4-(5-Amino-pyrazol-1-yl)benzenesulfonamide derivatives as novel multi-target anti-inflammatory agents endowed with inhibitory activity against COX-2, 5-LOX and carbonic anhydrase: Design, synthesis, and biological assessments

Fluorochrome Selection for Imaging Intraoperative Ovarian Cancer Probes

(2022) Maria Grazia Perrone et al.   Pharmaceuticals

Development of 4-((3-oxo-3-phenylpropyl)amino)benzenesulfonamide derivatives utilizing tail/dual-tail approaches as novel carbonic anhydrase inhibitors

(2022) Mostafa M. Elbadawi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design and synthesis of benzothiazole-based SLC-0111 analogues as new inhibitors for the cancer-associated carbonic anhydrase isoforms IX and XII

(2022) Tarfah Al-Warhi et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Design, synthesis, and molecular docking of novel pyrazole-chalcone analogs of lonazolac as 5-LOX, iNOS and tubulin polymerization inhibitors with potential anticancer and anti-inflammatory activities

(2022) Asmaa H.H. Ahmed et al.   BIOORGANIC CHEMISTRY

Development of novel benzofuran-based SLC-0111 analogs as selective cancer-associated carbonic anhydrase isoform IX inhibitors

(2021) Moataz Shaldam et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

OPLS4: Improving Force Field Accuracy on Challenging Regimes of Chemical Space

(2021) Chao Lu et al.   Journal of Chemical Theory and Computation

Deciphering the key heterocyclic scaffolds in targeting microtubules, kinases and carbonic anhydrases for cancer drug development

(2021) Mudasir Nabi Peerzada et al.   PHARMACOLOGY & THERAPEUTICS

Synthetically-tailored and nature-derived dual COX-2/5-LOX inhibitors: Structural aspects and SAR

(2021) Minakshi A. Meshram et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Carbonic anhydrase inhibitors: an update on experimental agents for the treatment and imaging of hypoxic tumors

(2021) Claudiu T. Supuran   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Synthesis and biological screening of some novel 6‐substituted 2‐alkylpyridazin‐3(2 H )‐ones as anti‐inflammatory and analgesic agents

(2020) Yasser M. Loksha et al.   ARCHIV DER PHARMAZIE

Inclusion of a 5-fluorouracil moiety in nitrogenous bases derivatives as human carbonic anhydrase IX and XII inhibitors produced a targeted action against MDA-MB-231 and T47D breast cancer cells

(2020) Andrea Petreni et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Potent Dual-Tailed Benzenesulfonamide Inhibitors of Human Carbonic Anhydrases Implicated in Glaucoma and in Vivo Profiling of Their Intraocular Pressure-Lowering Action

(2020) Mohamed Fares et al.   JOURNAL OF MEDICINAL CHEMISTRY

Benzylaminoethyureido-Tailed Benzenesulfonamides: Design, Synthesis, Kinetic and X-ray Investigations on Human Carbonic Anhydrases

(2020) Majid Ali et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Structural and mechanistic insights into 5-lipoxygenase inhibition by natural products

(2020) Nathaniel C. Gilbert et al.   Nature Chemical Biology

Benzofuran-Based Carboxylic Acids as Carbonic Anhydrase Inhibitors and Antiproliferative Agents against Breast Cancer

(2020) Wagdy M. Eldehna et al.   ACS Medicinal Chemistry Letters

Benzoxaboroles: New Potent Inhibitors of the Carbonic Anhydrases of the Pathogenic Bacterium Vibrio cholerae

(2020) Alessandro Bonardi et al.   ACS Medicinal Chemistry Letters

Carbonic Anhydrase Inhibitors Targeting Metabolism and Tumor Microenvironment

(2020) Andrea Angeli et al.   Metabolites

RCSB Protein Data Bank: powerful new tools for exploring 3D structures of biological macromolecules for basic and applied research and education in fundamental biology, biomedicine, biotechnology, bioengineering and energy sciences

(2020) Stephen K Burley et al.   NUCLEIC ACIDS RESEARCH

Editorial: Multi-Target-Directed Ligands (MTDL) as Challenging Research Tools in Drug Discovery: From Design to Pharmacological Evaluation

(2019) Stefano Alcaro et al.   Frontiers in Chemistry

Selective COX-2 inhibitors as anticancer agents: a patent review (2014-2018)

(2019) Sayyed Mohammad Ismail Mahboubi Rabbani et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Safer anti-inflammatory therapy through dual COX-2/5-LOX inhibitors: A structure-based approach

(2018) Jaismy Jacob P et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

The Acid–Base Balance and Gender in Inflammation: A Mini-Review

(2018) Georges Jacques Casimir et al.   Frontiers in Immunology

Enhancement of the tail hydrophobic interactions within the carbonic anhydrase IX active site via structural extension: Design and synthesis of novel N-substituted isatins-SLC-0111 hybrids as carbonic anhydrase inhibitors and antitumor agents

(2018) Wagdy M. Eldehna et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Highly Selective Cyclooxygenase-1 Inhibitors P6 and Mofezolac Counteract Inflammatory State both In Vitro and In Vivo Models of Neuroinflammation

(2017) Rosa Calvello et al.   Frontiers in Neurology

Structural insight into the inhibition of carbonic anhydrase by the COX-2-selective inhibitor polmacoxib (CG100649)

(2016) Hyun Tae Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Acidosis differently modulates the inflammatory program in monocytes and macrophages

(2016) Anne Riemann et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Overexpression of the transmembrane carbonic anhydrase isoforms IX and XII in the inflamed synovium

(2016) Francesca Margheri et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Isatin-pyrazole benzenesulfonamide hybrids potently inhibit tumor-associated carbonic anhydrase isoforms IX and XII

(2015) Hany S. Ibrahim et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Efficient Expression and Crystallization System of Cancer-Associated Carbonic Anhydrase Isoform IX

(2015) Janis Leitans et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inflammation and cancer: advances and new agents

(2015) Shanthini M. Crusz et al.   Nature Reviews Clinical Oncology

Selective Cyclooxygenase-1 Inhibition by P6 and Gastrotoxicity: Preliminary Investigation

(2015) Maria Grazia Perrone et al.   PHARMACOLOGY

Multi-target approach for natural products in inflammation

(2014) Andreas Koeberle et al.   DRUG DISCOVERY TODAY

Novel sulfonamides bearing pyrrole and pyrrolopyrimidine moieties as carbonic anhydrase inhibitors: Synthesis, cytotoxic activity and molecular modeling

(2014) Mostafa M. Ghorab et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

5-Lipoxygenase Antagonist therapy: a new approach towards targeted cancer chemotherapy

(2013) K. Bishayee et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Shifting from the single to the multitarget paradigm in drug discovery

(2013) José L. Medina-Franco et al.   DRUG DISCOVERY TODAY

New selective carbonic anhydrase IX inhibitors: Synthesis and pharmacological evaluation of diarylpyrazole-benzenesulfonamides

(2012) Tiphaine Rogez-Florent et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Multiple Binding Modes of Inhibitors to Carbonic Anhydrases: How to Design Specific Drugs Targeting 15 Different Isoforms?

(2012) Vincenzo Alterio et al.   CHEMICAL REVIEWS

Carbonic Anhydrases III and IV Autoantibodies in Rheumatoid Arthritis, Systemic Lupus Erythematosus, Diabetes, Hypertensive Renal Disease, and Heart Failure

(2012) Chengeng Liu et al.   Clinical & Developmental Immunology

Novel selective COX-1 inhibitors suppress neuroinflammatory mediators in LPS-stimulated N13 microglial cells

(2011) Rosa Calvello et al.   PHARMACOLOGICAL RESEARCH

Atomic resolution studies of carbonic anhydrase II

(2010) Craig A. Behnke et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part 2: The second clinical candidate having a shorter and favorable human half-life

(2010) Jane L. Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

COX-2's new role in inflammation

(2010) Chu Chen   Nature Chemical Biology

Synthesis and Biological Evaluation of Novel Pyrazoles and Pyrazolo[3,4-d]pyrimidines Incorporating a Benzenesulfonamide Moiety

(2009) Hayam M. A. Ashour et al.   ARCHIV DER PHARMAZIE

Carbonic anhydrases: novel therapeutic applications for inhibitors and activators

(2008) Claudiu T. Supuran   NATURE REVIEWS DRUG DISCOVERY