Plasma exosomes confer hypoxic pulmonary hypertension by transferring LOX-1 cargo to trigger phenotypic switching of pulmonary artery smooth muscle cells

ETAR silencing ameliorated neurovascular injury after SAH in rats through ERK/KLF4-mediated phenotypic transformation of smooth muscle cells

(2021) Zhaosi Zhang et al.   EXPERIMENTAL NEUROLOGY

PTBP1 Targets ILK to Regulate the Hypoxia-Induced Phenotypic Transformation of Pulmonary Artery Smooth Muscle Cells

(2021) Gaoliang Yan et al.   Drug Design Development and Therapy

Hypoxia-activated platelets stimulate proliferation and migration of pulmonary arterial smooth muscle cells by phosphatidylserine/LOX-1 signaling-impelled intercellular communication

(2021) Xiaoyue Ge et al.   CELLULAR SIGNALLING

NEAT1 silencing alleviates pulmonary arterial smooth muscle cell migration and proliferation under hypoxia through regulation of miR‑34a‑5p/KLF4 in vitro

(2021) Xiuli Dou et al.   Molecular Medicine Reports

Programmable dual responsive system reconstructing nerve interaction with small-diameter tissue-engineered vascular grafts and inhibiting intimal hyperplasia in diabetes

(2021) Yanzhao Li et al.   Bioactive Materials

The biology, function, and biomedical applications of exosomes

(2020) Raghu Kalluri et al.   SCIENCE

Therapeutic potential of KLF2-induced exosomal microRNAs in pulmonary hypertension

(2020) Hebah A. Sindi et al.   Nature Communications

Role of Lectin-like Oxidized LDL Receptor-1 and Syncytiotrophoblast Extracellular Vesicles in the Vascular Reactivity of Mouse Uterine Arteries During Pregnancy

(2020) Floor Spaans et al.   Scientific Reports

The preventive and therapeutic effects of AAV1‐KLF4‐shRNA in cigarette smoke‐induced pulmonary hypertension

(2020) Desheng Sun et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Exosomal miR-211 contributes to pulmonary hypertension via attenuating CaMK1/PPAR-γaxis

(2020) Shuhao Zhang et al.   VASCULAR PHARMACOLOGY

Loss of Endothelial Derived WNT5A is Associated with Reduced Pericyte Recruitment and Small Vessel Loss in Pulmonary Arterial Hypertension

(2019) Ke Yuan et al.   CIRCULATION

HIF1α‐induced upregulation of KLF4 promotes migration of human vascular smooth muscle cells under hypoxia

(2019) Fabo Shan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A Potential Role for Exosomal TCTP Export in Vascular Remodeling in Pulmonary Arterial Hypertension

(2018) Elisabet Ferrer et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

LOX-1 mediated phenotypic switching of pulmonary arterial smooth muscle cells contributes to hypoxic pulmonary hypertension

(2018) Weifang Zhang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Alterations in vascular function by syncytiotrophoblast extracellular vesicles via lectin-like oxidized low-density lipoprotein receptor-1 in mouse uterine arteries

(2018) Floor Spaans et al.   CLINICAL SCIENCE

Exosomal 15-LO2 mediates hypoxia-induced pulmonary artery hypertension in vivo and in vitro

(2018) Min Zhang et al.   Cell Death & Disease

Epigallocatechin-3-gallate ameliorates hypoxia-induced pulmonary vascular remodeling by promoting mitofusin-2-mediated mitochondrial fusion

(2017) Tian-Tian Zhu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

microRNA let-7g suppresses PDGF-induced conversion of vascular smooth muscle cell into the synthetic phenotype

(2017) Tzu-Ming Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Exosomes induce and reverse monocrotaline-induced pulmonary hypertension in mice

(2016) Jason M. Aliotta et al.   CARDIOVASCULAR RESEARCH

A global view of pulmonary hypertension

(2016) Marius M Hoeper et al.   Lancet Respiratory Medicine

MicroRNA-143 Activation Regulates Smooth Muscle and Endothelial Cell Crosstalk in Pulmonary Arterial HypertensionNovelty and Significance

(2015) Lin Deng et al.   CIRCULATION RESEARCH

Plasma Exosomes Protect the Myocardium From Ischemia-Reperfusion Injury

(2015) Jose M. Vicencio et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Smooth muscle cell progenitors are primed to muscularize in pulmonary hypertension

(2015) Abdul Q. Sheikh et al.   Science Translational Medicine

Disruption of miR-29 Leads to Aberrant Differentiation of Smooth Muscle Cells Selectively Associated with Distal Lung Vasculature

(2015) Leah Cushing et al.   PLoS Genetics

Membrane Cholesterol Modulates LOX-1 Shedding in Endothelial Cells

(2015) Magda Gioia et al.   PLoS One

Endothelial Krüppel-Like Factor 4 Modulates Pulmonary Arterial Hypertension

(2013) Mohammad A. Shatat et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Exosomes Mediate the Cytoprotective Action of Mesenchymal Stromal Cells on Hypoxia-Induced Pulmonary Hypertension

(2012) Changjin Lee et al.   CIRCULATION

PAR-2 Inhibition Reverses Experimental Pulmonary Hypertension

(2012) Grazyna Kwapiszewska et al.   CIRCULATION RESEARCH

Effects of C-reactive protein on human pulmonary vascular cells in chronic thromboembolic pulmonary hypertension

(2012) Marijke Wynants et al.   EUROPEAN RESPIRATORY JOURNAL

Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs

(2012) Eduard Hergenreider et al.   NATURE CELL BIOLOGY

ERK1/2 MAP kinases: Structure, function, and regulation

(2012) Robert Roskoski   PHARMACOLOGICAL RESEARCH

ATRA activates and PDGF-BB represses the SM22α promoter through KLF4 binding to, or dissociating from, its cis-DNA elements

(2011) Kun Yu et al.   CARDIOVASCULAR RESEARCH

Conditional Deletion of Krüppel-Like Factor 4 Delays Downregulation of Smooth Muscle Cell Differentiation Markers but Accelerates Neointimal Formation Following Vascular Injury

(2008) Tadashi Yoshida et al.   CIRCULATION RESEARCH