Article
Radiology, Nuclear Medicine & Medical Imaging
Colin Groot, Sylvia Villeneuve, Ruben Smith, Oskar Hansson, Rik Ossenkoppele
Summary: The introduction of PET ligands that bind tau pathology has allowed for the quantification and visualization of tau pathology in aging and Alzheimer's disease. While these ligands are effective in binding tau aggregates in advanced stages of AD, their binding in non-AD tauopathies is weaker and overlaps with known off-target binding regions. An increased neocortical tau PET signal holds important prognostic information, and tau PET shows great potential as a prognostic marker in symptomatic stages of AD. For differential diagnosis, tau PET is primarily useful in distinguishing AD dementia from other neurodegenerative diseases, but its performance decreases in the mild cognitive impairment stage of AD.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Neurosciences
Heike Endepols, Boris D. Zlatopolskiy, Johannes Zischler, Nazanin Alavinejad, Nadine Apetz, Stefanie Vus, Alexander Drzezga, Bernd Neumaier
Summary: The study demonstrated the visualization of inflammation related to the kynurenine pathway and changes in serotonin synthesis using the novel PET tracer. The 7-[F-18]FTrp PET tracer has great potential in localizing pathway alterations in the brain.
Article
Agriculture, Dairy & Animal Science
Sara Caceres, Julia Moreno, Belen Crespo, Gema Silvan, Juan Carlos Illera
Summary: In this study, the physiological stress response of calves during a sport similar to rodeo called persecution and takedown was assessed. The results showed that the sport produced a physiological response of adaptive stress for the animals, although the response varied between different breeds of calves.
Article
Radiology, Nuclear Medicine & Medical Imaging
Solveig Tiepolt, Philipp M. Meyer, Marianne Patt, Winnie Deuther-Conrad, Swen Hesse, Henryk Barthel, Osama Sabri
Summary: This review summarizes the current knowledge on positron emission tomography (PET) imaging of cholinergic neurotransmission in neurodegenerative diseases. Research suggests that PET imaging of cholinergic receptors, transporters, enzymes, and acetylcholinesterase can provide valuable insights into the diagnosis, monitoring, and treatment of neurodegenerative diseases.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Francesco Petragnano, Irene Fasciani, Clotilde Mannoury la Cour, Benjamin di Cara, Gabriella Aloisi, Marco Carli, Shivakumar Kolachalam, Mario Rossi, Francesco Marampon, Marco Scarselli, Mark J. Millan, Roberto Maggio
Summary: This study investigates the affinity and activation of (+)-4-Propyl-9-hydroxynaphthoxazine on various monoamine receptors. It is found to have high affinity for hD(4.4), h5-HT1A, and h5-HT7 receptors, as well as hD(3) and hD(2L) receptors. It also strongly activates dopamine hD(3)-hD(2L) heterodimers. These findings are important for interpreting PET studies and may have implications for the treatment of Parkinson's disease and other disorders.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Neurosciences
Takuya Toyonaga, Arman Fesharaki-Zadeh, Stephen M. Strittmatter, Richard E. Carson, Zhengxin Cai
Summary: The development of novel PET imaging agents for SV2A allowed for the in vivo detection of synaptic density changes, and preclinical SV2A PET imaging in animal models provides supporting information. This article discusses key considerations when designing preclinical SV2A PET imaging studies and strategies for data analysis, as well as the challenges and opportunities in small animal SV2A PET imaging.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Andreas-Antonios Roussakis, Zhou Zeng, Nicholas P. Lao-Kaim, Antonio Martin-Bastida, Paola Piccini
Summary: The study found that in moderate-stage Parkinson's disease, asymmetry in striatal dopaminergic degeneration becomes less prominent over time, while the asymmetry of motor symptoms remains consistent between the clinically most and least affected body sides.
JOURNAL OF NEUROLOGY
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Marianne Chapleau, Leonardo Iaccarino, David Soleimani-Meigooni, Gil D. Rabinovici
Summary: This article provides an up-to-date overview of the application of amyloid PET in neurodegenerative diseases, including analysis of clinical, pathological, and imaging data, comparison with other available biomarkers, and review of its use in clinical trials and clinical utility studies.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Physiology
Tomas Ros, Jessica Kwiek, Theo Andriot, Abele Michela, Patrik Vuilleumier, Valentina Garibotto, Nathalie Ginovart
Summary: The study aimed to evaluate the impact of neurofeedback on endogenous dopamine release using positron emission tomography (PET). Significant dopamine release was observed in the frontal cortex and anterior cingulate cortex in both neurofeedback and electromyography training groups, suggesting a potential link between changes in brain state and neuromodulation. This study represents the first direct investigation of neurofeedback's effect on endogenous release of a key neuromodulator, demonstrating its feasibility for future research.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Nuclear Science & Technology
Hankyeol Song, In Soo Kang, Kyu Bom Kim, Chanwoo Park, Min Kyu Baek, Seongyeon Lee, Yong Hyun Chung
Summary: A novel rectangular-shaped PET system with an adjustable gantry (AGPET) has been developed, utilizing a new depth of interaction (DOI) method and digital time pickoff method. Experimental results demonstrate that the AGPET system provides higher sensitivity and resolution for small animal imaging.
NUCLEAR ENGINEERING AND TECHNOLOGY
(2021)
Article
Behavioral Sciences
Young-A Lee, Yukiori Goto
Summary: ADHD and MDD, two seemingly unrelated psychiatric disorders, are actually associated with each other and exhibit high comorbidity rates. Genetic studies have shown substantial overlaps of susceptibility genes between the two disorders. The hypothesis proposes that habenula dysfunction may play a key role in both ADHD and MDD, with hyperactivity in response to stress potentially increasing vulnerability to MDD in adulthood.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Psychology, Biological
Qihang Liang, Boshan Zhu, Dapeng Liu, Yunliang Lu, Hanzun Zhang, Fang Wang
Summary: Bioamines play a crucial role in regulating aggressive behavior in animals as neuroendocrine substances. This study investigated the effects of serotonin and dopamine on the aggressiveness of swimming crabs. The results showed that both serotonin and dopamine can enhance aggressive behavior in a dose-dependent manner.
PHYSIOLOGY & BEHAVIOR
(2023)
Article
Environmental Sciences
Naseer Maliyakkal, Uzma Saleem, Fareeha Anwar, Muhammad Ajmal Shah, Bashir Ahmad, Filzah Umer, Mohammad Ali Abdullah Almoyad, Della Grace Thomas Parambi, Asmy Appadath Beeran, Lekshmi R. Nath, Lotfi Aleya, Bijo Mathew
Summary: Parkinson's disease is a progressive neurodegenerative disorder affecting primarily the elderly. The compound E7 demonstrated anti-Parkinson activity in a haloperidol-induced animal model of mice, showing improved locomotor activity and motor coordination in the treatment group. Oxidative stress biomarkers and neurotransmitter levels were influenced by E7 treatment, with dose-dependent effects observed. E7 compound exhibited more evident anti-Parkinson activity at 30 mg/kg oral dose in mice.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Daniel Aaron Vazquez-Matias, Erik F. J. de Vries, Rudi A. J. O. Dierckx, Janine Doorduin
Summary: Major depressive disorder is a growing and poorly understood pathology that requires research in animal paradigms due to technical and ethical limitations. PET imaging has been used in preclinical studies to investigate glucose metabolism, neuroreceptor populations, and the inflammatory response associated with depressive phenotypes. This review summarizes the findings in animal models and discusses the relevance of PET imaging for understanding depression and developing new therapies.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Psychology, Biological
Kristoffer A. Lundgren, Robin N. Abbey-Lee, Laura C. Garnham, Anastasia Kreshchenko, Sara Ryding, Hanne Lovlie
Summary: By manipulating the monoaminergic systems of Mediterranean field crickets, the study investigated the effect of the dopamine antagonist Fluphenazine on activity, exploration, boldness, and aggression. Results showed that Fluphenazine manipulation led to decreased levels of exploration and boldness, but had no effect on activity or aggression. This suggests a causal role of monoamines in explaining behavioral variation associated with animal personality, with effects being dependent on dose and behavior type.
BEHAVIOURAL PROCESSES
(2021)
Article
Chemistry, Medicinal
Longbin Liu, Peter D. Johnson, Michael E. Prime, Vinod Khetarpal, Matthew R. Lee, Christopher J. Brown, Xuemei Chen, Daniel Clark-Frew, Samuel Coe, Mike Conlon, Randall Davis, Samantha Ensor, Simone Esposito, Anton Forsberg Moren, Xinjie Gai, Samantha Green, Catherine Greenaway, James Haber, Christer Halldin, Sarah Hayes, Todd Herbst, Frank Herrmann, Manuela He-mann, Ming Min Hsai, Adrian Kotey, John E. Mangette, Matthew R. Mills, Edith Monteagudo, Sangram Nag, Martina Nibbio, Laura Orsatti, Sabine Schaertl, Christoph Scheich, Joanne Sproston, Vladimir Stepanov, Katarina Varnas, Andrea Varrone, John Wityak, Ladislav Mrzljak, Ignacio Munoz-Sanjuan, Jonathan A. Bard, Celia Dominguez
Summary: A class of ligands binding to oligomerized/aggregated mHTT has been developed as potential imaging biomarkers for HD therapeutic development. Optimization of the benzo[4,5]imidazo[1,2-a]pyrimidine series showed selective binding to mHTT aggregates. Compound [C-11]-2 was selected as a clinical candidate based on its high free fraction in the brain, specific binding in the HD mouse model, and rapid brain uptake/washout in nonhuman primate PET imaging studies.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Clinical Neurology
Sandra Tamm, Catarina Lensmar, Anna Andreasson, John Axelsson, Anton Forsberg Moren, Johan Grunewald, Par Gyllfors, Bianka Karshikoff, Eva Kosek, Jon Lampa, Caroline Olgart Hoglund, Victoria Strand, Simon Cervenka, Mats Lekander
Summary: The study tentatively indicates that both patients with allergy and RA display sleep alterations, but inflammation is not an independent predictor of sleep disturbance across these patient groups.
NATURE AND SCIENCE OF SLEEP
(2021)
Article
Biochemistry & Molecular Biology
Sangram Nag, Patricia Miranda-Azpiazu, Zhisheng Jia, Prodip Datta, Ryosuke Arakawa, Mohammad Mahdi Moein, Zhou Yang, Yaoquan Tu, Laetitia Lemoine, Hans Agren, Agneta Nordberg, Bengt Langstrom, Christer Halldin
Summary: The homo-pentameric alpha 7 receptor is a major type of neuronal nicotinic acetylcholine receptors related to cognition, memory formation, and attention processing. Mapping alpha 7-nAChRs by PET is important for understanding CNS diseases. F-18-ASEM is a functional PET radioligand for quantifying alpha 7-nAChRs in the human brain. In this study, in silico and machine learning techniques were used to predict binding energy and evaluate analogues of ASEM.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Neurosciences
Patrik Mattsson, Zsolt Cselenyi, Bengt Andree, Jacqueline Borg, Sangram Nag, Christer Halldin, Lars Farde
Summary: This study used positron emission tomography (PET) to examine the binding of the 5-HT1A receptor in mild Alzheimer's disease (AD) patients and elderly controls. The results showed lower receptor binding in AD patients compared to controls, with statistically significant differences in the hippocampus, entorhinal cortex, and amygdala. There was also a significant correlation between hippocampal binding and Disability Assessment for Dementia scores.
Article
Radiology, Nuclear Medicine & Medical Imaging
Ryosuke Arakawa, Akihiro Takano, Sangram Nag, Zhisheng Jia, Nahid Amini, Kevin P. Maresca, Lei Zhang, Edmund J. Keliher, Christopher R. Butler, Justin R. Piro, Tarek A. Samad, Deborah Smith, Deane Nason, Steve O'Neil, Patrick Trapa, Kari R. Fonseca, John Litchfield, Timothy McCarthy, Richard E. Carson, Christer Halldin
Summary: This study evaluated the feasibility of using [C-11]PF-06809247 as a PET ligand for MAGL in the non-human primate brain and measured its distribution in the whole body. The results suggest that [C-11]PF-06809247 has promising potential for use as a PET ligand for studying MAGL in the human brain.
Article
Biochemistry & Molecular Biology
Kenneth Dahl, Peter Johnstrom, Anton Forsberg-Moren, Bjorn Gustafsson, Patricia Miranda-Azpiazu, Yaser Khani, Christer Halldin, Lars Farde, Charles S. Elmore, Magnus Schou
Summary: This study reports the preparation and evaluation of two candidate 5-HT1A radioligands in vitro and in vivo. Although one of the radioligands showed high specific binding in human brain tissue, its regional binding potential values in cynomolgus monkey brain were low, suggesting it is not suitable for further investigation.
ACS CHEMICAL NEUROSCIENCE
(2022)
Correction
Biochemistry & Molecular Biology
Sangram Nag, Patricia Miranda-Azpiazu, Zhisheng Jia, Prodip Datta, Ryosuke Arakawa, Mohammad Moein, Zhou Yang, Yaoquan Tu, Laetitia Lemoine, Hans Agren, Agneta Nordberg, Bengt Langstrom, Christer Halldin
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Endocrinology & Metabolism
Joachim Brumberg, Richard Aarnio, Anton Forsberg, Paivi Marjamaki, Vera Kerstens, Mohammad M. Moein, Sangram Nag, Saara Wahlroos, Michael Kassiou, Albert D. Windhorst, Christer Halldin, Merja Haaparanta-Solin, Patrik Fazio, Vesa Oikonen, Juha O. Rinne, Andrea Varrone
Summary: This study evaluated the concentrations of the parent compound and metabolites of [C-11]SMW139 in the plasma of mice and humans using radioHPLC. Three major metabolite peaks were observed in the plasma of all subjects, and two metabolite peaks were also found in mouse brain homogenates. Compartment modeling with correction for brain-penetrant metabolites improved the accuracy of quantifying [C-11]SMW139 binding to P2X(7)R in the human brain.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Hemantha Mallapura, Laurent Tanguy, Bengt Langstrom, Ludovic Le Meunier, Christer Halldin, Sangram Nag
Summary: In this study, a fully automated microfluidic radiosynthesizer was used to produce [C-11]flumazenil and [C-11]L-deprenyl, two PET radioligands. The radiochemical purities of the final products were over 98%, and the molar activity met the requirements. The iMiDEV (TM) microfluidic radiosynthesizer proved to be a successful tool for the synthesis of these radiotracers.
Article
Biochemistry & Molecular Biology
Sangram Nag, Ryosuke Arakawa, Zhisheng Jia, Erik Lachapelle, Lei Zhang, Kevin Maresca, Laigao Chen, Mahabuba Jahan, Timothy Mccarthy, Christer Halldin
Summary: This study aimed to synthesize a novel M4 PAM PET radioligand [11C]PF06885190 and evaluate its brain distribution and radiometabolites in nonhuman primates (NHP). The results showed moderate brain uptake of [C-11]PF06885190 in NHP, but rapid wash-out after 10 minutes. These data suggest that [C-11]PF06885190 may have too low specific binding for further application in PET imaging.
Article
Biochemistry & Molecular Biology
Katarina Varnas, Sangram Nag, Christer Halldin, Lars Farde
Summary: In this study, a novel reversible radioligand[F-18]GEH200449 for MAO-B was evaluated as a PET imaging marker in non-human primates. The PET studies demonstrated that [F-18]GEH200449 had suitable brain exposure and regional distribution consistent with the known localization of MAO-B. The binding of [F-18]GEH200449 to MAO-B was reversible and could be displaced by the administration of selective MAO-B ligands.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Sangram Nag, Martin Bolin, Prodip Datta, Ryosuke Arakawa, Anton Forsberg Moren, Yasir Khani Maynaq, Edward Lin, Nathan Genung, Heike Hering, Kevin Guckian, Laurent Martarello, Maciej Kaliszczak, Christer Halldin
Summary: Imaging O-GlcNAcase OGA using positron emission tomography (PET) can provide important information on neurodegenerative diseases and drug-target engagement. This study aimed to develop a method for labeling BIO-1819578 with carbon-11 using CO-C-11 and evaluate its potential for measuring OGA enzyme levels in non-human primate brains. Radiolabeling was achieved through a one-pot carbonylation reaction using C-11 carbon monoxide. PET measurements were used to evaluate the brain distribution of [C-11]BIO-1819578 in non-human primates, showing specific binding to the OGA enzyme. This suggests that [C-11]BIO-1819578 has potential as a radioligand for imaging and measuring OGA target engagement in the human brain.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yuichi Wakabayashi, Per Stenkrona, Ryosuke Arakawa, Xuefeng Yan, Maia G. Van Buskirk, Madeline D. Jenkins, Jose A. Montero Santamaria, Kevin P. Maresca, Akihiro Takano, Jeih-San Liow, Thomas A. Chappie, Andrea Varrone, Sangram Nag, Lei Zhang, Zoe A. Hughes, Christopher J. Schmidt, Shawn D. Doran, Andrew Mannes, Paolo Zanotti-Fregonara, Maarten Ooms, Cheryl L. Morse, Sami S. Zoghbi, Christer Halldin, Victor W. Pike, Robert B. Innis
Summary: This study evaluated the properties of a newly developed selective PDE4B radioligand in the brains of rodents, monkeys, and humans. The results showed that the radioligand could quantify PDE4B in the human brain reasonably well, and it has the potential to be used in clinical studies.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Review
Chemistry, Medicinal
Aruna Korde, Renata Mikolajczak, Petra Kolenc, Penelope Bouziotis, Hadis Westin, Mette Lauritzen, Michel Koole, Matthias Manfred Herth, Manuel Bardies, Andre F. Martins, Antonio Paulo, Serge K. Lyashchenko, Sergio Todde, Sangram Nag, Efthimis Lamprou, Antero Abrunhosa, Francesco Giammarile, Clemens Decristoforo
Summary: This article summarizes the considerations for non-clinical studies in the clinical translation of radiopharmaceuticals, including pharmacology, radiation exposure and effects, toxicology studies, pharmacokinetic modeling, imaging studies, and standardization of different clinical applications.
EJNMMI RADIOPHARMACY AND CHEMISTRY
(2022)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
Sangram Nag, Ryosuke Arakawa, Prodip Datta, Anton Moren, Andrea Varrone, Mohammad Mahdi Moein, Martin Bolin, Edward Lin, Nathan Genung, Laurent Martarello, Maciej Kaliszczak, Christer Halldin
NUCLEAR MEDICINE AND BIOLOGY
(2022)