New Piperazine Derivatives of 6-Acetyl-7-hydroxy-4-methylcoumarin as 5-HT1A Receptor Agents

Structure-based discovery of nonhallucinogenic psychedelic analogs

(2022) Dongmei Cao et al.   SCIENCE

Design, Synthesis, and Biological Evaluation of a Series of 5- and 7-Hydroxycoumarin Derivatives as 5-HT1A Serotonin Receptor Antagonists

(2021) Kinga Ostrowska et al.   Pharmaceuticals

Structural insights into the lipid and ligand regulation of serotonin receptors

(2021) Peiyu Xu et al.   NATURE

Structure-based design of a novel third-generation antipsychotic drug lead with potential antidepressant properties

(2021) Zhangcheng Chen et al.   NATURE NEUROSCIENCE

6-Acetyl-5-hydroxy-4,7-dimethylcoumarin derivatives: Design, synthesis, modeling studies, 5-HT1A, 5-HT2A and D2 receptors affinity

(2020) Kinga Ostrowska et al.   BIOORGANIC CHEMISTRY

Design, synthesis, and biological activity of Schiff bases bearing salicyl and 7-hydroxycoumarinyl moieties

(2019) Elżbieta Hejchman et al.   MONATSHEFTE FUR CHEMIE

Coumarin-piperazine derivatives as biologically active compounds

(2019) Kinga Ostrowska   SAUDI PHARMACEUTICAL JOURNAL

Mercury 4.0: from visualization to analysis, design and prediction

(2019) Clare F. Macrae et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

5-HT 1A and 5-HT 2A receptors affinity, docking studies and pharmacological evaluation of a series of 8-acetyl-7-hydroxy-4-methylcoumarin derivatives

(2018) Kinga Ostrowska et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The Role of 5-HT1A Receptor in the Cancer as a New Opportunity in Medicinal Chemistry

(2018) Angela Corvino et al.   CURRENT MEDICINAL CHEMISTRY

Drug likeness prediction of 5-hydroxy-substituted coumarins with high affinity to 5-HT 1A and 5-HT 2A receptors

(2018) Teresa Żołek et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Binding Affinity via Docking: Fact and Fiction

(2018) Tatu Pantsar et al.   MOLECULES

Evaluation of blood-brain barrier penetration and examination of binding to human serum albumin of 7-O-arylpiperazinylcoumarins as potential antipsychotic agents

(2018) Teresa Żołek et al.   BIOORGANIC CHEMISTRY

Synthesis of a new series of aryl/heteroarylpiperazinyl derivatives of 8-acetyl-7-hydroxy-4-methylcoumarin with low nanomolar 5-HT 1A affinities

(2017) Kinga Ostrowska et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Development of selective agents targeting serotonin 5HT1A receptors with subnanomolar activities based on a coumarin core

(2017) K. Ostrowska et al.   MedChemComm

Cell permeability beyond the rule of 5

(2016) Pär Matsson et al.   ADVANCED DRUG DELIVERY REVIEWS

Synthesis and biological screening of a new series of 5-[4-(4-aryl-1-piperazinyl)butoxy]coumarins

(2016) Kinga Ostrowska et al.   MONATSHEFTE FUR CHEMIE

Comprehensive evaluation of ten docking programs on a diverse set of protein–ligand complexes: the prediction accuracy of sampling power and scoring power

(2016) Zhe Wang et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

What Do We Really Know About 5-HT1A Receptor Signaling in Neuronal Cells?

(2016) Paulina S. Rojas et al.   Frontiers in Cellular Neuroscience

Comparison of Several Molecular Docking Programs: Pose Prediction and Virtual Screening Accuracy

(2009) Jason B. Cross et al.   Journal of Chemical Information and Modeling

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Serotonin Receptors

(2008) David E. Nichols et al.   CHEMICAL REVIEWS