期刊
JOURNAL OF NEUROSCIENCE
卷 36, 期 36, 页码 9268-9282出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.1333-16.2016
关键词
behavior; cell-type specificity; chemogenetics; DREADD
资金
- Intramural Research Program of the National Institutes of Health, The National Institutes of Diabetes and Digestive and Kidney Diseases [DK075087, DK075089]
Designer receptors exclusively activated by designer drugs (DREADDs) have proven to be highly effective neuromodulatory tools for the investigation of neural circuits underlying behavioral outputs. They exhibit a number of advantages: they rely on cell-specific manipulations through canonical intracellular signaling pathways, they are easy and cost-effective to implement in a laboratory setting, and they are easily scalable for single-region or full-brain manipulations. On the other hand, DREADDs rely on ligand-G-protein-coupled receptor interactions, leading to coarse temporal dynamics. In this review we will provide a brief overview of DREADDs, their implementation, and the advantages and disadvantages of their use in animal systems. We also will provide numerous examples of their use across a broad variety of biomedical research fields.
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