Article
Biochemistry & Molecular Biology
Arbab Husain, Alvina Farooqui, Afreen Khanam, Shubham Sharma, Sadaf Mahfooz, Adeeba Shamim, Firoz Akhter, Abdulrahman A. Alatar, Mohammad Faisal, Saheem Ahmad
Summary: This study reported a highly selective extraction and purification method of C-phycocyanin (C-PC) from Plectonema sp. cyanobacteria, with comparative characterization using various spectroscopic techniques.
CELLULAR AND MOLECULAR BIOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Bhanu Priya Kilari, Priti Mudgil, Sheikh Azimullah, Nidhi Bansal, Shreesh Ojha, Sajid Maqsood
Summary: The study demonstrated that camel milk protein hydrolysates have antihyperglycemic and anti-hyperlipidemic effects, enhancing antioxidant enzyme activity and improving liver function. It suggests potential therapeutic benefits for managing diabetes and associated comorbidities.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Agricultural Engineering
Jinming Peng, Wenjun Wen, Guiqiang Liang, Wenye Huang, Zihui Qiu, Qin Wang, Gengsheng Xiao
Summary: The study optimized the extraction process of crude polyphenols from Cammelia oleifera shells using ultrasound-microwave synergistic extraction. The extracted polyphenols showed strong anti-glycation properties and inhibited AGEs-triggered inflammation.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Integrative & Complementary Medicine
Duosheng Luo, Yaru Zhao, Zhaoyan Fang, Yating Zhao, Yi Han, Jingyu Piao, Xianglu Rong, Jiao Guo
Summary: In this study, we found that Tianhuang formula (THF) can improve glucose and lipid metabolism disorders in type 2 diabetes mellitus (T2DM) mice through the improvement of AMPK/MICU1 pathway-dependent mitochondrial function in adipose tissue.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2023)
Review
Endocrinology & Metabolism
Rimesh Pal, Sanjay K. Bhadada
Summary: Various pathogenetic mechanisms are involved in the complications of diabetes mellitus, with advanced glycation end products (AGEs) playing a crucial role. Chronic hyperglycemia triggers the formation of AGEs, which accumulate in the bloodstream and tissues and lead to the activation of receptor for advanced glycation end products (RAGE). AGEs are involved in the pathogenesis of diabetic complications and their levels are positively associated with the development of these complications. Exogenous AGEs derived from diets also contribute to insulin resistance, obesity, and metabolic syndrome.
Article
Nutrition & Dietetics
Marialena Chrysanthou, Ignacio Miro Estruch, Ivonne M. C. M. Rietjens, Harry J. Wichers, Tamara Hoppenbrouwers
Summary: This review explores the potential role of AGEs in neuroinflammation and neurodegeneration, discussing in vitro methodologies, current findings, and challenges in the research field. The article provides an overview of the concepts linking AGEs to neurodegeneration and highlights the need for further research to elucidate their underlying modes of action.
Article
Medicine, Research & Experimental
Arbab Husain, Sultan Alouffi, Afreen Khanam, Rihab Akasha, Saif Khan, Mahvish Khan, Alvina Farooqui, Saheem Ahmad
Summary: Glycation occurs when glucose and Amadori products are auto-oxidized, resulting in the formation of early and late advanced glycation end products (AGEs) as well as free radicals. This study aimed to assess the antiglycation and antioxidant capacity of C-phycocyanin (C-PC) from Plectonema sp. In vitro tests showed that C-PC exhibited dose-dependent potent antioxidant activity but lacked significant antiglycation potential. Further studies are recommended to evaluate the antiglycation potential of C-PC.
REVISTA ROMANA DE MEDICINA DE LABORATOR
(2022)
Article
Endocrinology & Metabolism
Xu Wu, Yashan Li, Baohua Man, Dexuan Li
Summary: The study found significant differences in OGTT, C-peptide, and insulin tests between T2DM/FD-T2DM and NGT/FD-NGT groups, as well as significantly higher expression of miR-375 in T2DM and FD-T2DM groups compared to NGT and FD-NGT groups. MiR-375 may serve as a stable biomarker for the early prediction of T2DM among high-risk individuals.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Review
Endocrinology & Metabolism
Stella Papachristou, Kalliopi Pafili, Nikolaos Papanas
Summary: AGEs accumulation in peripheral nerves is independently correlated with diabetic neuropathy. Assessment of tissue AGEs with skin autofluorescence may serve as early biomarkers for DN, but the value of screening with skin AGEs for DN remains unclear.
BMC ENDOCRINE DISORDERS
(2021)
Review
Biochemistry & Molecular Biology
Aditi Chopra, Thilini N. Jayasinghe, Joerg Eberhard
Summary: Periodontitis can increase the levels of AGEs, even in the absence of hyperglycemia. This explains the relationship between periodontitis and related diseases such as diabetes.
Article
Chemistry, Applied
Zheng Chen, Riccardo Bertin, Raffaella Marin, Francine Medjiofack Djeujo, Guglielmina Froldi
Summary: The sap of Croton lechleri Mull. Arg. shows inhibitory effects on glycation, oxidative stress, and ROS generation, indicating its potential in combating ROS-related diseases.
NATURAL PRODUCT RESEARCH
(2022)
Article
Food Science & Technology
Maoyang Wei, Dandan Feng, Yulong Zhang, Yunyang Zuo, Jiuchang Li, Ling Wang, Ping Hu
Summary: Lactobacillus paracasei fermented Rosa roxburghii Tratt juice showed potential in improving type 2 diabetes mellitus (T2DM) by reducing dyslipidemia, alleviating oxidative stress, increasing short-chain fatty acids (SCFAs), and regulating gut microbiota composition. The medium dose of fermented juice could serve as a novel dietary strategy for preventing T2DM.
Article
Biochemistry & Molecular Biology
Mohd Shahnawaz Khan, Majed S. Alokail, Amal Majed H. Alenad, Nojood Altwaijry, Nouf Omar Alafaleq, Abdulaziz Mohammed Alamri, Mubarak Ali Zawba
Summary: Alpha-amylase plays an important role in the management of diabetes and its complications. This study explored the binding of caffeic acid and coumaric acid with alpha-amylase and their effects on the formation of advanced glycation end-products (AGEs). The results showed that both compounds could bind to alpha-amylase and inhibit the formation of AGEs. Caffeic acid exhibited stronger antiglycative activity compared to p-coumaric acid, which could be attributed to its additional -OH group and high antioxidant activity. The study also highlighted the role of hydrogen bonding in the complex formation. Molecular docking studies suggested that these compounds could be utilized in the design of antidiabetic drugs.
Article
Pharmacology & Pharmacy
Nazish Butt, Farhat Bano, Mansoor Ghani, Atif Mansoor Ahmed, Nauman Majeed
Summary: The study showed a significant relationship between serum levels of AGEs, Apo-B, and zinc with the severity of diabetic retinopathy (DR), with all three markers together impacting DR by 82.8%. This model serves as a good indicator of the severity of DR.
PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Abdul Rafey, Adnan Amin, Muhammad Kamran, Muhammad Imran Aziz, Varda Athar, Shah Iram Niaz, Luc Pieters
Summary: This study evaluated the pharmacological activities of several important plant constituents, including flavonoids and polyphenols, and found that they have potential therapeutic effects for the management of diabetes and its related complications.
Article
Biochemistry & Molecular Biology
Rabia Nabi, Sahir Sultan Alvi, Arunim Shah, Chandra P. Chaturvedi, Mohammad Faisal, Abdulrahman A. Alatar, Saheem Ahmad, M. Salman Khan
Summary: The study demonstrates the protective effects of ezetimibe (EZ) against AGEs-related pathologies in experimental diabetes, including improved biochemical markers, regulation of gene expression, maintenance of redox status, and protection of renal histopathological features.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Editorial Material
Biochemistry & Molecular Biology
Afreen Khanam, Saheem Ahmad, Arbab Husain
Summary: This article discusses the pathophysiological significance of advanced glycation end products (AGEs) and their receptor in diabetic nephropathy (DN).
CURRENT PROTEIN & PEPTIDE SCIENCE
(2023)
Review
Biotechnology & Applied Microbiology
Sultan Alouffi, Farah Maarfi, Mohd Yasir Khan, Saif Khan, M. Salman Khan, Saheem Ahmad
Summary: The antioxidant and antiglycation activities of Ficus leaf extracts were evaluated. The results showed that both the aqueous and methanolic extracts were rich in polyphenols and flavonoids, exhibiting potent antioxidant and antiglycation activities.
BIOTECHNOLOGY AND GENETIC ENGINEERING REVIEWS
(2023)
Article
Immunology
Saif Khan, Mohd Wajid Ali Khan, Subuhi Sherwani, Sultan Alouffi, Mohammad Jahoor Alam, Khalid Al-Motair, Shahper Khan
Summary: A probabilistic model based on binding scores and differential expression levels of cancer cell membrane proteins was used to predict the selective targeting efficiency of cancer cell membrane coated nanoparticles. The model was experimentally validated and showed high accuracy. This model has the potential to aid in the development of more specific cancer immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Plant Sciences
Saheem Ahmad, Mohammed Alrouji, Sharif Alhajlah, Othman Alomeir, Ramendra Pati Pandey, Mohammad Saquib Ashraf, Shafeeque Ahmad, Saif Khan
Summary: This study aims to investigate the therapeutic potential of C. nocturnum leaf extracts against diabetes and neurological disorders through inhibitory activities on alpha-amylase and acetylcholinesterase (AChE). Computational molecular docking studies support the inhibitory potential of C. nocturnum leaves-derived secondary metabolites on alpha-amylase and AChE. The methanolic fraction of the leaf extract showed strong antioxidant activity and inhibited alpha-amylase and AChE in a non-competitive and competitive manner, respectively. In silico analysis revealed high-affinity binding of compounds in the methanolic extract to the active sites of alpha-amylase and AChE.
Article
Medicine, General & Internal
Sultan Alouffi
Summary: This study found a negative association between serum bilirubin levels and atherogenic lipids in patients with type 2 diabetes, suggesting that serum bilirubin may protect against cardiovascular disease development. Further research in a larger cohort is needed to confirm these findings.
ELECTRONIC JOURNAL OF GENERAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Mohammad Kalim Ahmad Khan, Sultan Alouffi, Saheem Ahmad
Summary: The research aims to design small molecule inhibitors that can target CXCL10 in the JAK/STAT pathway. Structure-based virtual screening was used to identify potential compounds from the MCULE database, followed by toxicity profiling and ADME evaluation. The top two ligands were further assessed through molecular dynamics simulations and compared with reference drugs. MCULE2726078782-0-2 showed better performance than Baicalein based on various parameters.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biology
Amjad R. Alyahyawi, Mohd Yasir Khan, Sultan Alouffi, Farah Maarfi, Rihab Akasha, Saif Khan, Zeeshan Rafi, Talal Alharazi, Uzma Shahab, Saheem Ahmad
Summary: This study explores the immunological response of glycated LDL in experimental animals and the glycoxidative lesion detection in LDL of diabetes subjects. It found that LDL lesions specific to MG-associated glycoxidation are significantly higher in diabetes patients with longer disease duration, indicating structural alterations in LDL protein molecules and assessing the progression of diabetes mellitus.
Review
Biochemistry & Molecular Biology
Farah Maarfi, Saheem Ahmad, Sultan Alouffi, Rihab Akasha, M. Salman Khan, Zeeshan Rafi, Hemashri Basnet, Mohd Yasir Khan
Summary: Hyperglycemia, affecting about 70% of the global population, is a poorly controlled diabetic condition. Cardiovascular diseases (CVDs) are major risk factors causing the death of diabetic patients and promoting related comorbidities. Atherosclerosis and amyloidosis are strongly linked with CVDs. Apolipoprotein A-I (ApoA-I) of HDL plays a protective role against CVDs but easily becomes glycated under prolonged hyperglycemic conditions. ApoA-I also has an important role in maintaining glucose levels, providing a compelling link between diabetes and CVDs. Increased protein glycation in people with diabetes promotes atherosclerosis and possibly protein aggregation or amyloidosis.
Article
Health Care Sciences & Services
Abdulrahman Khulaif Alshammari, Abeer Alanazi, Haya Al-swedani, Mahvish Khan, Saheem Ahmad, Shafiul Haque, Saif Khan
Summary: The objective of this study was to explore the association of gender and practitioner classification with orthodontic knowledge and attitudes. Two groups of dentists in Saudi Arabia were surveyed in a descriptive cross-sectional research. The results showed significant differences in knowledge and attitudes between general practitioners and non-orthodontic specialists. However, there was no significant difference based on gender. This study highlights the importance of seeking orthodontic experts for orthodontic treatment.
Review
Biochemistry & Molecular Biology
Nilima S. Bangar, Armaan Gvalani, Saheem Ahmad, Mohd S. Khan, Rashmi S. Tupe
Summary: Glycation refers to the reaction between reducing sugars and free amino groups in proteins, resulting in the formation of various products. Glycation plays a significant role in metabolic diseases, brain disorders, aging, and gut microbiome dysregulation. It affects the development of diseases by altering protein structure and function.
