Article
Obstetrics & Gynecology
Nis Brix, Anne Gaml-Sorensen, Andreas Ernst, Linn Hakonsen Arendt, Lea Lykke Harrits Lunddorf, Gunnar Toft, Sandra S. Tottenborg, Katia Keglberg Haervig, Birgit Bjerre Hoyer, Karin S. Hougaard, Jens Peter E. Bonde, Cecilia Host Ramlau-Hansen
Summary: The timing of puberty is associated with semen characteristics, testicular volume, and reproductive hormone levels.
FERTILITY AND STERILITY
(2023)
Article
Obstetrics & Gynecology
Kajsa Ugelvig Petersen, Katia Keglberg Haervig, Jens Peter Bonde, Karin Sorig Hougaard, Gunnar Toft, Cecilia Host Ramlau-Hansen, Johan Hoy Jensen, Laura Deen, Sandra Sogaard Tottenborg
Summary: This study aimed to explore the association between maternal stress during pregnancy and reproductive function in young men. Through a nested cohort study in the Danish National Birth Cohort, the authors found no overall negative associations between maternal stress and male reproductive function. However, maternal emotional stress was associated with higher total sperm count, serum estradiol, and calculated free testosterone. The study highlights the need for further validation of stress measurement during pregnancy and improving our understanding of the full spectrum of fetal stress exposures and their consequences for health.
FERTILITY AND STERILITY
(2022)
Article
Environmental Sciences
Kajsa Ugelvig Petersen, Katia Keglberg Haervig, Esben Meulengracht Flachs, Jens Peter Bonde, Christian Lindh, Karin Sorig Hougaard, Gunnar Toft, Cecilia Host Ramlau-Hansen, Sandra Sogaard Tottenborg
Summary: This study examined the impact of PFAS exposure on reproductive function in young adult males. The results showed a slight association between higher levels of PFAS and follicle-stimulating hormone (FSH) levels, but no consistent associations with semen quality and testicular volume were found.
ENVIRONMENTAL RESEARCH
(2022)
Article
Nutrition & Dietetics
Laurel F. Moffat, Lorrene D. Ritchie, Wendi Gosliner, Kaela R. Plank, Lauren E. Au
Summary: This study found that parental perception of the food environment is associated with children's diet and weight outcomes. Optimizing access to fruits and vegetables at both neighborhood and home levels can help improve children's diet quality. However, the impact may be weaker for children living in food insecure or low-income households.
Article
Obstetrics & Gynecology
Linn H. Arendt, Anne Gaml-Sorensen, Andreas Ernst, Nis Brix, Gunnar Toft, Sandra S. Tottenborg, Karin S. Hougaard, Jens Peter E. Bonde, Cecilia H. Ramlau-Hansen
Summary: This study aimed to investigate the relationship between parental subfecundity, assessed by time to pregnancy and use of medically-assisted reproduction, and the reproductive health of young men. The results showed that there were no significant differences in semen quality or reproductive hormone levels among sons conceived by subfertile couples or with the use of medically-assisted reproduction.
FERTILITY AND STERILITY
(2022)
Article
Nutrition & Dietetics
Jennifer N. Baldwin, Lee M. Ashton, Peta M. Forder, Rebecca L. Haslam, Alexis J. Hure, Deborah J. Loxton, Amanda J. Patterson, Clare E. Collins
Summary: The study found that an increase in fruit and vegetable varieties is associated with lower healthcare claims for healthy weight women, and an increasing fruit and vegetable variety over time is associated with lower healthcare costs.
Article
Environmental Sciences
Qing Chen, Furong Wang, Huan Yang, Xiaogang Wang, Aihua Zhang, Xi Ling, Lianbing Li, Peng Zou, Lei Sun, Linping Huang, Hongqiang Chen, Lin Ao, Jinyi Liu, Jia Cao, Niya Zhou
Summary: The study revealed that various components of PAHs may impact reproductive parameters differently. Inhalation of PAHs in air, especially high molecular weight (HMW) PAHs, may pose a potential risk factor for male reproductive health.
ENVIRONMENTAL POLLUTION
(2021)
Article
Nutrition & Dietetics
Dawid Madej, Dominika Granda, Ewa Sicinska, Joanna Kaluza
Summary: The study found that the consumption of fruit and vegetables was positively correlated with sperm concentration, vitality, motility, and antioxidant status. High consumption of these products may positively influence selected sperm quality parameters by improving the antioxidant status of semen and blood.
FRONTIERS IN NUTRITION
(2021)
Article
Andrology
Ludmila Osadchuk, Larisa Shantanova, Ivan Troev, Maxim Kleshchev, Alexander Osadchuk
Summary: The study compared semen quality and reproductive hormone levels in young men from different cities and ethnic groups in the Siberian region of Russia, finding significant regional and ethnic differences. Ethnicity and environment were suggested to play key roles in these differences.
Article
Nutrition & Dietetics
Nathalie Komati, Florent Vieux, Matthieu Maillot, Nicole Darmon, Johanna Calvarin, Jean-Michel Lecerf, Marie-Josephe Amiot, Luc Belzunces, Delphine Tailliez
Summary: The nutritional quality and environmental impact of self-selected diets in France are related to fruit and vegetable consumption. Increasing fruit and vegetable intake is associated with higher nutritional quality and lower environmental impact, except for water use.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Chemistry, Analytical
Maciej Tankiewicz, Andrzej Berg
Summary: In this study, an enhanced methodology for the determination of 31 currently used pesticides in food samples was proposed. The method involves the use of QuEChERS coupled with GC-MS/MS, and an additional extract preconcentration step to improve the limits of quantification. The validated procedure has been successfully applied to various fruit and vegetable samples.
MICROCHEMICAL JOURNAL
(2022)
Article
Public, Environmental & Occupational Health
Anne Gaml-Sorensen, Nis Brix, Katia Keglberg Haervig, Christian Lindh, Sandra Sogaard Tottenborg, Karin Sorig Hougaard, Birgit Bjerre Hoyer, Andreas Ernst, Linn Hakonsen Arendt, Pernille Jul Clemmensen, Jens Peter Ellekilde Bonde, Tine Brink Henriksen, Gunnar Toft, Onyebuchi A. A. Arah, Cecilia Host Ramlau-Hansen
Summary: Maternal vitamin D levels during pregnancy may have an impact on reproductive health in male offspring, affecting testes volume and total sperm count. This study found that lower maternal vitamin D levels during pregnancy were associated with decreased testes volume and lower total sperm count in adult sons. The findings were supported by continuous models, spline plots, and instrumental variable analysis. Maternal vitamin D levels above 75 nmol/L during pregnancy may be beneficial for testes function in adult sons.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Endocrinology & Metabolism
Ludmila Osadchuk, Maxim Kleshchev, Alexander Osadchuk
Summary: The study found that heavy smokers among young Russian men had poorer semen quality compared to non-smokers, with reductions in sperm volume, count, concentration, and motility, and increases in sperm DNA fragmentation and teratozoospermia. Smoking also led to decreased serum and seminal zinc levels, and impaired metabolic health. The effects of smoking on reproductive function were ethnically specific, with the most significant impact observed in smoking Slavs.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Charlotte M. Hall, Laura Vang Rasmussen, Bronwen Powell, Cecilie Dyngeland, Suhyun Jung, Rasmus Skov Olesen
Summary: This study examines the impact of deforestation and forest fragmentation on people's dietary quality in rural Tanzania and finds that deforestation leads to a reduction in fruit and vegetable consumption, while forest fragmentation increases the consumption of these foods and dietary vitamin A adequacy.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Environmental Sciences
William Battaglin, Paul Bradley, Rebecca Weissinger, Brett Blackwell, Jenna Cavallin, Dan Villeneuve, Laura Decicco, Julie Kinsey
Summary: Long-term water-quality monitoring on the Colorado River downstream from Moab Utah revealed the presence of Bioactive Chemicals (BC), such as pesticides and pharmaceuticals. A study was conducted to investigate the impact of a new wastewater treatment plant (WWTP) on BC input to the river. The results showed that the new plant reduced the concentrations of nutrients, hormones, pharmaceuticals, and other BC. The study highlights the effectiveness of improved WWTP technology in reducing both regulated and non-regulated contaminants in the water.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Andrology
Nina Morup, Ailsa Maria Main, Niels Jorgensen, Gedske Daugaard, Anders Juul, Kristian Almstrup
Summary: This study is the first to report the identification of microbiome species in the seminal plasma of men with TGCT and GCNIS-only, and has found some species differences that may be involved in the pathogenesis of TGCTs. Further studies are needed to confirm these findings.
Article
Oncology
Julie Abildgaard, Hein Vincent Stroomberg, A. Kirstine Bang, Jakob Albrethsen, Laura Smedegaard Kruuse, Anders Juul, Klaus Brasso, Andreas Roder, Niels Jorgensen
Summary: Men with high-risk, non-metastatic prostate cancer receive adjuvant androgen deprivation therapy (ADT) for at least 2 years according to Danish guidelines. It remains unclarified if patients regain the function of the pituitary-testis axis after cessation of ADT. Our study investigated the function of the pituitary-testis axis following adjuvant ADT and found that persistent testosterone deficiency (TD) is a common long-term consequence, equally distributed between pituitary and testicular dysfunction. The study emphasizes the necessity for systematic follow-up of full pituitary-testis axis function in patients receiving adjuvant ADT.
ENDOCRINE-RELATED CANCER
(2023)
Article
Obstetrics & Gynecology
A. H. Hansen, L. Priskorn, L. S. Hansen, E. Carlsen, U. N. Joensen, F. M. Jacobsen, C. F. S. Jensen, N. Jorgensen
Summary: This study aimed to investigate whether prior testicular torsion is associated with testicular function in young men from the general population. The results showed no differences in semen parameters between men who had experienced testicular torsion and controls. However, subtle alterations in reproductive hormones were observed, with higher FSH and lower inhibin B levels in men with prior testicular torsion. Follow-up studies are needed to assess any long-term consequences for fertility.
HUMAN REPRODUCTION
(2023)
Review
Obstetrics & Gynecology
Hagai Levine, Niels Jorgensen, Anderson Martino-Andrade, Jaime Mendiola, Dan Weksler-Derri, Maya Jolles, Rachel Pinotti, Shanna H. Swan
Summary: This study reveals a significant decline in sperm count among men from all continents, with a more pronounced decrease observed post-2000. The decline in sperm count is not limited to North America-Europe-Australia, but also seen in South/Central America-Asia-Africa. Urgent research and action are needed to investigate the causes and prevent further disruption of male reproductive health.
HUMAN REPRODUCTION UPDATE
(2023)
Article
Environmental Sciences
Louise Scheutz Henriksen, Hanne Frederiksen, Niels Jorgensen, Anders Juul, Niels E. Skakkebaek, Jorma Toppari, Jorgen Holm Petersen, Katharina M. Main
Summary: This study aimed to explore if there is an association between fetal phthalate exposure and markers of testicular function in young adult men. The results showed that higher maternal phthalate exposure was associated with higher luteinizing hormone (LH) but unchanged testosterone in adult sons. Additionally, higher maternal exposure was associated with lower total and free testosterone/LH ratios in adult sons.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Medicine, General & Internal
Rune Holt, Sam Kafai Yahyavi, Ireen Kooij, Christine Hjorth Andreassen, Anna-Maria Andersson, Anders Juul, Niels Jorgensen, Martin Blomberg Jensen
Summary: This study investigated the role of circulating AMH in men and found that low serum AMH is associated with severely impaired gonadal function. Vitamin D supplementation had no effect on serum AMH.
Article
Public, Environmental & Occupational Health
Nina Vogel, Hanne Frederiksen, Rosa Lange, Niels Jorgensen, Holger M. Koch, Till Weber, Anna-Maria Andersson, Marike Kolossa-Gehring
Summary: It has been observed over the past 25 years that exposure to certain phthalates can have negative effects on human health, such as disrupting the endocrine system. As a result, the EU implemented regulations which led to a decrease in production of restricted phthalates and an increase in the production of substitutes. A recent study examined the impact of these regulations on exposure patterns in two European populations.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2023)
Article
Cardiac & Cardiovascular Systems
Leslie V. Farland, Yi-Xin Wang, Audrey J. Gaskins, Janet W. Rich-Edwards, Siwen Wang, Maria Christine Magnus, Jorge E. Chavarro, Kathryn M. Rexrode, Stacey A. Missmer
Summary: Infertility is associated with an increased risk of coronary heart disease, but not stroke. The risk differs depending on the age at first infertility diagnosis and the specific cause of infertility.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Endocrinology & Metabolism
Trine Holm Johannsen, Jakob Albrethsen, Vassos Neocleous, Federico Baronio, Martine Cools, Lise Aksglaede, Niels Jorgensen, Peter Christiansen, Meropi Toumba, Pavlos Fanis, Marie Lindhardt Ljubicic, Anders Juul
Summary: Congenital adrenal hyperplasia (CAH) is a recessive condition that affects the adrenal glands. Adult males with CAH, despite hormone replacement therapy, exhibit reduced levels of Leydig and Sertoli cell-derived hormones, including insulin-like factor 3 (INSL3) and testosterone. This study suggests that circulating INSL3 may serve as a biomarker to monitor Leydig cell function in CAH patients, particularly those with testicular adrenal rest tumors.
ENDOCRINE CONNECTIONS
(2023)
Article
Endocrinology & Metabolism
Hans Valdemar Lopez Krabbe, Jorgen Holm Petersen, Louise Laub Asserhoj, Trine Holm Johannsen, Peter Christiansen, Rikke Beck Jensen, Line Hartvig Cleemann, Casper P. Hagen, Laerke Priskorn, Niels Jorgensen, Katharina M. Main, Anders Juul, Lise Aksglaede
Summary: Adult patients with Klinefelter syndrome (KS) exhibit variable phenotypes and a high risk of metabolic disorders. Most adults require testosterone replacement therapy (TRT), but its use during puberty is debated. This study found that patients with KS have unfavorable body composition and impaired bone mineral status already during childhood and adolescence. Further research is needed to evaluate the effects of TRT during puberty on these parameters.
ENDOCRINE CONNECTIONS
(2023)
Article
Environmental Sciences
Nina Vogel, Rosa Lange, Phillipp Schmidt, Laura Rodriguez Martin, Sylvie Remy., Andrea Springer, Vladimira Puklova, Milena Cerna, Peter Rudnai, Szilvia Kozepesy, Beata Janasik, Danuta Ligocka, Lucia Fabelova, Branislav Kolena, Ida Petrovicova, Michal Jajcaj, Milada Estokova, Marta Esteban-Lopez, Argelia Castano, Janja Snoj Tratnik, Anja Stajnko, Lisbeth E. Knudsen, Jorma Toppari, Katharina M. Main, Anders Juul, Anna-Maria Andersson, Niels Jorgensen, Hanne Frederiksen, Cathrine Thomsen, Amrit Kaur Sakhi, Agneta Akesson, Christina Hartmann, Marie Christine Dewolf, Gudrun Koppen, Pierre Biot, Elly Den Hond, Stefan Voorspoels, Liese Gilles, Eva Govarts, Aline Murawski, Antje Gerofke, Till Weber, Maria Ruether, Arno C. Gutleb, Cedric Guignard, Tamar Berman, Holger M. Koch, Marike Kolossa-Gehring
Summary: Phthalates are widely used as plasticizers and can have negative impacts on reproductive functions. However, existing human biomonitoring studies on internal exposure to phthalates in Europe differ in many aspects, making comparability challenging. The HBM4EU initiative gathered data from 29 studies across Europe to describe the general population's exposure to phthalates from 2005 to 2019. This study is an important step towards making internal exposures to phthalates comparable across countries and provides suggestions for improved harmonization in future studies.
Article
Obstetrics & Gynecology
Siwen Wang, Audrey J. Gaskins, Leslie V. Farland, Dan Zhang, Brenda M. Birmann, Janet W. Rich-Edwards, Yi-Xin Wang, Rulla M. Tamimi, Stacey A. Missmer, Jorge E. Chavarro
Summary: This prospective cohort study examined the association between infertility and the incidence of invasive cancer in women. It found that women who reported infertility had a higher risk of developing cancer, especially obesity-related reproductive cancers. The risk was also higher for women who first reported infertility at a younger age.
FERTILITY AND STERILITY
(2023)
Article
Obstetrics & Gynecology
N. Jimenez-Cardozo, M. Mitsunami, L. Minguez-Alarcon, E. Ortiz-Panozo, S. Wang, I Souter, R. Hauser, J. E. Chavarro
Summary: This study found that supplemental iron intake above 45 mg/day is associated with lower ovarian reserve among women seeking fertility care.
HUMAN REPRODUCTION
(2023)
Article
Endocrinology & Metabolism
Diana C. C. Soria-Contreras, Izzuddin M. M. Aris, Sheryl L. L. Rifas-Shiman, Wei Perng, Marie-France Hivert, Jorge E. E. Chavarro, Emily Oken
Summary: This study aimed to evaluate the associations of age at first birth and parity with weight, waist circumference (WC), and body fat across midlife. A secondary data analysis was conducted with 735 participants from Project Viva. The results showed that women who had their first birth before age 23 years or after age 40 years, as well as those with four or more births, had a higher trajectory of weight, WC, and body fat after their final birth.
Article
Andrology
Rune Holt, Sam Kafai Yahyavi, Ireen Kooij, Nadia Nicholine Poulsen, Anders Juul, Niels Jorgensen, Martin Blomberg Jensen
Summary: This study aimed to investigate whether vitamin D supplementation has an impact on sex steroid production in infertile men with vitamin D insufficiency. The results showed that vitamin D supplementation did not alter sex steroid production in infertile men overall, but in men with vitamin D insufficiency, it significantly increased testosterone/luteinizing hormone ratio.