Article
Surgery
Perisa Ruhi-Williams, Baolin Wu, Jeffry Nahmias, Fabio Sagebin, Reza Fazl Alizadeh, Kishore M. Gadde, Alpesh Amin, Ninh T. Nguyen
Summary: This study analyzed the characteristics and outcomes of veno-venous (V-V) extracorporeal membrane oxygenation (ECMO) for acute respiratory distress syndrome (ARDS) due to COVID-19 versus non-COVID causes. The results showed that patients with COVID-19 ARDS requiring V-V ECMO support had higher in-hospital mortality, longer length of stay, and higher direct hospitalization cost compared to non-COVID etiologies.
Article
Engineering, Biomedical
Oliver Robak, Theresa Grafeneder-Weissteiner, Peter Schellongowski, Andja Bojic, Christopher Paschen, Alexander Hermann, Thomas Staudinger
Summary: This study analyzed the in vivo suction pressure for veno-venous extracorporeal membrane oxygenation (VV-ECMO) cannulas and found that the in vitro data largely overestimate the safely achievable flow rates in daily clinical practice by 44% for 25 Fr and 41% for 23 Fr drainage cannulas.
Article
Engineering, Biomedical
Aakash Shah, Jay Menaker, Michael A. Mazzeffi, Samuel M. Galvagno, Kristopher B. Deatrick, Ronson J. Madathil, Raymond Rector, James O'Connor, Thomas M. Scalea, Ali Tabatabai
Summary: Fluid overload in acute respiratory distress syndrome is associated with increased mortality. This study found that negative cumulative fluid balance during the first 7 days of veno-venous extracorporeal membrane oxygenation (VV ECMO) is associated with higher survival rates and is an independent predictor of 90-day mortality.
Article
Engineering, Biomedical
Aakash Shah, Chetan Pasrija, Anthony Kronfli, Eno-Obong Essien, Ya Zhou, Francis Brigante, Gregory Bittle, Jay Menaker, Daniel Herr, Michael A. Mazzeffi, Kristopher B. Deatrick, Zachary N. Kon
Summary: In this retrospective study on veno-venous extracorporeal membrane oxygenation (VV-ECMO) patients, a high-flow strategy with low-partial thromboplastin time (L-PTT) was found to be associated with fewer bleeding events compared to other strategies, without differences in thrombotic events.
Article
Biochemistry & Molecular Biology
Mirko Belliato, Francesco Epis, Luca Cremascoli, Fiorenza Ferrari, Maria Giovanna Quattrone, Christoph Fisser, Maximilian Valentin Malfertheiner, Fabio Silvio Taccone, Matteo Di Nardo, Lars Mikael Broman, Roberto Lorusso
Summary: In this study, mechanical power (MP) was analyzed in patients with severe acute respiratory distress syndrome undergoing VV ECMO. Changes in MV parameters after ECMO initiation were observed, with higher respiratory rate seen in ICU non-survivors. Monitoring of respiratory rate and MP during ECMO should not be overlooked.
Article
Critical Care Medicine
Matthias Kochanek, Jan Kochanek, Boris Boell, Dennis A. Eichenauer, Gernot Beutel, Hendrik Bracht, Stephan Braune, Florian Eisner, Sigrun Friesecke, Ulf Guenther, Gottfried Heinz, Michael Hallek, Christian Karagiannidis, Stefan Kluge, Klaus Kogelmann, Pia Lebiedz, Philipp M. Lepper, Tobias Liebregts, Catherina Lueck, Ralf M. Muellenbach, Matthias Hansen, Christian Putensen, Peter Schellongowski, Jens-Christian Schewe, Kathrin Schumann-Stoiber, Frederik Seiler, Peter Spieth, Steffen Weber-Carstens, Daniel Brodie, Elie Azoulay, Alexander Shimabukuro-Vornhagen
Summary: The overall survival of cancer patients requiring vv-ECMO is poor, and the value of vv-ECMO in cancer patients with respiratory failure remains unclear. Further research is needed to determine the benefits of vv-ECMO in this population. The risk factors identified in this study may help in better selection of patients who may benefit from vv-ECMO.
INTENSIVE CARE MEDICINE
(2022)
Article
Engineering, Biomedical
Lauren A. Raff, Rebecca G. Maine, Trista S. Reid
Summary: Despite improvements in critical care, mortality from ARDS remains high. V-V ECMO is used in severe cases, but the risk of hemorrhage may deter some providers.
Article
Medicine, General & Internal
Johannes Gehron, Dirk Bandorski, Konstantin Mayer, Andreas Boening
Summary: In patients with acute respiratory distress syndrome and ECMO, high recirculation rates are common and can be reduced by increasing ECMO flow and cardiac output. Patient oxygenation can be optimized by directly measuring recirculation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Anesthesiology
Samuel Heuts, Johannes F. Ubben, Vanessa Banks-Gonzales, Jan-Willem Sels, Roberto Lorusso, Walther N. K. A. van Mook, Thijs S. R. Delnoij
Summary: Patients with COVID-19 are prone to PAH and increased recirculation during ECMO treatment, but continuous inhaled iNO-enriched gas is shown to effectively reduce these issues in this case report.
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2021)
Article
Engineering, Biomedical
Kelly M. Ivins-O'Keefe, Michael S. Cahill, Arthur R. Mielke, Michal J. Sobieszczyk, Valerie G. Sams, Phillip E. Mason, Matthew D. Read
Summary: This study describes the use of percutaneous pulmonary artery cannulation for conversion from veno-venous to veno-pulmonary artery ECMO in patients with secondary right heart failure. The technique reduced vasoactive infusion requirements, but the mortality rate remained high, with some patients experiencing complications related to pericardial effusion during emergency treatment.
Article
Engineering, Biomedical
Marina Rieder, Daniel Duerschmied, Timm Zahn, Corinna Lang, Christoph Benk, Achim Lother, Paul Biever, Christoph Bode, Tobias Wengenmayer, Dawid Staudacher, Alexander Supady
Summary: This study reports on nine severe ARDS patients treated with V-V ECMO and CytoSorb adsorber, compared with a control group of nine similarly treated patients without cytokine adsorption. Despite prediction models suggesting higher mortality in the cytokine adsorption group, patients undergoing V-V ECMO and cytokine removal had reduced mortality compared to those receiving V-V ECMO alone. The cytokine adsorption group showed significant improvements in fluid resuscitation, vasopressor support, and lactate levels within 72 hours, indicating potential benefits for patients with severe ARDS requiring V-V ECMO support.
Article
Cardiac & Cardiovascular Systems
Yu Bai, Shengsong Chen, Zeyu Zhang, Xu Huang, Jingen Xia, Min Li, Qingyuan Zhan
Summary: This study analyzed the epidemiology and risk factors for barotrauma in ARDS patients undergoing ECMO treatment in a large ECMO center in China. The results showed that barotrauma occurred in 18.9% of ARDS patients during ECMO, mainly in the late stage of ARDS and after 8 days of ECMO. Young age, PJP, elevated body temperature, and low platelet count after establishing ECMO were identified as risk factors for barotrauma. This study highlights the importance of closely monitoring barotrauma in high-risk patients, especially in the late stage of ARDS.
RESPIRATORY MEDICINE
(2023)
Article
Health Care Sciences & Services
Jan Naar, Andreas Kruger, Dagmar Vondrakova, Marek Janotka, Jan Kubele, Robert Lischke, Milena Kolarova, Petr Neuzil, Petr Ostadal
Summary: This case report highlights the use of prolonged VV-ECMO therapy as a bridge to lung transplantation in severe COVID-19 cases, despite numerous infectious complications. The patient in this case experienced multiple superinfections and required antimicrobial treatment for an extended period before undergoing a successful lung transplantation after 207 days of VV-ECMO support.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Anesthesiology
Jose R. Navas-Blanco, Sofia A. Lifgren, Roman Dudaryk, Jeffrey Scott, Matthias Loebe, Ali Ghodsizad
Summary: This case presents a novel approach using parallel veno-venous and veno-arterial ECMO circuits for a patient with severe ARDS and cardiovascular collapse. The use of four-cannulation/parallel-circuits ECMO successfully controlled refractory hypoxemia and cardiogenic shock, illustrating the expanding capabilities of ECMO techniques in life-threatening situations.
BMC ANESTHESIOLOGY
(2021)
Article
Critical Care Medicine
Gregor Loosen, Alice Marguerite Conrad, Michael Hagman, Nils Essert, Manfred Thiel, Thomas Luecke, Joerg Krebs
Summary: In severe ARDS patients, ECMO blood flow does not affect SV measurements with TPTD, but does affect EVLWI. Echo and TPTD measurements are not interchangeable. Caution should be exercised when interpreting EVLWI, especially with high blood flow in the extracorporeal circulation.
ANNALS OF INTENSIVE CARE
(2021)
