Hypoxic mesenchymal stem cell-derived exosomes alleviate ulcerative colitis injury by limiting intestinal epithelial cells reactive oxygen species accumulation and DNA damage through HIF-1α

New Therapeutics for Ulcerative Colitis

(2021) Robert P. Hirten et al.   Annual Review of Medicine

Cyclosporine modulates neutrophil functions via the SIRT6–HIF‐1α–glycolysis axis to alleviate severe ulcerative colitis

(2021) Huiying Lu et al.   Clinical and Translational Medicine

Extracellular vesicles derived from EphB2-overexpressing bone marrow mesenchymal stem cells ameliorate DSS-induced colitis by modulating immune balance

(2021) Ting Yu et al.   Stem Cell Research & Therapy

Hif-1a suppresses ROS-induced proliferation of cardiac fibroblasts following myocardial infarction

(2021) Vaibhao Janbandhu et al.   Cell Stem Cell

Exosome-shuttled miR-216a-5p from hypoxic preconditioned mesenchymal stem cells repair traumatic spinal cord injury by shifting microglial M1/M2 polarization

(2020) Wei Liu et al.   Journal of Neuroinflammation

Exosomes in hypoxia-induced remodeling of the tumor microenvironment

(2020) Ashish Kumar et al.   CANCER LETTERS

Hypoxia-preconditioned olfactory mucosa mesenchymal stem cells abolish cerebral ischemia/reperfusion-induced pyroptosis and apoptotic death of microglial cells by activating HIF-1α

(2020) Yan Huang et al.   Aging-US

miR-155 antagomir protect against DSS-induced colitis in mice through regulating Th17/Treg cell balance by Jarid2/Wnt/β-catenin

(2020) Feng Zhu et al.   BIOMEDICINE & PHARMACOTHERAPY

Hypoxia-challenged MSC-derived exosomes deliver miR-210 to attenuate post-infarction cardiac apoptosis

(2020) Hao Cheng et al.   Stem Cell Research & Therapy

HIF-1α-BNIP3-mediated mitophagy in tubular cells protects against renal ischemia/reperfusion injury

(2020) Zong-Jie Fu et al.   Redox Biology

Matrix metalloproteinase 9 (MMP9) limits reactive oxygen species (ROS) accumulation and DNA damage in colitis-associated cancer

(2020) Lewins Walter et al.   Cell Death & Disease

Extracellular vesicle-packaged HIF-1α-stabilizing lncRNA from tumour-associated macrophages regulates aerobic glycolysis of breast cancer cells

(2019) Fei Chen et al.   NATURE CELL BIOLOGY

BMSC-EVs regulate Th17 cell differentiation in UC via H3K27me3

(2019) Qianyun Chen et al.   MOLECULAR IMMUNOLOGY

BMSCs-derived miR-223-containing exosomes contribute to liver protection in experimental autoimmune hepatitis

(2018) Lu Chen et al.   MOLECULAR IMMUNOLOGY

Immunoregulatory mechanisms of mesenchymal stem and stromal cells in inflammatory diseases

(2018) Yufang Shi et al.   Nature Reviews Nephrology

ROS signalling in the biology of cancer

(2018) Jennifer N. Moloney et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

(2018) Mathilde Mathieu et al.   NATURE CELL BIOLOGY

LincRNA-p21 promotes mesenchymal stem cell migration capacity and survival through hypoxic preconditioning

(2018) Shan-Shan Meng et al.   Stem Cell Research & Therapy

Ulcerative colitis

(2017) Ryan Ungaro et al.   LANCET

Cell transplantation therapy for spinal cord injury

(2017) Peggy Assinck et al.   NATURE NEUROSCIENCE

Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages

(2017) W. K. Eddie Ip et al.   SCIENCE

Concise Review: MSC-Derived Exosomes for Cell-Free Therapy

(2017) Donald G. Phinney et al.   STEM CELLS

Hypoxia ameliorates intestinal inflammation through NLRP3/mTOR downregulation and autophagy activation

(2017) Jesus Cosin-Roger et al.   Nature Communications

Exosomes derived from human platelet-rich plasma prevent apoptosis induced by glucocorticoid-associated endoplasmic reticulum stress in rat osteonecrosis of the femoral head via the Akt/Bad/Bcl-2 signal pathway

(2017) Shi-Cong Tao et al.   Theranostics

Exosomes derived from platelet-rich plasma promote the re-epithelization of chronic cutaneous wounds via activation of YAP in a diabetic rat model

(2017) Shang-Chun Guo et al.   Theranostics

Th1/Th2 Balance and Th17/Treg-Mediated Immunity in relation to Murine Resistance to Dextran Sulfate-Induced Colitis

(2017) Fangli Yang et al.   Journal of Immunology Research

ROS in gastrointestinal inflammation: Rescue Or Sabotage?

(2016) G Aviello et al.   BRITISH JOURNAL OF PHARMACOLOGY

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

(2016) Evanna L. Mills et al.   CELL

Dendritic cell–derived exosomes for cancer therapy

(2016) Jonathan M. Pitt et al.   JOURNAL OF CLINICAL INVESTIGATION

Oxygen metabolism and barrier regulation in the intestinal mucosa

(2016) Louise E. Glover et al.   JOURNAL OF CLINICAL INVESTIGATION

Hypoxia-inducible factors: key regulators of myeloid cells during inflammation

(2016) Nan Lin et al.   JOURNAL OF CLINICAL INVESTIGATION

The genetic background of inflammatory bowel disease: from correlation to causality

(2016) Werna TC Uniken Venema et al.   JOURNAL OF PATHOLOGY

Exosomes secreted from bone marrow-derived mesenchymal stem cells protect the intestines from experimental necrotizing enterocolitis

(2016) Terrence M. Rager et al.   JOURNAL OF PEDIATRIC SURGERY

Mesenchymal Stem Cells Deliver Exogenous MicroRNA-let7c via Exosomes to Attenuate Renal Fibrosis

(2016) Bo Wang et al.   MOLECULAR THERAPY

S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate

(2016) Petros A. Tyrakis et al.   NATURE

Extracellular Vesicles in Physiology, Pathology, and Therapy of the Immune and Central Nervous System, with Focus on Extracellular Vesicles Derived from Mesenchymal Stem Cells as Therapeutic Tools

(2016) Sylwia Koniusz et al.   Frontiers in Cellular Neuroscience

Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE): Determining Therapeutic Goals for Treat-to-Target

(2015) L Peyrin-Biroulet et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Exosomes: Vehicles of Intercellular Signaling, Biomarkers, and Vectors of Cell Therapy

(2015) Stella Kourembanas   Annual Review of Physiology

Cell cycle-dependent resolution of DNA double-strand breaks

(2015) Susanna Ambrosio et al.   Oncotarget

Hypoxia Pretreatment of Bone Marrow Mesenchymal Stem Cells Facilitates Angiogenesis by Improving the Function of Endothelial Cells in Diabetic Rats with Lower Ischemia

(2015) Jiejie Liu et al.   PLoS One

Severe hypoxia exerts parallel and cell-specific regulation of gene expression and alternative splicing in human mesenchymal stem cells

(2014) Xinyang Hu et al.   BMC GENOMICS

ROS Function in Redox Signaling and Oxidative Stress

(2014) Michael Schieber et al.   CURRENT BIOLOGY

Oxygen Sensing, Hypoxia-Inducible Factors, and Disease Pathophysiology

(2013) Gregg L. Semenza   Annual Review of Pathology-Mechanisms of Disease

Fundamental role for HIF-1α in constitutive expression of human β defensin-1

(2013) C J Kelly et al.   Mucosal Immunology

Achieving the Balance between ROS and Antioxidants: When to Use the Synthetic Antioxidants

(2013) Borut Poljsak et al.   Oxidative Medicine and Cellular Longevity

Microvesicles as mediators of tissue regeneration

(2013) Keith Sabin et al.   Translational Research

Extracellular vesicles as mediators of neuron-glia communication

(2013) Carsten Frühbeis et al.   Frontiers in Cellular Neuroscience

Systemic Macrophage Depletion Inhibits Helicobacter bilis-Induced Proinflammatory Cytokine-Mediated Typhlocolitis and Impairs Bacterial Colonization Dynamics in a BALB/cRag2−/−Mouse Model of Inflammatory Bowel Disease

(2012) Sureshkumar Muthupalani et al.   INFECTION AND IMMUNITY

Immune markers and differential signaling networks in ulcerative colitis and Crohnʼs disease

(2012) George P. Christophi et al.   INFLAMMATORY BOWEL DISEASES

HIF-1 in T cells ameliorated dextran sodium sulfate-induced murine colitis

(2012) Masaaki Higashiyama et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Therapeutic potential of mesenchymal stem cell-derived microvesicles

(2012) L. Biancone et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Malignant Tumor Formation After Transplantation of Short-Term Cultured Bone Marrow Mesenchymal Stem Cells in Experimental Myocardial Infarction and Diabetic Neuropathy

(2011) Jin-Ok Jeong et al.   CIRCULATION RESEARCH

Ulcerative Colitis as A Progressive Disease: The Forgotten Evidence

(2011) Joana Torres et al.   INFLAMMATORY BOWEL DISEASES

Oxygen in Stem Cell Biology: A Critical Component of the Stem Cell Niche

(2010) Ahmed Mohyeldin et al.   Cell Stem Cell