期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 81, 期 13, 页码 5417-5422出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.6b00779
关键词
-
资金
- NIIF, OTKA [K116034]
The mechanism of arylation of N-heterocycles with unsymmetric diaryliodonium salts is elucidated. The fast and efficient N-arylation reaction is interpreted in terms of the bifunctionality of the substrate: The consecutive actions of properly oriented Lewis base and Bronsted acid centers in sufficient proximity result in the fast and efficient N-arylation. The mechanistic picture points to a promising synthetic strategy where suitably positioned nucleophilic and acidic centers enable functionalization, and it is tested experimentally.
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