Discovery of a Novel, Highly Potent and Orally Bioavailable Pyrrolidinone Indole Series of Irreversible Myeloperoxidase (MPO) Inhibitors

Role of myeloperoxidase and oxidant formation in the extracellular environment in inflammation-induced tissue damage

(2021) Clare L. Hawkins et al.   FREE RADICAL BIOLOGY AND MEDICINE

Discovery of a novel indole pharmacophore for the irreversible inhibition of myeloperoxidase (MPO)

(2020) Anup Patnaik et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Early clinical experience with AZD4831, a novel myeloperoxidase inhibitor, developed for patients with heart failure with preserved ejection fraction

(2020) Karin Nelander et al.   CTS-Clinical and Translational Science

A patent review of myeloperoxidase inhibitors for treating chronic inflammatory syndromes (focus on cardiovascular diseases, 2013-2019)

(2020) Jalal Soubhye et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Population Pharmacokinetic Modeling With Enterohepatic Circulation for AZD3241 in Healthy Subjects and Patients With Multiple System Atrophy

(2018) Xiao Tong et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Discovery of 1-((6-Aminopyridin-3-yl)Methyl)-3-(4-Bromophenyl)Urea as a Potent, Irreversible Myeloperoxidase Inhibitor

(2018) Martin L. Marro et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The development of myeloperoxidase inhibitors

(2018) Semira Galijasevic   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

An exploratory look at NETosis in atherosclerosis

(2016) Chiara Mozzini et al.   Internal and Emergency Medicine

Effect of the myeloperoxidase inhibitor AZD3241 on microglia: a PET study in Parkinson’s disease

(2015) Aurelija Jucaite et al.   BRAIN

Discovery of 2-(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide (PF-06282999): A Highly Selective Mechanism-Based Myeloperoxidase Inhibitor for the Treatment of Cardiovascular Diseases

(2015) Roger B. Ruggeri et al.   JOURNAL OF MEDICINAL CHEMISTRY

Failure of Neuroprotection Despite Microglial Suppression by Delayed-Start Myeloperoxidase Inhibition in a Model of Advanced Multiple System Atrophy: Clinical Implications

(2015) Christine Kaindlstorfer et al.   NEUROTOXICITY RESEARCH

Development of rapid multistep carbon-11 radiosynthesis of the myeloperoxidase inhibitor AZD3241 to assess brain exposure by PET microdosing

(2015) Peter Johnström et al.   NUCLEAR MEDICINE AND BIOLOGY

Myeloperoxidase deficiency preserves vasomotor function in humans

(2011) Tanja K. Rudolph et al.   EUROPEAN HEART JOURNAL

Plasma myeloperoxidase level and peripheral arterial disease

(2011) Helmuth Haslacher et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

2-Thioxanthines Are Mechanism-based Inactivators of Myeloperoxidase That Block Oxidative Stress during Inflammation

(2011) Anna-Karin Tidén et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human myeloperoxidase in innate and acquired immunity

(2010) Juergen Arnhold et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

A new easy method for specific measurement of active myeloperoxidase in human biological fluids and tissue extracts

(2009) T. Franck et al.   TALANTA