Article
Microbiology
Giacomo DeMarco, Moez Chargui, Benoit Coulin, Benoit Borner, Christina Steiger, Romain Dayer, Dimitri Ceroni
Summary: K. kingae is considered the main bacterial cause of osteoarticular infections in children under 48 months, presenting with mild symptoms and moderate inflammatory response. Surgical intervention is often not necessary, as the infections respond well to short antibiotic treatments.
Article
Microbiology
Benoit Coulin, Giacomo DeMarco, Oscar Vazquez, Vasiliki Spyropoulou, Nathaly Gavira, Tanguy Vendeuvre, Anne Tabard-Fougere, Romain Dayer, Christina Steiger, Dimitri Ceroni
Summary: Osteoarticular infections in children require prompt diagnosis. A retrospective study was conducted on 335 children, and age, temperature, inflammatory markers were found to be valuable in discriminating between Kingella kingae and Staphylococcus aureus infections. Age, CRP concentration, temperature, and platelet count were the best predictors for K. kingae infections.
Article
Infectious Diseases
Laudi Olijve, Lahiru Amarasena, Emma Best, Christopher Blyth, Mirjam van den Boom, Asha Bowen, Penelope A. Bryant, Jim Buttery, Hazel C. Dobinson, Joshua Davis, Joshua Francis, Heidi Goldsmith, Elle Griffiths, Te-Yu Hung, Julie Huynh, Alison Kesson, Andrea Meehan, Brendan McMullan, Clare Nourse, Pamela Palasanthiran, Rushi Penumarthy, Katie Pilkington, Janine Searle, Anya Stephenson, Rachel Webb, Jonathan Williman, Tony Walls
Summary: The study collected information on hospitalized children aged 3-60 months with acute osteoarticular infections in 11 hospitals across Australia and New Zealand from 2012 to 2016. It found that Kingella kingae was the most frequently detected microorganism, while in the majority of cases, no microorganism was detected. The study highlights the need for more widespread use of molecular diagnostic techniques for accurate diagnosis of osteoarticular infections in pre-school aged children.
JOURNAL OF INFECTION
(2021)
Article
Microbiology
Pablo Yagupsky
Summary: Kingella kingae colonization and carriage play a crucial role in the person-to-person transmission of the bacterium and the pathogenesis of invasive infections.
Article
Microbiology
Romain Basmaci, Philippe Bidet, Stephane Bonacorsi
Summary: This narrative review explores the association between Kingella kingae (K. kingae) and viral infections. Symptoms of viral infections often occur concurrently with K. kingae infection, and specific viral syndromes have been described in children with K. kingae infection. Human rhinovirus and coxsackievirus, which belong to the Picornaviridae family, have been frequently identified in patients with K. kingae infection and are known to facilitate bacterial infections. However, the exact role of viral infection in the pathophysiology of K. kingae remains unclear and requires further molecular studies.
Article
Microbiology
Catarina Gouveia, Ana Subtil, Susana Norte, Joana Arcangelo, Madalena Almeida Santos, Rita Corte-Real, Maria Joao Simoes, Helena Canhao, Delfin Tavares
Summary: The study aimed to distinguish Kingella kingae from pyogenic septic arthritis, and the main predictive factors were age, fever status, and CRP concentration.
Article
Microbiology
Omer Murik, David A. A. Zeevi, Tzvia Mann, Livnat Kashat, Marc V. V. Assous, Orli Megged, Pablo Yagupsky
Summary: Sensitive nucleic acid amplification tests have led to the recognition of Kingella kingae as a common pathogen causing various medical conditions in early childhood. The genomic determinants associated with different clinical outcomes are yet to be identified.
MICROBIOLOGY SPECTRUM
(2023)
Article
Immunology
Ayelen Ivana Pesce Viglietti, Franco Agustin Sviercz, Cinthya Alicia Marcela Lopez, Rosa Nicole Freiberger, Jorge Quarleri, Maria Victoria Delpino
Summary: Kingella kingae is an emerging pathogen that causes septic arthritis, osteomyelitis, and bacteremia in children aged 6 to 48 months. Infection with K. kingae directly stimulates osteoclastogenesis and indirectly through a potent pro-inflammatory response that drives macrophages to become functional osteoclasts. Additionally, the osteoclastogenic capability of K. kingae is counteracted by their outer membrane vesicles in a concentration-dependent manner.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Pediatrics
Eric A. Porsch, Kevin A. Hernandez, Daniel P. Morreale, Nina R. Montoya, Taylor A. Yount, Joseph W. St. W. Geme III
Summary: Kingella kingae is an emerging pediatric pathogen known to cause septic arthritis, osteomyelitis, bacteremia, and occasionally endocarditis in young children. The pathogenesis of K. kingae disease involves colonization of the upper respiratory tract, breach of the respiratory epithelial barrier, and hematogenous spread to joints, bones, and endocardium. Surface factors of K. kingae, such as type IV pili, Knh trimeric autotransporter, and surface polysaccharides, play important roles in the pathogenic process of the disease.
FRONTIERS IN PEDIATRICS
(2022)
Article
Orthopedics
B. Coulin, G. Demarco, V Spyropoulou, C. Juchler, T. Vendeuvre, C. Habre, A. Tabard-Fougere, R. Dayer, C. Steiger, D. Ceroni
Summary: K. kingae should be recognized as the primary pathogen causing OAI in children younger than 48 months old. Diagnosis of an OAI caused by K. kingae is not always obvious, as this infection may occur with a mild-to-moderate clinical and biological inflammatory response. The use of nucleic acid amplification assays has improved pathogen detection and increased the observed incidence of OAIs, especially in children aged 6-48 months.
BONE & JOINT JOURNAL
(2021)
Review
Medicine, General & Internal
Pablo Yagupsky
Summary: Kingella kingae is increasingly recognized as the main cause of septic arthritis, osteomyelitis, and spondylodiscitis in children aged 6 to 48 months. Laboratory methods for detecting this bacterium, such as inoculating samples into blood culture vials and using nucleic acid amplification tests with species-specific primers, have been reviewed. These methods have improved the detection of Kingella kingae.
Article
Immunology
Ardian Ramadani, Benoit Coulin, Giacomo De Marco, Oscar Vazquez, Anne Tabard-Fougere, Nathaly Gavira, Christina N. Steiger, Romain Dayer, Dimitri Ceroni
Summary: This study aimed to report on the clinical course, biological parameters, and results of microbiological investigations among children with K. kingae-induced septic arthritis of the knee. The Kocher-Caird prediction algorithm is not sensitive enough to effectively detect K. kingae-induced septic arthritis of the knee, and nucleic acid amplification assays on oropharyngeal swabs and joint fluid are necessary to exclude this condition in young children presenting with knee effusion.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2023)
Review
Microbiology
Eric A. Porsch
Summary: In the past three decades, Kingella kingae has emerged as an important pathogen of pediatric osteoarticular infections, leading to significant research efforts to understand its pathogenicity. The identification of multiple virulence factors has provided potential targets for therapeutic intervention and vaccine antigens.
Article
Immunology
Moez Chargui, Giacomo De Marco, Christina Steiger, Benoit Borner, Celine Habre, Romain Dayer, Dimitri Ceroni
Summary: The article reports a rare case of primary pyomyositis caused by Kingella kingae in a 21-month-old girl. The case illustrates that primary pyomyositis may occur during invasive infections due to K. kingae, although it is a rare manifestation. Therefore, this bacterial etiology should be considered when observing primary pyomyositis, especially in children under 4 years of age.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2022)
Article
Pediatrics
Eleftheria Samara, Nicolas Lutz, Pierre-Yves Zambelli
Summary: Kingella kingae is an important cause of primary spinal infections in children, requiring MRI and nucleic acid amplification tests for diagnosis. Most patients respond well to antibiotic treatment, with a benign clinical course and no permanent sequelae.
