Deglycosylation Increases the Aggregation and Angiogenic Properties of Mutant Tissue Inhibitor of Metalloproteinase 3 Protein: Implications for Sorsby Fundus Dystrophy

Tissue Inhibitor of Metalloproteases 3 (TIMP-3): In Vivo Analysis Underpins Its Role as a Master Regulator of Ectodomain Shedding

(2022) Donatella Pia Spanò et al.   Membranes

Mucin-Type O-Glycosylation Proximal to β-Secretase Cleavage Site Affects APP Processing and Aggregation Fate

(2022) YashoNandini Singh et al.   Frontiers in Chemistry

3D iPSC modeling of the retinal pigment epithelium-choriocapillaris complex identifies factors involved in the pathology of macular degeneration

(2021) Kannan V. Manian et al.   Cell Stem Cell

Visual dysfunction and structural correlates in Sorsby Fundus Dystrophy

(2021) Kristin Raming et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Phosphorylation and O-GlcNAcylation of the PHF-1 Epitope of Tau Protein Induce Local Conformational Changes of the C-Terminus and Modulate Tau Self-Assembly Into Fibrillar Aggregates

(2021) François-Xavier Cantrelle et al.   Frontiers in Molecular Neuroscience

In vitro stem cell modelling demonstrates a proof‐of‐concept for excess functional mutant TIMP3 as the cause of S orsby f undus d ystrophy

(2020) Heidi Hongisto et al.   JOURNAL OF PATHOLOGY

Biology of Tissue Inhibitor of Metalloproteinase 3 (TIMP3), and Its Therapeutic Implications in Cardiovascular Pathology

(2020) Dong Fan et al.   Frontiers in Physiology

Inhibition of protein glycosylation is a novel pro-angiogenic strategy that acts via activation of stress pathways

(2020) Cuiling Zhong et al.   Nature Communications

Glycosylation in health and disease

(2019) Colin Reily et al.   Nature Reviews Nephrology

Sorsby Fundus Dystrophy Mutation in Tissue Inhibitor of Metalloproteinase 3 (TIMP3) promotes Choroidal Neovascularization via a Fibroblast Growth Factor-dependent Mechanism

(2019) Jian Hua Qi et al.   Scientific Reports

Glycosylation as new pharmacological strategies for diseases associated with excessive angiogenesis

(2018) Simon Bousseau et al.   PHARMACOLOGY & THERAPEUTICS

Sorsby fundus dystrophy: Insights from the past and looking to the future

(2018) Bela Anand-Apte et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Glycosylation Significantly Inhibits the Aggregation of Human Prion Protein and Decreases Its Cytotoxicity

(2018) Chuan-Wei Yi et al.   Scientific Reports

Sorsby fundus dystrophy – A review of pathology and disease mechanisms

(2017) David R.G. Christensen et al.   EXPERIMENTAL EYE RESEARCH

Whole exome sequencing using Ion Proton system enables reliable genetic diagnosis of inherited retinal dystrophies

(2017) Marina Riera et al.   Scientific Reports

Glycosylation of matrix metalloproteases and tissue inhibitors: present state, challenges and opportunities

(2016) L. Boon et al.   BIOCHEMICAL JOURNAL

Tissue inhibitor of metalloproteinase-3 (TIMP3) promotes endothelial apoptosis via a caspase-independent mechanism

(2015) Jian Hua Qi et al.   APOPTOSIS

Sulfated Glycosaminoglycans Control the Extracellular Trafficking and the Activity of the Metalloprotease Inhibitor TIMP-3

(2014) Linda Troeberg et al.   CHEMISTRY & BIOLOGY

Precision mapping of the human O-GalNAc glycoproteome through SimpleCell technology

(2013) Catharina Steentoft et al.   EMBO JOURNAL

A NOVEL MUTATION AT THE N-TERMINAL DOMAIN OF THE TIMP3 GENE IN SORSBY FUNDUS DYSTROPHY

(2012) Scott D. Schoenberger et al.   RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES

S156C Mutation in Tissue Inhibitor of Metalloproteinases-3 Induces Increased Angiogenesis

(2009) Jian Hua Qi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clinical Course and Treatment Outcomes of Sorsby Fundus Dystrophy

(2008) Sobha Sivaprasad et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Molecular dissection of TIMP3 mutation S156C associated with Sorsby fundus dystrophy

(2008) Marton Fogarasi et al.   MATRIX BIOLOGY