Article
Oncology
Pauline Rettman, Matthew D. Blunt, Rebecca J. Fulton, Andres F. Vallejo, Leidy Y. Bastidas-Legarda, Laura Espana-Serrano, Marta E. Polak, Aymen Al-Shamkhani, Christelle Retiere, Salim Khakoo
Summary: This study demonstrates the feasibility of a peptide-based KIR-targeting vaccine strategy to activate NK cells and enhance antitumor responses. The DNA vaccine upregulated genes associated with cellular metabolism and downregulated genes related to immune cell maturation. Vaccination led to enhanced antitumor responses against melanoma cells and a tumor model expressing the KIR2DS2 ligand HLA-C*0102.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Biochemistry & Molecular Biology
Tasneem Abaza, Mostafa K. Abd El-Aziz, Kerolos Ashraf Daniel, Paraskevi Karousi, Maria Papatsirou, Sherif Ashraf Fahmy, Nadia M. Hamdy, Christos K. Kontos, Rana A. Youness
Summary: Hepatocellular carcinoma (HCC) is a deadly malignancy with limited treatment options and high recurrence rates. Recently, immunotherapeutic agents such as immune checkpoint inhibitors (ICIs) and circular RNAs (circRNAs) have shown promise in HCC treatment. CircRNAs can influence the tumor immune microenvironment and may impact the effectiveness of ICIs. Therefore, circRNAs have the potential to serve as biomarkers for diagnosis, prognosis, and targeted therapy in HCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Rikang Wang, Weili Bao, Mouli Pal, Yunfeng Liu, Karina Yazdanbakhsh, Hui Zhong
Summary: This study identified the antimetastasis and pro-NK cell activity of IFN-IMo, identified FOXO1 as a key molecule for IFN-gamma driven monocyte differentiation and function, and found NR4A1 as an inhibitory molecule for IFN-IMo activity. It provided potential targets for developing superior monocytic cell therapy against cancer metastasis.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Malgorzata Bajor, Agnieszka Graczyk-Jarzynka, Katsiaryna Marhelava, Anna Burdzinska, Angelika Muchowicz, Agnieszka Goral, Andriy Zhylko, Karolina Soroczynska, Kuba Retecki, Marta Krawczyk, Marta Klopotowska, Zofia Pilch, Leszek Paczek, Karl-Johan Malmberg, Sebastien Walchli, Magdalena Winiarska, Radoslaw Zagozdzon
Summary: This study provides new information on the efficacy of PD-L1-targeted CAR against PD-L1(low) targets. The results show that PD-L1-CAR cells have strong reactivity and cytotoxicity against both PD-L1(high) and PD-L1(low) target cells. Additionally, PD-L1-CAR cells also exhibit potent cytotoxic effects against non-malignant cells.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Immunology
Rodolfo R. Favaro, Katherine Phillips, Romane Delaunay-Danguy, Kaja Ujcic, Udo R. Markert
Summary: Members of the innate immune system, specifically innate lymphoid cells (ILCs), play important roles in the uterine environment, supporting pregnancy and placental development. These cells demonstrate immune memory, allowing them to remember previously encountered antigens and mount enhanced responses. By studying ILCs, we can gain insights into the immunological mechanisms underlying female fertility/infertility, placental development, and distinct outcomes in second pregnancies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Siqi Liu, Lanlan Yang, Shengnan Jia, Rui Zhao, Zhenjing Jin
Summary: In patients with hepatocellular carcinoma (HCC), the levels of NKB cells and IL-18 secretion were decreased in both peripheral blood and liver-infiltrating sites. Elevated IL-35 levels were negatively correlated with the percentage of NKB cells and IL-18 production in HCC, suggesting a suppressive role of IL-35 on NKB cell activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Cinzia Fionda, Gianluca Scarno, Helena Stabile, Rosa Molfetta, Chiara Di Censo, Angela Gismondi, Rossella Paolini, Silvano Sozzani, Angela Santoni, Giuseppe Sciume
Summary: Colorectal cancer is a common malignancy globally, with NK cells and ILC playing crucial roles in the disease prognosis and outcome. Their cytotoxic functions are key in controlling CRC metastasis, and understanding their molecular mechanisms holds significance for CRC treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Ganesan Ramamoorthi, Krithika Kodumudi, Colin Snyder, Payal Grover, Hongtao Zhang, Mark Greene, Amrita Basu, Corey Gallen, Doris Wiener, Ricardo L. B. Costa, Hyo S. Han, Gary Koski, Brian J. Czerniecki
Summary: HER2-DC1 i.t. combined with anti-HER2 antibodies mediates tumor regression through combined activation of T and B cell compartments and provides evidence that HER2-DC1 i.t. in combination with anti-HER2 antibodies can be tested as an effective alternative therapeutic strategy to current chemotherapy and anti-HER2 antibodies in HER2(pos) BC.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Immunology
Sebastian Joyce, Gosife Donald Okoye, John P. Driver
Summary: The large majority of lymphocytes belong to the adaptive immune system, but there are also unconventional lymphocytes that behave more like innate immune cells. These unconventional lymphocytes, called innate/innate-like lymphocytes, can express rearranged antigen receptor genes or not. They integrate sensory signals from the innate immune system and relay them to downstream effector cells, contributing to an appropriate host immune response.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Peng Peng, Yue Lou, Shicheng Wang, Junjun Wang, Zelu Zhang, Peishan Du, Jiamin Zheng, Ping Liu, Lisa X. Xu
Summary: This study demonstrates that cryo-thermal therapy can induce effective CD4(+) Th1-dominant antitumor immunity by activating NK cells to reprogram MDSCs, offering a promising therapeutic strategy for cancer immunotherapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Medicine, Research & Experimental
Brandon S. Cox, Khaled Alharshawi, Irene Mena-Palomo, William P. Lafuse, Maria Eugenia Ariza
Summary: ME/CFS patients showed elevated levels of activin A and IL-21, which were associated with antibodies against EBV and HHV-6 proteins. Impaired T-FH cell function was observed in ME/CFS patients, potentially contributing to the progression of the disease. The study also suggests that viral dUTPases may lead to abnormal germinal center activity.
Article
Oncology
Annelisa M. Cornel, Ester Dunnebach, Damon A. Hofman, Sanjukta Das, Satyaki Sengupta, Femke van den Ham, Judith Wienke, Josephine G. M. Strijker, Denise A. M. H. van den Beemt, Anke H. W. Essing, Bianca Koopmans, Sem A. G. Engels, Vania Lo Presti, Celina S. Szanto, Rani E. George, Jan J. Molenaar, Sebastiaan van Heesch, Miranda P. Dierselhuis, S. Nierkens
Summary: This study explores the potential of combining immunotherapy with histone deacetylase inhibitors (HDACi) to enhance T cell-driven and NK cell-driven immune responses in high-risk neuroblastoma (HR-NBL). Screening drug repurposing libraries, the researchers identified compounds that upregulated major histocompatibility complex class I (MHC-I) surface expression in NBL cells. Treatment with HDACi enhanced the cytotoxic capacity of tumor-specific T cells against NBL in vitro and increased the expression of factors regulating T cell and NK cell cytotoxicity. The findings suggest a promising strategy to enhance immune responses in patients with HR-NBL through (immuno)therapy and HDACi.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
David B. Rosen, Anne Mansson Kvarnhammar, Burkhardt Laufer, Thomas Knappe, Jens Jakob Karlsson, Enping Hong, Yu-Chi Lee, Dhruv Thakar, Luis Alejandro Zuniga, Kathy Bang, Simran Singh Sabharwal, Karan Uppal, Janne Damm Olling, Kristian Kjaergaard, Thomas Kurpiers, Meike Schnabel, Diana Reich, Philipp Glock, Joachim Zettler, Mathias Krusch, Ana Bernhard, Stefan Heinig, Valentino Konjik, Thomas Wegge, Yvonne Hehn, Steffen Killian, Laura Viet, Josefine Runz, Frank Faltinger, Mohammad Tabrizi, Kristin Laura Abel, Vibeke Miller Breinholt, Stina M. Singel, Kennett Sprogoe, Juha Punnonen
Summary: Recombinant interleukin-2 (IL-2) is an approved cancer immunotherapy, but it has severe toxicities and suboptimal pharmacokinetics. TransCon IL-2 beta/gamma is a novel prodrug designed to address these issues, showing sustained release of IL-2 and potential antitumor activity in animal models.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Immunology
Margaret R. Dunne, Johannes Wagener, Juergen Loeffler, Derek G. Doherty, Thomas R. Rogers
Summary: This review examines evidence on the human immune response to invasive fungal diseases, with a focus on unconventional lymphocytes such as NK cells, gamma/delta T cells, MAIT cells, iNKT cells, and ILC. Recent discoveries about the roles of these novel lymphocyte groups in antifungal immunity are discussed, and the potential for improving antifungal treatment options through a better understanding of lymphocyte actions is explored.
CLINICAL IMMUNOLOGY
(2021)
Article
Oncology
Stefanie Renken, Takahiro Nakajima, Isabelle Magalhaes, Jonas Mattsson, Andreas Lundqvist, Elias S. J. Arner, Rolf Kiessling, Stina Linnea Wickstrom
Summary: Auranofin can significantly reduce intracellular ROS accumulation in human cytotoxic lymphocytes ex vivo, preserving their antitumoral activity and increasing resistance to oxidative stress.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Meeting Abstract
Biotechnology & Applied Microbiology
Gengwen Tian, Bipulendu Jena, Daofeng Liu, Andras Heczey, Hiroki Torikai, Dean Lee, Gianpietro Dotti, Laurence Cooper, Leonid S. Metelitsa
Meeting Abstract
Biotechnology & Applied Microbiology
Xin Xu, Suhrab Kurbanov, Linjie Guo, Xiuhua Gao, James E. Galen, Leonid S. Metelitsa
Meeting Abstract
Biotechnology & Applied Microbiology
Daofeng Liu, Amy N. Courtney, Andras Heczey, Ekaterina Marinova, Gengwen Tian, Linjie Guo, Xiuhua Gao, Gianpietro Dotti, Leonid S. Metelitsa
Meeting Abstract
Oncology
Andras Heczey, Daofeng Liu, Gengwen Tian, Ekaterina Marinova, Xiuhua Gao, Linjie Guo, John Hicks, Gianpietro Dotti, Leonid Metelitsa
CANCER IMMUNOLOGY RESEARCH
(2015)
Article
Medicine, Research & Experimental
Yang Xu, Arindam Chaudhury, Ming Zhang, Barbara Savoldo, Leonid S. Metelitsa, John Rodgers, Jason T. Yustein, Joel R. Neilson, Gianpietro Dotti
JOURNAL OF CLINICAL INVESTIGATION
(2016)
Meeting Abstract
Biotechnology & Applied Microbiology
Wei Huang, Daofeng Liu, Linjie Guo, Ekaterina Marinova, Andras Heczey, Leonid Metelitsa
Article
Oncology
Thomas Shum, Bilal Omer, Haruko Tashiro, Robert L. Kruse, Dimitrios L. Wagner, Kathan Parikh, Zhongzhen Yi, Tim Sauer, Daofeng Liu, Robin Parihar, Paul Castillo, Hao Liu, Malcolm K. Brenner, Leonid S. Metelitsa, Stephen Gottschalk, Cliona M. Rooney
Letter
Oncology
Gengwen Tian, Van Henry Savell, Jose M. Esquilin
PEDIATRIC BLOOD & CANCER
(2018)
Article
Oncology
Danielle M. Hsu, Saurabh Agarwal, Ashley Benham, Cristian Coarfa, Denae N. Trahan, Zaowen Chen, Paris N. Stowers, Amy N. Courtney, Anna Lakoma, Eveline Barbieri, Leonid S. Metelitsa, Preethi Gunaratne, Eugene S. Kim, Jason M. Shohet
Article
Oncology
Shahab Asgharzadeh, Jill A. Salo, Lingyun Ji, Andre Oberthuer, Matthias Fischer, Frank Berthold, Michael Hadjidaniel, Cathy Wei-Yao Liu, Leonid S. Metelitsa, Roger Pique-Regi, Peter Wakamatsu, Judith G. Villablanca, Susan G. Kreissman, Katherine K. Matthay, Hiroyuki Shimada, Wendy B. London, Richard Sposto, Robert C. Seeger
JOURNAL OF CLINICAL ONCOLOGY
(2012)
Article
Oncology
Yuhui Chen, Chuang Sun, Elisa Landoni, Leonid Metelitsa, Gianpietro Dotti, Barbara Savoldo
CLINICAL CANCER RESEARCH
(2019)
Article
Oncology
Elisa Landoni, Christof C. Smith, Giovanni Fuca, Yuhui Chen, Chuang Sun, Benjamin G. Vincent, Leonid S. Metelitsa, Gianpietro Dotti, Barbara Savoldo
CANCER IMMUNOLOGY RESEARCH
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zbigniew Starosolski, Amy N. Courtney, Mayank Srivastava, Linjie Guo, Igor Stupin, Leonid S. Metelitsa, Ananth Annapragada, Ketan B. Ghaghada
Summary: This study explored the use of nanoradiomics to differentiate tumors based on TAM burden, finding that conventional tumor metrics were ineffective in distinguishing tumors with varying TAM burden. However, machine learning-augmented nanoradiomic analysis revealed texture differences that enabled the differentiation of low and high TAM tumors.
CONTRAST MEDIA & MOLECULAR IMAGING
(2021)