Nebulized Menthol Impairs Mucociliary Clearance via TRPM8 and MUC5AC/MUC5B in Primary Airway Epithelial Cells

Hereditary Mucin Deficiency Caused by Biallelic Loss-of-Function of MUC5B

(2022) Gregory Costain et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Mucin Gene MUC5B is Required for Normal Lung Function

(2022) Maude A Liegeois et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The CFTR Amplifier Nesolicaftor Rescues TGF-β1 Inhibition of Modulator-Corrected F508del CFTR Function

(2022) Charles Bengtson et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Vegetable glycerin e-cigarette aerosols cause airway inflammation and ion channel dysfunction

(2022) Michael D. Kim et al.   Frontiers in Pharmacology

Flavour chemicals, synthetic coolants and pulegone in popular mint-flavoured and menthol-flavoured e-cigarettes

(2021) Esther E Omaiye et al.   TOBACCO CONTROL

Characteristics of e-Cigarette Use Behaviors Among US Youth, 2020

(2021) Teresa W. Wang et al.   JAMA Network Open

TRPM8 channels: A review of distribution and clinical role

(2020) Yuqian Liu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cinnamaldehyde in Flavored E-Cigarette Liquids Temporarily Suppresses Bronchial Epithelial Cell Ciliary Motility by Dysregulation of Mitochondrial Function

(2019) Phillip W. Clapp et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Transcriptomic response of primary human airway epithelial cells to flavoring chemicals in electronic cigarettes

(2019) Hae-Ryung Park et al.   Scientific Reports

Electronic Cigarette Vapor with Nicotine Causes Airway Mucociliary Dysfunction Preferentially via TRPA1 Receptors

(2019) Samuel Chung et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

E-cigarette flavored pods induce inflammation, epithelial barrier dysfunction, and DNA damage in lung epithelial cells and monocytes

(2019) Thivanka Muthumalage et al.   Scientific Reports

Gel-forming mucin interactome drives mucus viscoelasticity

(2018) Bastien Demouveaux et al.   ADVANCES IN COLLOID AND INTERFACE SCIENCE

Chronic E-Cigarette Exposure Alters the Human Bronchial Epithelial Proteome

(2018) Arunava Ghosh et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

E-Cigarette Use Causes a Unique Innate Immune Response in the Lung, Involving Increased Neutrophilic Activation and Altered Mucin Secretion

(2018) Boris Reidel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Mucins, Mucus, and Goblet Cells

(2018) Jonathan Ma et al.   CHEST

Evaluation of e-liquid toxicity using an open-source high-throughput screening assay

(2018) M. Flori Sassano et al.   PLOS BIOLOGY

Discovery of TRPM8 Antagonist (S)-6-(((3-Fluoro-4-(trifluoromethoxy)phenyl)(3-fluoropyridin-2-yl)methyl)carbamoyl)nicotinic Acid (AMG 333), a Clinical Candidate for the Treatment of Migraine

(2018) Daniel B. Horne et al.   JOURNAL OF MEDICINAL CHEMISTRY

The identification of the TRPM8 channel on primary culture of human nasal epithelial cells and its response to cooling

(2017) Shao-Cheng Liu et al.   MEDICINE

Airway Mucin Concentration as a Marker of Chronic Bronchitis

(2017) Mehmet Kesimer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Epithelial tethering of MUC5AC-rich mucus impairs mucociliary transport in asthma

(2016) Luke R. Bonser et al.   JOURNAL OF CLINICAL INVESTIGATION

Chronic electronic cigarette exposure in mice induces features of COPD in a nicotine-dependent manner

(2016) Itsaso Garcia-Arcos et al.   THORAX

Cilia and Mucociliary Clearance

(2016) Ximena M. Bustamante-Marin et al.   Cold Spring Harbor Perspectives in Biology

The polymeric mucin Muc5ac is required for allergic airway hyperreactivity

(2015) Christopher M. Evans et al.   Nature Communications

Transient receptor potential (TRP) channels in the airway: role in airway disease

(2013) M S Grace et al.   BRITISH JOURNAL OF PHARMACOLOGY

Muc5b is required for airway defence

(2013) Michelle G. Roy et al.   NATURE

Cold temperature induces mucin hypersecretion from normal human bronchial epithelial cells in vitro through a transient receptor potential melastatin 8 (TRPM8)–mediated mechanism

(2011) MinChao Li et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Human Lung Epithelial Cells Express a Functional Cold-Sensing TRPM8 Variant

(2008) Ashwini S. Sabnis et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY