Elevated granulocyte colony stimulating factor ( CSF ) causes cerebellar deficits and anxiety in a model of CSF ‐1 receptor related leukodystrophy

A kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy has a dominant inhibitory impact on CSF1R signalling

(2022) Jennifer Stables et al.   DEVELOPMENT

Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia associated with an A792D mutation in the CSF1R gene in a Polish patient

(2021) Kamila Żur-Wyrozumska et al.   Neurologia i Neurochirurgia Polska

White matter aging drives microglial diversity

(2021) Shima Safaiyan et al.   NEURON

Identification of Neuronal Pentraxins as Synaptic Binding Partners of C1q and the Involvement of NP1 in Synaptic Pruning in Adult Mice

(2021) Réka Á. Kovács et al.   Frontiers in Immunology

Analysis of homozygous and heterozygous Csf1r knockout in the rat as a model for understanding microglial function in brain development and the impacts of human CSF1R mutations

(2021) Omkar L. Patkar et al.   NEUROBIOLOGY OF DISEASE

Modeling CSF‐1 receptor deficiency diseases – how close are we?

(2021) Violeta Chitu et al.   FEBS Journal

Aging triggers an upregulation of a multitude of cytokines in the male and especially the female rodent hippocampus but more discrete changes in other brain regions

(2021) Latarsha Porcher et al.   Journal of Neuroinflammation

Microglial dyshomeostasis drives perineuronal net and synaptic loss in a CSF1R+/− mouse model of ALSP, which can be rescued via CSF1R inhibitors

(2021) Miguel A. Arreola et al.   Science Advances

A transcriptomic atlas of mouse cerebellar cortex comprehensively defines cell types

(2021) Velina Kozareva et al.   NATURE

Microglial Homeostasis Requires Balanced CSF-1/CSF-2 Receptor Signaling

(2020) Violeta Chitu et al.   Cell Reports

Loss of homeostatic microglial phenotype in CSF1R-related Leukoencephalopathy

(2020) Liam Kempthorne et al.   Acta Neuropathologica Communications

Altered structural and functional connectivity in CSF1R-related leukoencephalopathy

(2020) Fei-Xia Zhan et al.   Brain Imaging and Behavior

Correction to: Loss of homeostatic microglial phenotype in CSF1R-related Leukoencephalopathy

(2020) Liam Kempthorne et al.   Acta Neuropathologica Communications

Microglial reduction of colony stimulating factor‐1 receptor expression is sufficient to confer adult onset leukodystrophy

(2020) Fabrizio Biundo et al.   GLIA

Parkinsonism and Nigrostriatal Damage Secondary to CSF1R ‐Related Primary Microgliopathy

(2020) Salvatore Bonvegna et al.   MOVEMENT DISORDERS

Cerebellar modulation of the reward circuitry and social behavior

(2019) Ilaria Carta et al.   SCIENCE

Spatial and Temporal Locomotor Learning in Mouse Cerebellum

(2019) Dana M. Darmohray et al.   NEURON

CSF-1 controls cerebellar microglia and is required for motor function and social interaction

(2019) Veronika Kana et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Single-cell transcriptomic profiling of the aging mouse brain

(2019) Methodios Ximerakis et al.   NATURE NEUROSCIENCE

Increased interactions and engulfment of dendrites by microglia precede Purkinje cell degeneration in a mouse model of Niemann Pick Type-C

(2019) Larisa Kavetsky et al.   Scientific Reports

The Microglial Innate Immune Receptor TREM2 Is Required for Synapse Elimination and Normal Brain Connectivity

(2018) Fabia Filipello et al.   IMMUNITY

Quantifying Microglia Morphology from Photomicrographs of Immunohistochemistry Prepared Tissue Using ImageJ

(2018) Kimberly Young et al.   Jove-Journal of Visualized Experiments

Identification and functional characterization of novel mutations including frameshift mutation in exon 4 of CSF1R in patients with adult-onset leukoencephalopathy with axonal spheroids and pigmented glia

(2018) Takeshi Miura et al.   JOURNAL OF NEUROLOGY

CSF1R-related leukoencephalopathy

(2018) Takuya Konno et al.   NEUROLOGY

CD47 Protects Synapses from Excess Microglia-Mediated Pruning during Development

(2018) Emily K. Lehrman et al.   NEURON

Cell-specific deletion of C1qa identifies microglia as the dominant source of C1q in mouse brain

(2017) Maria I. Fonseca et al.   Journal of Neuroinflammation

Bidirectional Control of Anxiety-Related Behaviors in Mice: Role of Inputs Arising from the Ventral Hippocampus to the Lateral Septum and Medial Prefrontal Cortex

(2017) Gustavo Morrone Parfitt et al.   NEUROPSYCHOPHARMACOLOGY

Granulocyte-colony–stimulating factor (G-CSF) signaling in spinal microglia drives visceral sensitization following colitis

(2017) Lilian Basso et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

Emerging Roles for CSF-1 Receptor and its Ligands in the Nervous System

(2016) Violeta Chitu et al.   TRENDS IN NEUROSCIENCES

Deletion of the γ-secretase subunits Aph1B/C impairs memory and worsens the deficits of knock-in mice modeling the Alzheimer-like familial Danish dementia

(2016) Fabrizio Biundo et al.   Oncotarget

Comprehensive diagnostics in a case of hereditary diffuse leukodystrophy with spheroids

(2015) Marie Meyer-Ohlendorf et al.   BMC Neurology

Granulocyte Colony-Stimulating Factor for Amyotrophic Lateral Sclerosis: A Randomized, Double-Blind, Placebo-Controlled Study of Iranian Patients

(2015) Nasibeh Amirzagar et al.   Journal of Clinical Neurology

Hereditary leukoencephalopathy with axonal spheroids: a spectrum of phenotypes from CNS vasculitis to parkinsonism in an adult onset leukodystrophy series

(2015) David S Lynch et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia linked CSF1R mutation: Report of four Korean cases

(2015) Eun-Joo Kim et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Phenotypic characterization of a Csf1r haploinsufficient mouse model of adult-onset leukodystrophy with axonal spheroids and pigmented glia (ALSP)

(2015) Violeta Chitu et al.   NEUROBIOLOGY OF DISEASE

Interaction of ApoE3 and ApoE4 isoforms with an ITM2b/BRI2 mutation linked to the Alzheimer disease-like Danish dementia: Effects on learning and memory

(2015) Fabrizio Biundo et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Hereditary diffuse leukoencephalopathy with spheroids with phenotype of primary progressive multiple sclerosis

(2014) C. Sundal et al.   EUROPEAN JOURNAL OF NEUROLOGY

Early Pathologic Changes in Hereditary Diffuse Leukoencephalopathy With Spheroids

(2014) Yuichi Riku et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Phagocytic glial cells: sculpting synaptic circuits in the developing nervous system

(2013) Dorothy P. Schafer et al.   CURRENT OPINION IN NEUROBIOLOGY

Layer V cortical neurons require microglial support for survival during postnatal development

(2013) Masaki Ueno et al.   NATURE NEUROSCIENCE

De novo mutations in hereditary diffuse leukoencephalopathy with axonal spheroids (HDLS)

(2013) K. N. Karle et al.   NEUROLOGY

CSF1R mutations link POLD and HDLS as a single disease entity

(2013) A. M. Nicholson et al.   NEUROLOGY

Haploinsufficiency of CSF-1R and clinicopathologic characterization in patients with HDLS

(2013) T. Konno et al.   NEUROLOGY

Intrathecal granulocyte colony-stimulating factor modulate glial cell line-derived neurotrophic factor and vascular endothelial growth factor A expression in glial cells after experimental spinal cord ischemia

(2013) C.-H. Chen et al.   NEUROSCIENCE

Genetic Analysis of Inherited Leukodystrophies

(2013) Rita Guerreiro et al.   JAMA Neurology

The CSF-1 receptor ligands IL-34 and CSF-1 exhibit distinct developmental brain expression patterns and regulate neural progenitor cell maintenance and maturation

(2012) Sayan Nandi et al.   DEVELOPMENTAL BIOLOGY

Adult-born hippocampal neurons promote cognitive flexibility in mice

(2012) Nesha S. Burghardt et al.   HIPPOCAMPUS

Prefrontal Cortical Mechanisms Underlying Individual Differences in Cognitive Flexibility and Stability

(2012) Diana J. N. Armbruster et al.   JOURNAL OF COGNITIVE NEUROSCIENCE

Autistic-like behaviour and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice

(2012) Peter T. Tsai et al.   NATURE

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

(2012) Dorothy P. Schafer et al.   NEURON

Granulocyte colony stimulating factor attenuates inflammation in a mouse model of amyotrophic lateral sclerosis

(2011) Eveliina Pollari et al.   Journal of Neuroinflammation

Mutations in the colony stimulating factor 1 receptor (CSF1R) gene cause hereditary diffuse leukoencephalopathy with spheroids

(2011) Rosa Rademakers et al.   NATURE GENETICS

Gender-Specific Mechanism of Synaptic Impairment and Its Prevention by GCSF in a Mouse Model of ALS

(2011) Nikolay Naumenko et al.   Frontiers in Cellular Neuroscience

Microglia Shape Adult Hippocampal Neurogenesis through Apoptosis-Coupled Phagocytosis

(2010) Amanda Sierra et al.   Cell Stem Cell

Sporadic leucodystrophy with neuroaxonal spheroids: persistence of DWI changes and neurocognitive profiles: a case study

(2010) F. J. Mateen et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Are the Dorsal and Ventral Hippocampus Functionally Distinct Structures?

(2010) Michael S. Fanselow et al.   NEURON

The Role of Granulocyte-Colony Stimulating Factor (G-CSF) in the Healthy Brain: A Characterization of G-CSF-Deficient Mice

(2009) K. Diederich et al.   JOURNAL OF NEUROSCIENCE

Granulocyte colony stimulating factor decreases brain amyloid burden and reverses cognitive impairment in Alzheimer's mice

(2009) J. Sanchez-Ramos et al.   NEUROSCIENCE

Implications of functional anatomy on information processing in the deep cerebellar nuclei

(2009) Yuval Baumel   Frontiers in Cellular Neuroscience

Early deficits in motor coordination and cognitive dysfunction in a mouse model of the neurodegenerative lysosomal storage disorder, Sandhoff disease

(2008) Maria Gulinello et al.   BEHAVIOURAL BRAIN RESEARCH