Review
Oncology
Tian-Jiao Li, Jian Jiang, Ya-Ling Tang, Xin-Hua Liang
Summary: GABA is the main inhibitory neurotransmitter in the brain, and it regulates tumor development via several pathways. GABA signaling exists in the cancer microenvironment and has an immunosuppressive effect that contributes to metastasis and colonization.
Article
Biochemistry & Molecular Biology
Kayla M. Shumate, Sadik T. Tas, Ege T. Kavalali, Ronald B. Emeson
Summary: Caps editing plays a crucial role in modulating neurotransmission and synaptic plasticity, particularly at inhibitory synapses. The edited Cadps transcripts increase the proportion of synapses containing CAPS1, and editing is regulated by neuronal activity.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Chemistry, Analytical
Nicolaie Moldovan, Iuliu-Ioan Blaga, Sanjeev Billa, Imran Hossain, Chenggong Gong, Claire E. Jones, Teresa A. Murray, Ralu Divan, Shabnam Siddiqui, Prabhu U. Arumugam
Summary: Glutamate (GLU) and gamma-aminobutyric acid (GABA) play crucial roles in signal transmission in the brain. Imbalances in GLU-GABA homeostasis are linked to brain disorders, and a silicon multifunctional biosensor microarray probe has been developed for real-time simultaneous GLU-GABA detection with high sensitivity and selectivity in vivo.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Medicine, Research & Experimental
Jing Xie, Qi Zhong, Wen-tao Wu, Jian-jun Chen
Summary: This study observed the characteristics of gut microbiota, lipid metabolism, and neurotransmitters in depressed mice and identified the relationship between gut microbiota and depression. The results showed significant differences in gut microbiota and metabolic signatures between depressed mice and control mice, and suggested that lipid metabolism might play a crucial role in the link between gut microbiota and depression.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Gary Rudnick
Summary: Baruch Kanner and the author have parallel careers in investigating neurotransmitter transporters, collaborating and competing at various points but always learning from each other. This commentary focuses on interactions between the Kanner and Rudnick laboratories, specifically on transporters in the Neurotransmitter: Sodium Symporter (NSS) family of amino acid and amine transporters, with a key emphasis on the mechanism of chloride ion activation and transport driving.
NEUROCHEMICAL RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Mrinal Mandal, Hessam Sepasi Tehrani, Qianhua Mai, Emma Simon, Marie-Aude Plamont, Christine Rampon, Sophie Vriz, Isabelle Aujard, Thomas Le Saux, Ludovic Jullien
Summary: In this study, a series of hydrophobic and hydrophilic caged fluorophores based on a robust pyranine backbone were reported. These fluorophores can be used for the absolute quantification of light intensity in chemical and biological samples. The brightness of these fluorophores increases upon illumination, and their uncaging cross-sections have been thoroughly characterized.
Article
Multidisciplinary Sciences
Fujun Luo, Alessandra Sclip, Sean Merrill, Thomas C. Sudhof
Summary: This study shows that neurexins are essential for the localization and function of presynaptic GABA(B)-receptor signaling complexes. Deletion of neurexins results in decreased sensitivity of neurotransmitter release to GABA(B)-receptor activation and loss of GABA(B)-receptors from the presynaptic active zone. Neurexins play a crucial role in regulating presynaptic GABA(B) receptors at multiple central nervous system synapses.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Pinghui Wei, Guoge Han, Meiqin He, Yan Wang
Summary: This study aimed to investigate the changes in retinal neurotransmitters and the role of the dopamine D2 receptor (D2R) pathway in regulating myopic refractive state. The results showed that after forced occlusion for 4 weeks, dopamine (DA) and γ-aminobutyric acid (GABA) concentrations decreased, while glutamate (Glu), 3-methoxytyramine (3-MT), and glycine concentrations increased, accompanied by an increase in myopic refraction and axial length (AL). Treating with D2R antagonist sulpiride increased glycine and DA levels, while decreasing 3-MT and Glu levels, accompanied by a decrease in myopic refraction and AL. The ratio of Glu to GABA (RGG) represents the balance between excitatory and inhibitory neurotransmitters, and changes in RGG correlated with changes in AL.
ACS CHEMICAL NEUROSCIENCE
(2023)
Review
Neurosciences
Jing Wu, Leonard K. Kaczmarek
Summary: Accurate extraction and localization of auditory stimuli in complex environments rely on the precise encoding of sound information by auditory neurons, with the modulation of membrane properties playing a critical role in shaping firing patterns. Errors in the regulation of these channels can lead to deficits in decoding auditory information.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Chemistry, Physical
Sergej Friesen, Marina V. Fedotova, Sergey E. Kruchinin, Richard Buchner
Summary: Room-temperature aqueous solutions of GABA and AABA were studied using DRS and statistical mechanics calculations. The results showed that only about half of the water molecules in direct contact with the solute are affected in their dynamics. GABA moderately retards -10 H2O molecules, while AABA moderately retards -6 H2O molecules and freezes -6 H2O molecules.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Review
Computer Science, Interdisciplinary Applications
Dhwani Desai, Ninad Mehendale
Summary: Sound source localization (SSL) is an important technology in robots and humanoids to find the direction of a sound source. In the past two decades, research has been done to optimize SSL techniques and enhance their accuracy. This review categorizes various proposed SSL techniques into four types, including conventional algorithms and convolutional neural networks (CNN).
ARCHIVES OF COMPUTATIONAL METHODS IN ENGINEERING
(2022)
Article
Computer Science, Information Systems
Yang Li, Xiaoli Zhao, Zhuoyao Zhang
Summary: Compared to traditional unimodal methods, multimodal audio-visual correspondence learning has many advantages in video understanding, but it also faces significant challenges. In order to fully utilize the feature information from both modalities, accurate alignment of semantic information is crucial. Current algorithms heavily rely on sound-object localization but neglect the potential issue of suppressed feature information. Thus, we propose a sound promotion method (SPM) to increase the contribution of voices and improve audiovisual learning performance.
Article
Neurosciences
Harrison J. Ramsay, Sara E. Gookin, Austin M. Ramsey, Dean J. Kareemo, Kevin C. Crosby, Dominik G. Stich, Samantha S. Olah, Hannah S. Actor-Engel, Katharine R. Smith, Matthew J. Kennedy
Summary: Postsynaptic neurotransmitter receptors and their associated scaffolding proteins form nanometer-scale subsynaptic domains (SSDs) within the postsynaptic membrane. The role of neurotransmitter signaling in the initial assembly of these SSDs during synapse development is still unknown.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Neurosciences
K. S. Varadarajan, Puneet Bagga, Akila Ramesh, Anup N. Chugani, Anant B. Patel
Summary: Chronic lead exposure in mice leads to impaired forelimb strength and perturbed neurometabolism in brain regions involved in cognition and movement.
Review
Neurosciences
Tingyan Wu, Weili Cai, Xi Chen
Summary: Neurotransmission signaling is a conserved system with important regulatory events. The role of excitatory and inhibitory neurotransmitter systems in brain function is well established. Recent research has shown that epigenetic regulation plays a crucial role in controlling the expression of neurotransmitter-related genes and its dysregulation is associated with neurological disorders. This article explores the epigenetic regulation of dopamine, GABA, glutamate, and serotonin genes, and discusses how targeting these mechanisms can lead to improved treatments for neurological disorders.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Neurosciences
Hanmi Lee, Eva Bach, Jihyun Noh, Eric Delpire, Karl Kandler
JOURNAL OF NEUROPHYSIOLOGY
(2016)
Article
Neurosciences
Joshua J. Sturm, Ying-Xin Zhang-Hooks, Hannah Roos, Tuan Nguyen, Karl Kandler
JOURNAL OF NEUROSCIENCE
(2017)
Article
Neurosciences
Catherine J. C. Weisz, Elisabeth Glowatzki, Paul Albert Fuchs
JOURNAL OF NEUROSCIENCE
(2014)
Article
Neurosciences
Joshua Sturm, Tuan Nguyen, Karl Kandler
JOURNAL OF NEUROSCIENCE
(2014)
Article
Neurosciences
Lester Torres Cadenas, Matthew J. Fischl, Ctatherine J. C. Weisz
JOURNAL OF NEUROSCIENCE
(2020)
Article
Neurosciences
Flora M. Antunes, Maria E. Rubio, Karl Kandler
JOURNAL OF NEUROSCIENCE
(2020)
Editorial Material
Medicine, Research & Experimental
Sian R. Kitcher, Catherine J. C. Weisz
EMBO MOLECULAR MEDICINE
(2020)
Article
Neurosciences
Catherine J. C. Weisz, Sean-Paul G. Williams, Chad S. Eckard, Christopher B. Divito, David W. Ferreira, Kristen N. Fantetti, Shenin A. Dettwyler, Hou-Ming Cai, Maria E. Rubio, Karl Kandler, Rebecca P. Seal
Summary: The study reveals that cochlear outer hair cells, unlike inner hair cells, are capable of releasing glutamate and activating neurons in the cochlear nucleus at moderate sound levels.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Audiology & Speech-Language Pathology
Sian R. Kitcher, Alia M. Pederson, Catherine J. C. Weisz
Summary: This review article mainly introduces the release, action, and function of neurotransmitters in the mammalian cochlea, with an emphasis on the complexity of signaling.
Article
Neurosciences
Lester Torres Cadenas, Hui Cheng, Catherine J. C. Weisz
Summary: The descending auditory system modulates the ascending system, and the MOC neurons are involved in inhibiting the OHC-mediated cochlear amplification. The MNTB-MOC synapses exhibit enhanced short-term depression at higher calcium concentrations and at room temperature. High rates of MNTB activity cause a tonic synaptic depression of MNTB-MOC synapses. MNTB inhibition of MOC neurons persists despite tonic synaptic depression.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Biology
Michelle M. Frank, Austen A. Sitko, Kirupa Suthakar, Lester Torres Cadenas, Mackenzie Hunt, Mary Caroline Yuk, Catherine J. C. Weisz, Lisa Goodrich
Summary: We characterized murine brainstem olivocochlear neurons (OCNs) during postnatal development, in mature animals, and after sound exposure using single-nucleus sequencing, anatomical reconstructions, and electrophysiology. We identified markers for known medial (MOC) and lateral (LOC) OCN subtypes and found that they express distinct physiologically relevant genes that change over development. We also discovered a neuropeptide-enriched LOC subtype producing Neuropeptide Y along with other neurotransmitters. Acoustic trauma leads to strong upregulation of LOC neuropeptide expression, potentially providing sustained cochlear protection. OCNs have diffuse, dynamic effects on early auditory processing over timescales ranging from milliseconds to days.
Article
Neurosciences
Rodrigo Martinez-Monedero, Chang Liu, Catherine Weisz, Pankhuri Vyas, Paul Albert Fuchs, Elisabeth Glowatzki