期刊
JOURNAL OF NUCLEAR MEDICINE
卷 58, 期 7, 页码 1037-1042出版社
SOC NUCLEAR MEDICINE INC
DOI: 10.2967/jnumed.116.183335
关键词
F-18-fluciclovine; PET/CT; ductal breast cancer; lobular breast cancer; response
资金
- Susan G. Komen for the Cure [KG110441]
- Memorial Sloan Kettering Cancer Center (MSKCC) Biostatistics Core Facility and Radiochemistry and Molecular Imaging Probes Core Facility [P30 CA008748]
- MSKCC
- GE Healthcare
F-18-labeled 1-amino-3-fluorocyclobutane-1-carboxylic acid (F-18-fluciclovine) is a leucine analog radiotracer that depicts amino acid transport into cells. F-18-fluciclovine PET/CT visualizes malignancy, including prostate cancer, invasive ductal breast cancer, and invasive lobular breast cancer. Whether changes in F-18-fluciclovine avidity reflect changes in tumor burden resulting from treatment has not been shown. In this prospective clinical trial (clinical trials.gov: NCT01864083), changes in F-18-fluciclovine avidity after neoadjuvant therapy were compared to breast cancer therapy response, as determined by residual tumor burden on pathology, were evaluated. Methods: Twenty-four women with a new diagnosis of locally advanced invasive ductal breast cancer (n = 18) or invasive lobular breast cancer (n = 6) underwent F-18-fluciclovine PET/CT before and after the completion of neoadjuvant systemic therapy. SUVmax, SUVmean, metabolic tumor volume, and total lesion avidity were obtained for the primary breast tumor, axillary lymph nodes, and extraaxillary lymph nodes on each examination and corrected for background F-18-fluciclovine avidity. The relationship between changes in F-18-fluciclovine avidity and the percentage of reduction of tumor on pathology was assessed with the Spearman rank correlation. Results: The median decrease in the corrected SUVmax of the primary breast lesions was 99% (range, 33%-100%). The median reduction of tumor on pathology was 92% (range, 10%-100%). Changes in F-18-fluciclovine avidity were strongly correlated with the percentage of reduction of tumor on pathology (Spearman rho, 0.79; 95% CI, 0.56-0.90; P < 0.001). Conclusion: Changes in F-18-fluciclovine avidity strongly correlated with the tumor response on pathology in this pilot study.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据