Article
Clinical Neurology
Haijing Huang, Fan Wang, Yiming Chen, Shuqi Kong, Qinte Huang, Dongbin Lyu, Weichieh Yang, Zheyi Wei, Nuoshi Qian, Mengke Zhang, Chenglin Wu, Jie Zhao, Lan Cao, Zhiguo Wu, Daihui Peng, Yiru Fang, Wu Hong
Summary: This study aimed to investigate the efficacy of escitalopram and mirtazapine in improving circadian rhythm, DMV, and daily activity in MDD patients. Results showed that both medications have superior anti-depressive effects, especially in patients without DMV. Escitalopram was more effective in daily activity, feeling slowed down, and concentration difficulty, while mirtazapine was more effective in improving sleep, appetite, and weight in MDD patients.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
Hang-Ju Yang, Wan-Ju Cheng, Mi-Chun Hsiao, Sheng-Che Huang, Tomohide Kubo, Liang-Wen Hang, Wei-Sheng Lee
Summary: This study examined the association between rest-activity rhythm changes and mood symptoms and attention in patients with depressive disorder. The results showed that changes in rest-activity rhythm were associated with depressive symptom severity and attention.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Cell Biology
Shiwan Tao, Yamin Zhang, Qiang Wang, Chunxia Qiao, Wei Deng, Sugai Liang, Jinxue Wei, Wei Wei, Hua Yu, Xiaojing Li, Mingli Li, Wanjun Guo, Xiaohong Ma, Liansheng Zhao, Tao Li
Summary: This study identified transdiagnostic subtypes of schizophrenia, bipolar disorder, and major depressive disorder based on lipidomics abnormalities. The two subtypes differed in clinical diagnosis, functional impairment, and brain white matter abnormalities.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Endocrinology & Metabolism
Xu He, Ruihuan Zhang, Zhe Li, Zhen Yao, Xiaoxia Xie, Ruoxue Bai, Lan Li, Xu Zhang, Sha Zhang, Yan Shen, Shaowei Li, Zhenliang Hui, Rongrong Liu, Jun Chen
Summary: Circadian rhythm disorder is a significant risk factor for mental diseases, and the recovery of circadian rhythm function has gradually become a signal of effective antidepressant therapy. This study explored the efficacy of Sini powder (SNP) on depression by regulating circadian rhythm. The results showed that SNP had a positive impact on improving circadian rhythms in patients with major depressive disorder.
JOURNAL OF PINEAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Laura Orsolini, Simone Pompili, Silvia Tempia Valenta, Virginio Salvi, Umberto Volpe
Summary: This study reviewed the literature on the association between C-Reactive Protein (CRP) and depression. Evidence suggested dysregulation in the inflammation system in individuals with depression, with higher blood CRP levels being associated with greater symptom severity and worse treatment response. Some depressed patients showed a low-grade inflammatory state, suggesting a distinct subgroup within major depressive disorder.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Laura K. M. Han, Richard Dinga, Tim Hahn, Christopher R. K. Ching, Lisa T. Eyler, Lyubomir Aftanas, Moji Aghajani, Andre Aleman, Bernhard T. Baune, Klaus Berger, Ivan Brak, Geraldo Busatto Filho, Angela Carballedo, Colm G. Connolly, Baptiste Couvy-Duchesne, Kathryn R. Cullen, Udo Dannlowski, Christopher G. Davey, Danai Dima, Fabio L. S. Duran, Verena Enneking, Elena Filimonova, Stefan Frenzel, Thomas Frodl, Cynthia H. Y. Fu, Beata R. Godlewska, Ian H. Gotlib, Hans J. Grabe, Nynke A. Groenewold, Dominik Grotegerd, Oliver Gruber, Geoffrey B. Hall, Ben J. Harrison, Sean N. Hatton, Marco Hermesdorf, Ian B. Hickie, Tiffany C. Ho, Norbert Hosten, Andreas Jansen, Claas Kaehler, Tilo Kircher, Bonnie Klimes-Dougan, Bernd Kraemer, Axel Krug, Jim Lagopoulos, Ramona Leenings, Frank P. MacMaster, Glenda MacQueen, Andrew McIntosh, Quinn McLellan, Katie L. McMahon, Sarah E. Medland, Bryon A. Mueller, Benson Mwangi, Evgeny Osipov, Maria J. Portella, Elena Pozzi, Liesbeth Reneman, Jonathan Repple, Pedro G. P. Rosa, Matthew D. Sacchet, Philipp G. Saemann, Knut Schnell, Anouk Schrantee, Egle Simulionyte, Jair C. Soares, Jens Sommer, Dan J. Stein, Olaf Steinstraeter, Lachlan T. Strike, Sophia I. Thomopoulos, Marie-Jose van Tol, Ilya M. Veer, Robert R. J. M. Vermeiren, Henrik Walter, Nic J. A. van der Wee, Steven J. A. van der Werff, Heather Whalley, Nils R. Winter, Katharina Wittfeld, Margaret J. Wright, Mon-Ju Wu, Henry Voelzke, Tony T. Yang, Vasileios Zannias, Greig I. de Zubicaray, Giovana B. Zunta-Soares, Christoph Abe, Martin Alda, Ole A. Andreassen, Erlend Boen, Caterina M. Bonnin, Erick J. Canales-Rodriguez, Dara Cannon, Xavier Caseras, Tiffany M. Chaim-Avancini, Torbjorn Elvsashagen, Pauline Favre, Sonya F. Foley, Janice M. Fullerton, Jose M. Goikolea, Bartholomeus C. M. Haarman, Tomas Hajek, Chantal Henry, Josselin Houenou, Fleur M. Howells, Martin Ingvar, Rayus Kuplicki, Beny Lafer, Mikael Landen, Rodrigo Machado-Vieira, Ulrik F. Malt, Colm McDonald, Philip B. Mitchell, Leila Nabulsi, Maria Concepcion Garcia Otaduy, Bronwyn J. Overs, Mircea Polosan, Edith Pomarol-Clotet, Joaquim Radua, Maria M. Rive, Gloria Roberts, Henricus G. Ruhe, Raymond Salvador, Salvador Sarro, Theodore D. Satterthwaite, Jonathan Savitz, Aart H. Schene, Peter R. Schofield, Mauricio H. Serpa, Kang Sim, Marcio Gerhardt Soeiro-de-Souza, Ashley N. Sutherland, Henk S. Temmingh, Garrett M. Timmons, Anne Uhlmann, Eduard Vieta, Daniel H. Wolf, Marcus V. Zanetti, Neda Jahanshad, Paul M. Thompson, Dick J. Veltman, Brenda W. J. H. Penninx, Andre F. Marquand, James H. Cole, Lianne Schmaal
Summary: Major depressive disorder is associated with increased risk of brain atrophy, aging-related diseases, and mortality. This study found that MDD patients showed a higher brain-predicted age difference compared to controls, but this difference did not seem to be driven by specific clinical characteristics. Subtle patterns of age-related structural brain abnormalities in MDD were observed, highlighting the need for further longitudinal studies to assess the clinical value of these findings.
MOLECULAR PSYCHIATRY
(2021)
Article
Psychiatry
Iman Hashemzadeh, Julia E. Marquez-Arrico, Kosar Hashemzadeh, Jose Francisco Navarro, Ana Adan
Summary: This study examined the circadian functioning and quality of life in substance use disorder (SUD) patients with and without comorbid major depressive disorder (MDD). Results showed that SUD + MDD patients had worse sleep quality and lower quality of life compared to SUD patients. These findings highlight the importance of precise assessment and potential therapeutic implications for this patient population.
FRONTIERS IN PSYCHIATRY
(2021)
Review
Biochemistry & Molecular Biology
Seok-Won Jeoung, Hyun-Sun Park, Zae Young Ryoo, Dong-Hyung Cho, Hyun-Shik Lee, Hong-Yeoul Ryu
Summary: SUMOylation plays a significant role in maintaining neuronal function in the development of major depressive disorder (MDD).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
V. Vadim Tarasov, N. Nikolay Ivanets, A. Andrey Svistunov, N. Vladimir Chubarev, A. Marina Kinkulkina, G. Yuliya Tikhonova, S. Nikita Syzrantsev, V. Ivan Chubarev, Cristian Muresanu, G. Siva Somasundaram, E. Cecil Kirkland, Gjumrakch Aliev
Summary: This review summarizes recent findings in molecular biology and neuroimaging for the classification and identification of depression. While there are currently no reliable biomarkers for the diagnosis of depression types, further research into the molecular mechanisms of different types of depression is promising.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Article
Clinical Neurology
Andrew D. Krystal, Aurelia Mittoux, Annika Lindsten, Ross A. Baker
Summary: The study indicates that adjunctive brexpiprazole may help correct circadian dysfunction in patients with MDD. The phase angle between peak cortisol and DLMO could be a potential biomarker for depression and therapeutic response.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Neurosciences
Ruilan Yang, Yanmeng Zhao, Zewen Tan, Juan Lai, Jianshan Chen, Xiaofei Zhang, Jiaqi Sun, Lei Chen, Kangrong Lu, Liping Cao, Xuemei Liu
Summary: This study utilized bibliometric and visual analyses to summarize the important directions in differential diagnostic studies of BD and MDD among adolescents. The research found that clinical characteristics, genetic factors, and neuroimaging are current research hotspots in the field.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Review
Medical Laboratory Technology
Masoomeh Dadkhah, Mohsen Jafarzadehgharehziaaddin, Soheila Molaei, Morteza Akbari, Negin Gholizadeh, Farzaneh Fathi
Summary: Depressive disorders, characterized by loss of interest in previously enjoyed activities and a depressed mood, are highly heterogeneous psychiatric diseases. Diagnosis and treatment of major depressive disorder (MDD) remain challenging due to significant clinical presentation heterogeneity and lack of applicable biomarkers. Identification of relevant biomarkers would enhance disease classification and personalized treatment strategies. In this review, we discuss the current state of these biomarkers and diagnostic techniques specifically targeting these analytes using state-of-the-art biosensor technology.
CLINICA CHIMICA ACTA
(2023)
Article
Biochemistry & Molecular Biology
Jing Wang, Pan Ai, Yi Sun, Hui Shi, Anshi Wu, Changwei Wei
Summary: This study developed a novel prognostic gene signature based on TRRGs in MDD, identifying six TRRDEGs primarily involved in malaria, cardiac muscle contraction, and the calcium-signaling pathway. Four key TRRDEGs genes were identified through ROC curve analysis. The study also found a relationship between TRRDEGs and the immune microenvironment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Rosana Carvalho Silva, Elisabetta Maffioletti, Massimo Gennarelli, Bernhard T. Baune, Alessandra Minelli
Summary: Major depressive disorder (MDD) is the most common psychiatric disorder with important psychosocial consequences, influenced by stressful life events especially early life stress (ELS) which may lead to severe and chronic manifestation. Biological dysregulations at genetic, epigenetic, expression, and protein levels are linked to the association between ELS and MDD. Studies suggest involvement of systems like the hypothalamic-pituitary-adrenal (HPA) axis, serotonergic, dopaminergic, neurotrophin, and oxytocin in mediating the relationship between ELS and MDD.
PSYCHONEUROENDOCRINOLOGY
(2021)
Article
Immunology
Rui Peng, Yan Li
Summary: Elevated levels of tenascin-C were found in the serum of MDD patients, while serum testosterone levels were inversely correlated with tenascin-C levels. This negative association persisted even after adjusting for other factors. The combination of high tenascin-C levels and testosterone deficiency may be associated with MDD progression.
JOURNAL OF INFLAMMATION RESEARCH
(2021)