期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 81, 期 18, 页码 8464-8469出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.6b01645
关键词
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资金
- National Research Foundation of Korea (NRF) - Korean Government [NRF-2015R1D1A1A01057200, NRF-20100020209]
- NRF grant - Korean Government (Center for New Directions in Organic Synthesis) [NRF-2014-011165]
A new protocol for the enantioselective synthesis of 3,3'-disubstituted-1,1'-bi-6-methoxy-2-phenol (BIPhOL) derivatives is described. Diastereomeric resolution of racemic BIPhOL boronic acid using a boronic acid moiety as a resolving group generated two diastereomers and subsequent Suzuki-Miyaura coupling reaction of the resulting diastereomers with aryl halides provided BIPhOL derivatives without any loss of enantioselectivity. In addition, the absolute stereochemistry of chiral BIPhOL was determined by comparison of the optical rotation with the reported value.
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