Inhibition of Eicosanoid Degradation Mitigates Fibrosis of the Heart

15-Hydroxyprostaglandin dehydrogenase inhibitor prevents contrast-induced acute kidney injury

(2021) Byeong Woo Kim et al.   RENAL FAILURE

Cardiovascular safety of the tyrosine kinase inhibitor nintedanib

(2021) Pietro Ameri et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

HDAC Inhibition Reverses Preexisting Diastolic Dysfunction and Blocks Covert Extracellular Matrix Remodeling

(2021) Joshua G. Travers et al.   CIRCULATION

Myofibroblast de-differentiation proceeds via distinct transcriptomic and phenotypic transitions

(2021) Sean M. Fortier et al.   JCI Insight

15-PGDH inhibition activates the splenic niche to promote hematopoietic regeneration

(2021) Julianne N.P. Smith et al.   JCI Insight

Prevention of Fibrosis and Pathological Cardiac Remodeling by Salinomycin

(2021) Ryan M Burke et al.   CIRCULATION RESEARCH

Pirfenidone in heart failure with preserved ejection fraction: a randomized phase 2 trial

(2021) Gavin A. Lewis et al.   NATURE MEDICINE

Cardiac fibrosis models using human induced pluripotent stem cell-derived cardiac tissues allow anti-fibrotic drug screening in vitro

(2021) Hiroko Iseoka et al.   Stem Cell Research

Effects of SW033291 on the myogenesis of muscle-derived stem cells and muscle regeneration

(2020) Yuanqiang Dong et al.   Stem Cell Research & Therapy

Sensory nerves regulate mesenchymal stromal cell lineage commitment by tuning sympathetic tones

(2020) Bo Hu et al.   JOURNAL OF CLINICAL INVESTIGATION

A high-content, in vitro cardiac fibrosis assay for high-throughput, phenotypic identification of compounds with anti-fibrotic activity

(2020) G. Palano et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Pharmacologic Blockade of 15-PGDH Protects Against Acute Renal Injury Induced by LPS in Mice

(2020) Shuying Miao et al.   Frontiers in Physiology

Therapeutic targeting of 15-PGDH in murine pulmonary fibrosis

(2020) Julianne N. P. Smith et al.   Scientific Reports

Prostaglandin E2 mediates sensory nerve regulation of bone homeostasis

(2019) Hao Chen et al.   Nature Communications

Myofibroblast Phenotype and Reversibility of Fibrosis in Patients With End-Stage Heart Failure

(2019) Chandan K. Nagaraju et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Nitrosative stress drives heart failure with preserved ejection fraction

(2019) Gabriele G. Schiattarella et al.   NATURE

Inhibiting eicosanoid degradation exerts antifibrotic effects in a pulmonary fibrosis mouse model and human tissue

(2019) Thomas Bärnthaler et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Extracellular signal-regulated kinase (ERK) activation preserves cardiac function in pressure overload induced hypertrophy

(2018) Michael Mutlak et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Resident fibroblast expansion during cardiac growth and remodeling

(2018) Malina J. Ivey et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

FGF2-mediated attenuation of myofibroblast activation is modulated by distinct MAPK signaling pathways in human dermal fibroblasts

(2017) David M. Dolivo et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

IL11 is a crucial determinant of cardiovascular fibrosis

(2017) Sebastian Schafer et al.   NATURE

Redefining the identity of cardiac fibroblasts

(2017) Michelle D. Tallquist et al.   Nature Reviews Cardiology

The Processes and Mechanisms of Cardiac and Pulmonary Fibrosis

(2017) Lucy A. Murtha et al.   Frontiers in Physiology

Targeted Ablation of Periostin-Expressing Activated Fibroblasts Prevents Adverse Cardiac Remodeling in MiceNovelty and Significance

(2016) Harmandeep Kaur et al.   CIRCULATION RESEARCH

Cardiac Fibrosis

(2016) Joshua G. Travers et al.   CIRCULATION RESEARCH

Origins of cardiac fibroblasts

(2016) Thomas Moore-Morris et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

(2016) Maxim V. Kuleshov et al.   NUCLEIC ACIDS RESEARCH

Genetic lineage tracing defines myofibroblast origin and function in the injured heart

(2016) Onur Kanisicak et al.   Nature Communications

Myocardial Stiffness in Patients With Heart Failure and a Preserved Ejection Fraction: Contributions of Collagen and Titin

(2015) M. R. Zile et al.   CIRCULATION

Hepatic stellate cell-expressed endosialin balances fibrogenesis and hepatocyte proliferation during liver damage

(2015) C. Mogler et al.   EMBO Molecular Medicine

Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration

(2015) Y. Zhang et al.   SCIENCE

High-efficiency reprogramming of fibroblasts into cardiomyocytes requires suppression of pro-fibrotic signalling

(2015) Yuanbiao Zhao et al.   Nature Communications

Repair and Regeneration of the Respiratory System: Complexity, Plasticity, and Mechanisms of Lung Stem Cell Function

(2014) Brigid L.M. Hogan et al.   Cell Stem Cell

Reversible Modulation of Myofibroblast Differentiation in Adipose-Derived Mesenchymal Stem Cells

(2014) Vivek D. Desai et al.   PLoS One

Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool

(2013) Edward Y Chen et al.   BMC BIOINFORMATICS

EGF Positively Regulates the Proliferation and Migration, and Negatively Regulates the Myofibroblast Differentiation of Periodontal Ligament-Derived Endothelial Progenitor Cells through MEK/ERK- and JNK-Dependent Signals

(2013) Hitomichi Kimura et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials

(2013)   LANCET

Stromal cells in tissue homeostasis: balancing regeneration and fibrosis

(2013) Ton J. Rabelink et al.   Nature Reviews Nephrology

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Identification of the Orphan G Protein-coupled Receptor GPR31 as a Receptor for 12-(S)-Hydroxyeicosatetraenoic Acid

(2011) Yande Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The contribution of prostaglandins versus prostacyclin in ventricular remodeling during heart failure

(2011) Pamela Harding et al.   LIFE SCIENCES

Extracellular Signal-Regulated Kinases 1 and 2 Regulate the Balance Between Eccentric and Concentric Cardiac Growth

(2010) Izhak Kehat et al.   CIRCULATION RESEARCH

Novel trends in high-throughput screening

(2009) Lorenz M Mayr et al.   CURRENT OPINION IN PHARMACOLOGY

Myocardial remodeling after infarction: the role of myofibroblasts

(2009) Susanne W. M. van den Borne et al.   Nature Reviews Cardiology

Transcellular biosynthesis of cysteinyl leukotrienes in vivo during mouse peritoneal inflammation

(2009) S. Zarini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fibroblast growth factor represses Smad-mediated myofibroblast activation in aortic valvular interstitial cells

(2008) Melinda C. Cushing et al.   FASEB JOURNAL