The Novel AT2 Receptor Agonist β-Pro7-AngIII Exerts Cardiac and Renal Anti-Fibrotic and Anti-Inflammatory Effects in High Salt-Fed Mice

Preclinical rodent models of cardiac fibrosis

(2021) Yan Wang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Angiotensin AT2 Receptor is Anti-inflammatory and Reno-Protective in Lipopolysaccharide Mice Model: Role of IL-10

(2021) Naureen Fatima et al.   Frontiers in Pharmacology

Renal functional effects of the highly selective AT2R agonist, β-Pro7 Ang III, in normotensive rats

(2020) Lucinda M. Hilliard Krause et al.   CLINICAL SCIENCE

Transforming growth factor β (TGFβ) and related molecules in chronic kidney disease (CKD)

(2019) Pacific Huynh et al.   CLINICAL SCIENCE

Prevention of lipopolysaccharide-induced CD11b+ immune cell infiltration in the kidney: role of AT2 receptors

(2019) Sanket Patel et al.   BIOSCIENCE REPORTS

Angiotensin II Type 2 Receptor and Receptor Mas Are Colocalized and Functionally Interdependent in Obese Zucker Rat KidneyNovelty and Significance

(2017) Sanket N. Patel et al.   HYPERTENSION

High sodium diet converts renal proteoglycans into pro-inflammatory mediators in rats

(2017) Ryanne S. Hijmans et al.   PLoS One

Anti-fibrotic Potential of AT2 Receptor Agonists

(2017) Yan Wang et al.   Frontiers in Pharmacology

The Biological Basis for Cardiac Repair After Myocardial Infarction

(2016) Sumanth D. Prabhu et al.   CIRCULATION RESEARCH

Macrophages dictate the progression and manifestation of hypertensive heart disease

(2016) David Kain et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Renin Angiotensin Aldosterone System Inhibitors in Hypertension: Is There Evidence for Benefit Independent of Blood Pressure Reduction?

(2016) Chirag Bavishi et al.   PROGRESS IN CARDIOVASCULAR DISEASES

Sodium Intake and Cardiovascular Health

(2015) M. O'Donnell et al.   CIRCULATION RESEARCH

β-Pro7Ang III is a novel highly selective angiotensin II type 2 receptor (AT2R) agonist, which acts as a vasodepressor agent via the AT2R in conscious spontaneously hypertensive rats

(2015) Mark Del Borgo et al.   CLINICAL SCIENCE

AT2R Agonist, Compound 21, Is Reno-Protective Against Type 1 Diabetic Nephropathy

(2015) C. Koulis et al.   HYPERTENSION

Origin of myofibroblasts and cellular events triggering fibrosis

(2015) Matthias Mack et al.   KIDNEY INTERNATIONAL

Relative affinity of angiotensin peptides and novel ligands at AT1and AT2receptors

(2015) Sanja Bosnyak et al.   CLINICAL SCIENCE

Picrosirius Red Staining

(2014) Raed Lattouf et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Relaxin requires the angiotensin II type 2 receptor to abrogate renal interstitial fibrosis

(2014) Bryna S. Man Chow et al.   KIDNEY INTERNATIONAL

Proximal Tubule Angiotensin AT 2 Receptors Mediate an Anti-Inflammatory Response via Interleukin-10

(2013) Isha Dhande et al.   HYPERTENSION

Angiotensin-converting enzyme inhibitors reduce mortality in hypertension: a meta-analysis of randomized clinical trials of renin-angiotensin-aldosterone system inhibitors involving 158 998 patients

(2012) L. C. van Vark et al.   EUROPEAN HEART JOURNAL

Relaxin Signals through a RXFP1-pERK-nNOS-NO-cGMP-Dependent Pathway to Up-Regulate Matrix Metalloproteinases: The Additional Involvement of iNOS

(2012) Bryna Suet Man Chow et al.   PLoS One

Sodium Intake and Cardiovascular Disease

(2011) Alanna C. Morrison et al.   Annual Review of Public Health

A Single β-Amino Acid Substitution to Angiotensin II Confers AT 2 Receptor Selectivity and Vascular Function

(2011) Emma S. Jones et al.   HYPERTENSION

Angiotensin Type 2 Receptor Agonist Compound 21 Reduces Vascular Injury and Myocardial Fibrosis in Stroke-Prone Spontaneously Hypertensive Rats

(2011) Asia Rehman et al.   HYPERTENSION

Cellular and molecular mechanisms of renal fibrosis

(2011) Youhua Liu   Nature Reviews Nephrology

Angiotensin AT 2 Receptor Stimulation Inhibits Early Renal Inflammation in Renovascular Hypertension

(2010) Luis C. Matavelli et al.   HYPERTENSION

Salt-Induced Cardiac Hypertrophy and Interstitial Fibrosis Are Due to a Blood Pressure–Independent Mechanism in Wistar Rats

(2010) Daniele N. Ferreira et al.   JOURNAL OF NUTRITION

The chemically synthesized human relaxin-2 analog, B-R13/17K H2, is an RXFP1 antagonist

(2009) Mohammed Akhter Hossain et al.   AMINO ACIDS

Stimulation of AT2 receptor exerts beneficial effects in stroke-prone rats: focus on renal damage

(2009) Paolo Gelosa et al.   JOURNAL OF HYPERTENSION

Fibroblast activation and myofibroblast generation in obstructive nephropathy

(2009) María T. Grande et al.   Nature Reviews Nephrology

Angiotensin II Type 2 Receptor Stimulation

(2008) Elena Kaschina et al.   CIRCULATION