Review
Endocrinology & Metabolism
Siyu Zhou, Shu Wen, Yongcheng Sheng, Meina Yang, Xiaoyang Shen, Yan Chen, Deying Kang, Liangzhi Xu
Summary: The study found no significant associations between ESR1 and ESR2 gene polymorphisms and PCOS susceptibility, even after considering ethnicity as a major source of heterogeneity.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Obstetrics & Gynecology
Amin Ullah, Mei-Jiao Wang, Jun-Pu Yang, Enoch Appiah Adu-Gyamfi, Armin Czika, Sanjay Kumar Sah, Qian Feng, Ying-Xiong Wang
Summary: This study investigated the expression pattern of inflammatory mRNA profiles in the ovarian tissues of a DHEA plus HFD-induced PCOS mouse model. The differentially expressed genes were found to be associated with PCOS inflammation and could potentially serve as therapeutic options against the disease.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Biochemistry & Molecular Biology
Yue Wu, Lingping Yang, Xianglu Wu, Lidan Wang, Hongbo Qi, Qian Feng, Bin Peng, Yubin Ding, Jing Tang
Summary: Revealing key genes and elucidating pathogenic mechanism of PCOS is crucial for targeted clinical therapy. Integrating PCOS-associated molecules, an integrative PPMI network identified potential PCOS-associated genes and significant differences in PCOS-specific tissue. The novel gene FXR2 was found to be significantly increased in PCOS patients' ovarian granulosa cells.
Article
Multidisciplinary Sciences
Maria Camila Alarcon-Granados, Harold Moreno-Ortiz, Clara Ines Esteban-Perez, Atilio Ferrebuz-Cardozo, Gloria Eugenia Camargo-Villalba, Maribel Forero-Castro
Summary: This study evaluated the frequency of five gene polymorphisms in a sample of Colombian women with PCOS and studied their association with clinical and endocrine-metabolic parameters. The study found that certain genotypes were associated with an increase in levels of free testosterone and androstenedione. However, THADA gene SNPs were not associated with PCOS risk.
Review
Cell Biology
Xue-Ling Xu, Shou-Long Deng, Zheng-Xing Lian, Kun Yu
Summary: Female infertility is mainly caused by ovulation disorders, with polycystic ovary syndrome (PCOS) being the most prevalent. PCOS is associated with abnormal function of estrogen and estrogen receptors (ERs), affecting cellular activities. Selective estrogen receptor modulators (SERMs) like tamoxifen and clomiphene have shown clinical applications for subfertility with PCOS, but further understanding of the role of ER in PCOS is needed.
Article
Medical Laboratory Technology
M. Farsimadan, F. Moammadzadeh Ghosi, S. Takamoli, H. Vaziri
Summary: This study found that KISS1 gene polymorphisms rs12998 G > A and rs4889 C > G may be linked to the pathophysiology of PCOS, while rs35431622 A > G is unrelated to PCOS. Further analysis showed that the C-G-G haplotype was more common in cases, while the G-A-G haplotype was less prevalent in controls.
BRITISH JOURNAL OF BIOMEDICAL SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Solmaz Chamanara, Vahid Hozouri, Elnaz Irandoost
Summary: This review article explores the relationship between NLRP3 inflammasome and the risk of developing PCOS. The activation of NLRP3 inflammasome plays a significant role in the pathophysiology of PCOS, and inhibiting its activation and pyroptosis could offer novel therapeutic strategies.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Youngjae Ryu, Yong Jin Kim, Yoon Young Kim, Jungwoo Kim, Sung Woo Kim, Hoon Kim, Seung Yup Ku
Summary: This study successfully established a PCOS model in mice using STZ, with findings indicating that low doses of STZ can induce PCOS features without causing diabetes features. Different doses of STZ treatment had varying effects on body weight, blood glucose levels, and hormone levels in mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Congshun Ma, Qianru Xiang, Ge Song, Xuefei Wang
Summary: Polycystic ovary syndrome (PCOS) is a reproductive endocrine disease with no specific drug treatment. Quercetin (QUR), a flavonoid, has potential therapeutic effects for PCOS patients. However, the mechanisms of QUR in PCOS patients remain unclear.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Environmental Sciences
Min Zhang, Chong Liu, Xiao-Qiong Yuan, Fei-Peng Cui, Yu Miao, Wen Yao, Dan-Yu Qin, Yan-Ling Deng, Pan-Pan Chen, Jia-Yue Zeng, Xiao-Ying Liu, Yang Wu, Cheng-Ru Li, Wen-Qing Lu, Yu-Feng Li, Qiang Zeng
Summary: Phthalate exposures are associated with increased prevalence of polycystic ovary (PCO) and polycystic ovary syndrome (PCOS).
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Yue Che, Jie Yu, Yu-Shan Li, Yu-Chen Zhu, Tao Tao
Summary: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age, affecting fertility and increasing the risk of various health problems. The current understanding of its pathogenesis is still incomplete, leading to difficulties in accurate diagnosis and personalized treatment. This article summarizes the current findings on the genetic, epigenetic, gut microbiota, brain responses, and metabolomics aspects of PCOS, highlighting the challenges in phenotyping and potential treatment approaches. It also discusses the intergenerational transmission of PCOS, providing insights for better management in the future.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Jiayu Huang, Baoyi Huang, Yanxiang Kong, Yazhu Yang, Chengzi Tian, Lin Chen, Yan Liao, Lin Ma
Summary: This study aimed to identify autophagy-related genes (ATGs) that may play a pivotal role in PCOS and provide potential biomarkers for therapeutic intervention. The analysis of gene expression profiles of PCOS and control samples revealed hub ATGs enriched in autophagy-related functions and pathways, leading to the identification of new molecular subgroups.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medical Laboratory Technology
Ying-yi Luan, Lei Zhang, Yi-qiu Peng, Ying-ying Li, Rui-xia Liu, Cheng-hong Yin
Summary: Polycystic ovarian syndrome (PCOS) is a common endocrine disorder affecting females, characterized by chronic low-level inflammation, hormonal and immune dysregulation. It can lead to infertility, irregular menstruation, acne, hirsutism, and obesity.
CLINICA CHIMICA ACTA
(2022)
Article
Immunology
Chaoyi Lu, Hui Wang, Jihong Yang, Xinyue Zhang, Yao Chen, Ruizhi Feng, Yun Qian
Summary: The vaginal microbiome of PCOS patients shows significant changes under different dominant bacterial types, with a marked decrease in alpha diversity when Lactobacillus dominates. Actinomyces may serve as a potential biomarker for identifying PCOS, while Streptococcus could impact pathological changes in PCOS by affecting the female reproductive endocrine environment.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Medicine, Research & Experimental
Leticia Morales-Ledesma, Angelica Trujillo Hernandez, Maria Isabel Ramirez, Gabriela Rosas, Rosa Linares
Summary: In both cyclic animals and EV-PCOS models, blocking VIP receptors reveals differential effects on ovarian function, with changes in steroidogenesis and ovarian catecholamine levels. The binding of VIP to its receptors regulates the responses of steroid hormones and catecholamines in the ovaries, highlighting the importance of VIP signaling in the pathophysiology of PCOS.