Article
Chemistry, Physical
Austin S. Mills, Evan Chou, Zachary Baierl, Kathryn A. Daltorio, Gary E. Wnek
Summary: This study focuses on the behavior modeling of simple polymeric bilayers and finds that the Generalized Maxwell model can most accurately predict their curvature and relaxation time, laying the foundation for designing more complex bilayer systems.
Article
Chemistry, Inorganic & Nuclear
Jeong-Hun Jang, Junhyung Kim, Jae-Deok Seo, Seung-Han Hwang, Man Park
Summary: This study investigated the release properties of sulfides encapsulated in zeolite 4A, and identified S-6(2-) in the alpha-cage and S-3(center dot-) in the beta-cage as the major encapsulated sulfides. The results showed that 77% of the encapsulated sulfides were rapidly released within 3 days, while the remaining portion was gradually released within 3 weeks, suggesting a potential new strategy for exploring advanced applications.
JOURNAL OF SOLID STATE CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Khaled H. Elfakhri, Mengmeng Niu, Priyanka Ghosh, Tannaz Ramezanli, Sam G. Raney, Snober Ahmed, Daniel R. Willett, Huzeyfe Yilmaz, Muhammad Ashraf, Ahmed S. Zidan
Summary: This study investigated the spatial distribution of drugs within microparticle matrices and its impact on the critical performance attributes of topical gels. The results showed that factors such as particle size, drug loading efficiency, and solid-state interaction affect the release of drugs. Further characterization of the drug products is necessary to understand their impact on the bioavailability and efficacy of tretinoin gels.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Chemistry, Physical
Degong Yang, Liang Fang, Chunrong Yang
Summary: This study aimed to develop long-acting controlled release transdermal patches containing ionic liquids (ILs) of weak acid drugs and investigate the effects of pressure sensitive adhesives (PSAs) on drug-ILs loading and release. The results showed that carboxyl PSAs enhanced the solubility of drug-ILs and had a significant influence on drug skin penetration. Ionic hydrogen bonding determined drug-ILs loadings, with the strongest interaction observed between drug-ILs and carboxyl PSAs.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Pharmacology & Pharmacy
Zahra Khabir, Connie Partalis, Jimit Vijay Panchal, Anand Deva, Aparajita Khatri, Alfonso Garcia-Bennett
Summary: A new delivery vehicle based on encapsulation of cannabidiol within organosilica particles has been proposed, which can release stable cannabidiol and enhance its transdermal penetration. This design opens up a new route for membrane technologies for cannabidiol and other cannabinoid products.
Article
Pharmacology & Pharmacy
Qihui Xu, Takayuki Furuishi, Kaori Fukuzawa, Etsuo Yonemochi
Summary: This study aimed to develop a transdermal system containing an amorphous complex of the nonsteroidal anti-inflammatory drug (NSAID) flurbiprofen (FLU) and lidocaine (LDC) for alleviating chronic pain. The complex between FLU and LDC was obtained by heating in ethanol, and various spectroscopic methods confirmed the interaction between the two drugs. The addition of LDC significantly increased the solubility and skin permeation of FLU, suggesting that this formulation could be useful for treating chronic pain and inflammatory diseases.
Article
Chemistry, Physical
Yong -Tao Duan, Yongfang Yao, Rakesh Kumar Ameta
Summary: To develop an efficient and inexpensive green adsorbent for the removal of organic pollutants from wastewater, a sustainable environment is needed. This study focuses on the adsorption of cationic and anionic dyes on ash of dry leaves of Neem prepared at different temperatures. The results showed that cationic dyes had higher adsorption capacity compared to anionic dyes, and the adsorption process could be explained by the Ameta Physicochemical Adsorption Analysis model. Crystal violet and methylene blue were found to have high adsorption capacities, with over 700 mg per gram of ash. The recovered dyes were analyzed using FTIR and UV/Visible spectroscopy, and the reusability of the adsorbent was demonstrated.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Nanoscience & Nanotechnology
Muhammad Sikandar, Muhammad Harris Shoaib, Rabia Ismail Yousuf, Farrukh Rafiq Ahmed, Fatima Ramzan Ali, Muhammad Talha Saleem, Kamran Ahmed, Sana Sarfaraz, Sabahat Jabeen, Fahad Siddiqui, Tazeen Husain, Faaiza Qazi, Muhammad Suleman Imtiaz
Summary: This study demonstrated that HNTs can be effectively used as rate controlling agents in matrix type transdermal formulations.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Polymer Science
Mullaicharam Bhupathyraaj, K. Reeta Vijaya Rani, Sathvik B. Sridhar, Javed Shareef, Sabin Thomas, Nirmala Halligudi, Anbazhagan Sockalingam, Kiruba Mohandoss, Shyam Sundar
Summary: With the help of permeation enhancers, Quetiapine Fumarate can be easily delivered across the skin, and the prepared transdermal patches exhibited desirable characteristics in physicochemical evaluations and release studies. Among them, the F2 formulation was selected as the optimized formulation and showed good results in skin irritation test and stability study.
Article
Polymer Science
Matin Karpour, Nina Alizadeh
Summary: In this study, highly soluble MSZ-beta-Cyclodextrin (/3-CD) was prepared and successfully encapsulated into positively charged biodegradable chitosan nanoparticles. The inclusion complex of MSZ-beta-CD was characterized and showed promising stability. Antioxidant activity and release behavior were investigated, and molecular modeling was used to detect the binding of the host-guest molecule. The results confirmed the formation of MSZ complexes with beta-CD and the potential clinical application and delivery system of MSZ in the future.
Article
Polymer Science
Qida Zong, Rong Zhou, Zhining Zhao, Yan Wang, Cheng Liu, Peng Zhang
Summary: In this study, a simplified method for the preparation of insulin microneedle patch with rapid and controlled drug release was developed using phenylboronic acid modified methacrylate hyaluronic acid as the drug carrier. This approach offers a direction for simplifying the concept of controlled-release insulin microneedle patch and facilitating production.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Pharmacology & Pharmacy
Haoyuan Song, Chao Liu, Jiuheng Ruan, Degong Yang, Ting Zhong, Yuxue Liu, Liang Fang
Summary: The aim of this study was to develop a tofacitinib (TOF) transdermal patch using ion-pairs and chemical permeation enhancer strategies. The study investigated the formulation factors and evaluated the optimized patch through pharmacokinetic study. Molecular interactions between the components of the patch were studied, providing references for future TOF patch development.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Engineering, Environmental
Nicole C. Rockey, Yun Shen, Sarah-Jane Haig, Madeleine Wax, James Yonts, Krista R. Wigginton, Lutgarde Raskin, Terese M. Olson
Summary: The switch in drinking water source in Flint from Detroit to Flint River water without corrosion control led to the leaching of lead and other metals. Replacement of service lines had significant short-term and long-term benefits by reducing lead concentrations in drinking water, but short-term advantages were less apparent in sites with prior lead seeding.
ENVIRONMENTAL SCIENCE-WATER RESEARCH & TECHNOLOGY
(2021)
Article
Materials Science, Biomaterials
Anna Olejnik, Joanna Goscianska
Summary: The study focused on the use of non-modified and copper and aminosilane modified mesoporous silica materials as nanocarriers for hydroxychloroquine, with differences observed in the adsorption and release behavior of the drug. Non-modified silicas formed hydrogen bonds with hydroxychloroquine, while functionalized materials generated complexes with drug molecules. The release of hydroxychloroquine from the silica samples was influenced by factors such as pH conditions, textural parameters, and surface functional groups, with the hexagonal structure materials showing higher drug desorption rates.
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Review
Biotechnology & Applied Microbiology
Xue Jiang, Huanhuan Zhao, Wei Li
Summary: This paper discusses the importance of drug-carrying nanoparticles in disease treatments and the advantages of microneedle-mediated delivery of nanoparticles. It provides an overview of several methods for nanoparticle delivery and the potential clinical applications.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yu Cai, Qi Tian, Chao Liu, Liang Fang
Summary: The study successfully developed a long-acting drug-in-adhesive patch of rivastigmine with controlled and stable drug release achieved through optimized formulation. This provides a new concept for long-term drug delivery in Alzheimer's disease.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Mingxin Li, Chao Liu, Yu Cai, Haoyuan Song, Liang Fang
Summary: The objective of this study was to develop a lappaconitine transdermal patch with counter-ion to increase drug permeability, and a theory of counter-ion altering the conformation of the skin keratin was proposed. The optimized patch showed good absorption and excellent analgesic effect. Mechanistic studies revealed that counter-ions could alter the conformation of skin keratin and enhance transdermal drug penetration.
Article
Engineering, Environmental
Yu Cai, Chao Liu, Kaihua Gong, Hui Li, Haoyuan Song, Yang Zhang, Dawei Ding, Jie Liu, Jianpeng Guo, Liang Fang
Summary: A quaternary composite hydrogel, PAHDP, was designed to enhance the cohesion and adhesion through multiple hydrogen bonds, achieving strong bio-adhesion to the skin. It exhibits high skin adhesion, excellent mechanical properties, non-irritation, and high drug release ability.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)