期刊
JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY
卷 62, 期 4, 页码 249-256出版社
CENTER ACADEMIC PUBL JAPAN
DOI: 10.3177/jnsv.62.249
关键词
green tea; eriodictyol; hypercholesterolemia; LDL; HMGCR
资金
- Project of the NARO Bio-oriented Technology Research Advancement Institution
- JSPS Kakenhi [22228002, 15H02448, 15K18821]
- Grants-in-Aid for Scientific Research [15H02448, 15K18821, 16J06809] Funding Source: KAKEN
Western diets induce obesity associated with an increased risk of hypercholesterolaemia. Indeed, obesity-induced hypercholesterolaemia is correlated with increased coronary cardiovascular disease (CVD) risk. Male C57BL/6J mice were fed a normal diet, high fat and high-sucrose diet (HF/HS), HF/HS with green tea extract powder diet (HF/HS+GT), HF/HS with eriodictyol diet (HF/HS+Eri), or HP/HS with green tea extract powder and eriodictyol diet (HF/HS + GT +Eri) for 8 wk. Body weight was lower in the HF/HS + GT +Eri group than in the BF/HS group (-8.3%, p<0.01). The HP/HS diet elicited an upregulation of total cholesterol levels (-63%, p<0.001), and low-density lipoprotein (LDL) levels (-89%, p<0.001) were significantly suppressed by the GT+Eri diet. Conversely, no change (p>0.05) was observed in the HP/HS+GT and HF/HS+Eri groups. The HF/HS diet-induced hepatic mRNA increase in 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) was ameliorated (-73%) by the oral administration of green tea extract and eriodictyol. Moreover, the GT+Eri diet suppressed HF/HS diet-induced upregulation of 3-hydroxy-3-methylglutaryl-coenzyme A synthase (HMGCS) (-75%, p<0.05). Furthermore, the LDL receptor (LDLR) levels were higher in the HF/HS+GT+Eri group (+50%, p<0.05) than in the HF/HS group. These results suggest that a combination of green tea and eriodictyol decreases cholesterol levels, particularly LDL levels, accompanied by the suppression of HMGCR and HMGCS levels and upregulation of LDLR levels in the liver.
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