Article
Genetics & Heredity
Ruyi Liu, Yifan Zhou, Qiaoli Li, Biaobang Chen, Zhou Zhou, Lan Wang, Lei Wang, Qing Sang, Lei Jin
Summary: This study identified a novel homozygous missense mutation in the BTG4 gene in a female infertility patient with zygotic cleavage failure phenotype, and demonstrated its functional effect on protein interaction in HeLa cells. These findings expand the mutational spectrum of BTG4 and suggest its potential as a therapeutic target for zygotic cleavage failure patients.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2021)
Article
Physiology
Huiling Hu, Shuoping Zhang, Jing Guo, Fei Meng, Xueqin Chen, Fei Gong, Guangxiu Lu, Wei Zheng, Ge Lin
Summary: The study identified TRIP13 missense variants as an important genetic cause of Zygotic cleavage failure (ZCF) and highlighted the significant role of TRIP13 in meiosis and mitosis.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Maria Manuel Casteleiro Alves, Micaela Almeida, Antonio Helio Oliani, Luiza Breitenfeld, Ana Cristina Ramalhinho
Summary: Oxidative stress is an important factor in the development of conditions such as infertility. This study examined the role of CYP19A1, GSTM1, and GSTT1 in female infertility risk. The results showed that carriers of specific genotypes in these genes had a significantly increased risk of female infertility. Furthermore, the risk was even higher when both GSTs were deleted, regardless of the CYP19A1 genotype.
Article
Reproductive Biology
Robert T. Rydze, Bethany K. Patton, Shawn M. Briley, Hannia Salazar Torralba, Gregory Gipson, Rebecca James, Aleksandar Rajkovic, Thomas Thompson, Stephanie A. Pangas
Summary: The study on Grem2 (-/-) mice shows that the lack of the BMP antagonist Grem2 leads to a complex reproductive phenotype, primarily resulting from disruptions in the hypothalamic-pituitary-ovarian axis causing irregular estrous cycles.
BIOLOGY OF REPRODUCTION
(2021)
Article
Cell Biology
Lin Zhao, Yichun Guan, Qingxia Meng, Weijie Wang, Ling Wu, Biaobang Chen, Jijun Hu, Jiawei Zhu, Zhihua Zhang, Jian Mu, Yao Chen, Yiming Sun, Tianyu Wu, Wenjing Wang, Zhou Zhou, Jie Dong, Yang Zeng, Ruyi Liu, Qiaoli Li, Jing Du, Yanping Kuang, Qing Sang, Lei Wang
Summary: Mutations in the CDC20 gene play a crucial role in oocyte maturation and fertilization, leading to various infertility phenotypes. This study expands the spectrum of known mutations in CDC20 and provides new evidence for its involvement in female infertility characterized by oocyte maturation arrest and fertilization failure.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Yi Luan, Pauline Xu, Seok-Yeong Yu, So-Youn Kim
Summary: The p63 transcription factor is crucial in female reproduction, serving as a genomic guardian in the ovaries and its mutations are increasingly associated with female infertility.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Obstetrics & Gynecology
Zhenxing Liu, Qingsong Xi, Lixia Zhu, Xue Yang, Lei Jin, Jiarui Wang, Tao Zhang, Xiaopei Zhou, Dazhi Zhang, Xuejie Peng, Yalin Luo, Zhou Li, Xianqin Zhang
Summary: The study identified two heterozygous missense mutations in the TUBB8 gene that resulted in oocytes with large polar bodies and fertilization failure in two patients. Bioinformatics analysis showed that these mutations are harmful.
REPRODUCTIVE SCIENCES
(2021)
Article
Medicine, Research & Experimental
Zongzhuang Wen, Haixia Zhu, Jing Wang, Bin Wu, Aizhen Zhang, Hui Zhao, Chenyang Song, Shuangyuan Liu, Yin Cheng, Hongxiang Wang, Jianyuan Li, Daqing Sun, Xiaolong Fu, Jiangang Gao, Min Liu
Summary: This study generated a germ cell-specific deletion mutant of the Hspa5 gene (Hspa5-cKO) using CRISPR/Cas9 technology and the Cre/Loxp system. Hspa5 knockout resulted in severe germ cell loss and vacuolar degeneration of seminiferous tubules, leading to complete arrest of spermatogenesis, testicular atrophy, and male infertility in adult mice. Single-cell RNA sequencing analysis further confirmed that HSPA5 is crucial for germ cell development.
Review
Medicine, Research & Experimental
Xiaobo Liu, Jiajia Li, Wenjun Wang, Xue Ren, Ji-Fan Hu
Summary: Millions of women worldwide suffer from infertility associated with gynecologic disorders. Stem cell therapy has emerged as a new therapeutic option for the treatment of female reproductive and endocrine dysfunction. This review discusses the recent development and underlying mechanisms of stem cell therapy for a variety of female reproductive diseases.
Article
Cardiac & Cardiovascular Systems
Emily S. Lau, Dongyu Wang, Mary Roberts, Christy N. Taylor, Gayathree Murugappan, Aladdin H. Shadyab, Peter F. Schnatz, Leslie Farland, Malissa J. Wood, Nandita S. Scott, Charles B. Eaton, Jennifer E. Ho
Summary: Infertility is associated with an increased risk of heart failure, particularly heart failure with preserved ejection fraction (HFpEF).
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Review
Endocrinology & Metabolism
Marcelle Cedars
Summary: This article discusses the integration of anti-Mullerian hormone (AMH) into the diagnosis and treatment of infertility. AMH can be used to estimate ovarian reserve, determine the dosage of ovarian stimulation, and predict stimulation response. However, it does not reflect oocyte health or chances for pregnancy. Low AMH levels may suggest a shortened reproductive window. AMH levels need to be interpreted in the context of the endogenous endocrine environment, and there is an inverse correlation between body mass index and AMH.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Chemistry, Multidisciplinary
Haitao Qin, Wangshui Cai, Shuang Wang, Ting Guo, Guigen Li, Hongjian Lu
Summary: The study introduces a versatile and novel method for excising N-atoms from N-heterocycles, which can be used to synthesize various cyclic products using readily available substrates. Additionally, examples are provided for nitrogen excision from natural products and synthesis of chiral O-heterocycles.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Biochemistry & Molecular Biology
Sahar Esfandyari, Hoda Elkafas, Rishi Man Chugh, Hang-soo Park, Antonia Navarro, Ayman Al-Hendy
Summary: Cell-cell communication through exosomes plays a crucial role in female reproductive diseases, offering potential therapeutic targets and biomarkers for regulating reproductive system development and pregnancy outcomes in abnormal conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Ling Wang, Jinhua Tang, Lei Wang, Feng Tan, Huibin Song, Jiawei Zhou, Fenge Li
Summary: Oxidative stress plays a significant role in oocyte aging, leading to a gradual decrease in oocyte quantity and quality, as well as various reproductive pathologies. Strategies to delay oocyte aging include targeting oxidative stress through autophagy antioxidant pathways and antioxidants, along with creating a hypoxic culture environment for oocytes in vitro.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Reproductive Biology
Dorota Lechniak, Ewa Sell-Kubiak, Ewelina Warzych
Summary: This study investigates the impact of the Primo Vision embryo culture system on embryo development and quality compared to the classical system, as well as the effect of first zygotic cleavage (FZC) dysmorphisms on the metabolomic profile of blastocysts. The results show that Primo Vision embryos have a higher cleavage rate but a reduced blastocyst rate. Metabolomic analysis reveals differences in the activity of five pathways between the Primo Vision and classical systems. Furthermore, the FZC pattern significantly affects the metabolite profiles of blastocysts.
Article
Immunology
Yu Song, Peishan Li, Liping Qin, Zhiliang Xu, Baichun Jiang, Chunhong Ma, Changshun Shao, Yaoqin Gong
Summary: CUL4B functions as an intrinsic negative regulator of the TLR-triggered inflammatory response, enhancing proinflammatory cytokine production and reducing anti-inflammatory cytokine IL-10 production when deleted in macrophages. Enhanced TLR-induced inflammatory responses in the absence of CUL4B are mediated by increased GSK3β activity. By regulating the PI3K-AKT-GSK3β pathway, CUL4B restricts TLR-triggered inflammatory responses.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hao Dou, Yuyao Duan, Xiaohui Zhang, Qian Yu, Qian Di, Yu Song, Peishan Li, Yaoqin Gong
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
Article
Oncology
Yuxing Wang, Xiaohua Pan, Yanjun Li, Ru Wang, Yuanyuan Yang, Baichun Jiang, Gongping Sun, Changshun Shao, Molin Wang, Yaoqin Gong
Summary: CUL4B promotes TAM resistance in breast cancer cells by upregulating ER-alpha 36 expression through the regulation of miR-32-5p. This mechanism involves epigenetic modifications mediated by CRL4B, PRC2, and HDAC complexes, and targeting these complexes can increase sensitivity to TAM in breast cancer cells.
JOURNAL OF PATHOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Lili Sun, Chen Yao, Xiaojiao Li, Yuxing Wang, Ru Wang, Molin Wang, Qiao Liu, Denise J. Montell, Changshun Shao, Yaoqin Gong, Gongping Sun
Summary: This study reveals that cells can survive executioner caspase activation through a process called anastasis, and these surviving cells have enhanced migration and pro-angiogenic capacity. The activation of p38 MAPK plays a crucial role in anastasis and is essential for the elevated migratory and angiogenic capacity in these cells.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Biochemistry & Molecular Biology
Liping Qin, Yu Song, Fan Zhang, Ru Wang, Li Zhou, Shiqi Jin, Chaojia Chen, Chunyang Li, Molin Wang, Baichun Jiang, Gongping Sun, Chunhong Ma, Yaoqin Gong, Peishan Li
Summary: CUL4B plays a critical role in Th cell differentiation through regulating histone modifications.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Oncology
Yuxing Wang, Ru Wang, Xiaohe Liu, Menghao Liu, Lili Sun, Xiaohua Pan, Huili Hu, Baichun Jiang, Yongxin Zou, Qiao Liu, Yaoqin Gong, Molin Wang, Gongping Sun
Summary: Cancer relapse and metastasis pose challenges for effective treatment. Recent evidence suggests that cancer cells can survive even after executioner caspase activation, a key step in apoptosis, through a process called anastasis. In this study, breast cancer cells that experienced anastasis showed enhanced proliferation and migration, which was attributed to the persistent upregulation of CDH12. The activation of ERK and CREB by CDH12 promoted breast cancer malignancy. Additionally, executioner caspase activation led to increased CDH12 expression due to loss of DNA methylation and repressive histone modifications in the CDH12 promoter region. These findings provide insights into the mechanism underlying anastasis-induced enhancement in breast cancer malignancy and offer potential therapeutic targets for preventing post-chemotherapy cancer relapse and metastasis.
Article
Biotechnology & Applied Microbiology
Zhendong Wang, Baichun Jiang, Shiqi Jin, Zhao Hu, Guangyi Liu
BIOMED RESEARCH INTERNATIONAL
(2020)