Article
Chemistry, Physical
Guodong Zhao, Lixin Liang, Eryu Wang, Rongbiao Tong
Summary: The Achmatowicz rearrangement is a significant transformation for the synthesis of various heterocyclic building blocks and natural products. The discovery of Fenton chemistry for AchR using a bifunctional catalyst has environmental friendliness and a broad substrate scope, addressing limitations of conventional chemical and enzymatic methods. Reactice brominating species (RBS) is found to be the true catalyst for AchR, and the in situ RBS generation from M-Br-x-H2O2 under neutral conditions solves the longstanding issue of acidic additives required for bromide oxidation with H2O2, creating opportunities for other bromine-mediated organic reactions.
Article
Chemistry, Organic
Miguel Adrian Marquez-Cadena, Wei Zhang, Rongbiao Tong
Summary: This study presents an efficient strategy for the construction of the tetracyclic core system of berkeleyacetal, utilizing two cycloadditions to form the core and Achmatowicz rearrangement for the preparation of cyclization substrates containing B and E rings.
Article
Materials Science, Composites
Shengtao Dai, Peikun Li, Xuyang Li, Chen Ning, Lingqiang Kong, Lanqing Fang, Yu Liu, Liu Liu, Yuhui Ao
Summary: A novel self-catalytic waterborne polyurethane was designed and utilized to prepare sizing agent for carbon fibers, showing significant improvement in mechanical properties compared to unsized composites. The use of bio-based tartaric acid in the synthesis process contributes to potential industrial production of green WPU sizing agent.
COMPOSITES COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Mahdi Shahmiri, Saadi Bayat, Sharmin Kharrazi
Summary: This study established a simple and environmentally friendly method to synthesize a highly efficient, recoverable and stable CuO nanosheets catalyst to overcome public health and environmental problems caused by nitro aromatic compounds.
Article
Chemistry, Physical
Seonmyeong Noh, Thanh-Hai Le, Changjun Kim, Minseong Ju, Haney Lee, S. K. Nataraj, Hyeonseok Yoon
Summary: This study presents a simple and environmentally friendly liquid-phase co-exfoliation strategy to prepare heterolayered 2D nanohybrids with excellent electrocatalytic performance. By modifying the MoS2 material with binary metal oxides (NiFe2O4) and graphene functional groups, the phase conversion from semiconductive MoS2 to metallic MoS2 was achieved. The resulting nanohybrids showed outstanding electrocatalytic activity for hydrogen and oxygen evolution reactions due to the synergetic effects of the modified MoS2/graphene/NiFe2O4 components.
JOURNAL OF MATERIALS CHEMISTRY A
(2023)
Article
Chemistry, Multidisciplinary
Sergey Tkachev, Miguel Monteiro, Joao Santos, Ernesto Placidi, Mohamed Ben Hassine, Pedro Marques, Paulo Ferreira, Pedro Alpuim, Andrea Capasso
Summary: An efficient and inexpensive method has been proposed to produce high-quality graphene dispersions for spray-coating flexible electrodes and assembling touch screen prototypes, overcoming environmental issues associated with hazardous solvents. The combination of liquid-phase exfoliation with shear-mixing and tip sonication techniques in cyrene produces high-concentration graphene inks. The resulting electrodes exhibit low sheet resistance, high optical transmittance, high signal-to-noise ratio, and multi-touch functionality, showcasing the potential integration of LPE-graphene in commercial flexible electronics.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Xiaolei Zhao, Yuwei Wang, Qi Wang, Qiang Li, Zhenxing Liu, Wei-Hong Zhu
Summary: In this study, we introduce a sensitive AIE probe named EDS for the determination of critical micelle concentration (CMC). The incorporation of a sulfonate group (-SO3-) into the QM moiety allows for testing the CMC value in a water-based system, eliminating the need for toxic organic solvents or corrosive acid reagents.
MATERIALS CHEMISTRY FRONTIERS
(2022)
Article
Chemistry, Physical
Miroslav Dangalov, Adolfo Fernandez-Figueiras, Martin A. Ravutsov, Ekaterina Vakarelska, Maya K. Marinova, Nuno R. Candeias, Svilen P. Simeonov
Summary: A Ru-catalyzed isomerization reaction of Achmatowicz derivatives is reported, providing unexplored routes for diversification of the biogenic furanic platform. Mechanistic insights were studied using computational and deuterium labeling techniques. This transformation proved to be a robust tool for the synthesis of bioderived monomers and 4-keto-o-valerolactones, enabling the flexible synthesis of acetogenins. Additionally, a concise and protective group-free asymmetric total synthesis of two natural products, (S,S)-muricatacin and (S,S)-L-factor, is described.
Article
Chemistry, Applied
Sergey Lopatin, Andrey Elyshev, Andrey Zagoruiko
Summary: The article presents a prototype device based on structured microfiber catalysts for the combustion of liquid fuels and disposal of liquid toxic waste. The technology combines a two-stage approach to achieve optimal combustion mode and emissions practically free of toxic impurities.
Article
Chemistry, Inorganic & Nuclear
Changzhou Chen, Dichao Wu, Jurong Ren, Peng Liu, Haihong Xia, Minghao Zhou, Jianchun Jiang
Summary: This study successfully synthesized ultra-thin metal-based carbon nanosheets via a template method and characterized their structure and properties. The use of environmentally-friendly materials and methods in the synthesis process led to highly efficient catalytic reactions and significantly increased product yields.
INORGANIC CHEMISTRY COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Deeksha Mudgal, Nisha Yadav, Jay Singh, Gaurav Kumar Srivastava, Vivek Mishra
Summary: In this study, a novel copper nano-magnetite doped carbon aerogel was successfully created using a simple graft co-polymerization approach with xanthan gum as a template. The CXMCA exhibited outstanding magnetic properties as well as strong catalytic activity for dye degradation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Multidisciplinary
Lian-Dong Guo, Zejun Xu, Rongbiao Tong
Summary: The asymmetric total syntheses of three paspaline-derived IDTs were reported, featuring green Achmatowicz rearrangement/bicycloketalization and cascade ring-closing metathesis of dienyne, as well as four palladium-mediated reactions. These synthetic strategies are expected to facilitate the chemical synthesis of other paspaline-derived IDTs and further bioactivity studies.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Chemistry, Applied
Sheng Xiong, Rongdi Tang, Daoxin Gong, Yaocheng Deng, Jiangfu Zheng, Ling Li, Zhanpeng Zhou, Lihua Yang, Long Su
Summary: Currently, the world is facing the crucial issue of the energy crisis, and photocatalytic hydrogen (H-2) production is considered a promising solution. The use of noble metal catalysts has limitations due to their scarcity and high cost, necessitating the search for a cheaper, more efficient, and stable catalyst. The emergence of carbon nanostructured materials (CNMs) has provided a solution with their excellent structure and semiconductor performance. This review summarizes the latest progress in CNMs and strategies for enhancing their performance in photocatalytic H-2 production.
CHINESE JOURNAL OF CATALYSIS
(2022)
Article
Chemistry, Physical
Yasukazu Kobayashi, Heng Yi Teah, Shota Yokoyama, Ryo Shoji, Nobuko Hanada
Summary: High-entropy AlCoCrFeNi alloy powder with a high specific surface area was successfully synthesized using a molten salt method, demonstrating excellent catalytic activity in hydrogenation reactions. Compared to a previously reported dealloying method, this approach significantly reduces greenhouse gas emissions.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2023)
Article
Materials Science, Multidisciplinary
Taehee Lee, Christopher P. Camp, Bumjoon Kim, Minkyu Kim
Summary: A newly developed methylcellulose blend (MCB) has been shown to enhance the filtration efficiency of filter membranes and reduce the generation of inhalable dust. This advancement is significant for environmental protection and public health.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Guodong Zhao, Eryu Wang, Rongbiao Tong
Summary: Fenton chemistry can generate reactive brominating species under neutral conditions, addressing the safety and environmental challenges of existing oxidative bromination methods. This new method for generating RBS will significantly benefit the wide applications of brominated organic compounds in various industries.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2021)
Article
Chemistry, Multidisciplinary
Lian-Dong Guo, Zejun Xu, Rongbiao Tong
Summary: The asymmetric total syntheses of three paspaline-derived IDTs were reported, featuring green Achmatowicz rearrangement/bicycloketalization and cascade ring-closing metathesis of dienyne, as well as four palladium-mediated reactions. These synthetic strategies are expected to facilitate the chemical synthesis of other paspaline-derived IDTs and further bioactivity studies.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Organic
Chenxi He, Foqing Ma, Wei Zhang, Rongbiao Tong
Summary: In this study, the authors reinvestigated the green alcohol oxidation method using FeBr3(cat.)/H2O2 and proposed a different mechanism involving a reactive brominating species (RBS). They provided evidence to support this RBS-based mechanism and discovered that a RBS generated from CeBr3/H2O2 is more efficient for the oxidation of secondary and benzylic alcohols, presenting a new green protocol for selective alcohol oxidation to carbonyls.
Review
Chemistry, Multidisciplinary
Lixin Liang, Lian-Dong Guo, Rongbiao Tong
Summary: The six-membered heterocycles containing oxygen and nitrogen are commonly found in bioactive molecules and the chemical synthesis of fully functionalized pyrans and piperidines has attracted interest from synthetic chemists. The Achmatowicz rearrangement represents a unique strategy using biomass-derived furfuryl alcohols as starting materials, providing opportunities for addressing synthetic challenges. This Account summarizes the work done on exploiting AchR to address challenges in various organic synthesis, focusing on green chemistry, organic methodology, and total synthesis of natural products.
ACCOUNTS OF CHEMICAL RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Xiayan Y. Zhang, Yi Tong, Gang Li, Hao Zhao, Guanye Chen, Hongliang Yao, Rongbiao Tong
Summary: This article reports an unexpected discovery of a formal 1,5-allyl shift method and provides a mechanistic explanation. This method shows potential applications in organic synthesis and materials chemistry.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Organic
Liyan Song, Yunrong Lai, Hongzuo Li, Jipeng Ding, Hongliang Yao, Qian Su, Binbin Huang, Ming-An Ouyang, Rongbiao Tong
Summary: This study reports a green and user-friendly method for the in situ generation of nitrile imines through oxidation of hydrazones and dehydrobromination. Nitrile imines demonstrated excellent reactivity in 1,3-dipolar cycloaddition reactions with various dipolarophiles, making it a valuable tool in organic synthesis.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Peilin Tian, Rongbiao Tong
Summary: The Suzuki coupling of haloarenes with arylboronic acids is a crucial C-C bond-forming reaction in organic chemistry. By replacing the pre-functionalized haloarenes with arenes for the oxidative coupling, a milder and more environmentally friendly approach to the classical Suzuki reaction has been achieved. This involves conducting the reaction in water using hydrogen peroxide as the oxidant, which eliminates the use of flammable organic solvents and generates water as the only byproduct. The strategy has been successfully applied to expand the utility of green chemistry in organic synthesis, including two cross-dehydrogenative couplings.
Article
Chemistry, Organic
Liyan Song, Yiqin Zhou, Hanbin Liang, Hongzuo Li, Yunrong Lai, Hongliang Yao, Ran Lin, Rongbiao Tong
Summary: Semipinacol rearrangement is a valuable method for the synthesis of natural products and construction of highly congested quaternary carbons. Here, a safe and green protocol for halogenative semipinacol rearrangement is reported, which offers the advantages of easy operation and insensitivity to air and moisture.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Organic
Rongbiao Tong
Summary: This Account presents the use of two synthetic strategies (Phenol Oxidative Dearomatization, POD; and Fur an Oxidative Dearomatization, FOD) in the total synthesis of natural products. It focuses on how these total synthesis projects are conceived and connected from the perspective of laboratory development. Total synthesis is shown to be a connecting and inspirational point that sparks new ideas and projects.
Article
Chemistry, Multidisciplinary
Wai Fung Cheng, Shiqiang Ma, Yin Tung Lai, Yuen Tsz Cheung, Kornkamon Akkarasereenon, Yiqin Zhou, Rongbiao Tong
Summary: An intramolecular aza-Prins cyclization of aza-Achmatowicz rearrangement products was developed using bismuth tribromide as both an efficient Lewis acid and a bromide nucleophile source. This approach enables the construction of highly functionalized 9-azabicyclo[3.3.1]nonanes, which are valuable building blocks for alkaloid natural products and drug molecules. The application of this method to the total synthesis of six indole alkaloids demonstrates its significant synthetic utility.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Medicinal
Wenjun Wang, Foqing Ma, Yuen Tsz Cheung, Guihua Zeng, Yiqin Zhou, Zijing Chen, Lixin Liang, Tuoping Luo, Rongbiao Tong
Summary: Induction of ferroptosis has been found to be an effective method for cancer treatment. In this study, marine alkaloid lepadins E and H were discovered as new ferroptosis inducers. In vitro experiments showed that lepadins E and H exhibited significant cytotoxicity and induced ferroptosis through the p53-SLC7A11-GPX4 pathway. Animal model studies further confirmed their in vivo antitumor efficacy. This discovery highlights the potential of lepadins as a new class of ferroptosis inducers for anticancer therapy.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Organic
Tao Zheng, Jun Xu, Shaojun Cheng, Jianghai Ye, Shiqiang Ma, Rongbiao Tong
Summary: Oxidative functionalization of indoles is widely used in synthetic chemistry. In this study, we explored the oxidation of indoles using oxone-halide and found that the protecting group on the nitrogen of indoles determines the pathways of oxidation. An electron-withdrawing group on the nitrogen enables C2 halogenation, while C3 halogenation can be achieved without dependence on the protecting group. This environmentally friendly and efficient method allows for the synthesis of 2- or 3-haloindoles without the use of stoichiometric halogenating agents or production of toxic byproducts.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Liyan Song, Yufei Meng, Tongchao Zhao, Lifang Liu, Xiaohong Pan, Binbin Huang, Hongliang Yao, Ran Lin, Rongbiao Tong
Summary: The Hofmann and Curtius rearrangements have been achieved through a green oxidation method using oxone and halide (and NaN3) to generate N-halo amides and acyl azides from amides and aldehydes, respectively. These intermediates further rearrange into stable carbamates or ureas (the Hofmann and Curtius rearrangements) when trapped with alcohols or amines. The method is efficient, environmentally friendly, and produces only non-toxic K2SO4 as a byproduct.
Article
Chemistry, Multidisciplinary
Peilin Tian, Wenkang Ye, Xiayan Zhang, Yi Tong, Pei-Yuan Qian, Rongbiao Tong
Summary: The increase in antibiotic resistance necessitates the development of new antibiotics with novel molecular structures and mechanisms of action. However, the discovery of new antibiotics and their progression into clinical use have been limited in recent decades. The potent anthracimycin antibiotic represents a significant advancement in this field, with its unique structural features and excellent biological activity against various bacteria, including drug-resistant strains. Researchers have successfully achieved the total synthesis of anthracimycin through a 10-step asymmetric synthesis, providing a reliable supply for further studies and allowing the preparation of analogues for structure-activity relationship studies.
Article
Chemistry, Multidisciplinary
Guodong Zhao, Yaxin Wang, Cheng Wang, Haimin Lei, Bingqing Yi, Rongbiao Tong
Summary: Fenton-like chemistry (FLC: CeBr3-H2O2) is utilized for the oxidative desulfurization of thioacetals and thioketals, providing a green, efficient, and chemoselective method for the transformation into carbonyls or alcohols.
