Ion Channel Chameleons: Switching Ion Selectivity by Alternative Splicing

A lysine residue from an extracellular turret switches the ion preference in a Cav3 T-Type channel from calcium to sodium ions

(2022) Wendy Guan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

T-type Channels Become Highly Permeable to Sodium Ions Using an Alternative Extracellular Turret Region (S5-P) Outside the Selectivity Filter

(2014) Adriano Senatore et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of a Prokaryotic Sodium Channel Pore Reveals Essential Gating Elements and an Outer Ion Binding Site Common to Eukaryotic Channels

(2013) David Shaya et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural basis for Ca2+ selectivity of a voltage-gated calcium channel

(2013) Lin Tang et al.   NATURE

Adaptive evolution of voltage-gated sodium channels: The first 800 million years

(2012) H. H. Zakon   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ancestral Ca2+ Signaling Machinery in Early Animal and Fungal Evolution

(2011) X. Cai et al.   MOLECULAR BIOLOGY AND EVOLUTION