Review
Biochemistry & Molecular Biology
Kendal L. Stewart, Edwin D. Lephart
Summary: Benign prostatic hyperplasia (BPH) is a common age-related disorder with a significant impact globally. Current pharmaceutical or surgical treatments for BPH have serious side effects, prompting the exploration of alternative options such as botanicals and vitamins. This overview highlights the potential of these natural ingredients, both individually and in combination, for BPH symptom relief based on clinical and experimental studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Lulu Gao, Xudong Liu, Xiaoyan Luo, Xiaofan Lou, Pusen Li, Xian Li, Xiaomeng Liu
Summary: Aging is influenced by various factors and has led to an increase in aging-related diseases globally. Natural products have been used for a long time and have been proven to have antiaging effects through various cellular pathways. This article reviews several natural products with potential antiaging properties and highlights their cellular and molecular mechanisms.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Microbiology
Ronan Lordan, Halie M. Rando, Casey S. Greene
Summary: This review critically evaluates the evidence surrounding the potential prophylactic and therapeutic value of dietary supplements and nutraceuticals for COVID-19. While nutritional status plays a significant role in patient outcomes and certain products like vitamin D may hold promise, further research is necessary to formulate evidence-based recommendations. Sales of these products have surged during the pandemic, but more research is needed to determine their efficacy against SARS-CoV-2 and COVID-19.
Review
Food Science & Technology
Hui Duan, Jiani Pan, Min Guo, Jinwei Li, Leilei Yu, Liuping Fan
Summary: Dietary intervention is a safe, broad-spectrum, and low-cost strategy for slowing aging. It regulates nutrient-sensing pathways, gut microbiota, metabolism, and immunity. Different dietary patterns and supplements, as well as the proportion of macronutrients, have varying effects on aging.
FOOD RESEARCH INTERNATIONAL
(2022)
Review
Nutrition & Dietetics
Gabriel Cosmin Petre, Francesco Francini-Pesenti, Amerigo Vitagliano, Giuseppe Grande, Alberto Ferlin, Andrea Garolla
Summary: The use of nutraceutical products for male sexual enhancement, especially in treating erectile dysfunction, has a long history. Alternative treatments for erectile dysfunction are gaining popularity, with increasing interest from consumers and higher revenue for manufacturers. Dietary supplements, which are a combination of active ingredients, are mainly sold online. However, studies have not provided sufficient evidence to consider these products as a first-line therapy, raising doubts about their real effectiveness. A systematic review of the literature identified some nutraceuticals, such as Panax ginseng, Tribulus terrestris, and L-arginine, that can improve male sexual function.
Review
Endocrinology & Metabolism
Andrea Garolla, Gabriel Cosmin Petre, Francesco Francini-Pesenti, Luca De Toni, Amerigo Vitagliano, Andrea Di Nisio, Giuseppe Grande, Carlo Foresta
Summary: A systematic review of dietary supplements for male infertility in Italy revealed that many supplements on the market contain a blend of ingredients with negligible doses or without any evidence of efficacy. However, some ingredients have been shown to be effective on specific sperm parameters. This study can assist in selecting supplements that are more likely to be effective on specific sperm alterations.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Nutrition & Dietetics
Saumya Singh, Prithwish Kola, Dalveer Kaur, Gisha Singla, Vibhu Mishra, Parmjit S. Panesar, Kumar Mallikarjunan, Meena Krishania
Summary: Despite significant scientific advancements, viral diseases continue to be the leading cause of illness worldwide, with the potential for pandemics. Nutrition plays a crucial role in supporting the immune system and combating various viral infections. Studies suggest that bioactive compounds such as nutraceuticals, vitamins, and functional foods, along with milk proteins and peptides, can strengthen the immune system and aid in treating virus-induced infections.
FRONTIERS IN NUTRITION
(2021)
Article
Nutrition & Dietetics
Biyu Wan, Pinli Lin, Mengya Wang, Jintao Zhong, Lu Peng, Xiaona Tang, Lingzhen Wang, Fang Tang, Yuyan Liang, Xusheng Liu, Lili Deng
Summary: This study examined the relationship between the inflammatory potential of diet and cognitive function in individuals with or without chronic kidney disease (CKD). The results showed that higher dietary inflammatory potential was associated with an increased risk of cognitive impairment.
FRONTIERS IN NUTRITION
(2023)
Review
Geriatrics & Gerontology
Andrew Murphy, Sagar Vyavahare, Sandeep Kumar, Tae Jin Lee, Ashok Sharma, Satish Adusumilli, Mark Hamrick, Carlos M. Isales, Sadanand Fulzele
Summary: This study summarizes the research on age-associated diseases and the efforts to extend a healthy lifespan. It discusses the positive effects of dietary protocols such as caloric restriction and protein restriction on human longevity. The study also analyzes the impacts of these protocols on bone and muscle biology, identifying new genes and signaling pathways involved in musculoskeletal tissue.
Article
Medicine, General & Internal
Konstantinos Prokopidis, Panagiotis Giannos, Theocharis Ispoglou, Oliver C. Witard, Masoud Isanejad
Summary: Dietary fiber intake is associated with cognitive function in older adults, and higher intake is linked to improved specific cognitive functions.
AMERICAN JOURNAL OF MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Matthew Lam, Parsa Khoshkhat, Mehdi Chamani, Shadab Shahsavari, Farid A. Dorkoosh, Anthony Rajabi, Mohammed Maniruzzaman, Ali Nokhodchi
Summary: This comprehensive review article provides comprehensive information about dietary supplements from multiple perspectives, including clinical, manufacturing, regulatory, and market aspects. It offers important background and discussion of key issues related to dietary supplements.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Clinical Neurology
Klodian Dhana, Lisa L. Barnes, Puja Agarwal, Xiaoran Liu, Anisa Dhana, Pankaja Desai, Neelum Aggarwal, Denis A. Evans, Kumar B. Rajan
Summary: The intake of vitamin D, especially dietary vitamin D, is associated with a slower decline in cognitive function among Blacks. However, there is no association between vitamin D intake and cognitive decline among Whites.
ALZHEIMERS & DEMENTIA
(2023)
Review
Medicine, Research & Experimental
Muhammad Mazhar Fareed, Sana Ullah, Maryam Qasmi, Sergey Shityakov
Summary: Epigenetic modifications play a vital role in gene regulation associated with different pathologies. Various nutrients, such as vitamins, in our diet can modulate these epigenetic mechanisms. A better understanding of vitamin-mediated epigenetic alterations is needed. The role of vitamins as nutraceuticals in DNA methylation might be important for targeted therapy of various human diseases.
CURRENT MOLECULAR MEDICINE
(2023)
Article
Geriatrics & Gerontology
Sergej M. Ostojic, Darinka Korovljev, Valdemar Stajer
Summary: Recent study using NHANES data found a positive correlation between dietary creatine intake and cognitive function in older adults. Adjusting for sociodemographic and nutritional variables, the association between creatine consumption and cognitive function remained significant. Participants consuming more than 0.95g of creatine per day showed higher cognitive functioning scores compared to those with lower intake.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Article
Medicine, Legal
Suren B. Bandara, Ania Urban, Lisa G. Liang, Jillian Parker, Ernest Fung, Andrew Maier
Summary: Researchers developed a tier-based framework to assess the human health risk associated with APIs in dietary supplements, finding that some products contained levels of APIs above the recommended dose, posing a significant health risk to consumers and potentially workers involved in manufacturing these supplements.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Martina Ferrillo, Mario Migliario, Nicola Marotta, Francesco Fortunato, Marino Bindi, Federica Pezzotti, Antonio Ammendolia, Amerigo Giudice, Pier Luigi Foglio Bonda, Alessandro de Sire
Summary: This study evaluated the association between temporomandibular disorder (TMD) and neck pain in patients with primary headaches. The results showed that migraine patients reported higher TMD and neck pain. Machine learning analysis demonstrated that TMD was correlated to migraine, while neck pain was correlated to tension-type headache (TTH) or migraine.
ACTA ODONTOLOGICA SCANDINAVICA
(2023)
Review
Nutrition & Dietetics
Irene Ciancarelli, Giovanni Morone, Marco Iosa, Antonio Cerasa, Rocco Salvatore Calabro, Giovanni Iolascon, Francesca Gimigliano, Paolo Tonin, Maria Giuliana Tozzi Ciancarelli
Summary: The effectiveness of neurorehabilitation in stroke patients is influenced by their baseline clinical features and nutritional status. Malnutrition, either pre-stroke or due to ischemic injury, impairs rehabilitation outcomes, while a proper nutritional status promotes neuroplasticity and functional recovery. Nutrition strategies based on food components with oxidative and anti-inflammatory properties can help improve nutritional status and support satisfactory rehabilitative outcomes in stroke patients.
Article
Oncology
Mauro Nascimben, Lorenzo Lippi, Alessandro De Sire, Marco Invernizzi, Lia Rimondini
Summary: The current study employed a cohort of 294 patients to stratify the risk of breast cancer-related lymphedema (BCRL) and identify factors associated with high-risk patients. The findings of this study provide potential insight into precise risk assessment of BCRL patients, with implications in prevention strategies.
Review
Medicine, General & Internal
Nicola Marotta, Alessandro de Sire, Dario Calafiore, Francesco Agostini, Lorenzo Lippi, Claudio Curci, Francesco Ferraro, Andrea Bernetti, Marco Invernizzi, Antonio Ammendolia
Summary: The COVID-19 pandemic has significantly impacted the surgical intervention and rehabilitation plan for ACL injuries. This scoping review examines the potential persistent symptoms and residual effects after COVID-19 disease, focusing on fatigue and neuromuscular disorders. Undertraining and knee muscular imbalance may lead to inefficient movement strategies, lack of knee stability, and increased load in ACL injuries. Telerehabilitation approaches have shown promise in maintaining strength and range of motion during the post-surgery period of COVID-19. However, further research is needed to determine the most effective interventions.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Oncology
Lorenzo Lippi, Alessio Turco, Stefano Moalli, Marco Gallo, Claudio Curci, Antonio Maconi, Alessandro de Sire, Marco Invernizzi
Summary: This review provides a comprehensive overview of prehabilitation and rehabilitation strategies for thyroid cancer survivors, focusing on optimizing functional outcomes and enhancing quality of life. Physical exercise is highlighted as an important component of the rehabilitation process, improving cardiovascular fitness, muscle strength, body composition, and reducing fatigue. Scar management techniques and addressing dysphonia and dysphagia are also emphasized for functional recovery and cosmetic outcomes. Digital innovation and patient-centered approaches are suggested as effective strategies for implementing rehabilitative treatment. Valuable insights are provided for optimizing functional outcomes and enhancing quality of life for thyroid cancer survivors.
Article
Chemistry, Medicinal
Valentina Vassallo, Celeste Di Meo, Giuseppe Toro, Alberto Alfano, Giovanni Iolascon, Chiara Schiraldi
Summary: This study compared the properties of two commercial injective medical devices. The device based on HA/BC complexes showed potentially better performances in treating joint diseases.
Article
Sport Sciences
Antonio Ammendolia, Alessandro de Sire, Lorenzo Lippi, Valerio Ammendolia, Riccardo Spano, Andrea Reggiani, Marco Invernizzi, Nicola Marotta
Summary: This study confirms the positive impact of cryo-ultrasound therapy combined with conventional physical therapy on the short-term recovery of elite football players with acute lateral ankle sprains, accelerating their rehabilitation and early return to sport. However, further research is needed to validate and optimize the long-term effects of this physical therapy modality.
Review
Chemistry, Multidisciplinary
Lorenzo Lippi, Alessio Turco, Stefano Moalli, Mauro Nascimben, Claudio Curci, Alessandro de Sire, Lia Rimondini, Marco Invernizzi
Summary: Upper-limb lymphedema is a chronic condition characterized by lymphatic fluid accumulation, leading to swelling and impairment in the arm or hand. Various methods for volumetric assessment of upper-limb lymphedema have been proposed, but each has specific strengths and limitations. Factors such as operator experience and equipment availability also impact the accuracy and practicality of volume assessment. Precise volumetric assessment is crucial for improving rehabilitation, patient education, and research outcomes.
APPLIED SCIENCES-BASEL
(2023)
Review
Rheumatology
Alessandro de Sire, Lorenzo Lippi, Nicola Marotta, Martina Ferrillo, Arianna Folli, Alessio Turco, Antonio Ammendolia, Marco Invernizzi
Summary: Musculoskeletal disorders (MSD) have significant impacts on physical function, social, and economic costs, making them an important issue in current literature. Rehabilitation has shown positive effects in improving functional outcomes for individuals with MSD, but there are still questions about the underlying mechanisms. This review focuses on the biophysical dimensions of available treatments for MSD and highlights the potential of integrating a biophysical approach to enhance regenerative processes and improve pain management.
THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE
(2023)
Review
Rheumatology
Silvia Migliaccio, Antimo Moretti, Annalisa Biffi, Raffaella Ronco, Gloria Porcu, Giovanni Adami, Rosaria Alvaro, Riccardo Bogini, Achille Patrizio Caputi, Luisella Cianferotti, Bruno Frediani, Davide Gatti, Stefano Gonnelli, Andrea Lenzi, Salvatore Leone, Tiziana Nicoletti, Marco Paoletta, Annalisa Pennini, Eleonora Piccirilli, Raffaella Michieli, Umberto Tarantino, Maurizio Rossini, Giovanni Corrao, Maria Luisa Brandi, Giovanni Iolascon
Summary: This article summarizes the results of a systematic review that examined the association between the continuity of medication treatment and various outcomes in patients with fragility fractures. The findings indicate that adherence to antiosteoporotic drugs can reduce the risk of nonvertebral fractures and refracture, and improve survival rates in patients who continue treatment. Therefore, clinicians should encourage patients to adhere to antiosteoporotic medication.
THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE
(2023)
Review
Geriatrics & Gerontology
Lorenzo Lippi, Alessio Turco, Arianna Folli, Francesco D'Abrosca, Claudio Curci, Kamal Mezian, Alessandro de Sire, Marco Invernizzi
Summary: Several technological advances have been proposed to improve Health-Related Quality of Life (HR-QoL) in older adults with COPD. This study aimed to assess the effects of tele-monitoring devices on HR-QoL in these patients. The findings show that tele-monitoring devices did not significantly improve HR-QoL, but showed positive effects on respiratory events and hospitalization.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Review
Rheumatology
Antimo Moretti, Sara Liguori, Marco Paoletta, Silvia Migliaccio, Giuseppe Toro, Francesca Gimigliano, Giovanni Iolascon
Summary: Bone fragility is associated with aging, comorbidities, disability, poor quality of life, and increased mortality. International guidelines recommend a nutritional approach for managing patients with bone fragility, focusing on optimal protein, calcium, and vitamin D intake. Patients with major fragility fractures often have poor dietary habits and lack intake of nutrients that affect bone health, which can be further worsened during the COVID-19 pandemic. This narrative review discusses the role of macro- and micronutrients in patients with bone fragility during this pandemic.
THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE
(2023)
Review
Biochemistry & Molecular Biology
Cristina Fantini, Clarissa Corinaldesi, Andrea Lenzi, Silvia Migliaccio, Clara Crescioli
Summary: Aging is a natural and unavoidable process that is characterized by the accumulation of biomolecular damage and defective cellular components, resulting in weakened overall body function. Aging is associated with changes in immune system cells, leading to a decline in immune surveillance and an increased risk of inflammation and oxidative stress-related diseases. Nutrition, including micronutrients like vitamins and elements, can play a role in regulating the aging process by impacting cell function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Rheumatology
Maria Chiara Massari, Viviana Maria Bimonte, Lavinia Falcioni, Antimo Moretti, Carlo Baldari, Giovanni Iolascon, Silvia Migliaccio
Summary: 'Frailty' is a state of increased vulnerability caused by impairment of homeostasis due to stress. Frail individuals are more likely to experience significant health decline and have a higher risk of adverse outcomes such as osteoporosis, falls, and disability. Frailty is becoming increasingly important due to global population aging. The pathophysiology of frailty involves cumulative molecular and cellular damage and is partially independent of aging but closely related. Uncorrected nutrition and sedentary behavior worsen frailty.
THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE
(2023)
Review
Medicine, General & Internal
Lorenzo Lippi, Martina Ferrillo, Alessio Turco, Arianna Folli, Stefano Moalli, Fjorelo Refati, Luca Perrero, Antonio Ammendolia, Alessandro de Sire, Marco Invernizzi
Summary: The aim of this narrative review is to elucidate the multilevel benefits and synergies of integrating rehabilitation and hyaluronic acid injections in multidisciplinary osteoarthritis (OA) rehabilitation. Results show that HA injections can improve joint biomechanics, and rehabilitation can enhance muscle strength and overall function. Optimizing rehabilitation following HA injection may provide additional benefits in joint health. OA management requires a multidisciplinary approach integrating HA injections, rehabilitation, and personalized care.
MEDICINA-LITHUANIA
(2023)
