 sensitizes endothelial cells to inflammatory cytokines by antagonizing VEGF receptor-mediated signalling

(2010) T. Cindrova-Davies et al.   CARDIOVASCULAR RESEARCH

The preeclampsia biomarkers soluble fms-like tyrosine kinase-1 and placental growth factor: current knowledge, clinical implications and future application

(2010) Olav Lapaire et al.   European Journal of Obstetrics & Gynecology and Reproductive Biology

Differential expression of VE-cadherin and VEGFR2 in placental syncytiotrophoblast during preeclampsia – New perspectives to explain the pathophysiology

(2010) T. Groten et al.   PLACENTA

Transcriptional Regulation of VEGF-A by the Unfolded Protein Response Pathway

(2010) Rajarshi Ghosh et al.   PLoS One

Molecular Regulation of Human Placental Growth Factor (PlGF) Gene Expression in Placental Villi and Trophoblast Cells is Mediated via the Protein Kinase A Pathway

(2010) Christophe Depoix et al.   Reproductive Sciences

Evidence of increased oxidative stress and a change in the plasminogen activator inhibitor (PAI)-1 to PAI-2 ratio in early-onset but not late-onset preeclampsia

(2009) Anna-Karin Wikström et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Evidence of Placental Translation Inhibition and Endoplasmic Reticulum Stress in the Etiology of Human Intrauterine Growth Restriction

(2008) Hong-wa Yung et al.   AMERICAN JOURNAL OF PATHOLOGY

ATF4-Mediated Induction of 4E-BP1 Contributes to Pancreatic β Cell Survival under Endoplasmic Reticulum Stress

(2008) Suguru Yamaguchi et al.   Cell Metabolism

ATF6 Is a Transcription Factor Specializing in the Regulation of Quality Control Proteins in the Endoplasmic Reticulum

(2008) Yusuke Adachi et al.   CELL STRUCTURE AND FUNCTION

ATF4 is an oxidative stress–inducible, prodeath transcription factor in neurons in vitro and in vivo

(2008) Philipp S. Lange et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A longitudinal study of angiogenic (placental growth factor) and anti-angiogenic (soluble endoglin and soluble vascular endothelial growth factor receptor-1) factors in normal pregnancy and patients destined to develop preeclampsia and deliver a small for gestational age neonate

(2008) Roberto Romero et al.   Journal of Maternal-Fetal & Neonatal Medicine

Placental Endoplasmic Reticulum Stress and Oxidative Stress in the Pathophysiology of Unexplained Intrauterine Growth Restriction and Early Onset Preeclampsia

(2008) G.J. Burton et al.   PLACENTA

Glial Cell Missing 1 Regulates Placental Growth Factor (PGF) Gene Transcription in Human Trophoblast1

(2007) Miao Chang et al.   BIOLOGY OF REPRODUCTION

Placental Productions and Expressions of Soluble Endoglin, Soluble fms-Like Tyrosine Kinase Receptor-1, and Placental Growth Factor in Normal and Preeclamptic Pregnancies

(2007) Yang Gu et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM